annexin a2

Summary

Summary: A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.

Top Publications

  1. Rezvanpour A, Phillips J, Shaw G. Design of high-affinity S100-target hybrid proteins. Protein Sci. 2009;18:2528-36 pubmed publisher
    ..S100A10 does not bind calcium but is able to recruit the N-terminus of annexin A2 important for membrane fusion events, and to form larger multiprotein complexes such as that with the cation ..
  2. Melas P, Rogdaki M, Lennartsson A, Björk K, Qi H, Witasp A, et al. Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. Int J Neuropsychopharmacol. 2012;15:669-79 pubmed publisher
    ..In conclusion, our data further support a role for P11 in depression-like states and suggest that this gene is controlled by epigenetic mechanisms that can be affected by antidepressant treatment. ..
  3. Sharma M, Blackman M, Sharma M. Antibody-directed neutralization of annexin II (ANX II) inhibits neoangiogenesis and human breast tumor growth in a xenograft model. Exp Mol Pathol. 2012;92:175-84 pubmed publisher
    ..Taken together, these data suggest that selective disruption of the fibrinolytic activity of ANX II may provide a novel strategy for specific inhibition of neoangiogenesis in human breast cancer...
  4. Yee D, Narula N, Ramzy I, Boker J, Ahlering T, Skarecky D, et al. Reduced annexin II protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. Arch Pathol Lab Med. 2007;131:902-8 pubmed
    ..Although commonly underexpressed in prostate cancer, the association of reduced expression with pathologic grade and stage is unknown...
  5. Streicher W, Lopez M, Makhatadze G. Annexin I and annexin II N-terminal peptides binding to S100 protein family members: specificity and thermodynamic characterization. Biochemistry. 2009;48:2788-98 pubmed publisher
    ..In fact, the functional overlap can explain previous failures of S100 knockout constructs to show any detectable changes in phenotype despite numerous implications of these proteins in important cellular processes. ..
  6. Hayes M, Moss S. Annexin 2 has a dual role as regulator and effector of v-Src in cell transformation. J Biol Chem. 2009;284:10202-10 pubmed publisher
    ..Our findings reveal a dual role for annexin 2, first as a regulator of v-Src trafficking and targeting and second as a v-Src effector in the reorganization of actin. ..
  7. Huang Y, Jin Y, Yan C, Yu Y, Bai J, Chen F, et al. Involvement of Annexin A2 in p53 induced apoptosis in lung cancer. Mol Cell Biochem. 2008;309:117-23 pubmed
    ..However, the exactly mechanism in the pathway is still unclear. Here we found that Annexin A2, a Ca2+ -dependent phospholipid-binding protein, is involved in p53-mediated apoptosis...
  8. Hayes M, Shao D, Grieve A, Levine T, Bailly M, Moss S. Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphate. Biochim Biophys Acta. 2009;1793:1086-95 pubmed publisher
    ..The calcium and anionic phospholipid-binding protein annexin A2 is necessary for macropinocytic rocketing and has been shown to bind both PI(4,5)P2 and the barbed-ends of F-..
  9. O Connell P, Madureira P, Berman J, Liwski R, Waisman D. Regulation of S100A10 by the PML-RAR-? oncoprotein. Blood. 2011;117:4095-105 pubmed publisher
    ..These experiments show that S100A10 plays a crucial role in the generation of plasmin leading to fibrinolysis, thus providing a link to the clinical hemorrhagic phenotype of APL. ..
  10. Allen K, Fonseca F, Betapudi V, Willard B, Zhang J, McCrae K. A novel pathway for human endothelial cell activation by antiphospholipid/anti-?2 glycoprotein I antibodies. Blood. 2012;119:884-93 pubmed publisher
    ..2)GPI, and activate endothelial cells (ECs) in a ?(2)GPI-dependent manner after binding of ?(2)GPI to EC annexin A2. Because annexin A2 is not a transmembrane protein, the mechanisms of APLA/anti-?(2)GPI Ab-mediated EC ..

Detail Information

Publications62

  1. Rezvanpour A, Phillips J, Shaw G. Design of high-affinity S100-target hybrid proteins. Protein Sci. 2009;18:2528-36 pubmed publisher
    ..S100A10 does not bind calcium but is able to recruit the N-terminus of annexin A2 important for membrane fusion events, and to form larger multiprotein complexes such as that with the cation ..
