uncoupling protein 1


Summary: A mitochondrial uncoupling protein that is expressed in BROWN ADIPOSE TISSUE. It is critical for NONSHIVERING THERMOGENESIS to prevent heat loss in NEONATES.

Top Publications

  1. Bal N, Singh S, Reis F, Maurya S, Pani S, Rowland L, et al. Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice. J Biol Chem. 2017;292:16616-16625 pubmed publisher
    ..Both brown adipose tissue (BAT) (i.e. uncoupling protein 1 (UCP1)-based) and skeletal muscle (i.e...
  2. Salisbury E, Dickerson A, Davis T, Forsberg J, Davis A, Olmsted Davis E. Characterization of Brown Adipose-Like Tissue in Trauma-Induced Heterotopic Ossification in Humans. Am J Pathol. 2017;187:2071-2079 pubmed publisher
    ..Immunohistochemical analysis revealed extensive expression of uncoupling protein 1 (UCP1), a definitive marker of brown adipocytes, within HO-containing tissues but not normal tissues...
  3. Emmett M, Lim H, Jager J, Richter H, Adlanmerini M, Peed L, et al. Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature. 2017;546:544-548 pubmed publisher
    ..b>Uncoupling protein 1 (UCP1) is nearly absent in brown adipose tissue lacking HDAC3, and there is also marked downregulation of ..
  4. Gianotti M, Clapés J, Llado I, Palou A. Effect of 12, 24 and 72 hours fasting in thermogenic parameters of rat brown adipose tissue mitochondrial subpopulations. Life Sci. 1998;62:1889-99 pubmed
    ..Important fasting-induced changes in both morphological and biochemical parameters in BAT mitochondrial subtypes reflect their role in the physiological response of BAT to starvation. ..
  5. Meng W, Liang X, Chen H, Luo H, Bai J, Li G, et al. Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway. Diabetes. 2017;66:1198-1213 pubmed publisher
    ..other hand, overexpression of Rheb in primary adipocytes significantly inhibited CREB phosphorylation and uncoupling protein 1 (UCP1) expression...
  6. Zandoná M, Rodrigues R, Albiero G, Campagnolo P, Vitolo M, Almeida S, et al. Polymorphisms in LEPR, PPARG and APM1 genes: associations with energy intake and metabolic traits in young children. Arq Bras Endocrinol Metabol. 2013;57:603-11 pubmed
    ..leptin receptor (LEPR), adiponectin (APM1), peroxisome proliferator-activated receptor gamma (PPARG) and uncoupling protein 1 - with anthropometric, metabolic, and dietary parameters in a Southern Brazilian cohort of 325 children ..
  7. Champigny O, Ricquier D. Effects of fasting and refeeding on the level of uncoupling protein mRNA in rat brown adipose tissue: evidence for diet-induced and cold-induced responses. J Nutr. 1990;120:1730-6 pubmed
    ..Under the same environmental conditions (28 degrees C), refeeding still triggered a sharp, though transient, increase in UCP mRNA, showing that DIT was dissociated from NST. ..
  8. Larson K, Russo K, Fang Y, Mohajerani N, Goodson M, Ryan K. Sex Differences in the Hormonal and Metabolic Response to Dietary Protein Dilution. Endocrinology. 2017;158:3477-3487 pubmed publisher
    ..This is accompanied by blunted circulating levels of FGF21 and requires an intact female reproductive system. ..
  9. Liu P, Ji Y, Yuen T, Rendina Ruedy E, DeMambro V, Dhawan S, et al. Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature. 2017;546:107-112 pubmed publisher
    ..These actions result from the specific binding of the antibody to the ?-subunit of Fsh to block its action. Our studies uncover opportunities for simultaneously treating obesity and osteoporosis. ..

