vitamin d binding protein

Summary

Summary: An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.

Top Publications

  1. Engelman C, Fingerlin T, Langefeld C, Hicks P, Rich S, Wagenknecht L, et al. Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab. 2008;93:3381-8 pubmed publisher
    ..After adjusting for gender and age within the site, two single nucleotide polymorphisms (SNPs) in the vitamin D binding protein gene (DBP), rs4588 and rs7041, were associated with 25(OH)D, and one SNP in the DBP, rs4588, was ..
  2. Gressner O, Lahme B, Gressner A. Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca(2+)-dependent interaction with the megalin/gp330 receptor. Clin Chim Acta. 2008;390:28-37 pubmed publisher
    Gc-globulin or vitamin D binding protein is a highly expressed, multifunctional and polymorphic serum protein, which also serves as the major transporter for vitamin D metabolites in the circulation...
  3. Speeckaert M, Huang G, Delanghe J, Taes Y. Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta. 2006;372:33-42 pubmed
    The vitamin D binding protein (DBP) is the major plasma carrier protein of vitamin D and its metabolites. Unlike other hydrophobic hormone-binding systems, it circulates in a considerably higher titer compared to its ligands...
  4. Gomme P, Bertolini J. Therapeutic potential of vitamin D-binding protein. Trends Biotechnol. 2004;22:340-5 pubmed
    ..Exploitation of the unique properties of DBP could enable the development of important therapeutic agents for the treatment of a variety of diseases. ..
  5. Gravholt C, Leth Larsen R, Lauridsen A, Thiel S, Hansen T, Holmskov U, et al. The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome. Eur J Endocrinol. 2004;150:355-62 pubmed
    ..of MBL and two other proteins partaking in the innate immune defence, surfactant protein D (SP-D) and vitamin D binding protein (DBP)...
  6. Nestler J, McLeod J, Kowalski M, Strauss J, Haddad J. Detection of vitamin D binding protein on the surface of cytotrophoblasts isolated from human placentae. Endocrinology. 1987;120:1996-2002 pubmed
    b>Vitamin D binding protein (DBP), a Mr 56,000-58,000 alpha 2-glycoprotein, is the major serum protein involved in the transport of vitamin D sterols...
  7. Shen L, Zhang X, Su D, Yao S, Yu B, Wang H, et al. Association of vitamin D binding protein variants with susceptibility to chronic obstructive pulmonary disease. J Int Med Res. 2010;38:1093-8 pubmed
    ..These data suggest that the VDBP gene may be involved in COPD susceptibility in Chinese Han population. ..
  8. Braun A, Bichlmaier R, Cleve H. Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types. Hum Genet. 1992;89:401-6 pubmed
    ..We discuss this finding as a recombination event or a possible silent allele in IEF typing. The GC polymorphism revealed by Southern blot analysis of StyI-digests provides an informative DNA marker system for chromosome 4q11-q13. ..
  9. Jirikowski G, Kaunzner U, Kauntzer U, Dief A, Caldwell J. Distribution of vitamin D binding protein expressing neurons in the rat hypothalamus. Histochem Cell Biol. 2009;131:365-70 pubmed publisher
    We observed immunostaining for vitamin D binding protein (DBP) in rat hypothalamus. Part of the supraoptic and of the paraventricular neurons showed DBP immunoreactivity, in part colocalized with Arg-vasopressin...

More Information

Publications62

  1. Shah A, DiMartino S, Trujillo G, Kew R. Selective inhibition of the C5a chemotactic cofactor function of the vitamin D binding protein by 1,25(OH)2 vitamin D3. Mol Immunol. 2006;43:1109-15 pubmed
    The Vitamin D binding protein (DBP) is a multifunctional plasma protein that can significantly enhance the chemotactic response to complement fragment C5a...
  2. Norman A, Ishizuka S, Okamura W. Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding protein. J Steroid Biochem Mol Biol. 2001;76:49-59 pubmed
    ..and other tissues which metabolize vitamin D(3) into biologically active metabolites; (b) the plasma vitamin D binding protein (DBP) which selectively transports these hydrophobic molecules to the various target organs of the ..
  3. Swamy N, Ghosh S, Schneider G, Ray R. Baculovirus-expressed vitamin D-binding protein-macrophage activating factor (DBP-maf) activates osteoclasts and binding of 25-hydroxyvitamin D(3) does not influence this activity. J Cell Biochem. 2001;81:535-46 pubmed
    ..coli expressed recombinant DBP is non-glycosylated, whereas the baculovirus expressed form is glycosylated. These data support the essential role of glycosylation for the osteoclast activating property of DBP-maf. ..
