Summary: Secretagogins are EF HAND MOTIF-containing calcium-binding proteins that are involved in early neuronal migration and neurogenesis. They are also present in many adult organs and in brain and endocrine neoplasms.

Top Publications

  1. MaleŇĄczyk K, Girach F, Szodorai E, Storm P, Segerstolpe A, Tortoriello G, et al. A TRPV1-to-secretagogin regulatory axis controls pancreatic ?-cell survival by modulating protein turnover. EMBO J. 2017;36:2107-2125 pubmed publisher
    ..Therefore, and considering the desensitization of TRPV1s in diabetic pancreata, a TRPV1-to-secretagogin regulatory axis seems critical to maintain the structural integrity and signal competence of ?-cells. ..
  2. Dudczig S, Currie P, Jusuf P. Developmental and adult characterization of secretagogin expressing amacrine cells in zebrafish retina. PLoS ONE. 2017;12:e0185107 pubmed publisher
    ..This characterization forms the basis of functional studies assessing how the expression of distinct calcium binding proteins might be regulated to compensate for the loss of one of the others. ..

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