annexin a7


Summary: An annexin family member that plays a role in MEMBRANE FUSION and signaling via VOLTAGE-DEPENDENT CALCIUM CHANNELS.

Top Publications

  1. Chander A, Chen X, Naidu D. A role for diacylglycerol in annexin A7-mediated fusion of lung lamellar bodies. Biochim Biophys Acta. 2007;1771:1308-18 pubmed
    Lung surfactant secretion in alveolar type II cells occurs following lamellar body fusion with plasma membrane. Annexin A7 is a Ca2+-dependent membrane-binding protein that is postulated to promote membrane fusion during exocytosis in ..
  2. Lang P, Kasinathan R, Brand V, Duranton C, Lang C, Koka S, et al. Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency. Cell Physiol Biochem. 2009;24:415-28 pubmed publisher
    ..In conclusion, PS exposure on erythrocytes results in accelerated clearance of Plasmodium ring stage-infected HbA/S or annexin-A7(-/-) erythrocytes and thus confers partial protection against malaria in vivo. ..
  3. Yu F, Finley R, Raz A, Kim H. Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation. J Biol Chem. 2002;277:15819-27 pubmed
    ..Taken together, these results suggest that synexin mediates galectin-3 translocation to the perinuclear mitochondrial membranes, where it regulates mitochondrial integrity critical for apoptosis regulation. ..
  4. Chander A, Sen N, Spitzer A. Synexin and GTP increase surfactant secretion in permeabilized alveolar type II cells. Am J Physiol Lung Cell Mol Physiol. 2001;280:L991-8 pubmed
    ..Thus our results support a direct role for synexin in surfactant secretion. Our study also suggests that membrane fusion during surfactant secretion may be mediated by two independent mechanisms...
  5. Ji H, Moritz R, Kim Y, Zhu H, Simpson R. Analysis of Ras-induced oncogenic transformation of NIH-3T3 cells using differential-display 2-DE proteomics. Electrophoresis. 2007;28:1997-2008 pubmed
    ..pathways include S-methyl-5-thioadenosine phosphorylase, stress-induced-phosphoprotein 1, galectin-1, annexin A7 (synexin), 60S acidic ribosomal protein P0, serine/threonine protein phosphatase type 1 (PP1alpha) and ..
  6. Jin Y, Mao J, Wang H, Hou Z, Ma W, Zhang J, et al. Enhanced tumorigenesis and lymphatic metastasis of CD133+ hepatocarcinoma ascites syngeneic cell lines mediated by JNK signaling pathway in vitro and in vivo. Biomed Pharmacother. 2013;67:337-45 pubmed publisher
    ..We propose that tumorigenesis and lymphatic metastasis are regulated by JNK/P53/annexin VII and JNK/ATF-2/CDH1/annexin VII signal transduction pathways...
  7. Doring V, Veretout F, Albrecht R, Muhlbauer B, Schlatterer C, Schleicher M, et al. The in vivo role of annexin VII (synexin): characterization of an annexin VII-deficient Dictyostelium mutant indicates an involvement in Ca(2+)-regulated processes. J Cell Sci. 1995;108 ( Pt 5):2065-76 pubmed
    ..The data suggest that annexin VII is not required for membrane fusion events but rather contributes to proper Ca2+ homeostasis in the cell. ..
  8. Qazi A, Sun M, Huang Y, Wei Y, Tang J. Subcellular proteomics: determination of specific location and expression levels of lymphatic metastasis associated proteins in hepatocellular carcinoma by subcellular fractionation. Biomed Pharmacother. 2011;65:407-16 pubmed publisher
    ..High expression levels were found in high lymphatic metastasis potential cell lines which indicate their roles according to different expression sites in the disease. ..
  9. Ibrahim M, Sun M, Huang Y, Jun M, Jin Y, Yue D, et al. Down-regulation of ANXA7 decreases metastatic potential of human hepatocellular carcinoma cells in vitro. Biomed Pharmacother. 2013;67:285-91 pubmed publisher
    ..We have found ANXA7 to be functioning like a tumour promoter in HepG2 human hepatocellular carcinoma cells and could have a potential as a therapeutic window into the management of liver cancer. ..

