neuronal calcium sensor proteins


Summary: A family of intracellular calcium-sensing proteins found predominately in NEURONS and PHOTORECEPTOR CELLS. They contain EF HAND MOTIFS and undergo conformational changes upon calcium-binding. Neuronal calcium-sensor proteins interact with other regulatory proteins to mediate physiological responses to a change in intracellular calcium concentration.

Top Publications

  1. Sippy T, Cruz Martin A, Jeromin A, Schweizer F. Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1. Nat Neurosci. 2003;6:1031-8 pubmed
    ..We conclude that separate mechanisms are responsible for determining basal synaptic strength and short-term plasticity. ..
  2. Petko J, Kabbani N, Frey C, Woll M, Hickey K, Craig M, et al. Proteomic and functional analysis of NCS-1 binding proteins reveals novel signaling pathways required for inner ear development in zebrafish. BMC Neurosci. 2009;10:27 pubmed publisher
  3. Iketani M, Imaizumi C, Nakamura F, Jeromin A, Mikoshiba K, Goshima Y, et al. Regulation of neurite outgrowth mediated by neuronal calcium sensor-1 and inositol 1,4,5-trisphosphate receptor in nerve growth cones. Neuroscience. 2009;161:743-52 pubmed publisher
    ..In addition, NCS-1 is functionally linked to InsP(3)R1, which may play an important role in the regulation of neurite outgrowth. ..
  4. Mikhaylova M, Reddy P, Munsch T, Landgraf P, Suman S, Smalla K, et al. Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking. Proc Natl Acad Sci U S A. 2009;106:9093-8 pubmed publisher
    ..The opposing roles of calneurons and NCS-1 provide a molecular switch to decode local calcium transients at the Golgi and impose a calcium threshold for PI-4Kbeta activity and vesicle trafficking...
  5. Saab B, Georgiou J, Nath A, Lee F, Wang M, Michalon A, et al. NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. Neuron. 2009;63:643-56 pubmed publisher
    ..These data demonstrate a role for NCS-1 and D2R in DG plasticity and provide insight for understanding how the DG contributes to the origin of exploration and spatial memory acquisition. ..
  6. Guo J, Zhang H, Ding K, Dai X, Chen Y, Duan Y, et al. [Cloning and transcriptional profiling of PsNCS1 from Puccinia striiformis f. sp. tritici]. Wei Sheng Wu Xue Bao. 2010;50:962-8 pubmed
    ..PsNCS1 might be involved in the process of urediospore formation and germ tube elongation. The present results may provide basic data for further analysis of the role of PsCNS1 in pathogenesis process and calcium signaling. ..
  7. Kurz A, Double K, Lastres Becker I, Tozzi A, Tantucci M, Bockhart V, et al. A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PLoS ONE. 2010;5:e11464 pubmed publisher
    ..As a model of preclinical stages of PD, such insights may help to develop neuroprotective therapeutic approaches. ..
  8. Handley M, Lian L, Haynes L, Burgoyne R. Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder. PLoS ONE. 2010;5:e10534 pubmed publisher
    ..From these data we speculate that impairment of the normal cycling of NCS-1 by the R102Q mutation could have subtle effects on neuronal signalling and physiology in the developing and adult brain. ..
  9. Guimarães M, Reis H, Guimarães L, Carneiro D, Ribeiro F, Gomez M, et al. Modulation of muscarinic signaling in PC12 cells overexpressing neuronal Ca2+ sensor-1 protein. Cell Mol Biol (Noisy-le-grand). 2009;55 Suppl:OL1138-50 pubmed

More Information


  1. Gambino F, Kneib M, Pavlowsky A, Skala H, Heitz S, Vitale N, et al. IL1RAPL1 controls inhibitory networks during cerebellar development in mice. Eur J Neurosci. 2009;30:1476-86 pubmed publisher
    ..Thus, we conclude that IL1RAPL1 exerts a key function during cerebellar development in establishing local excitation/inhibition balance. ..
  2. Lim S, Ames J. (1)H, (15)N, and (13)C chemical shift assignments of neuronal calcium sensor-1 homolog from fission yeast. Biomol NMR Assign. 2009;3:269-71 pubmed publisher
    ..We report complete NMR chemical shift assignments of the NCS homolog from fission yeast (Schizosaccharomyces pombe), referred to in this study as Ncs1p. (BMRB no. 16446). ..
  3. Amici M, Doherty A, Jo J, Jane D, Cho K, Collingridge G, et al. Neuronal calcium sensors and synaptic plasticity. Biochem Soc Trans. 2009;37:1359-63 pubmed publisher
    ..The present minireview aims to bring together evidence supporting a role for NCS proteins in plasticity, focusing on emerging roles of NCS-1 and hippocalcin. ..
  4. Rosa D, Souza R, Souza B, Lima F, Valvassori S, Gomez M, et al. Inhibitory avoidance task does not change NCS-1 level in rat brain. Brain Res Bull. 2010;82:289-92 pubmed publisher
    ..Furthermore, other experiments are needed to shed more light on the role of NCS-1 and other mechanisms linked to signaling pathways related to inhibitory avoidance task. ..
  5. Yip P, Wong L, Sears T, Yáñez Muñoz R, McMahon S. Cortical overexpression of neuronal calcium sensor-1 induces functional plasticity in spinal cord following unilateral pyramidal tract injury in rat. PLoS Biol. 2010;8:e1000399 pubmed publisher
    ..These findings demonstrate that increasing the levels of intracellular NCS1 in injured and uninjured central neurons enhances their intrinsic anatomical plasticity within the injured adult central nervous system. ..
  6. McCue H, Haynes L, Burgoyne R. The diversity of calcium sensor proteins in the regulation of neuronal function. Cold Spring Harb Perspect Biol. 2010;2:a004085 pubmed publisher
    ..In this article, we summarize synaptotagmins in neurotransmitter release, the neuronal roles of calmodulin, and the functional significance of the NCS and the CaBP/calneuron protein families of neuronal Ca(2+) sensors. ..
  7. Sallese M, Iacovelli L, Cumashi A, Capobianco L, Cuomo L, De Blasi A. Regulation of G protein-coupled receptor kinase subtypes by calcium sensor proteins. Biochim Biophys Acta. 2000;1498:112-21 pubmed
  8. Blachford C, Celic A, Petri E, Ehrlich B. Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding. Cell Calcium. 2009;46:257-62 pubmed publisher