Summary: A calbindin protein that is differentially expressed in distinct populations of NEURONS throughout the vertebrate and invertebrate NERVOUS SYSTEM, and modulates intrinsic neuronal excitability and influences LONG-TERM POTENTIATION. It is also found in LUNG, TESTIS, OVARY, KIDNEY, and BREAST, and is expressed in many tumor types found in these tissues. It is often used as an immunohistochemical marker for MESOTHELIOMA.
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..We conclude that calretinin levels have an impact on the progression of the cell cycle of WiDr cells. ..
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..It also demonstrates the selective sparing of these chemospecific striatal neurons in Huntington's disease. ..
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..Furthermore, calretinin appears to be a particularly reliable molecular maker for all the neuronal elements associated with the granular layer in the primate cerebellum. ..
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. Comparative differential proteomic analysis of minimal change disease and focal segmental glomerulosclerosis. BMC Nephrol. 2017;18:49 pubmed publisher
..These biomarkers would reduce the number of misdiagnoses, avoiding unnecessary or inadequate treatments. ..
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. Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study. Mol Carcinog. 2017;56:2258-2266 pubmed publisher
..These findings, if confirmed, may provide a new avenue for the personalized prevention of colorectal adenoma and cancer. ..
Micello D, Bossi A, Marando A, Dainese E, Sessa F, Capella C. Expression of calretinin in high-grade hormone receptor-negative invasive breast carcinomas: correlation with histological and molecular subtypes. Virchows Arch. 2017;471:13-21 pubmed publisher
..Calretinin expression is most common in high-grade IBCs with histological medullary features, type II IDC-NST and BL phenotype, and is associated with high neoplastic proliferative index. ..