transferrin binding proteins


Summary: A class of carrier proteins that bind to TRANSFERRIN. Many strains of pathogenic bacteria utilize transferrin-binding proteins to acquire their supply of iron from serum.

Top Publications

  1. Baltes N, Hennig Pauka I, Gerlach G. Both transferrin binding proteins are virulence factors in Actinobacillus pleuropneumoniae serotype 7 infection. FEMS Microbiol Lett. 2002;209:283-7 pubmed
    ..This result clearly implies that each transferrin binding protein on its own is a virulence factor of A. pleuropneumoniae serotype 7...
  2. Gray Owen S, Schryvers A. Characterization of transferrin binding proteins 1 and 2 in invasive type b and nontypeable strains of Haemophilus influenzae. Infect Immun. 1995;63:3809-15 pubmed
    ..influenzae has the ability to obtain iron from human transferrin via two bacterial cell surface transferrin binding proteins, Tbp1 and Tbp2...
  3. Reyes Lopez M, Serrano Luna J, Negrete Abascal E, Leon Sicairos N, Guerrero Barrera A, de la Garza M. Entamoeba histolytica: transferrin binding proteins. Exp Parasitol. 2001;99:132-40 pubmed
    ..we report that amoebas are able to utilize human holo-Tf as iron source and to recognize it through transferrin binding proteins. By use of an anti-human transferrin antiserum in an immunoblotting assay, two main polypeptides with ..
  4. Vonder Haar R, Legrain M, Kolbe H, Jacobs E. Characterization of a highly structured domain in Tbp2 from Neisseria meningitidis involved in binding to human transferrin. J Bacteriol. 1994;176:6207-13 pubmed
  5. Bhatt R, Ala Aldeen D, Baldwin T, Borriello S. The 126 kDa iron-regulated protein of Listeria monocytogenes is not a transferrin binding protein. FEMS Microbiol Lett. 1994;123:119-23 pubmed
    ..It is evident from results presented here that this is not so and that the observation of others resulted from interaction of this 126 kDa protein with streptavidin. ..
  6. Hastings R, Walker G, Eyheralde I, Dawson S, Billett M, Mayer R. Activator complexes containing the proteasomal regulatory ATPases S10b (SUG2) and S6 (TBP1) in different tissues and organisms. Mol Biol Rep. 1999;26:35-8 pubmed
    ..Finally, there is no evidence for other ATPases in the activator complex. ..
  7. Wilke M, Franz B, Gerlach G. Characterization of a large transferrin-binding protein from Actinobacillus pleuropneumoniae serotype 7. Zentralbl Veterinarmed B. 1997;44:73-86 pubmed
    ..A preliminary animal experiment showed that TfbB-containing outer membrane preparations from recombinant E. coli can reduce significantly the mortality of an A.pp. infection with the homologous strain. ..
  8. Boulton I, Gorringe A, Carr R, Gorinsky B, Joannou C, Evans R. Characterisation of the meningococcal transferrin binding protein complex by photon correlation spectroscopy. FEBS Lett. 1997;414:409-13 pubmed
    ..Purified TbpA and TbpB had similar apparent sizes but showed distinctive size profiles suggesting that TbpA forms a largely homogeneous population while TbpB may produce more variable particle sizes under these conditions. ..
  9. Potter A, Schryvers A, Ogunnariwo J, Hutchins W, Lo R, Watts T. Protective capacity of the Pasteurella haemolytica transferrin-binding proteins TbpA and TbpB in cattle. Microb Pathog. 1999;27:197-206 pubmed
    ..Sera from the TbpB-immunized animals was cross-reactive with TbpBs from other P. haemolytica serotypes. ..

More Information

Publications106 found, 100 shown here

  1. Landry C, Topham R. Purification and characterization of an iron-binding protein from the blue crab (Callinectes sapidus). Comp Biochem Physiol B. 1990;97:831-6 pubmed
  2. Lissolo L, Maitre Wilmotte G, Dumas P, Mignon M, Danve B, Quentin Millet M. Evaluation of transferrin-binding protein 2 within the transferrin-binding protein complex as a potential antigen for future meningococcal vaccines. Infect Immun. 1995;63:884-90 pubmed
    ..This suggests that Tbp2 plays an important role in the protective activity of the complex, eliciting antibodies that are not only bactericidal but also inhibitory for meningococcal growth. ..
  3. Pintor M, Ferron L, Gomez J, Gorringe A, Criado M, Ferreiros C. Blocking of iron uptake by monoclonal antibodies specific for the Neisseria meningitidis transferrin-binding protein 2. J Med Microbiol. 1996;45:252-7 pubmed
    ..These epitopes may become denatured after drying for dot-blot assays or after SDS-PAGE and electroblotting. ..
