period circadian proteins


Summary: Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.

Top Publications

  1. Qian J, Thomas A, SCHROEDER A, Rakshit K, Colwell C, Matveyenko A. Development of diabetes does not alter behavioral and molecular circadian rhythms in a transgenic rat model of type 2 diabetes mellitus. Am J Physiol Endocrinol Metab. 2017;313:E213-E221 pubmed publisher
  2. Akiyama T, Katsumura T, Nakagome S, Lee S, Joh K, Soejima H, et al. An ancestral haplotype of the human PERIOD2 gene associates with reduced sensitivity to light-induced melatonin suppression. PLoS ONE. 2017;12:e0178373 pubmed publisher
    ..Hence, we speculate that the high light-sensitive haplotypes have spread throughout the world after the Out-of-Africa migration of modern humans. ..
  3. Lee J, Hirota T, Peters E, Garcia M, Gonzalez R, Cho C, et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011;50:10608-11 pubmed publisher
  4. Rybakowski J, Dmitrzak Weglar M, Kliwicki S, Hauser J. Polymorphism of circadian clock genes and prophylactic lithium response. Bipolar Disord. 2014;16:151-8 pubmed
    ..Of special interest may be polymorphisms of these genes involved both in the predisposition to bipolar mood disorder and the lithium response. ..
  5. Matsumura R, Akashi M. Multiple circadian transcriptional elements cooperatively regulate cell-autonomous transcriptional oscillation of Period3, a mammalian clock gene. J Biol Chem. 2017;292:16081-16092 pubmed publisher
    ..These results indicate that three E box-like and two D box-like elements cooperatively and redundantly regulate cell-autonomous transcriptional oscillation of Per3. ..
  6. Schallner N, Lieberum J, Gallo D, LeBlanc R, Fuller P, Hanafy K, et al. Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice. Stroke. 2017;48:2565-2573 pubmed publisher
    ..Exposure to CO rescues the loss of HO-1 and thus merits further investigation in patients with SAH. ..
  7. Bartman C, Oyama Y, Brodsky K, Khailova L, Walker L, Koeppen M, et al. Intense light-elicited upregulation of miR-21 facilitates glycolysis and cardioprotection through Per2-dependent mechanisms. PLoS ONE. 2017;12:e0176243 pubmed publisher
    ..Together, we identified miR-21 as cardioprotective downstream target of Per2 and suggest intense light therapy as a potential strategy to enhance miR-21 activity and subsequent carbohydrate metabolism in humans. ..
  8. Koinuma S, Kori H, Tokuda I, Yagita K, Shigeyoshi Y. Transition of phase response properties and singularity in the circadian limit cycle of cultured cells. PLoS ONE. 2017;12:e0181223 pubmed publisher
    ..These findings support the existence of a circadian limit cycle oscillator in mammalian cells and suggest that a small number of variables determine the relaxation process after a perturbation. ..
  9. Gustafson C, Parsley N, Asimgil H, Lee H, Ahlbach C, Michael A, et al. A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms. Mol Cell. 2017;66:447-457.e7 pubmed publisher
    ..Furthermore, isomerization is regulated by the cyclophilin family of peptidyl-prolyl isomerases, highlighting the potential for regulation of BMAL1 protein dynamics in period determination. ..

