uncoupling protein 2


Summary: A mitochondrial uncoupling protein that is expressed in many tissues and exhibits the greatest expression in SKELETAL MUSCLE. It regulates mitochondrial ATP production and the generation of REACTIVE OXYGEN SPECIES.

Top Publications

  1. Hoshovs ka I, Shymans ka T, Sahach V. [Effect of UCP2 activity inhibitor genipin on heart function of aging rats]. Fiziol Zh. 2009;55:28-34 pubmed
    ..Thus, genipin inhibition of UCP2 activity has cardiodepressive effects that imply UCPs in cardiac calcium regulation. ..
  2. Ma S, Zhang Y, Wang Q, Yang D, Li D, Tang B, et al. Ablation of uncoupling protein 2 exacerbates salt-induced cardiovascular and renal remodeling associated with enhanced oxidative stress. Int J Cardiol. 2014;175:206-10 pubmed publisher
  3. Zhou Y, Cai T, Xu J, Jiang L, Wu J, Sun Q, et al. UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2017;313:F926-F937 pubmed publisher
    ..Thus UCP2 attenuates I/R-induced AKI, probably by reducing cell apoptosis through protection of autophagy. ..
  4. Della Morte D, Dong C, Bartels S, Cabral D, Blanton S, Sacco R, et al. Association of the sirtuin and mitochondrial uncoupling protein genes with carotid intima-media thickness. Transl Res. 2012;160:389-90 pubmed publisher
  5. Hu X, Yuan P, Yan J, Feng F, Li X, Liu W, et al. Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study. PLoS ONE. 2013;8:e67275 pubmed publisher
    ..the association between each of the IR-related gene polymorphisms of adiponectin (ADIPOQ) rs2241766, uncoupling protein 2 (UCP2) rs659366, and fatty acid-binding protein (FABP2) rs1799883 and CRC risk...
  6. Sreedhar A, Lefort J, Petruska P, Gu X, Shi R, Miriyala S, et al. UCP2 upregulation promotes PLCγ-1 signaling during skin cell transformation. Mol Carcinog. 2017;56:2290-2300 pubmed publisher
    b>Uncoupling protein 2 (UCP2), whose physiological role is to decrease mitochondrial membrane potential and reactive oxygen species (ROS) production, is often overexpressed in human cancers...
  7. Yan P, Chen K, Wang Q, Yang D, Li D, Yang Y. UCP-2 is involved in angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice. PLoS ONE. 2017;12:e0179743 pubmed publisher
    ..This study provides a mechanism by which UCP-2, via anti-oxidants and anti-apoptosis, participates in the preventing of AAA formation. ..
  8. Gupta A, Ghosh K, Palit S, Barua J, Das P, Ukil A. Leishmania donovani inhibits inflammasome-dependent macrophage activation by exploiting the negative regulatory proteins A20 and UCP2. FASEB J. 2017;31:5087-5101 pubmed publisher
    ..Macrophage ROS is primarily regulated by mitochondrial uncoupling protein 2 (UCP2), and UCP2-silenced infected cells showed an increased IL-1β level...
  9. Heise V, Zsoldos E, Suri S, Sexton C, Topiwala A, Filippini N, et al. Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults. PLoS ONE. 2017;12:e0181392 pubmed publisher
    b>Uncoupling protein 2 (UCP2) is a mitochondrial membrane protein that plays a role in uncoupling electron transport from adenosine triphosphate (ATP) formation...

More Information


  1. Sorokina E, Solntseva T, Radzhabkadiev R, Samoĭlov A. [Identification of genetic polymorphisms associated with overweight in athletes of winter sports]. Vopr Pitan. 2013;82:58-61 pubmed
    ..4%). The results of the identification of polymorphism -866G> A gene UCP2 in biathletes and bobsledders, found the incidence of obesity risk allele, respectively, 52 and 58.7%. ..