More Information


  1. Rick M, Ramos Garrido S, Herr C, Thal D, Noegel A, Clemen C. Nuclear localization of Annexin A7 during murine brain development. BMC Neurosci. 2005;6:25 pubmed
    b>Annexin A7 is a member of the annexin protein family, which is characterized by its ability to interact with phospholipids in the presence of Ca2+-ions and which is thought to function in Ca2+-homeostasis...
  2. Naidu D, Raha A, Chen X, Spitzer A, Chander A. Partial truncation of the NH2-terminus affects physical characteristics and membrane binding, aggregation, and fusion properties of annexin A7. Biochim Biophys Acta. 2005;1734:152-68 pubmed
    b>Annexin A7 (synexin, annexin VII), a member of the annexin family of proteins, causes aggregation of membranes in a Ca2+-dependent manner and has been suggested to promote membrane fusion during exocytosis of lung surfactant, ..
  3. Srivastava M, Bubendorf L, Raffeld M, Bucher C, Torhorst J, Sauter G, et al. Prognostic impact of ANX7-GTPase in metastatic and HER2-negative breast cancer patients. Clin Cancer Res. 2004;10:2344-50 pubmed
    ..This simple and reliable immunohistochemical assay may therefore become an important biomarker for metastatic breast cancer diagnosis and management of HER2-negative breast tumor patients. ..
  4. Herr C, Smyth N, Ullrich S, Yun F, Sasse P, Hescheler J, et al. Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes. Mol Cell Biol. 2001;21:4119-28 pubmed
    b>Annexin A7 has been proposed to function in the fusion of vesicles, acting as a Ca(2+) channel and as Ca(2+)-activated GTPase, thus inducing Ca(2+)/GTP-dependent secretory events...
  5. Smitherman A, Mohler J, Maygarden S, Ornstein D. Expression of annexin I, II and VII proteins in androgen stimulated and recurrent prostate cancer. J Urol. 2004;171:916-20 pubmed
    ..Annexin VII protein expression is decreased in R-CaP, although AS-CaP and BPE are similar. This study suggests that the dysregulations of annexin proteins I, II and VII are important events in prostate carcinogenesis and progression. ..
  6. Clemen C, Herr C, Hövelmeyer N, Noegel A. The lack of annexin A7 affects functions of primary astrocytes. Exp Cell Res. 2003;291:406-14 pubmed
    b>Annexin A7 is a Ca(2+)- and phospholipid-binding protein, which is thought to function in membrane organization and Ca(2+)-dependent signaling processes...
  7. Herr C, Clemen C, Lehnert G, Kutschkow R, Picker S, Gathof B, et al. Function, expression and localization of annexin A7 in platelets and red blood cells: insights derived from an annexin A7 mutant mouse. BMC Biochem. 2003;4:8 pubmed
    b>Annexin A7 is a Ca2+- and phospholipid-binding protein expressed as a 47 and 51 kDa isoform, which is thought to be involved in membrane fusion processes...
  8. Schrickel J, Brixius K, Herr C, Clemen C, Sasse P, Reetz K, et al. Enhanced heterogeneity of myocardial conduction and severe cardiac electrical instability in annexin A7-deficient mice. Cardiovasc Res. 2007;76:257-68 pubmed
    b>Annexin A7 is involved in cardiomyocyte membrane organization and Ca(2+)-dependent signalling processes...
  9. Caohuy H, Pollard H. Protein kinase C and guanosine triphosphate combine to potentiate calcium-dependent membrane fusion driven by annexin 7. J Biol Chem. 2002;277:25217-25 pubmed
    ..These results thus lead us to hypothesize that annexin 7 may serve as a common site of action for calcium, guanine nucleotide, and protein kinase C in the exocytotic membrane fusion process in chromaffin cells. ..
  10. Hsu P, Huang M, Chen H, Hsu P, Lai T, Wang J, et al. The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer. J Surg Oncol. 2008;97:609-14 pubmed publisher
    ..159). A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed. The loss of expression of ANXA7 is associated with distant metastasis. ..