  4. Rokbi B, Mignon M, Caugant D, Quentin Millet M. Heterogeneity of tbpB, the transferrin-binding protein B gene, among serogroup B Neisseria meningitidis strains of the ET-5 complex. Clin Diagn Lab Immunol. 1997;4:522-9 pubmed
  5. Retzer M, Yu R, Schryvers A. Identification of sequences in human transferrin that bind to the bacterial receptor protein, transferrin-binding protein B. Mol Microbiol. 1999;32:111-21 pubmed
    ..Collectively, these results provide evidence that TbpB consists of two lobes, each with distinct yet homologous Tf-binding regions. ..
  6. Yu R, Schryvers A. The interaction between human transferrin and transferrin binding protein 2 from Moraxella (Branhamella) catarrhalis differs from that of other human pathogens. Microb Pathog. 1993;15:433-45 pubmed
    The interaction between human transferrin and the transferrin binding proteins of Moraxella catarrhalis was studied by binding and affinity isolation experiments with transferrin and its derivatives...
  7. Rokbi B, Renauld Mongenie G, Mignon M, Danve B, Poncet D, Chabanel C, et al. Allelic diversity of the two transferrin binding protein B gene isotypes among a collection of Neisseria meningitidis strains representative of serogroup B disease: implication for the composition of a recombinant TbpB-based vaccine. Infect Immun. 2000;68:4938-47 pubmed
  8. Kahler C, Blum E, Miller Y, Ryan D, Popovic T, Stephens D. exl, an exchangeable genetic island in Neisseria meningitidis. Infect Immun. 2001;69:1687-96 pubmed publisher
    ..The structure of these cassettes and their correlation with clonal groups emphasize the extensive gene pool and frequent horizontal DNA transfer events that contribute to the evolution and virulence of N. meningitidis...
  9. Nunez M, Pinto I, Glass J. Assay and characteristics of the iron binding moiety of reticulocyte endocytic vesicles. J Membr Biol. 1989;107:129-35 pubmed
  10. Karalus R, Campagnari A. Moraxella catarrhalis: a review of an important human mucosal pathogen. Microbes Infect. 2000;2:547-59 pubmed
    ..This review will summarize the research pertaining to the epidemiology and components of pathogenesis in M. catarrhalis. ..
  11. Katoh H, Hagino N, Ogawa T. Iron-binding activity of FutA1 subunit of an ABC-type iron transporter in the cyanobacterium Synechocystis sp. Strain PCC 6803. Plant Cell Physiol. 2001;42:823-7 pubmed
    ..High concentrations of citrate inhibited ferric iron uptake. These results suggest that the natural iron source transported by the Fut system is not ferric citrate...
  12. Rokbi B, Maitre Wilmotte G, Mazarin V, Fourrichon L, Lissolo L, Quentin Millet M. Variable sequences in a mosaic-like domain of meningococcal tbp2 encode immunoreactive epitopes. FEMS Microbiol Lett. 1995;132:277-83 pubmed
    ..Sequence analysis suggested a mosaic-like organisation of the tbp2 genes. Taken together, these data suggest that the antigenic variation in this part of the protein may result from a strong host immune pressure. ..
  13. Gray Owen S, Loosmore S, Schryvers A. Identification and characterization of genes encoding the human transferrin-binding proteins from Haemophilus influenzae. Infect Immun. 1995;63:1201-10 pubmed
  14. Gulbis B, Jauniaux E, Decuyper J, Thiry P, Jurkovic D, Campbell S. Distribution of iron and iron-binding proteins in first-trimester human pregnancies. Obstet Gynecol. 1994;84:289-93 pubmed
    ..The exocoelomic fluid is probably the main iron reservoir in early pregnancy, and the secondary yolk sac is probably the principal route of entry of iron to the embryo. ..
  15. Rokbi B, Mignon M, Maitre Wilmotte G, Lissolo L, Danve B, Caugant D, et al. Evaluation of recombinant transferrin-binding protein B variants from Neisseria meningitidis for their ability to induce cross-reactive and bactericidal antibodies against a genetically diverse collection of serogroup B strains. Infect Immun. 1997;65:55-63 pubmed
  16. Lehmann A, Gorringe A, Reddin K, West K, Smith I, Halstensen A. Human opsonins induced during meningococcal disease recognize transferrin binding protein complexes. Infect Immun. 1999;67:6526-32 pubmed
    ..The anti-TbpA+B opsonic activities were not affected by the variability of the TbpB proteins of the disease-causing strains, which further adds to the evidence for the vaccine potential of meningococcal TbpA+B complexes. ..