  2. Melas P, Rogdaki M, Lennartsson A, Björk K, Qi H, Witasp A, et al. Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. Int J Neuropsychopharmacol. 2012;15:669-79 pubmed publisher
    ..In conclusion, our data further support a role for P11 in depression-like states and suggest that this gene is controlled by epigenetic mechanisms that can be affected by antidepressant treatment. ..
  3. Sharma M, Blackman M, Sharma M. Antibody-directed neutralization of annexin II (ANX II) inhibits neoangiogenesis and human breast tumor growth in a xenograft model. Exp Mol Pathol. 2012;92:175-84 pubmed publisher
    ..Taken together, these data suggest that selective disruption of the fibrinolytic activity of ANX II may provide a novel strategy for specific inhibition of neoangiogenesis in human breast cancer...
  4. Yee D, Narula N, Ramzy I, Boker J, Ahlering T, Skarecky D, et al. Reduced annexin II protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. Arch Pathol Lab Med. 2007;131:902-8 pubmed
    ..Although commonly underexpressed in prostate cancer, the association of reduced expression with pathologic grade and stage is unknown...
  5. Streicher W, Lopez M, Makhatadze G. Annexin I and annexin II N-terminal peptides binding to S100 protein family members: specificity and thermodynamic characterization. Biochemistry. 2009;48:2788-98 pubmed publisher
    ..In fact, the functional overlap can explain previous failures of S100 knockout constructs to show any detectable changes in phenotype despite numerous implications of these proteins in important cellular processes. ..
  6. Hayes M, Moss S. Annexin 2 has a dual role as regulator and effector of v-Src in cell transformation. J Biol Chem. 2009;284:10202-10 pubmed publisher
    ..Our findings reveal a dual role for annexin 2, first as a regulator of v-Src trafficking and targeting and second as a v-Src effector in the reorganization of actin. ..
  7. Huang Y, Jin Y, Yan C, Yu Y, Bai J, Chen F, et al. Involvement of Annexin A2 in p53 induced apoptosis in lung cancer. Mol Cell Biochem. 2008;309:117-23 pubmed
    ..However, the exactly mechanism in the pathway is still unclear. Here we found that Annexin A2, a Ca2+ -dependent phospholipid-binding protein, is involved in p53-mediated apoptosis...
  8. Hayes M, Shao D, Grieve A, Levine T, Bailly M, Moss S. Annexin A2 at the interface between F-actin and membranes enriched in phosphatidylinositol 4,5,-bisphosphate. Biochim Biophys Acta. 2009;1793:1086-95 pubmed publisher
    ..The calcium and anionic phospholipid-binding protein annexin A2 is necessary for macropinocytic rocketing and has been shown to bind both PI(4,5)P2 and the barbed-ends of F-..
  9. O Connell P, Madureira P, Berman J, Liwski R, Waisman D. Regulation of S100A10 by the PML-RAR-? oncoprotein. Blood. 2011;117:4095-105 pubmed publisher
    ..These experiments show that S100A10 plays a crucial role in the generation of plasmin leading to fibrinolysis, thus providing a link to the clinical hemorrhagic phenotype of APL. ..
  10. Allen K, Fonseca F, Betapudi V, Willard B, Zhang J, McCrae K. A novel pathway for human endothelial cell activation by antiphospholipid/anti-?2 glycoprotein I antibodies. Blood. 2012;119:884-93 pubmed publisher
    ..2)GPI, and activate endothelial cells (ECs) in a ?(2)GPI-dependent manner after binding of ?(2)GPI to EC annexin A2. Because annexin A2 is not a transmembrane protein, the mechanisms of APLA/anti-?(2)GPI Ab-mediated EC ..
  11. Zhu H, Fan X, Yu Z, Liu J, Murata Y, Lu J, et al. Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. J Cereb Blood Flow Metab. 2010;30:1137-46 pubmed publisher
    Recent studies showed that soluble annexin A2 dramatically increases tissue plasminogen activator (tPA)-mediated plasmin generation in vitro, and reduces thrombus formation in vivo...
  12. Swisher J, Burton N, Bacot S, Vogel S, Feldman G. Annexin A2 tetramer activates human and murine macrophages through TLR4. Blood. 2010;115:549-58 pubmed publisher
    ..Specifically, annexin A2, found in a heterotetrameric complex with S100A10, not only serves as a key extracellular binding partner for ..