  11. Clemen C, Herr C, Lie A, Noegel A, Schroder R. Annexin VII: an astroglial protein exhibiting a Ca2+-dependent subcellular distribution. Neuroreport. 2001;12:1139-44 pubmed
    ..Our findings indicate a role of annexin VII in the regulation of intracellular Ca(2+)-dependent processes in astroglial cells. ..
  12. Srivastava M, Bubendorf L, Srikantan V, Fossom L, Nolan L, Glasman M, et al. ANX7, a candidate tumor suppressor gene for prostate cancer. Proc Natl Acad Sci U S A. 2001;98:4575-80 pubmed
    ..We conclude that the ANX7 gene exhibits many biological and genetic properties expected of a TSG and may play a role in prostate cancer progression. ..
  13. Jin Y, Wang Z, Qu H, Wang H, Ibrahim M, Zhang J, et al. Annexin A7 gene is an important factor in the lymphatic metastasis of tumors. Biomed Pharmacother. 2013;67:251-9 pubmed publisher
    ..These results indicated that ANXA7 is a critical factor in the development of lymphatic metastasis in hepatocarcinoma progression. ..
  14. Torosyan Y, Simakova O, Naga S, Mezhevaya K, Leighton X, Diaz J, et al. Annexin-A7 protects normal prostate cells and induces distinct patterns of RB-associated cytotoxicity in androgen-sensitive and -resistant prostate cancer cells. Int J Cancer. 2009;125:2528-39 pubmed publisher
    ..Thus, ANXA7 revived the RB-associated cell survival control and overcame androgen resistance and dysfunctional status of major tumor suppressors commonly mutated in prostate cancer. Published 2009 UICC. ..
  15. Hoyer D, Grönke S, Frank K, Addicks K, Wettschureck N, Offermanns S, et al. Diabetes-related defects in sarcoplasmic Ca2+ release are prevented by inactivation of G(alpha)11 and G(alpha)q in murine cardiomyocytes. Mol Cell Biochem. 2010;341:235-44 pubmed publisher
    ..6, sorcin, and annexin A7 were analyzed by immunoblot and RT-PCR...
  16. Lang E, Lang P, Shumilina E, Qadri S, Kucherenko Y, Kempe D, et al. Enhanced eryptosis of erythrocytes from gene-targeted mice lacking annexin A7. Pflugers Arch. 2010;460:667-76 pubmed publisher
    b>Annexin A7 is a ubiquitously expressed Ca(2+)- and phospholipid-binding protein. Erythrocytes from mice lacking annexin A7 (anxA7(-/-)) are deformed and relatively resistant to osmotic swelling...
  17. Zhang Keck Z, Burns A, Pollard H. Mouse synexin (annexin VII) polymorphisms and a phylogenetic comparison with other synexins. Biochem J. 1993;289 ( Pt 3):735-41 pubmed
  18. Magendzo K, Shirvan A, Cultraro C, Srivastava M, Pollard H, Burns A. Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain. J Biol Chem. 1991;266:3228-32 pubmed
    ..0- and 2.4-kilobase) when hybridized to a cDNA fragment of the coding region of synexin, but only the 2.4-kilobase band hybridized to a probe made from the longer 3' end. ..
  19. Sun M, Liu S, Tang J, Wang Z, Gong X, Sun C, et al. Proteomics analysis of two mice hepatocarcinoma ascites syngeneic cell lines with high and low lymph node metastasis rates provide potential protein markers for tumor malignancy attributes to lymphatic metastasis. Proteomics. 2009;9:3285-302 pubmed publisher
    ..Totally, 113 unique proteins were identified by HPLC-nano ESI-MS/MS analysis. The expression levels of Annexin A7, Ulch3, and ER protein 29 were validated by Western blotting analyses...
  20. Wang L, Dong Z, Huang B, Zhao B, Wang H, Zhao J, et al. Distinct patterns of autophagy evoked by two benzoxazine derivatives in vascular endothelial cells. Autophagy. 2010;6:1115-24 pubmed
    ..manner, respectively; ABO-stimulated autophagy was attributed to the elevation of the Ca2+ channel annexin A7 (ANXA7), whereas DBO's effect was due to the level of intracellular reactive oxygen species (ROS)...