  17. Brieske N, Schenker M, Schnibbe T, Quentin Millet M, Achtman M. Human antibody responses to A and C capsular polysaccharides, IgA1 protease and transferrin-binding protein complex stimulated by infection with Neisseria meningitidis of subgroup IV-1 or ET-37 complex. Vaccine. 1999;17:731-44 pubmed
    ..5 microg ml(-1)). The concentrations of IgG to TBP complex in acute phase sera were higher and IgG to IgA1 protease was even higher, suggesting that intermediate levels of IgG to these proteins do not protect against disease. ..
  18. Sorrentino S, D Alessandro A, Maras B, Di Ciccio L, D Andrea G, De Prisco R, et al. Purification of a 76-kDa iron-binding protein from human seminal plasma by affinity chromatography specific for ribonuclease: structural and functional identity with milk lactoferrin. Biochim Biophys Acta. 1999;1430:103-10 pubmed
    ..When tested for its iron binding capacity, with Fe-NTA as iron donor, the protein purified was able to bind iron up to 100% saturation, as judged by absorbance at 465 nm. ..
  19. Holland J, Langford P, Towner K, Williams P. Evidence for in vivo expression of transferrin-binding proteins in Haemophilus influenzae type b. Infect Immun. 1992;60:2986-91 pubmed
    ..These findings indicate that the H. influenzae type b transferrin receptor is expressed during experimental animal and human infections. ..
  20. Lambrecht R, Collins M. Inability to detect mycobactin in mycobacteria-infected tissues suggests an alternative iron acquisition mechanism by mycobacteria in vivo. Microb Pathog. 1993;14:229-38 pubmed
    ..In addition, evidence is presented that suggests iron-containing transferrin and lactoferrin at low pH may circumvent the need for mycobactin by M. paratuberculosis. ..
  21. Marchetti M, Longhi C, Conte M, Pisani S, Valenti P, Seganti L. Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells. Antiviral Res. 1996;29:221-31 pubmed
    ..BLf interacts with both Vero cell surfaces and HSV-1 particles, suggesting that the hindrance of cellular receptors and/or of viral attachment proteins may be involved in its antiviral mechanism. ..
  22. Stevenson P, Williams P, Griffiths E. Common antigenic domains in transferrin-binding protein 2 of Neisseria meningitidis, Neisseria gonorrhoeae, and Haemophilus influenzae type b. Infect Immun. 1992;60:2391-6 pubmed
    ..influenzae type b, thus showing the presence of common antigenic domains among these functionally equivalent proteins in different pathogens; no cross-reaction was detected with a purified sample of the human transferrin receptor. ..
  23. Kennard M, Feldman H, Yamada T, Jefferies W. Serum levels of the iron binding protein p97 are elevated in Alzheimer's disease. Nat Med. 1996;2:1230-5 pubmed
    ..This biochemical marker has the potential for identifying subjects afflicted with the disease and possibly for monitoring the onset and longitudinal progression of the disease. ..
  24. Cho S, Lucas J. Immunocytochemical study with an anti-transferrin binding protein serum: a marker for avian oligodendrocytes. Brain Res. 1995;674:15-25 pubmed
    ..We conclude that this chick TfBP antiserum will prove useful in studies of oligodendrocytes and myelination in the avian CNS. ..
  25. Cornelissen C, Anderson J, Boulton I, Sparling P. Antigenic and sequence diversity in gonococcal transferrin-binding protein A. Infect Immun. 2000;68:4725-35 pubmed
    ..In addition, we evaluated a panel of gonococcal strains for antigenic diversity using these antipeptide sera...
  26. Wösten M, Kox L, Chamnongpol S, Soncini F, Groisman E. A signal transduction system that responds to extracellular iron. Cell. 2000;103:113-25 pubmed
    ..A pmrA mutant was hypersensitive to killing by iron but displayed wild-type resistance to a variety of oxidants, suggesting PmrA/PmrB controls a novel pathway mediating the avoidance of iron toxicity. ..
  27. Gerlach G, Anderson C, Potter A, Klashinsky S, Willson P. Cloning and expression of a transferrin-binding protein from Actinobacillus pleuropneumoniae. Infect Immun. 1992;60:892-8 pubmed
    ..Southern blot analysis of several other A. pleuropneumoniae strains indicated that highly homologous sequence is present in eight of eight isolates of serotype 7 and in some isolates of serotypes 2, 3, and 4. ..