  13. Woodham A, Da Silva D, Skeate J, Raff A, Ambroso M, Brand H, et al. The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection. PLoS ONE. 2012;7:e43519 pubmed publisher
    ..Here, we demonstrate that the annexin A2 heterotetramer (A2t) contributes to HPV16 infection and co-immunoprecipitates with HPV16 particles on the ..
  14. Takano S, Togawa A, Yoshitomi H, Shida T, Kimura F, Shimizu H, et al. Annexin II overexpression predicts rapid recurrence after surgery in pancreatic cancer patients undergoing gemcitabine-adjuvant chemotherapy. Ann Surg Oncol. 2008;15:3157-68 pubmed publisher
    ..Analysis of Annexin II expression in cancer tissues may predict the clinical outcome of gemcitabine treatment, leading to the development of a new method for tailor-made treatment for this disease. ..
  15. Sharathchandra A, Lal R, Khan D, Das S. Annexin A2 and PSF proteins interact with p53 IRES and regulate translation of p53 mRNA. RNA Biol. 2012;9:1429-39 pubmed publisher
    ..In the current study, using RNA affinity approach we have identified Annexin A2 and PTB associated Splicing Factor (PSF/SFPQ) as novel ITAFs for p53 IRESs...
  16. Aukrust I, Evensen L, Hollås H, Berven F, Atkinson R, Trave G, et al. Engineering, biophysical characterisation and binding properties of a soluble mutant form of annexin A2 domain IV that adopts a partially folded conformation. J Mol Biol. 2006;363:469-81 pubmed
    ..We designed five constructs of domain IV of annexin A2 in which several interfacial hydrophobic residues were substituted by hydrophilic residues...
  17. Yamane T, Hachisu R, Yuguchi M, Takeuchi K, Murao S, Yamamoto Y, et al. Knockdown of legumain inhibits cleavage of annexin A2 in the mouse kidney. Biochem Biophys Res Commun. 2013;430:482-7 pubmed publisher
    ..We previously reported that bovine kidney annexin A2 was co-purified with legumain and that legumain cleaved the N-terminal region of annexin A2 at an Asn residue in ..
  18. Yang T, Peng H, Wang J, Yang J, Nice E, Xie K, et al. Prognostic and diagnostic significance of annexin A2 in colorectal cancer. Colorectal Dis. 2013;15:e373-81 pubmed publisher
    b>Annexin A2 (ANXA2) is known to be a tumourigenic molecule and is highly expressed in colorectal cancer (CRC). Its diagnostic and prognostic value is not fully understood...
  19. Swisher J, Khatri U, Feldman G. Annexin A2 is a soluble mediator of macrophage activation. J Leukoc Biol. 2007;82:1174-84 pubmed
    On the surface of the macrophage, annexin A2 tetramer (A2t) serves as a docking protein or recognition element for bacterial and viral pathogens...
  20. Zhang L, Li H, Su T, Barker J, Maric D, Fullerton C, et al. p11 is up-regulated in the forebrain of stressed rats by glucocorticoid acting via two specific glucocorticoid response elements in the p11 promoter. Neuroscience. 2008;153:1126-34 pubmed publisher
  21. Zhang L, Su T, Choi K, Maree W, Li C, Chung M, et al. P11 (S100A10) as a potential biomarker of psychiatric patients at risk of suicide. J Psychiatr Res. 2011;45:435-41 pubmed publisher
    ..These results suggest that PBMC p11 mRNA levels may be a potential adjunctive biomarker for the assessment of suicide risk in mental disorders and warrants a larger translational study to determine its clinical utility. ..
  22. Fang Y, Lin C, Wang C, Anderson R, Lin Y. Interferon-? stimulates p11-dependent surface expression of annexin A2 in lung epithelial cells to enhance phagocytosis. J Cell Physiol. 2012;227:2775-87 pubmed publisher
    b>Annexin A2 (p36) is usually present together with its natural ligand p11 as a heterotetramer complex, which has multiple biological functions depending on its cellular localization...
  23. Yoo J, Hayman M. Annexin II binds to SHP2 and this interaction is regulated by HSP70 levels. Biochem Biophys Res Commun. 2007;356:906-11 pubmed
    ..Our findings indicate that Annexin II is binding partner of SHP2 and the binding of SHP2 with Annexin II is affected by EGF stimulation, extracellular calcium levels, and the levels of HSP70. ..