More Information


  1. Pagel R, Bär F, Schröder T, Sünderhauf A, Künstner A, Ibrahim S, et al. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. FASEB J. 2017;31:4707-4719 pubmed publisher
    ..König, P., Tsang, A. H., Bettenworth, D., Divanovic, S., Lehnert, H., Fellermann, K., Oster, H., Derer, S., Sina, C. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. ..
  2. Zhang Z, Lai S, Wang Y, Li L, Yin H, Wang Y, et al. Rhythmic expression of circadian clock genes in the preovulatory ovarian follicles of the laying hen. PLoS ONE. 2017;12:e0179019 pubmed publisher
    ..In addition, our results support the hypothesis that gonadotropins provide a cue for the development of the functional cellular clock in immature GCs. ..
  3. Sun Q, Zhao Y, Yang Y, Yang X, Li M, Xu X, et al. Loss of the clock protein PER2 shortens the erythrocyte life span in mice. J Biol Chem. 2017;292:12679-12690 pubmed publisher
    ..Our findings reveal that Per2 function in the bone marrow is required for the regulation of life span in circulating erythrocytes. ..
  4. Tsuchiya S, Buhr E, Higashide T, Sugiyama K, Van Gelder R. Light entrainment of the murine intraocular pressure circadian rhythm utilizes non-local mechanisms. PLoS ONE. 2017;12:e0184790 pubmed publisher
    ..These results suggest that IOP rhythm entrainment is mediated by a systemic rather than local signal in mice. ..
  5. Fu Y. Oscillating per-cision. PLoS Biol. 2008;6:e192 pubmed publisher
  6. Aryal R, Kwak P, Tamayo A, Gebert M, Chiu P, Walz T, et al. Macromolecular Assemblies of the Mammalian Circadian Clock. Mol Cell. 2017;67:770-782.e6 pubmed publisher
    ..Our results define the macromolecular assemblies comprising the circadian feedback loop and provide an initial structural view of endogenous eukaryotic clock machinery. ..
  7. Liu L, Jiang G, Peng Z, Li Y, Li J, Zou L, et al. The effect of high fat diet on daily rhythm of the core clock genes and muscle functional genes in the skeletal muscle of Chinese soft-shelled turtle (Trionyx sinensis). Comp Biochem Physiol B Biochem Mol Biol. 2017;213:17-27 pubmed publisher
  8. Kozlov A, Jaumouillé E, Machado Almeida P, Koch R, Rodriguez J, Abruzzi K, et al. A Screening of UNF Targets Identifies Rnb, a Novel Regulator of Drosophila Circadian Rhythms. J Neurosci. 2017;37:6673-6685 pubmed publisher
    ..Our results provide additional evidence to the emerging view that the differential regulation of the molecular clocks underlies the functional differences among the pacemaker neuron subgroups. ..
  9. Eng G, Edison -, Virshup D. Site-specific phosphorylation of casein kinase 1 ? (CK1?) regulates its activity towards the circadian regulator PER2. PLoS ONE. 2017;12:e0177834 pubmed publisher
    ..The regulation of CK1? by site-specific phosphorylation via the cell cycle and other signaling pathways provides a mechanism to couple external stimuli to regulation of CK1?-dependent pathways including the circadian clock. ..
  10. Frederick A, Goldsmith J, de Zavalía N, Amir S. Mapping the co-localization of the circadian proteins PER2 and BMAL1 with enkephalin and substance P throughout the rodent forebrain. PLoS ONE. 2017;12:e0176279 pubmed publisher
    ..These results indicate that clock genes are not unique to specific cell types, and further studies will be required to determine the factors that contribute to the regulation of clock gene expression throughout the brain. ..
  11. Lee J, Yoo E, Lee H, Park K, Hur J, Lim C. LSM12 and ME31B/DDX6 Define Distinct Modes of Posttranscriptional Regulation by ATAXIN-2 Protein Complex in Drosophila Circadian Pacemaker Neurons. Mol Cell. 2017;66:129-140.e7 pubmed publisher
    ..Taken together, these data suggest that the ATX2 complex may switch distinct modes of posttranscriptional regulation through its associating factors to control circadian clocks and ATX2-related physiology. ..
  12. Taylor S, Wang T, Granados Fuentes D, Herzog E. Resynchronization Dynamics Reveal that the Ventral Entrains the Dorsal Suprachiasmatic Nucleus. J Biol Rhythms. 2017;32:35-47 pubmed publisher
    ..Taken together, these results provide direct evidence that the ventral SCN entrains the dorsal SCN in constant conditions. ..
  13. Stevanovic K, Yunus A, Joly Amado A, Gordon M, Morgan D, Gulick D, et al. Disruption of normal circadian clock function in a mouse model of tauopathy. Exp Neurol. 2017;294:58-67 pubmed publisher
    ..Furthermore, these results establish the Tg4510 mouse line as a model to study how tauopathy disrupts normal circadian rhythm biology. ..
  14. Fahrenkrug J, Georg B, Hannibal J, Jørgensen H. Hypophysectomy abolishes rhythms in rat thyroid hormones but not in the thyroid clock. J Endocrinol. 2017;233:209-216 pubmed publisher
    ..Our findings indicate that the daily rhythm of thyroid hormone secretion is governed by SCN signalling via the rhythmic TSH secretion rather than by the local thyroid clock, which was still ticking after hypophysectomy. ..
  15. Seron Ferre M, Torres Farfan C, Valenzuela F, Castillo Galan S, Rojas A, Méndez N, et al. Deciphering the Function of the Blunt Circadian Rhythm of Melatonin in the Newborn Lamb: Impact on Adrenal and Heart. Endocrinology. 2017;158:2895-2905 pubmed publisher
  16. Musiek E, Lim M, Yang G, Bauer A, Qi L, Lee Y, et al. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest. 2013;123:5389-400 pubmed publisher
    ..Our findings indicate that BMAL1 in a complex with CLOCK or NPAS2 regulates cerebral redox homeostasis and connects impaired clock gene function to neurodegeneration. ..