  28. Boulton I, Yost M, Anderson J, Cornelissen C. Identification of discrete domains within gonococcal transferrin-binding protein A that are necessary for ligand binding and iron uptake functions. Infect Immun. 2000;68:6988-96 pubmed
    ..The phenotype of the DeltaL8TbpA mutant suggests that high-affinity ligand interaction is required for transferrin-iron internalization. ..
  29. Park S, Lim H, Roh E, Kim D, Jeon G, Cho S. Developmental expression of transferrin binding protein in oligodendrocyte lineage cells of the embryonic chick spinal cord. Neurochem Res. 2007;32:11-8 pubmed
    ..Our observations suggest that TfBP is expressed in the subpopulation of oligodendrocyte lineage in the development and a putative role of TfBP in relation to transferrin and iron trafficking is considered. ..
  30. Gonzalez G, Yu R, Rosteck P, Schryvers A. Sequence, genetic analysis, and expression of Actinobacillus pleuropneumoniae transferrin receptor genes. Microbiology. 1995;141 ( Pt 10):2405-16 pubmed
    ..and Haemophilus influenzae, and that functional studies performed with recombinant receptor proteins need to consider differences in processing and export of these proteins when expressed in heterologous hosts...
  31. McNamara L, MacPhail A, Mandishona E, Bloom P, Paterson A, Rouault T, et al. Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload. J Gastroenterol Hepatol. 1999;14:126-32 pubmed
    ..The independent relationship between NTBI and elevated liver function tests suggests that it may be part of a pathway leading to hepatic injury. ..
  32. Danielsen E, van Deurs B. A transferrin-like GPI-linked iron-binding protein in detergent-insoluble noncaveolar microdomains at the apical surface of fetal intestinal epithelial cells. J Cell Biol. 1995;131:939-50 pubmed
  33. Ferron L, Ferreiros C, Criado M, Pintor M. Reliability of laboratory models in the analysis of TBP2 and other meningococcal antigens. FEMS Immunol Med Microbiol. 1994;9:299-305 pubmed
    ..We suggest that careful analysis and evaluation of experimental results and their comparison with in vivo elicited immune responses are essential in order to get accurate extrapolations for experimental vaccine designs. ..
  34. Myers L, Yang Y, Du R, Wang Q, Harkness R, Schryvers A, et al. The transferrin binding protein B of Moraxella catarrhalis elicits bactericidal antibodies and is a potential vaccine antigen. Infect Immun. 1998;66:4183-92 pubmed
    ..Thus, if bactericidal ability is clinically relevant, a vaccine comprising multiple rTbpB antigens may protect against M. catarrhalis disease. ..
  35. Lim Y, Shin S, Jang I, Rhee J, Kim I. A human transferrin-binding protein of Staphylococcus aureus is immunogenic in vivo and has an epitope in common with human transferrin receptor. FEMS Microbiol Lett. 1998;166:225-30 pubmed
    ..We conclude, there are at least two kinds of epitopes in the SA-tbp; one able to bind to human transferrin is immunogenic in humans, but the other sharing epitopes common with human transferrin receptor is not immunogenic in humans. ..
  36. Gorringe A, Woods G, Robinson A. Growth and siderophore production by Bordetella pertussis under iron-restricted conditions. FEMS Microbiol Lett. 1990;54:101-5 pubmed
    ..pertussis, B. bronchiseptica and B. parapertussis. Siderophores were identified as hydroxamates and were produced by both virulent and avirulent strains of B. pertussis. ..
  37. Ferreiros C, Ferron L, Criado M. In vivo human immune response to transferrin-binding protein 2 and other iron-regulated proteins of Neisseria meningitidis. FEMS Immunol Med Microbiol. 1994;8:63-8 pubmed
    ..s two-group classification of N. meningitidis strains, and provide evidence against the possibility that the antigenic domains shared by the TBP2s of all N. meningitidis strains induce immune responses in vivo. ..
  38. Park S, Lee H, Jeon G, Sim K, Cho I, Cho S. The expression of transferrin binding protein in the turtle nervous system. Arch Histol Cytol. 2009;72:65-76 pubmed
    ..These results may reflect the fact that the homology of nervous system genes is conserved between close phylogenetic lines, and proove the potential of TfBP as a marker for oligodendrocytes in avian as well as reptile. ..
  39. Bullen J, Ward C, Rogers H. The critical role of iron in some clinical infections. Eur J Clin Microbiol Infect Dis. 1991;10:613-7 pubmed
    ..In several clinical conditions an abnormal availability of iron is responsible for fatal septicaemia. This is because the phagocytic system is overwhelmed by rapidly growing organisms when iron is freely available. ..
