perilipins

Summary

Summary: A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.

Top Publications

  1. Goetzl E, Schwartz J, Mustapic M, Lobach I, Daneman R, Abner E, et al. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. FASEB J. 2017;31:3689-3694 pubmed publisher
    ..Goetzl, E. J., Schwartz, J. B., Mustapic, M., Lobach, I. V., Daneman, R., Abner, E. L., Jicha, G. A. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. ..
  2. Dany M, Elston D. Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa. J Am Acad Dermatol. 2017;77:268-273.e6 pubmed publisher
    ..Our study suggests that sphingolipid metabolism is altered in HS lesional skin compared with normal skin. ..
  3. Zheng X, Ning C, Dong Y, Zhao P, Li J, Fan Z, et al. Quantitative proteome analysis of bovine mammary gland reveals protein dynamic changes involved in peak and late lactation stages. Biochem Biophys Res Commun. 2017;494:292-297 pubmed publisher
    ..We expect findings in this study could be a valuable resource for future studies investigating the bovine proteome and functional studies...