  4. Cooke N. Rat vitamin D binding protein. Determination of the full-length primary structure from cloned cDNA. J Biol Chem. 1986;261:3441-50 pubmed
    b>Vitamin D binding protein (DBP) is an abundant serum glycoprotein secreted by the liver which transports vitamin D sterols, binds to actin, and is found on the surface of B-lymphocytes and subpopulations of T-lymphocytes...
  5. Schiødt F, Bangert K, Shakil A, McCashland T, Murray N, Hay J, et al. Predictive value of actin-free Gc-globulin in acute liver failure. Liver Transpl. 2007;13:1324-9 pubmed
    ..A new enzyme-linked immunosorbent assay for actin-free Gc-globulin provides the same (but not optimal) prognostic information as KCH criteria in a single measurement at admission. ..
  6. Nykjaer A, Dragun D, Walther D, Vorum H, Jacobsen C, Herz J, et al. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell. 1999;96:507-15 pubmed
    ..Megalin-/- mice are unable to retrieve the steroid from the glomerular filtrate and develop vitamin D deficiency and bone disease. ..
  7. Song Y, Naumova A, Liebhaber S, Cooke N. Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster. Genome Res. 1999;9:581-7 pubmed
    The vitamin D binding protein/Gc-globulin (DBP) gene is a member of a multigene cluster that includes albumin (ALB), alpha-fetoprotein (AFP), and alpha-albumin/afamin (AFM)...
  8. Yokoyama Y, Terai S, Ishikawa T, Aoyama K, Urata Y, Marumoto Y, et al. Proteomic analysis of serum marker proteins in recipient mice with liver cirrhosis after bone marrow cell transplantation. Proteomics. 2006;6:2564-70 pubmed
    ..ApoA1 increased at early stage (48 h and 1 wk) after BMC transplantation in this mouse model of liver cirrhosis. The early elevation of apoA1 might be useful to predict liver regeneration in cirrhotic mice after BMC transplantation. ..
  9. Fang Y, van Meurs J, Arp P, van Leeuwen J, Hofman A, Pols H, et al. Vitamin D binding protein genotype and osteoporosis. Calcif Tissue Int. 2009;85:85-93 pubmed publisher
    ..As a candidate gene for osteoporosis, we studied vitamin D binding protein (DBP, or group-specific component, Gc), which binds to and transports vitamin D to target tissues to ..
  10. Fu L, Yun F, Oczak M, Wong B, Vieth R, Cole D. Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation. Clin Biochem. 2009;42:1174-7 pubmed publisher
    To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year...
  11. Ray K, Wang X, Zhao M, Cooke N. The rat vitamin D binding protein (Gc-globulin) gene. Structural analysis, functional and evolutionary correlations. J Biol Chem. 1991;266:6221-9 pubmed
    The complete rat vitamin D binding protein (DBP) gene has been cloned and characterized. Genomic mapping suggests that there is only one copy of this gene in the haploid genome. The gene spans 35 kilobase pairs and contains 13 exons...
  12. Witke W, Gibbs P, Zielinski R, Yang F, Bowman B, Dugaiczyk A. Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family. Genomics. 1993;16:751-4 pubmed
    ..Although the mRNA and protein expressed from the Gc gene are significantly smaller, the gene itself is about 2.5 times larger than the other genes of the family.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  13. Bolland M, Grey A, Ames R, Horne A, Mason B, Wattie D, et al. Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binding protein. Clin Endocrinol (Oxf). 2007;67:259-64 pubmed
    ..We hypothesized that these findings might be explained by effects of these variables on vitamin D binding protein (DBP) levels...
  14. Antoniades C, Berry P, Bruce M, Cross T, Portal A, Hussain M, et al. Actin-free Gc globulin: a rapidly assessed biomarker of organ dysfunction in acute liver failure and cirrhosis. Liver Transpl. 2007;13:1254-61 pubmed
  15. Yang F, Brune J, Naylor S, Cupples R, Naberhaus K, Bowman B. Human group-specific component (Gc) is a member of the albumin family. Proc Natl Acad Sci U S A. 1985;82:7994-8 pubmed
    ..Gc cDNA was used as a probe in Southern blot analysis of somatic-cell hybrids to confirm that the Gc locus is on chromosome 4. ..