  40. Kokot F, Warmuz A. [Iron balance in hemodialysis in chronic uremia]. Z Urol Nephrol. 1988;81:263-8 pubmed
    ..Hyperfunction of the parathyroid glands does not seem to play an important role in the pathogenesis of abnormal iron metabolism in hemodialyzed patients. ..
  41. Topham R, Cooper B, Tesh S, Godette G, Bonaventura C, Bonaventura J. Isolation, purification and characterization of an iron-binding protein from the horseshoe crab (Limulus polyphemus). Biochem J. 1988;252:151-7 pubmed
    ..The isolation of an iron-binding protein from L. polyphemus supports the proposal that such proteins are an ancient evolutionary development not necessarily linked to the appearance of iron proteins which serve as oxygen carriers...
  42. Bruice T, Sengupta D, Blasko A, Chiang S, Beerman T. A microgonotropen branched decaaza decabutylamine and its DNA and DNA/transcription factor interactions. Bioorg Med Chem. 1997;5:685-92 pubmed
    ..Results of studies of the inhibition of the binding of several proteins to target DNA are discussed. Binding of the E2F1 transcription factor to its DNA target is 50% inhibited at approximately 2 nM concentration of 8...
  43. McMichael J. Vaccines for Moraxella catarrhalis. Vaccine. 2000;19 Suppl 1:S101-7 pubmed
    ..Antigens of unknown function, such as the 200K protein, may also be vaccine candidates. The antigens that are most suitable will be determined in clinical studies that are only beginning now. ..
  44. Bøg Y, Andresen L, Bastholm L, Elling F, Angen O, Heegaard P. The transferrin receptor of Actinobacillus pleuropneumoniae: quantitation of expression and structural characterization using a peptide-specific monoclonal antibody. Vet Microbiol. 2001;81:51-64 pubmed
    When Actinobacillus pleuropneumoniae (A. pp) is grown under iron-restricted conditions in vitro, transferrin binding proteins (Tbps) are induced. The functional transferrin receptor of A...
  45. Leon Sicairos N, Reyes Lopez M, Canizalez Roman A, Bermúdez Cruz R, Serrano Luna J, Arroyo R, et al. Human hololactoferrin: endocytosis and use as an iron source by the parasite Entamoeba histolytica. Microbiology. 2005;151:3859-71 pubmed
    ..histolytica trophozoites bind to hololactoferrin through specific membrane lactoferrin-binding proteins. This ferric protein might be internalized via caveolae-like microdomains, then used as an iron source, and degraded. ..
  46. Curran R, Hardie K, Towner K. Analysis by pulsed-field gel electrophoresis of insertion mutations in the transferrin-binding system of Haemophilus influenzae type b. J Med Microbiol. 1994;41:120-6 pubmed
  47. Kemp J. The role of iron and iron binding proteins in lymphocyte physiology and pathology. J Clin Immunol. 1993;13:81-92 pubmed
  48. Ueda F, Raja K, Simpson R, Trowbridge I, Bradbury M. Rate of 59Fe uptake into brain and cerebrospinal fluid and the influence thereon of antibodies against the transferrin receptor. J Neurochem. 1993;60:106-13 pubmed
    ..Although a major portion of iron transport across the blood-brain barrier is normally transferrin-mediated, non-transferrin-bound iron readily crosses it at low serum transferrin levels. ..
  49. Cho S, Shin D, Lee K, Hwang D, Chang K. Localization of transferrin binding protein in relation to iron, ferritin, and transferrin receptors in the chicken cerebellum. Brain Res. 1998;794:174-8 pubmed
    ..The results of this study suggest that Bergmann glia have previously undescribed functions related to iron regulation such as sequestration of iron and the maintenance of iron homeostasis in the cerebellum. ..
  50. Menendez T, Perez M, Alvarez A. Antigenic and genetic characterization of a putative hybrid transferrin-binding protein B from Neisseria meningitidis. Can J Microbiol. 1999;45:1050-4 pubmed
    ..This report illustrates a TbpB that shows hybrid antigenic and genetic behaviour. ..
  51. Nurizzo D, Baker H, He Q, MacGillivray R, Mason A, Woodworth R, et al. Crystal structures and iron release properties of mutants (K206A and K296A) that abolish the dilysine interaction in the N-lobe of human transferrin. Biochemistry. 2001;40:1616-23 pubmed
    ..Added chloride ions are shown to accelerate iron release close to the pH at which iron is naturally lost and the closed structure becomes destabilized, and to retard it at higher pH. ..