  21. Mears D, Zimliki C, Atwater I, Rojas E, Glassman M, Leighton X, et al. The Anx7(+/-) knockout mutation alters electrical and secretory responses to Ca(2+)-mobilizing agents in pancreatic ?-cells. Cell Physiol Biochem. 2012;29:697-704 pubmed publisher
  22. Srivastava M, Montagna C, Leighton X, Glasman M, Naga S, Eidelman O, et al. Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse. Proc Natl Acad Sci U S A. 2003;100:14287-92 pubmed
  23. Guo C, Liu S, GREENAWAY F, Sun M. Potential role of annexin A7 in cancers. Clin Chim Acta. 2013;423:83-9 pubmed publisher
    b>Annexin A7 (Anxa7) is a member of the multigene annexin superfamily of Ca(2+)-regulated and phospholipid-binding proteins...
  24. Li H, Liu N, Wang S, Wang L, Zhao J, Su L, et al. Identification of a small molecule targeting annexin A7. Biochim Biophys Acta. 2013;1833:2092-9 pubmed publisher
    Autophagy involves multiple membrane trafficking and fusion events. Annexin A7 (ANXA7) is postulated to play a role in membrane fusion during exocytosis, while the contribution of ANXA7 to autophagy is poorly understood...
  25. Caohuy H, Pollard H. Activation of annexin 7 by protein kinase C in vitro and in vivo. J Biol Chem. 2001;276:12813-21 pubmed
    ..These results thus lead us to hypothesize that annexin 7 may be a positive mediator for protein kinase C action in the exocytotic membrane fusion reaction in chromaffin cells. ..
  26. Clemen C, Hofmann A, Zamparelli C, Noegel A. Expression and localisation of annexin VII (synexin) isoforms in differentiating myoblasts. J Muscle Res Cell Motil. 1999;20:669-79 pubmed
    ..By sucrose gradient centrifugation of postnuclear supernatants we identified two distinct annexin VII-containing membrane populations that cofractionated with caveolin 3- and sorcin-containing membranes. ..
  27. Srivastava M, Atwater I, Glasman M, Leighton X, Goping G, Caohuy H, et al. Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse. Proc Natl Acad Sci U S A. 1999;96:13783-8 pubmed
    ..This is a direct demonstration of a connection between glucose-activated insulin secretion and Ca(2+) signaling through IP(3)-sensitive Ca(2+) stores. ..
  28. Nir S, Stutzin A, Pollard H. Effect of synexin on aggregation and fusion of chromaffin granule ghosts at pH 6. Biochim Biophys Acta. 1987;903:309-18 pubmed
    ..The analysis showed that the main activity of synexin was an enhancement of the rate of aggregation. At intermediate or excessive synexin concentrations it, respectively, promoted moderately, or inhibited the actual fusion step. ..
  29. Srivastava M, Torosyan Y, Raffeld M, Eidelman O, Pollard H, Bubendorf L. ANXA7 expression represents hormone-relevant tumor suppression in different cancers. Int J Cancer. 2007;121:2628-36 pubmed
    ..With tumor suppressor pattern validated in different tumors, ANXA7 can be an attractive diagnostic and therapeutic target associated with the hormone and/or neurotransmitter-mediated modulation of tumorigenesis. ..
  30. Salzer U, Hinterdorfer P, Hunger U, Borken C, Prohaska R. Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin. Blood. 2002;99:2569-77 pubmed
    ..Synexin, which is known to be vital to the process of membrane fusion, is suggested to be a key component in the process of vesicle release from erythrocytes. ..
  31. Brownawell A, Creutz C. Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII). J Biol Chem. 1997;272:22182-90 pubmed
    ..Therefore, the interaction between sorcin and synexin may serve to regulate the functions of these proteins on membrane surfaces in a Ca2+-dependent manner. ..
  32. Selbert S, Fischer P, Pongratz D, Stewart M, Noegel A. Expression and localization of annexin VII (synexin) in muscle cells. J Cell Sci. 1995;108 ( Pt 1):85-95 pubmed
    ..The results obtained indicate a developmentally and Ca(2+)-regulated localization and expression of annexin VII and raise the possibility that annexin VII may play a role in excitation-contraction coupling in skeletal muscle. ..