  16. Taes Y, Goemaere S, Huang G, Van Pottelbergh I, De Bacquer D, Verhasselt B, et al. Vitamin D binding protein, bone status and body composition in community-dwelling elderly men. Bone. 2006;38:701-7 pubmed
    The vitamin D binding protein (DBP) is the major carrier protein for vitamin D metabolites in plasma. Polymorphisms in DBP have been described to be associated with an increased bone fracture risk and diabetes...
  17. Lauridsen A, Vestergaard P, Hermann A, Brot C, Heickendorff L, Mosekilde L, et al. Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women. Calcif Tissue Int. 2005;77:15-22 pubmed
    ..In conclusion, plasma 1,25(OH)(2)D, 25OHD, and 25OHD index are related to Gc phenotype, and we speculate that the thresholds for vitamin D sufficiency differ between Gc phenotypes. ..
  18. Lu M, Yang B, Cai Y. [The relationship between vitamin D binding protein gene polymorphism and chronic obstructive pulmonary disease]. Zhonghua Nei Ke Za Zhi. 2004;43:117-20 pubmed
    To determine the association between vitamin D binding protein (VDBP) gene and chronic obstructive pulmonary disease (COPD) susceptibility in Han Nationality in China. This was a case-control study...
  19. Zhang J, Habiel D, Ramadass M, Kew R. Identification of two distinct cell binding sequences in the vitamin D binding protein. Biochim Biophys Acta. 2010;1803:623-9 pubmed publisher
    The vitamin D binding protein (DBP) is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions...
  20. Borges C, Jarvis J, Oran P, Rogers S, Nelson R. Population studies of intact vitamin D binding protein by affinity capture ESI-TOF-MS. J Biomol Tech. 2008;19:167-76 pubmed
    ..required to couple mass spectrometric immunoassay with electrospray ionization mass spectrometry for the purpose of qualitatively characterizing a prototypical large plasma protein, vitamin D binding protein, across populations.
  21. Sinotte M, Diorio C, Bérubé S, Pollak M, Brisson J. Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. Am J Clin Nutr. 2009;89:634-40 pubmed publisher
    ..b>Vitamin D binding protein (DBP) is the major carrier of vitamin D and its metabolites, but the role of DBP single nucleotide ..
  22. Kisker O, Onizuka S, Becker C, Fannon M, Flynn E, D AMATO R, et al. Vitamin D binding protein-macrophage activating factor (DBP-maf) inhibits angiogenesis and tumor growth in mice. Neoplasia. 2003;5:32-40 pubmed
    We have isolated a selectively deglycosylated form of vitamin D binding protein (DBP-maf) generated from systemically available DBP by a human pancreatic cancer cell line...
  23. Laing C, Fraser D. Changes with malnutrition in the concentration of plasma vitamin D binding protein in growing rats. Br J Nutr. 2002;88:133-9 pubmed
    ..deficiencies on the characteristics of the plasma transport protein for vitamin D and its metabolites (vitamin D binding protein, DBP) in the growing rat...
  24. Lauridsen A, Vestergaard P, Hermann A, Moller H, Mosekilde L, Nexo E. Female premenopausal fracture risk is associated with gc phenotype. J Bone Miner Res. 2004;19:875-81 pubmed
    ..The multifunctional plasma protein Gc, also known as group-specific component, Gc globulin, or vitamin D binding protein (DBP), has two functions with relation to bone tissue: it is the major carrier protein of vitamin D in ..
  25. McLeod J, Cooke N. The vitamin D-binding protein, alpha-fetoprotein, albumin multigene family: detection of transcripts in multiple tissues. J Biol Chem. 1989;264:21760-9 pubmed
  26. Qin Z, Qin Y, Liu S. Alteration of DBP levels in CSF of patients with MS by proteomics analysis. Cell Mol Neurobiol. 2009;29:203-10 pubmed publisher
    ..These results support a correlation between the level of DBP and MS. DBP may be a potential useful biomarker for diagnosis or a medicine target for treatment of MS. ..
  27. Rehder D, Nelson R, Borges C. Glycosylation status of vitamin D binding protein in cancer patients. Protein Sci. 2009;18:2036-42 pubmed publisher
    On the basis of the results of activity studies, previous reports have suggested that vitamin D binding protein (DBP) is significantly or even completely deglycosylated in cancer patients, eliminating the molecular precursor of the ..
  28. Gasparri C, Curcio A, Torella D, Gaspari M, Celi V, Salituri F, et al. Proteomics reveals high levels of vitamin D binding protein in myocardial infarction. Front Biosci (Elite Ed). 2010;2:796-804 pubmed
    ..Moreover, fresh thrombotic plaques, obtained during primary angioplasty, showed high expression of VDB protein. Mechanistically, VDB protein reduces platelet aggregation and prolongs coagulation time ex vivo. ..