  52. Momotani E, Whipple D, Thiermann A. The distribution of ferritin, lactoferrin and transferrin in granulomatous lymphadenitis of bovine paratuberculosis. J Comp Pathol. 1988;99:205-14 pubmed
  53. de Sousa M, Breedvelt F, Dynesius Trentham R, Trentham D, Lum J. Iron, iron-binding proteins and immune system cells. Ann N Y Acad Sci. 1988;526:310-22 pubmed
  54. Strutzberg K, von Olleschik L, Franz B, Pyne C, Schmidt M, Gerlach G. Mapping of functional regions on the transferrin-binding protein (TfbA) of Actinobacillus pleuropneumoniae. Infect Immun. 1995;63:3846-50 pubmed
    ..meningitidis (Tbp2), and Haemophilus influenzae (Tbp2). ..
  55. Ekins A, Niven D. Identification of fur and fldA homologs and a Pasteurella multocida tbpA homolog in Histophilus ovis and effects of iron availability on their transcription. J Bacteriol. 2002;184:2539-42 pubmed
  56. Jerse A, Crow E, Bordner A, Rahman I, Cornelissen C, Moench T, et al. Growth of Neisseria gonorrhoeae in the female mouse genital tract does not require the gonococcal transferrin or hemoglobin receptors and may be enhanced by commensal lactobacilli. Infect Immun. 2002;70:2549-58 pubmed
    ..In summary, these studies support the potential role of nontransferrin, nonhemoglobin iron sources during gonococcal infection of the female genital tract. ..
  57. Alexis N, Richards J, Carter J, Ghio A. Iron-binding and storage proteins in sputum. Inhal Toxicol. 2002;14:387-400 pubmed
    ..The finding of decreased transferrin with increased ferritin suggests a local cellular response via iron-response elements (IRE) associated with the mRNAs for these two iron-binding proteins. ..
  58. Holland J, Towner K, Williams P. Tn916 insertion mutagenesis in Escherichia coli and Haemophilus influenzae type b following conjugative transfer. J Gen Microbiol. 1992;138:509-15 pubmed
    ..Tn916 insertion mutagenesis, following transfer by conjugation, is a convenient method for isolating mutations in genes concerned with iron acquisition by this important human pathogen. ..
  59. Hardie K, Adams R, Towner K. Transferrin-binding ability of invasive and commensal isolates of Haemophilus spp. J Med Microbiol. 1993;39:218-24 pubmed
    ..influenzae type b isolates from invasive infections, and was also recognised for the first time in isolates of H. parainfluenzae and H. parahaemolyticus. ..
  60. Chen Y, Drysdale J. Detection of iron binding proteins by a blotting technique. Anal Biochem. 1993;212:47-9 pubmed
    ..This binding is specific and is not affected by other metal ions. The method has allowed identification of new iron binding proteins in intestinal mucosa and in Hela cells. ..
  61. Ala Aldeen D, Borriello S. The meningococcal transferrin-binding proteins 1 and 2 are both surface exposed and generate bactericidal antibodies capable of killing homologous and heterologous strains. Vaccine. 1996;14:49-53 pubmed
    ..These results strongly support consideration of these Tbps as future vaccine components. ..
  62. Johnson A, Gorringe A, Fox A, Borrow R, Robinson A. Analysis of the human Ig isotype response to individual transferrin binding proteins A and B from Neisseria meningitidis. FEMS Immunol Med Microbiol. 1997;19:159-67 pubmed
    Subcapsular antigens, including transferrin binding proteins, are being considered as potential vaccines against serogroup B meningococci...
  63. Prinz T, Tommassen J. Association of iron-regulated outer membrane proteins of Neisseria meningitidis with the RmpM (class 4) protein. FEMS Microbiol Lett. 2000;183:49-53 pubmed
    ..Furthermore, all TonB-dependent receptors investigated here appeared to exist as oligomers (probably dimers), suggesting that this is a general feature of this class of proteins. ..
  64. Masri H, Cornelissen C. Specific ligand binding attributable to individual epitopes of gonococcal transferrin binding protein A. Infect Immun. 2002;70:732-40 pubmed
    ..These results suggest that individual epitopes of TbpA are both immunogenic and functional with respect to ligand binding capabilities, and the vaccine implications of these findings are discussed. ..
  65. Brooks J, Wessel G. The major yolk protein in sea urchins is a transferrin-like, iron binding protein. Dev Biol. 2002;245:1-12 pubmed
    ..We suggest that one of MYP's transferrin-like properties is to shuttle iron to developing germ cells. ..
