type iib sodium phosphate cotransporter proteins


Summary: A sodium-dependent phosphate transporter present primarily at apical sites of EPITHELIAL CELLS in the SMALL INTESTINE.

Top Publications

  1. Shibasaki Y, Etoh N, Hayasaka M, Takahashi M, Kakitani M, Yamashita T, et al. Targeted deletion of the tybe IIb Na(+)-dependent Pi-co-transporter, NaPi-IIb, results in early embryonic lethality. Biochem Biophys Res Commun. 2009;381:482-6 pubmed publisher
    ..Expression patterns of NaPi-IIb suggest that NaPi-IIb plays an important role in Pi absorption from maternal circulation. ..
  2. Coulibaly B, Fernandez C, Reynaud Gaubert M, D Journo X, Doddoli C, Tasei A. [Alveolar microlithiasis with severe interstitial fibrosis leading to lung transplantation]. Ann Pathol. 2009;29:241-4 pubmed publisher
    ..Pathological examination confirmed the diagnosis of diffuse pulmonary alveolar microlithiasis with interstitial fibrosis. The patient died 3 months after surgery in an infectious context. ..
  3. Sabbagh Y, O Brien S, Song W, Boulanger J, Stockmann A, Arbeeny C, et al. Intestinal npt2b plays a major role in phosphate absorption and homeostasis. J Am Soc Nephrol. 2009;20:2348-58 pubmed publisher
    ..In summary, Npt2b is largely responsible for intestinal phosphate absorption and contributes to the maintenance of systemic phosphate homeostasis. ..
  4. Ozcelik U, Yalcin E, Ariyurek M, Ersoz D, Cinel G, Gulhan B, et al. Long-term results of disodium etidronate treatment in pulmonary alveolar microlithiasis. Pediatr Pulmonol. 2010;45:514-7 pubmed publisher
    ..The pathogenetic mechanism of this treatment on the genetic basis of disease is discussed. ..
  5. Ito M, Sakurai A, Hayashi K, Ohi A, Kangawa N, Nishiyama T, et al. An apical expression signal of the renal type IIc Na+-dependent phosphate cotransporter in renal epithelial cells. Am J Physiol Renal Physiol. 2010;299:F243-54 pubmed publisher
    ..We conclude that targeting of NaPi-IIc to the apical cell surface is regulated by a unique amino acid motif in the cytoplasmic C-terminal domain. ..
  6. Tomoe Y, Segawa H, Shiozawa K, Kaneko I, Tominaga R, Hanabusa E, et al. Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice. Am J Physiol Renal Physiol. 2010;298:F1341-50 pubmed publisher
    ..These findings suggest that Npt2a, Npt2c, and PiT-2 are necessary for the phosphaturic activity of FGF23. Thus complementary regulation of Npt2 family proteins may be involved in systemic P(i) homeostasis. ..
  7. Chen D, Chien S, Kuo S, Teng Y, Tsai H, Kuo J, et al. SLC34A2 as a novel marker for diagnosis and targeted therapy of breast cancer. Anticancer Res. 2010;30:4135-40 pubmed
    ..Our results suggested SLC34A2 to be involved in the development of breast cancer; this gene may therefore be a novel marker for the detection of breast cancer and act as a target gene in therapeutic strategies. ..
  8. Yin B, Kiyamova R, Chua R, Caballero O, Gout I, Gryshkova V, et al. Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas. Cancer Immun. 2008;8:3 pubmed
    ..Membrane transporter molecules, such as NaPi2b, represent a new family of potential cell surface targets for the immunotherapy of cancer with monoclonal antibodies. ..
  9. Bell T, Luo Z, Welch W. Glomerular tubular balance is suppressed in adenosine type 1 receptor-deficient mice. Am J Physiol Renal Physiol. 2010;299:F1158-63 pubmed publisher
    ..In conclusion, GTB is dependent on adenosine acting on type 1 receptors in the proximal tubule. This may contribute to acute changes in Na(+) and fluid reabsorption. ..