  24. Paudel N, Sadagopan S, Balasubramanian S, Chandran B. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen and angiogenin interact with common host proteins, including annexin A2, which is essential for survival of latently infected cells. J Virol. 2012;86:1589-607 pubmed publisher
    ..LANA-1 and ANG interaction with one of the proteins, annexin A2, was validated...
  25. Vedeler A, Hollås H, Grindheim A, Raddum A. Multiple roles of annexin A2 in post-transcriptional regulation of gene expression. Curr Protein Pept Sci. 2012;13:401-12 pubmed
    Increasing evidence points to the participation of the multifunctional protein Annexin A2 (AnxA2) in mRNA localisation as well as the translation of certain mRNAs on cytoskeleton-bound polysomes, and thereby in the regulation of the ..
  26. Liu J, Vishwanatha J. Regulation of nucleo-cytoplasmic shuttling of human annexin A2: a proposed mechanism. Mol Cell Biochem. 2007;303:211-20 pubmed
    Studies have long been focused on the functions of annexin A2 in the cytoplasm...
  27. Ito Y, Arai K, Nozawa R, Yoshida H, Higashiyama T, Takamura Y, et al. S100A10 expression in thyroid neoplasms originating from the follicular epithelium: contribution to the aggressive characteristic of anaplastic carcinoma. Anticancer Res. 2007;27:2679-83 pubmed
    ..3% of these lesions were classified in the high group. These findings suggest that S100A10 and annexin II contribute to the aggressive characteristics of anaplastic carcinoma, while playing a constitutive role in papillary carcinoma. ..
  28. Zhang H, Yao D, Yao M, Huang H, Wu W, Yan M, et al. Expression characteristics and diagnostic value of annexin A2 in hepatocellular carcinoma. World J Gastroenterol. 2012;18:5897-904 pubmed publisher
    To investigate the characteristics and diagnostic value of annexin A2 (ANXA2) expression in cancerous tissues and sera of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)...
  29. Sun Y, Gao G, Cai J, Wang Y, Qu X, He L, et al. Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma. Carcinogenesis. 2013;34:595-604 pubmed publisher
    To date, the useful markers of hepatocellular carcinoma (HCC) remains incompletely developed. Here, we show that annexin A2 complement alpha-fetoprotein (AFP), a widely used liver cancer marker, in the serologically surveillance and early ..
  30. He K, Deora A, Xiong H, Ling Q, Weksler B, Niesvizky R, et al. Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11. J Biol Chem. 2008;283:19192-200 pubmed publisher
    The annexin A2 (A2) heterotetramer, consisting of two copies of A2 and two copies of S100A10/p11, promotes fibrinolytic activity on the surface of vascular endothelial cells by assembling plasminogen and tissue plasminogen activator (tPA) ..
  31. Ozorowski G, Milton S, Luecke H. Structure of a C-terminal AHNAK peptide in a 1:2:2 complex with S100A10 and an acetylated N-terminal peptide of annexin A2. Acta Crystallogr D Biol Crystallogr. 2013;69:92-104 pubmed publisher
    AHNAK, a large 629 kDa protein, has been implicated in membrane repair, and the annexin A2-S100A10 heterotetramer [(p11)(2)(AnxA2)(2))] has high affinity for several regions of its 1002-amino-acid C-terminal domain...
  32. He K, Sui G, Xiong H, Broekman M, Huang B, Marcus A, et al. Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2. J Biol Chem. 2011;286:15428-39 pubmed publisher
    ..b>Annexin A2 (A2) heterotetramer (A2·p11)(2) is a key profibrinolytic complex that assembles plasminogen and tissue ..
  33. Genetos D, Wong A, Watari S, Yellowley C. Hypoxia increases Annexin A2 expression in osteoblastic cells via VEGF and ERK. Bone. 2010;47:1013-9 pubmed publisher
    ..This suggests that VEGF induction of Annexin A2 is not mediated via VEGF-R1 agonism alone but by VEGF-R1 and Neuropilin-1 or Neuropilin-2 heterodimers...