  33. Leighton X, Srikantan V, Pollard H, Sukumar S, Srivastava M. Significant allelic loss of ANX7region (10q21) in hormone receptor negative breast carcinomas. Cancer Lett. 2004;210:239-44 pubmed
    ..06). These results suggest that the ANX7 gene, or other genes of the 10q21 region, could be functionally related to breast cancer, probably influencing the hormone receptor expression associated with poor prognosis during development. ..
  34. Gerelsaikhan T, Chen X, Chander A. Secretagogues of lung surfactant increase annexin A7 localization with ABCA3 in alveolar type II cells. Biochim Biophys Acta. 2011;1813:2017-25 pubmed publisher
    ..Previous studies have postulated a role for annexin A7 (A7) in membrane fusion during exocytosis in some cells including alveolar type II cells...
  35. Liu C, Fann C, Chen C, Liu Y, Oyang Y, Yang W, et al. ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function. Biol Psychiatry. 2011;70:51-8 pubmed publisher
    ..ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes are potential candidate genes for schizophrenia, especially in patients with deficits in sustained attention and executive function. The responsible functional variants remained to be clarified. ..
  36. Brownawell A, Creutz C. Calcium-dependent binding of the plasma protein apolipoprotein A-I to two members of the annexin family. Biochemistry. 1996;35:6839-45 pubmed
    ..Other annexins, such as annexin IV and annexin VI, do not exhibit this binding. The results suggest that certain annexins may function as extracellular binding sites for plasma proteins. ..
  37. Taniuchi K, Yokotani K, Saibara T. BART inhibits pancreatic cancer cell invasion by PKC? inactivation through binding to ANX7. PLoS ONE. 2012;7:e35674 pubmed publisher
    ..Thus, it is possible that BART and ANX7 can distinctly regulate the downstream signaling of PKC? that is potentially relevant to cell invasion by acting as anti-invasive molecules. ..
  38. Gerelsaikhan T, Vasa P, Chander A. Annexin A7 and SNAP23 interactions in alveolar type II cells and in vitro: a role for Ca(2+) and PKC. Biochim Biophys Acta. 2012;1823:1796-806 pubmed publisher
    ..b>Annexin A7 (A7) is postulated to play a role in membrane fusion during exocytosis...
  39. Zhou S, Li C, Liu L, Shen L, Li Y. Expression and localization of annexin A7 in the rat lithium-pilocarpine model of acquired epilepsy. Chin Med J (Engl). 2010;123:2410-5 pubmed
    b>Annexin A7 (synexin, ANXA7) is a member of annexins, which plays an essential role in the regulation of calcium homeostasis...
  40. Mrówczyńska L, Salzer U, Perutkova S, Iglic A, Hagerstrand H. Echinophilic proteins stomatin, sorcin, and synexin locate outside gangliosideM1 (GM1) patches in the erythrocyte membrane. Biochem Biophys Res Commun. 2010;401:396-400 pubmed publisher
    ..Echinophilicity is suggested to contribute to the DRM association of a membrane component in general. ..
  41. Chen J, Sheldon A, Pincus M. Structure-function correlations of calcium binding and calcium channel activities based on 3-dimensional models of human annexins I, II, III, V and VII. J Biomol Struct Dyn. 1993;10:1067-89 pubmed
    ..Residue 267, found on the convex surface at the pore opening, may also be important in modifying channel activity. ..
  42. Torosyan Y, Dobi A, Naga S, Mezhevaya K, Glasman M, Norris C, et al. Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription. Cancer Res. 2006;66:9609-16 pubmed
    Tumor suppressor function for Annexin A7 (ANXA7; 10q21) is based on cancer-prone phenotype in Anxa7(+/-) mouse and ANXA7 prognostic role in human cancers...
  43. Prignano F, Ricceri F, Bonan P, Cannarozzo G, Campolmi P. Induction of apoptosis by fractional CO2 laser treatment. J Cosmet Laser Ther. 2012;14:267-71 pubmed publisher
    ..Apoptosis, one of the major mechanisms of cell death, might play a key role in initiating the paracrine cascades that lead to cell proliferation. ..