  66. Kim D, Lee H, Song J, Jung K, Yang W, Kwon K, et al. Expression of transferrin binding protein in the capillaries of the brain in the developing chick embryo. Neurochem Res. 2008;33:2288-93 pubmed publisher
    ..The up-regulated expression of TfBP, together with the Tf-receptor of the brain capillaries, suggests that pericytes may be associated with the high iron uptake required for the metabolic demands of the developing brain. ..
  67. Rosenmund A, Köchli H, König M. Sex-related differences in hematological values. A study on the erythrocyte and granulocyte count, plasma iron and iron-binding proteins in human transsexuals on contrasexual hormone therapy. Blut. 1988;56:13-7 pubmed
    ..The present study demonstrates the potential of human transsexualism as a model for the study of sex-related biological processes. ..
  68. Chaudhri M, Steverding D, Kittelberger D, Tjia S, Overath P. Expression of a glycosylphosphatidylinositol-anchored Trypanosoma brucei transferrin-binding protein complex in insect cells. Proc Natl Acad Sci U S A. 1994;91:6443-7 pubmed
    ..However, their expression results in a cell surface complex of ESAG 6 and 7 products that specifically binds transferrin. This shows that both ESAG 6 and 7 products are necessary and sufficient for binding to transferrin. ..
  69. Wesselius L, Nelson M, Skikne B. Increased release of ferritin and iron by iron-loaded alveolar macrophages in cigarette smokers. Am J Respir Crit Care Med. 1994;150:690-5 pubmed
    ..4% +/- 1.1, p < 0.01) than did AM from NS (3.2% +/- 0.6). Release of lactate dehydrogenase (LDH) over 4 h was substantially less (2.9% +/- 0.3, p < 0.001) than ferritin release.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  70. Ferron L, Ferreiros C, Criado M, Andrade M. Purification of the Neisseria meningitidis transferrin binding protein-2 (TBP2) to homogeneity using column chromatography. FEMS Microbiol Lett. 1993;109:159-65 pubmed
    ..Our results demonstrate the conservation of the antigenic reactivity of this protein, which produces monospecific serum with the antibodies elicited reacting exclusively with the TBP2 in whole outer membrane vesicles. ..
  71. Legrain M, Mazarin V, Irwin S, Bouchon B, Quentin Millet M, Jacobs E, et al. Cloning and characterization of Neisseria meningitidis genes encoding the transferrin-binding proteins Tbp1 and Tbp2. Gene. 1993;130:73-80 pubmed
    ..These comparisons should be extended to other Neisseria strains in order to evaluate further this genetic divergence further...
  72. Conrad M, Umbreit J. A concise review: iron absorption--the mucin-mobilferrin-integrin pathway. A competitive pathway for metal absorption. Am J Hematol. 1993;42:67-73 pubmed
    ..Enhanced mucosal transfer of iron into the body occurs with increased body need for iron. The exact mechanism for mucosal transfer of iron into the plasma has not been defined but may also be mediated by an integrin. ..
  73. Weiner K, Hayes G, Lucas J. Binding specificity of avian heat shock protein 108. Biochem Biophys Res Commun. 1997;240:673-6 pubmed
    ..Neither do denatured ovalbumin or ovalbumin tryptic peptides. Thus, the binding activity of HSP108 is not restricted to Fe-OTf, nor is it universal. ..
  74. Miyauchi T, Takahashi N, Hirose M. Periplasmic secretion of functional ovotransferrin N-lobe in Escherichia coli. Biosci Biotechnol Biochem. 1997;61:2125-6 pubmed
    ..The cytoplasmic and periplasmic production systems of ovotransferrin N-lobe in Escherichia coli were constructed. The periplasmic, but not cytoplasmic product, was found to have the iron-binding function. ..
  75. Taylor J, Heinrichs D. Transferrin binding in Staphylococcus aureus: involvement of a cell wall-anchored protein. Mol Microbiol. 2002;43:1603-14 pubmed
  76. Eitan Y, Kashi Y. Direct micro-haplotyping by multiple double PCR amplifications of specific alleles (MD-PASA). Nucleic Acids Res. 2002;30:e62 pubmed
  77. Barton A, Bowie J, Ebmeier K. Low plasma iron status and akathisia. J Neurol Neurosurg Psychiatry. 1990;53:671-4 pubmed
    ..In addition, akathisia ratings were found to be correlated with a scale measuring symptoms of tardive dyskinesia. ..
  78. Ahmadzadeh N, Shingu M, Nobunaga M. Iron-binding proteins and free iron in synovial fluids of rheumatoid arthritis patients. Clin Rheumatol. 1989;8:345-51 pubmed
    ..Also the capacity of iron-binding proteins to bind free iron is inadequate in the presence of a large amount of iron-binding proteins which are present in RA SF. ..