More Information


  1. Reining S, Liesegang A, Betz H, Biber J, Murer H, Hernando N. Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP. Pflugers Arch. 2010;460:207-17 pubmed publisher
    ..However, in response to low Pi diets, the upregulation of NaPi-IIa is greater in the mutant mice. Thus, both the basal expression and the dietary-induced upregulation of NaPi-IIa are increased in the absence of GABARAP. ..
  2. Giral H, Caldas Y, Sutherland E, Wilson P, Breusegem S, Barry N, et al. Regulation of rat intestinal Na-dependent phosphate transporters by dietary phosphate. Am J Physiol Renal Physiol. 2009;297:F1466-75 pubmed publisher
    ..the jejunum and that postprandial upregulation of NaPi-2b could be a potential target for treatment of hyperphosphatemia. ..
  3. Saddoris K, Fleet J, Radcliffe J. Sodium-dependent phosphate uptake in the jejunum is post-transcriptionally regulated in pigs fed a low-phosphorus diet and is independent of dietary calcium concentration. J Nutr. 2010;140:731-6 pubmed publisher
    ..These data suggest that restricting dietary aP concentration by only 43% stimulates Na(+)-dependent phosphate uptake and expression of the NaPi-IIb protein in the BBM of the small intestine and through a post-transcriptional mechanism. ..
  4. Dogan O, Ozsahin S, Gul E, Arslan S, Koksal B, Berk S, et al. A frame-shift mutation in the SLC34A2 gene in three patients with pulmonary alveolar microlithiasis in an inbred family. Intern Med. 2010;49:45-9 pubmed
    ..These findings suggest that impaired activity of the SLC34A2 gene may be responsible for familial PAM. ..
  5. Zhong Y, Hu C, Cai X, Nie H. [A novel mutation of the SLC34A2 gene in a Chinese pedigree with pulmonary alveolar microlithiasis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:365-8 pubmed
    ..A novel homozygous mutation in SLC34A2 gene, leading to a premature stop codon therefore a truncated protein, was probably responsible for the PAM in this family. The SNP in intron 2 needs further study. ..
  6. Konno Y, Moore R, Kamiya N, Negishi M. Nuclear xenobiotic receptor PXR-null mouse exhibits hypophosphatemia and represses the Na/Pi-cotransporter SLC34A2. Pharmacogenet Genomics. 2010;20:9-17 pubmed publisher
    ..The lack of PXR results in a severe repression of the Na/Pi cotransporter NaPi-IIb/Npt2b (SLC34A2), thus leading Pxr-/- males and females to develop a type of hypophosphatemia. ..
  7. Jin C, Zoidis E, Ghirlanda C, Schmid C. Dexamethasone and cyclic AMP regulate sodium phosphate cotransporter (NaPi-IIb and Pit-1) mRNA and phosphate uptake in rat alveolar type II epithelial cells. Lung. 2010;188:51-61 pubmed publisher
    ..1 mmol/l cAMP treatment. Although NaPi-IIb mRNA expression was maintained to some extent by AT II cells kept in primary culture, Pi uptake was more closely related to Pit-1 mRNA expression. ..
  8. Villa Bellosta R, Sorribas V. Arsenate transport by sodium/phosphate cotransporter type IIb. Toxicol Appl Pharmacol. 2010;247:36-40 pubmed publisher
    ..7 microM), which are very similar to the affinities for Pi. Therefore, NaPiIIb can have a prominent role in the toxicokinetics of arsenic following oral exposure to freshwater or food contaminated with As(V). ..
  9. Xu C, Jin H, Lim H, Ha Y, Chae C, An G, et al. Low dietary inorganic phosphate stimulates lung tumorigenesis through altering protein translation and cell cycle in K-ras(LA1) mice. Nutr Cancer. 2010;62:525-32 pubmed publisher
    ..Our results clearly demonstrated that low Pi also promoted lung tumorigenesis, thus suggesting that an appropriate intake of dietary Pi may be critical for lung cancer prevention as well as treatment. ..
  10. Tachibana T, Hagiwara K, Johkoh T. Pulmonary alveolar microlithiasis: review and management. Curr Opin Pulm Med. 2009;15:486-90 pubmed publisher
    ..Scrutiny of the long-term follow-up data of PAM patients reveals that the prognosis for PAM is poor. The establishment of an effective treatment, which is not yet available, is mandatory. ..