  34. Zheng L, Foley K, Huang L, Leubner A, Mo G, Olino K, et al. Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. PLoS ONE. 2011;6:e19390 pubmed publisher
    ..We identified Annexin A2 (ANXA2), a member of the Annexin family of calcium-dependent phospholipid binding proteins, as a new molecule ..
  35. Zhang J, Guo B, Zhang Y, Cao J, Chen T. Silencing of the annexin II gene down-regulates the levels of S100A10, c-Myc, and plasmin and inhibits breast cancer cell proliferation and invasion. Saudi Med J. 2010;31:374-81 pubmed
    ..Additionally, the treatment with siRNA resulted in reduction of plasmin generation as well as a loss of the invasive capacity of breast cancer cells. Annexin II might be a key contributor to breast cancer proliferation and invasion. ..
  36. Whittemore J, Hawley J, Jensen W, Lappin M. Antibodies against Crandell Rees feline kidney (CRFK) cell line antigens, alpha-enolase, and annexin A2 in vaccinated and CRFK hyperinoculated cats. J Vet Intern Med. 2010;24:306-13 pubmed publisher
    ..The identities of common CRFK antigens are unknown...
  37. Hayes M, Longbottom R, Evans M, Moss S. Annexinopathies. Subcell Biochem. 2007;45:1-28 pubmed
    ..In this chapter we will outline some of the more recent observations in regard to these conditions, and describe the involvement of annexins in some other major causes of human morbidity. ..
  38. Morel E, Gruenberg J. Annexin A2 binding to endosomes and functions in endosomal transport are regulated by tyrosine 23 phosphorylation. J Biol Chem. 2009;284:1604-11 pubmed publisher
    The phospholipid-binding annexin A2 (AnxA2) is known to play a role in the regulation of membrane and actin dynamics, in particular in the endocytic pathway...
  39. Ortiz Zapater E, Peiro S, Roda O, Corominas J, Aguilar S, Ampurdanés C, et al. Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2. Am J Pathol. 2007;170:1573-84 pubmed
    ..We also show that at least two membrane receptors, epidermal growth factor receptor and annexin A2, which are overexpressed in pancreatic cancer, are involved in the transduction of tPA signaling in pancreatic ..
  40. Huang B, Deora A, He K, Chen K, Sui G, Jacovina A, et al. Hypoxia-inducible factor-1 drives annexin A2 system-mediated perivascular fibrin clearance in oxygen-induced retinopathy in mice. Blood. 2011;118:2918-29 pubmed publisher
    ..Here, we report that the proliferative phase of OIR requires transcriptional induction of the annexin A2 (A2) gene through the direct action of the hypoxia-inducible factor-1 complex...
  41. Zhang W, Zhao P, Xu X, Cai L, Song Z, Cao D, et al. Annexin A2 promotes the migration and invasion of human hepatocellular carcinoma cells in vitro by regulating the shedding of CD147-harboring microvesicles from tumor cells. PLoS ONE. 2013;8:e67268 pubmed publisher
    It has been reported that Annexin A2 (ANXA2) is up-regulated in hepatocellular carcinoma (HCC), but the roles of ANXA2 in the migration and invasion of HCC cells have not been determined...
  42. Martin Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, et al. PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell. 2007;128:383-97 pubmed
    ..We conclude that the mechanism of PTEN, PtdIns(4,5)P2, Anx2, Cdc42, and aPKC controls apical plasma membrane and lumen formation. ..
  43. Gauthier Kemper A, Weissmann C, Golovyashkina N, Sebö Lemke Z, Drewes G, Gerke V, et al. The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner. J Cell Biol. 2011;192:647-61 pubmed publisher
    ..tag purification and mass spectrometry identify the calcium-regulated plasma membrane-binding protein annexin A2 (AnxA2) as a potential interaction partner of tau...
  44. Lin L, Wu C, Hu K. Tissue plasminogen activator activates NF-?B through a pathway involving annexin A2/CD11b and integrin-linked kinase. J Am Soc Nephrol. 2012;23:1329-38 pubmed publisher
    ..The protease-independent action of tPA required its membrane receptor, annexin A2. tPA induced the aggregation and interaction of annexin A2 with integrin CD11b, and ablation of CD11b or ..
  45. Kesavan K, Ratliff J, Johnson E, Dahlberg W, Asara J, Misra P, et al. Annexin A2 is a molecular target for TM601, a peptide with tumor-targeting and anti-angiogenic effects. J Biol Chem. 2010;285:4366-74 pubmed publisher
    ..Here, we identify annexin A2 as a novel binding partner for TM601 in multiple human tumor cell lines and human umbilical vein endothelial ..