  79. McKenna W, Mickelsen P, Sparling P, Dyer D. Iron uptake from lactoferrin and transferrin by Neisseria gonorrhoeae. Infect Immun. 1988;56:785-91 pubmed
    ..We conclude that the availability of protein-bound Fe probably does not limit growth of N. gonorrhoeae in the human body. ..
  80. Conrad M, Umbreit J, Moore E. Rat duodenal iron-binding protein mobilferrin is a homologue of calreticulin. Gastroenterology. 1993;104:1700-4 pubmed
    ..Competitive binding of metals by mobilferrin provides insight into the absorptive pathway shared by both essential and toxic transitional metals. ..
  81. Grzegorzewska A, Chmurak A, Dobrowolska Zachwieja A. Nutrition of uremic patients in the course of CAPD treatment. Adv Perit Dial. 1996;12:293-7 pubmed
    ..When protein calorie malnutrition is prolonged, plasma proteins decrease. On the other hand, the greater the peritoneal permeability the lower the plasma protein intake. ..
  82. Haesebrouck F, Chiers K, van Overbeke I, Ducatelle R. Actinobacillus pleuropneumoniae infections in pigs: the role of virulence factors in pathogenesis and protection. Vet Microbiol. 1997;58:239-49 pubmed
    ..This paper discusses the possible role of virulence factors of Actinobacillus pleuropneumoniae in pathogenesis and protection. Special attention is paid to the Apx-exotoxins and to adhesins. ..
  83. Pintor M, Gomez J, Ferron L, Ferreiros C, Criado M. Analysis of TbpA and TbpB functionality in defective mutants of Neisseria meningitidis. J Med Microbiol. 1998;47:757-60 pubmed
    ..These results emphasise that TbpA should be considered in future vaccine trials in which iron-restricted proteins are to be included in the vaccine formulation. ..
  84. Webb D, Cripps A. Immunization with recombinant transferrin binding protein B enhances clearance of nontypeable Haemophilus influenzae from the rat lung. Infect Immun. 1999;67:2138-44 pubmed
  85. Gutteridge J, Quinlan G. Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for iron-binding and iron-oxidising proteins. Biochim Biophys Acta. 1992;1159:248-54 pubmed
  86. Holland J, Towner K, Williams P. Isolation and characterisation of Haemophilus influenzae type b mutants defective in transferrin-binding and iron assimilation. FEMS Microbiol Lett. 1991;61:283-7 pubmed
    ..Such mutants should prove useful in further elucidating the mechanism of transferrin iron-acquisition and its contribution to the virulence of H. influenzae. ..
  87. Pidcock K, Wooten J, Daley B, Stull T. Iron acquisition by Haemophilus influenzae. Infect Immun. 1988;56:721-5 pubmed
    ..We conclude that the sources of iron for H. influenzae are diverse. The significance of hydroxamate production and iron-related outer membrane proteins to H. influenzae iron acquisition is not yet clear. ..
  88. Mochizuki H, Yamada H, Oikawa Y, Murakami K, Ishiguro J, Kosuzume H, et al. Bactericidal activity of M14659 enhanced in low-iron environments. Antimicrob Agents Chemother. 1988;32:1648-54 pubmed
    ..These findings indicate that M14659 may be actively taken up with Fe3+ into bacterial cells, probably through the iron transport systems under conditions of low iron and, thus, kills bacteria effectively. ..
  89. Adhikari P, Kirby S, Nowalk A, Veraldi K, Schryvers A, Mietzner T. Biochemical characterization of a Haemophilus influenzae periplasmic iron transport operon. J Biol Chem. 1995;270:25142-9 pubmed
  90. Ala Aldeen D, Stevenson P, Griffiths E, Gorringe A, Irons L, Robinson A, et al. Immune responses in humans and animals to meningococcal transferrin-binding proteins: implications for vaccine design. Infect Immun. 1994;62:2984-90 pubmed
  91. Castelnau P, Garrett R, Palinski W, Witztum J, Campbell I, Powell H. Abnormal iron deposition associated with lipid peroxidation in transgenic mice expressing interleukin-6 in the brain. J Neuropathol Exp Neurol. 1998;57:268-82 pubmed
  92. Kim D, Chang J, Park S, Jeon G, Seo J, Cho S. Activated cyclic AMP-response element binding protein (CREB) is expressed in a myelin-associated protein in chick. Neurochem Res. 2005;30:1133-7 pubmed
    ..Immunoblot analyses showed that phospho-CREB recognized a protein with molecular weights of approximately 70 kDa. Our data suggest that the antigen recognized by phospho-CREB is a myelin-associated protein in the chick CNS. ..