  29. Pawlik T, Hawke D, Liu Y, Krishnamurthy S, Fritsche H, Hunt K, et al. Proteomic analysis of nipple aspirate fluid from women with early-stage breast cancer using isotope-coded affinity tags and tandem mass spectrometry reveals differential expression of vitamin D binding protein. BMC Cancer. 2006;6:68 pubmed
    ..Proteomic screening techniques using ICAT and NAF may be used to find markers for diagnosis of breast cancer. ..
  30. Lichenstein H, Lyons D, Wurfel M, Johnson D, McGinley M, Leidli J, et al. Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family. J Biol Chem. 1994;269:18149-54 pubmed
    ..Both rAFM and AFM purified from human serum react with a polyclonal antibody that was raised against a synthetic peptide derived from the deduced amino acid sequence of AFM. ..
  31. Safadi F, Thornton P, Magiera H, Hollis B, Gentile M, Haddad J, et al. Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J Clin Invest. 1999;103:239-51 pubmed
    A line of mice deficient in vitamin D binding protein (DBP) was generated by targeted mutagenesis to establish a model for analysis of DBP's biological functions in vitamin D metabolism and action...
  32. Song Y, Ray K, Liebhaber S, Cooke N. Vitamin D-binding protein gene transcription is regulated by the relative abundance of hepatocyte nuclear factors 1alpha and 1beta. J Biol Chem. 1998;273:28408-18 pubmed
  33. Powe C, Seely E, Rana S, Bhan I, Ecker J, Karumanchi S, et al. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension. 2010;56:758-63 pubmed publisher
    ..Circulating vitamin D is almost entirely bound to vitamin D binding protein, which increases 2-fold during pregnancy and previous studies have not examined vitamin D binding ..
  34. Yang F, Bergeron J, Linehan L, Lalley P, Sakaguchi A, Bowman B. Mapping and conservation of the group-specific component gene in mouse. Genomics. 1990;7:509-16 pubmed
    ..The mouse GC gene was mapped to chromosome 5, where the ALB and AFP genes are also located, demonstrating conservation of the three genes in vertebrate species. ..
  35. Rowling M, Kemmis C, Taffany D, Welsh J. Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells. J Nutr. 2006;136:2754-9 pubmed
    ..is 25-hydroxycholecalciferol [25(OH)D3], which is delivered to target tissues in complex with the serum vitamin D binding protein (DBP)...
  36. Cooke N, David E. Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family. J Clin Invest. 1985;76:2420-4 pubmed
    ..Based upon this structural comparison, we establish that DBP is a member of the ALB and AFP gene family. ..
  37. Kew R, Sibug M, Liuzzo J, Webster R. Localization and quantitation of the vitamin D binding protein (Gc-globulin) in human neutrophils. Blood. 1993;82:274-83 pubmed
    Plasma-derived vitamin D binding protein (DBP) is an important physiologic regulator of the neutrophil chemotactic response to activated complement. A cell-associated form of DBP has been observed in numerous cell types...
  38. Malecki M, Klupa T, Wanic K, Cyganek K, Frey J, Sieradzki J. Vitamin D binding protein gene and genetic susceptibility to type 2 diabetes mellitus in a Polish population. Diabetes Res Clin Pract. 2002;57:99-104 pubmed
    ..For example, there is evidence suggesting that vitamin D binding protein (DBP) amino acid variants at codons 416 (aspartic acid-->glutamic acid) and 420 (threonine-->..
  39. Kidd L, Paltoo D, Wang S, Chen W, Akereyeni F, Isaacs W, et al. Sequence variation within the 5' regulatory regions of the vitamin D binding protein and receptor genes and prostate cancer risk. Prostate. 2005;64:272-82 pubmed
    ..Confirmation of these findings is needed in larger observational studies. ..
  40. Dahl B, Schiødt F, Ott P, Wians F, Lee W, Balko J, et al. Plasma concentration of Gc-globulin is associated with organ dysfunction and sepsis after injury. Crit Care Med. 2003;31:152-6 pubmed
  41. Braun A, Bichlmaier R, Muller B, Cleve H. Molecular evaluation of an Alu repeat including a polymorphic variable poly(dA) (AluVpA) in the vitamin D binding protein (DBP) gene. Hum Genet. 1993;90:526-32 pubmed
  42. López Farré A, Mateos Cáceres P, Sacristán D, Azcona L, Bernardo E, de Prada T, et al. Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients: a proteomic study. J Proteome Res. 2007;6:2481-7 pubmed
    ..Three vitamin D binding protein isotypes were increased in ASA-resistant patients...
