intracellular calcium sensing proteins


Summary: Intracellular signaling peptides and proteins that bind to CALCIUM. They undergo allosteric changes when bound to CALCIUM that affects their interaction with other signal-transducing molecules. They differ from CALCIUM-SENSING RECEPTORS which sense extracellular calcium levels.

Top Publications

  1. Marie P. The calcium-sensing receptor in bone cells: a potential therapeutic target in osteoporosis. Bone. 2010;46:571-6 pubmed publisher
    ..The development of drugs that preferentially target the CaSR and possibly other cation-sensing receptors in bone cells may thus be helpful for the treatment of osteoporosis. ..
  2. Uhász G, Barkóczi B, Vass G, Datki Z, Hunya A, Fülöp L, et al. Fibrillar Abeta (1-42) enhances NMDA receptor sensitivity via the integrin signaling pathway. J Alzheimers Dis. 2010;19:1055-67 pubmed publisher
    ..These results support the hypothesis that aggregated Abeta (1-42) is recognized by the beta1 subunit containing integrins and may induce a Src kinase dependent NMDA receptor phosphorylation. ..
  3. Granstedt A, Kuhn B, Wang S, Enquist L. Calcium imaging of neuronal circuits in vivo using a circuit-tracing pseudorabies virus. Cold Spring Harb Protoc. 2010;2010:pdb.prot5410 pubmed publisher
    ..The procedure describes the delivery of PRV369 to the glands and shows how SMG neurons can then be imaged post-inoculation to explore connectivity and activity. ..
  4. Liu Z, Klaavuniemi T, Ono S. Distinct roles of four gelsolin-like domains of Caenorhabditis elegans gelsolin-like protein-1 in actin filament severing, barbed end capping, and phosphoinositide binding. Biochemistry. 2010;49:4349-60 pubmed publisher
    ..These results reveal both conserved and different utilization of G domains between C. elegans GSNL-1 and mammalian gelsolin for actin regulatory functions. ..
  5. Dell Orco D, Muller M, Koch K. Quantitative detection of conformational transitions in a calcium sensor protein by surface plasmon resonance. Chem Commun (Camb). 2010;46:7316-8 pubmed publisher
    ..The phenomenon appears to be related to changes in the refractive index at the metal/dielectric interface. ..