More Information


  1. Chu D, Gawronska Kozak B. Brown and brite adipocytes: Same function, but different origin and response. Biochimie. 2017;138:102-105 pubmed publisher
    ..The objectives of this review are (1) to discuss the fate of primary adipocytes based on tissue origins, and (2) to discuss mechanisms of brown and brite adipogenesis which could lead to their different responses to browning reagents. ..
  2. Chung K, Chatzigeorgiou A, Economopoulou M, Garcia Martin R, Alexaki V, Mitroulis I, et al. A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity. Nat Immunol. 2017;18:654-664 pubmed publisher
    ..Our findings, established in both mouse systems and human systems, reveal a self-sustained cycle of inflammation-driven impairment of beige adipogenesis in obesity. ..
  3. Chouchani E, Kazak L, Spiegelman B. Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms. J Biol Chem. 2017;292:16810-16816 pubmed publisher
    ..tissues can catabolize stored energy to generate heat, relying on the principal effector of thermogenesis: uncoupling protein 1 (UCP1). This unique capability could be leveraged as a therapy for metabolic disease...
  4. Wojtczak L, Schonfeld P. Effect of fatty acids on energy coupling processes in mitochondria. Biochim Biophys Acta. 1993;1183:41-57 pubmed
    ..As anionic amphiphiles, long-chain fatty acids increase the negative surface charge of biomembranes, thus interfering in their enzymic and transporting functions. ..
  5. Bertholet A, Kazak L, Chouchani E, Bogaczyńska M, Paranjpe I, Wainwright G, et al. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 2017;25:811-822.e4 pubmed publisher
    ..Similar to brown fat, beige adipocytes are assumed to express mitochondrial uncoupling protein 1 (UCP1) and are thermogenic due to the UCP1-mediated H+ leak across the inner mitochondrial ..
  6. Pei X, Liu L, Cai J, Wei W, Shen Y, Wang Y, et al. Haplotype-based interaction of the PPARGC1A and UCP1 genes is associated with impaired fasting glucose or type 2 diabetes mellitus. Medicine (Baltimore). 2017;96:e6941 pubmed publisher
    ..745, 95% confidence interval [95% CI] 1.069-2.847) and CTCA (OR?=?0.239, 95% CI 0.060-0.958) of the UCP1 gene.Haplotype-based interaction between the PPARGC1A and UCP1 genes is associated with IFG or T2DM among residents in Henan, China. ..
  7. Tsujino Y. A New Agonist for Peroxisome Proliferation-activated Receptor ? (PPAR?), Fraglide-1 from Zhenjiang Fragrant Vinegar: Screening and Characterization Based on Cell Culture Experiments. J Oleo Sci. 2017;66:615-622 pubmed publisher
    ..The active ingredient of Kozu was successfully found and the results unraveled a longtime mystery about Kozu for its beneficial health effect. ..
  8. Skulachev V. Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation. FEBS Lett. 1991;294:158-62 pubmed
    ..It is suggested that both the ATP/ADP antiporter and thermogenin facilitate translocation of the fatty anions through the mitochondrial membrane. ..
  9. Trayhurn P, Temple N, Van Aerde J. Evidence from immunoblotting studies on uncoupling protein that brown adipose tissue is not present in the domestic pig. Can J Physiol Pharmacol. 1989;67:1480-5 pubmed
    ..It is concluded that the pig does not contain adipose tissue that is functionally "brown;" adipose tissues in this species appear to be exclusively "white." ..
  10. Fischer K, Ruiz H, Jhun K, Finan B, Oberlin D, van der Heide V, et al. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nat Med. 2017;23:623-630 pubmed publisher
    ..media from IL-4-stimulated macrophages failed to induce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1), in adipocytes cultured with the conditioned media...
  11. Cozer A, Trapp M, Martins T, de Fraga L, Vieira Marques C, Model J, et al. Effects of Stanniocalcin-1 on glucose flux in rat brown adipose tissue. Biochimie. 2017;138:50-55 pubmed publisher
    ..The uncoupling protein 1 (UCP-1) expression was not altered by hSTC-1 either...
  12. Gundra U, Girgis N, Gonzalez M, San Tang M, Van Der Zande H, Lin J, et al. Vitamin A mediates conversion of monocyte-derived macrophages into tissue-resident macrophages during alternative activation. Nat Immunol. 2017;18:642-653 pubmed publisher
  13. McGowan S, McCoy D. Glucocorticoids Retain Bipotent Fibroblast Progenitors during Alveolar Septation in Mice. Am J Respir Cell Mol Biol. 2017;57:111-120 pubmed publisher
  14. Collins S, Daniel K, Petro A, Surwit R. Strain-specific response to beta 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology. 1997;138:405-13 pubmed
  15. Della Morte D, Dong C, Bartels S, Cabral D, Blanton S, Sacco R, et al. Association of the sirtuin and mitochondrial uncoupling protein genes with carotid intima-media thickness. Transl Res. 2012;160:389-90 pubmed publisher
  16. Porter C. Quantification of UCP1 function in human brown adipose tissue. Adipocyte. 2017;6:167-174 pubmed publisher
    ..BAT mitochondria are equipped with a specialized protein known as uncoupling protein 1 (UCP1)...
  17. Doig C, Fletcher R, Morgan S, McCabe E, Larner D, Tomlinson J, et al. 11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice. Endocrinology. 2017;158:1964-1976 pubmed publisher
    ..11β-HSD1 KO BAT resisted the suppression of uncoupling protein 1 (UCP1) and mitochondrial respiratory chain subunit proteins normally imposed by GC excess...