  43. Willnow T, Nykjaer A. Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3. Curr Opin Lipidol. 2002;13:255-60 pubmed
    ..In the present review, we describe the molecular components (e.g. steroid carriers, endocytic receptors and intracellular transport proteins) that constitute this novel pathway for tissue-specific uptake of vitamin D metabolites. ..
  44. Otterbein L, Cosio C, Graceffa P, Dominguez R. Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system. Proc Natl Acad Sci U S A. 2002;99:8003-8 pubmed
    ..Formation of the strong actin-DBP complex proceeds with limited conformational changes to both proteins, demonstrating how DBP has evolved to become an effective actin-scavenger protein. ..
  45. Ezura Y, Nakajima T, Kajita M, Ishida R, Inoue S, Yoshida H, et al. Association of molecular variants, haplotypes, and linkage disequilibrium within the human vitamin D-binding protein (DBP) gene with postmenopausal bone mineral density. J Bone Miner Res. 2003;18:1642-9 pubmed
    ..029, p = 0.005). These results indicate a complex combined effect of several SNPs within the DBP gene that might underlie susceptibility to low radial BMD and osteoporosis. ..
  46. Laufs J, Andrason H, Sigvaldason A, Halapi E, Thorsteinsson L, Jonasson K, et al. Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland. Am J Pharmacogenomics. 2004;4:63-8 pubmed
    Previous studies of vitamin D binding protein (VDBP, also known as group-specific component, Gc, encoded by the GC gene) have implicated two gene variants, GC*2 and GC*1F, as possible contributors with chronic obstructive pulmonary ..
  47. Cooke N, Willard H, David E, George D. Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism. Hum Genet. 1986;73:225-9 pubmed
    Using a characterized human vitamin D binding protein (DBP) cDNA probe and a panel of rodent X human somatic cell hybrids, we established the chromosomal location of the structural gene for DBP on human chromosome 4...
  48. Meier U, Gressner O, Lammert F, Gressner A. Gc-globulin: roles in response to injury. Clin Chem. 2006;52:1247-53 pubmed
    ..Considering the important physiologic roles of Gc-globulin in responses to tissue injury, such as clearance of actin, measurement of Gc-globulin may have value in directing the care of patients in many clinical disorders. ..
  49. Leheste J, Melsen F, Wellner M, Jansen P, Schlichting U, Renner Müller I, et al. Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J. 2003;17:247-9 pubmed
    ..These features are consistent with osteomalacia (softening of the bones) as a consequence of hypovitaminosis D and demonstrate the crucial importance of the megalin pathway for systemic calcium homeostasis and bone metabolism. ..
  50. Borges C, Jarvis J, Oran P, Nelson R. Population studies of Vitamin D Binding Protein microheterogeneity by mass spectrometry lead to characterization of its genotype-dependent O-glycosylation patterns. J Proteome Res. 2008;7:4143-53 pubmed publisher
    ..the genotype-dependent glycosylation patterns for each of the three major allele products of Vitamin D Binding Protein found in the general human population...
  51. Abbas S, Linseisen J, Slanger T, Kropp S, Mutschelknauss E, Flesch Janys D, et al. The Gc2 allele of the vitamin D binding protein is associated with a decreased postmenopausal breast cancer risk, independent of the vitamin D status. Cancer Epidemiol Biomarkers Prev. 2008;17:1339-43 pubmed publisher
    ..The association between polymorphisms in the vitamin D binding protein (Gc) and postmenopausal breast cancer risk, with additional focus on the influence of serum 25-..
  52. Ho A, Cheng C, Lee S, Liu M, Lee J, Wang W, et al. Novel biomarkers predict liver fibrosis in hepatitis C patients: alpha 2 macroglobulin, vitamin D binding protein and apolipoprotein AI. J Biomed Sci. 2010;17:58 pubmed publisher
    ..Three prominent candidate biomarkers were identified: alpha 2 macroglobulin (A2M) is up regulated; vitamin D binding protein (VDBP) and apolipoprotein AI (ApoAI) are down regulated...
  53. Speeckaert M, Wehlou C, Vandewalle S, Taes Y, Robberecht E, Delanghe J. Vitamin D binding protein, a new nutritional marker in cystic fibrosis patients. Clin Chem Lab Med. 2008;46:365-70 pubmed publisher
    b>Vitamin D binding protein (DBP) is a multifunctional transport protein with a decreased serum concentration in cystic fibrosis (CF)...