  44. Gramage E, Herradon G, Martin Y, Vicente Rodríguez M, Rojo L, Gnekow H, et al. Differential phosphoproteome of the striatum from pleiotrophin knockout and midkine knockout mice treated with amphetamine: correlations with amphetamine-induced neurotoxicity. Toxicology. 2013;306:147-56 pubmed publisher
    ..It is very interesting to note that 4 of these phosphoproteins, annexin A7 (ANXA7), COP9 signalosome subunit 5 (COPS5), aldehyde dehydrogenase family 1 member A1 (ALDH1A1) and creatine ..
  45. Voelkl J, Alesutan I, Pakladok T, Viereck R, Feger M, Mia S, et al. Annexin A7 deficiency potentiates cardiac NFAT activity promoting hypertrophic signaling. Biochem Biophys Res Commun. 2014;445:244-9 pubmed publisher
    b>Annexin A7 (Anxa7) is a cytoskeletal protein interacting with Ca(2+) signaling which in turn is a crucial factor for cardiac remodeling following cardiac injury...
  46. Matsuo K, Arito M, Noyori K, Nakamura H, Kurokawa M, Masuko K, et al. Arthritogenicity of annexin VII revealed by phosphoproteomics of rheumatoid synoviocytes. Ann Rheum Dis. 2011;70:1489-95 pubmed publisher
    ..To identify novel proteins involved in the pathogenesis of rheumatoid arthritis (RA) and to characterise the identified proteins based on pathogenic and therapeutic aspects...
  47. Torosyan Y, Dobi A, Glasman M, Mezhevaya K, Naga S, Huang W, et al. Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells. Oncogene. 2010;29:2457-66 pubmed publisher
    ..Thus, a multi-hnRNP complex can be responsible for aberrant ANXA7 transcription and splicing, thereby affecting ANXA7 expression pattern and tumor suppressor function in prostate cancer. ..
  48. Wu J, Wang F, Gong Y, Li D, Sha J, Huang X, et al. Proteomic analysis of changes induced by nonylphenol in Sprague-Dawley rat Sertoli cells. Chem Res Toxicol. 2009;22:668-75 pubmed publisher
    ..Of these 41 spots, we focused on Raf kinase inhibitor protein (RKIP), Annexin A7 (ANXA7), ERp57, and Peroxiredoxin 6 (PRDX6) for further analysis by Western blot...
  49. Lam W, Leung K, Law P, Lee S, Chan H, Fung K, et al. Antiviral effect of Phyllanthus nanus ethanolic extract against hepatitis B virus (HBV) by expression microarray analysis. J Cell Biochem. 2006;97:795-812 pubmed
    ..The microarray results indicated that there was up-regulation of expression of several genes, including annexin A7 (Axn7)...
  50. Doring V, Schleicher M, Noegel A. Dictyostelium annexin VII (synexin). cDNA sequence and isolation of a gene disruption mutant. J Biol Chem. 1991;266:17509-15 pubmed
    ..Lack of annexin VII is not a lethal event for D. discoideum, and the cells are able to undergo development on agar plates. ..
  51. Lehnigk U, Zimmermann U, Woenckhaus C, Giebel J. Localization of annexins I, II, IV and VII in whole prostate sections from radical prostatectomy patients. Histol Histopathol. 2005;20:673-80 pubmed publisher
    ..In contrast, as progression from PIN to PCa is characterized by a reduction of ANX I and II this suggests that downregulation of these proteins could represent an important event in prostate carcinogenesis. ..
  52. Srivastava M, Eidelman O, Leighton X, Glasman M, Goping G, Pollard H. Anx7 is required for nutritional control of gene expression in mouse pancreatic islets of Langerhans. Mol Med. 2002;8:781-97 pubmed
    ..We believe that the requirement for complete Anx7 gene dosage and IPTR3 expression in islets of Langerhans will prove to be of fundamental importance for understanding the mechanism of nutritional sensing in health and disease. ..
  53. Chander A, Sen N, Naidu D, Spitzer A. Calcium ionophore and phorbol ester increase membrane binding of annexin a7 in alveolar type II cells. Cell Calcium. 2003;33:11-7 pubmed
    ..body with plasma membrane, a distal obligatory step in exocytosis of lung surfactant, may be mediated by annexin a7 (anx a7; synexin)...