  18. Magnusson L, Hansen N, Saba K, Nilsson J, Fioretos T, Rissler P, et al. Loss of the tumour suppressor gene AIP mediates the browning of human brown fat tumours. J Pathol. 2017;243:160-164 pubmed publisher
    ..We conclude that this white-to-brown phenotype switch in brown fat tumours is mediated by the loss of AIP. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  19. Skulachev V. Uncoupling: new approaches to an old problem of bioenergetics. Biochim Biophys Acta. 1998;1363:100-24 pubmed
  20. Richard J, López Ferreras L, Chanclón B, Eerola K, Micallef P, Skibicka K, et al. CNS β3-adrenergic receptor activation regulates feeding behavior, white fat browning, and body weight. Am J Physiol Endocrinol Metab. 2017;313:E344-E358 pubmed publisher
    ..Collectively, our results identify the brain as a new site of action for the anorexic and browning impact of β3AR activation. ..
  21. Hou L, Shi J, Cao L, Xu G, Hu C, Wang C. Pig has no uncoupling protein 1. Biochem Biophys Res Commun. 2017;487:795-800 pubmed publisher
    Brown adipose tissue (BAT) is critical for mammal's survival in the cold environment. Uncoupling protein 1 (UCP1) is responsible for the non-shivering thermogenesis in the BAT. Pig is important economically as a meat-producing livestock...
  22. Timmons J, Pedersen B. The importance of brown adipose tissue. N Engl J Med. 2009;361:415-6; author reply 418-21 pubmed publisher
  23. Winn N, Grunewald Z, Gastecki M, Woodford M, Welly R, Clookey S, et al. Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction. Am J Physiol Endocrinol Metab. 2017;313:E402-E412 pubmed publisher
    ..sensitive than males, which may be partly attributed to greater brown adipose tissue (BAT) activity and uncoupling protein 1 (UCP1) content...
  24. Lee K, Chai V, Kanachamy S, Say Y. Association of UCP1 -3826A/G and UCP3 -55C/T gene polymorphisms with obesity and its related traits among multi-ethnic Malaysians. Ethn Dis. 2015;25:65-71 pubmed
  25. Hu Z, Chen M, Zhou H, Tharakan A, Wang X, Qiu L, et al. Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5. Toxicology. 2017;390:100-108 pubmed publisher
    ..marked fat droplet accumulation in brown adipose tissues of WT mice and significantly decreased their uncoupling protein 1 (UCP1) expression, and these effects were markedly exacerbated in TNF/LT KO mice...
  26. Zuo J, Zhao D, Yu N, Fang X, Mu Q, Ma Y, et al. Cinnamaldehyde Ameliorates Diet-Induced Obesity in Mice by Inducing Browning of White Adipose Tissue. Cell Physiol Biochem. 2017;42:1514-1525 pubmed publisher
    ..Additionally, CA inhibited the hypertrophy of adipose tissue and induced browning of white adipose tissue. Uncoupling protein 1 (UCP1) was expressed in white adipose tissue after the oral administration of CA...
  27. Ying F, Cai Y, Cai Y, Wang Y, Tang E. Prostaglandin E receptor subtype 4 regulates lipid droplet size and mitochondrial activity in murine subcutaneous white adipose tissue. FASEB J. 2017;31:4023-4036 pubmed publisher
    ..Ying, F., Cai, Y., Cai, Y., Wang, Y., Tang, E. H. C. Prostaglandin E receptor subtype 4 regulates lipid droplet size and mitochondrial activity in murine subcutaneous white adipose tissue. ..
  28. Fenzl A, Kiefer F. Brown adipose tissue and thermogenesis. Horm Mol Biol Clin Investig. 2014;19:25-37 pubmed publisher
    ..Despite the tremendous progress in brown fat research in recent years, pharmacological concepts to harness BAT function therapeutically are currently still lacking. ..
  29. Williams J, Elvington A, Ivanov S, Kessler S, Luehmann H, Baba O, et al. Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood. Circ Res. 2017;121:662-676 pubmed publisher
    ..cardiovascular events, but paradoxically, cold exposure is metabolically protective because of UCP1 (uncoupling protein 1)-dependent thermogenesis...
  30. Finlin B, Zhu B, Confides A, Westgate P, Harfmann B, Dupont Versteegden E, et al. Mast Cells Promote Seasonal White Adipose Beiging in Humans. Diabetes. 2017;66:1237-1246 pubmed publisher
    ..Together, these data show that mast cells sense colder temperatures, release factors that promote UCP1 expression, and are an important immune cell type in the beiging response of WAT. ..
  31. Dore R, Levata L, Gachkar S, Jöhren O, Mittag J, Lehnert H, et al. The thermogenic effect of nesfatin-1 requires recruitment of the melanocortin system. J Endocrinol. 2017;235:111-122 pubmed publisher
    ..accompanied by a significant increase in iodothyronine deiodinase 2 and by a nonsignificant increase in uncoupling protein 1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha mRNA in the iBAT...
  32. Wu C, Zhang H, Fan C, Wu P, Wei Q, Cai Y, et al. [Expressions of inflammatory and fibrogenic factors in perinephric and subcutaneous adipose tissues of patients with adrenocorticotropic hormone-independent Cushing's syndrome]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;37:563-566 pubmed
    ..inhibitor 1 (TIMP-1), early growth response 1 (EGR1), CCAAT/enhancer binding protein ?(CEBP?), uncoupling protein 1(UCP-1), PPAR? coactivator 1 alpha (PGC1?) and cell death-inducing DFFA-like effector a (CIDEA)...
  33. Nishikawa T, Edelstein D, Du X, Yamagishi S, Matsumura T, Kaneda Y, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature. 2000;404:787-90 pubmed
    ..Normalizing levels of mitochondrial reactive oxygen species with each of these agents prevents glucose-induced activation of protein kinase C, formation of advanced glycation end-products, sorbitol accumulation and NFkappaB activation. ..