  46. Babbin B, Parkos C, Mandell K, Winfree L, Laur O, Ivanov A, et al. Annexin 2 regulates intestinal epithelial cell spreading and wound closure through Rho-related signaling. Am J Pathol. 2007;170:951-66 pubmed
    ..These findings suggest that annexin 2 plays a role in targeting Rho to cellular membranes, thereby modulating Rho-related signaling events regulating cytoskeletal reorganization during epithelial cell migration. ..
  47. Aukrust I, Hollås H, Strand E, Evensen L, Trave G, Flatmark T, et al. The mRNA-binding site of annexin A2 resides in helices C-D of its domain IV. J Mol Biol. 2007;368:1367-78 pubmed
    b>Annexin A2 (AnxA2) is a Ca(2+)-binding and phospholipid-binding protein involved in different intracellular processes including exocytosis, endocytosis and membrane-cytoskeleton movements...
  48. Kittaka N, Takemasa I, Takeda Y, Marubashi S, Nagano H, Umeshita K, et al. Molecular mapping of human hepatocellular carcinoma provides deeper biological insight from genomic data. Eur J Cancer. 2008;44:885-97 pubmed publisher
    ..Our integrative approach should significantly enhance the power of microarray data in identifying novel potential targets in human cancer. ..
  49. Shiozawa Y, Havens A, Jung Y, Ziegler A, Pedersen E, Wang J, et al. Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. J Cell Biochem. 2008;105:370-80 pubmed publisher
    ..These data strongly suggest that annexin II and its receptor axis plays a central role in prostate cancer metastasis, and that prostate cancer utilize the hematopoietic stem cell homing mechanisms to gain access to the niche. ..
  50. Dassah M, Deora A, He K, Hajjar K. The endothelial cell annexin A2 system and vascular fibrinolysis. Gen Physiol Biophys. 2009;28 Spec No Focus:F20-8 pubmed
    Vascular endothelial cell surface expression of annexin A2 and its binding partner p11 is a key element in maintaining fibrinolytic balance on blood vessel surfaces...
  51. Zhang L, Peng X, Zhang Z, Feng Y, Jia X, Shi Y, et al. Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis. J Cell Biochem. 2010;110:219-28 pubmed publisher
    ..PM with 149-fold purification was obtained and 22 differentially expressed proteins were identified. Of which, annexin A2 (ANXA2) was detected to be increased obviously in S4 compared with S0-1, and verified by Western blotting of rat ..
  52. Umbrecht Jenck E, Demais V, Calco V, Bailly Y, Bader M, Chasserot Golaz S. S100A10-mediated translocation of annexin-A2 to SNARE proteins in adrenergic chromaffin cells undergoing exocytosis. Traffic. 2010;11:958-71 pubmed publisher
  53. Lima e Silva R, Shen J, Gong Y, Seidel C, Hackett S, Kesavan K, et al. Agents that bind annexin A2 suppress ocular neovascularization. J Cell Physiol. 2010;225:855-64 pubmed publisher
    ..It has recently been demonstrated to bind annexin A2 on cultured tumor and vascular endothelial cells and to suppress blood vessel growth on chick chorioallantoic ..
  54. Rezvanpour A, Shaw G. Unique S100 target protein interactions. Gen Physiol Biophys. 2009;28 Spec No Focus:F39-46 pubmed
    ..This review focuses on potential multiprotein complexes involving calcium-insensitive S100A10, annexin A2 and several other proteins including AHNAK, dysferlin, NS3, TASK-1 and TRPV5/6.
  55. Das S, Shetty P, Valapala M, Dasgupta S, Gryczynski Z, Vishwanatha J. Signal transducer and activator of transcription 6 (STAT6) is a novel interactor of annexin A2 in prostate cancer cells. Biochemistry. 2010;49:2216-26 pubmed publisher
    b>Annexin A2 (AnxA2) is a multifunctional Ca(2+)-dependent phospholipid-binding protein, and its overexpression is implicated in malignant transformation of several cancers...
  56. Sharma M, Ownbey R, Sharma M. Breast cancer cell surface annexin II induces cell migration and neoangiogenesis via tPA dependent plasmin generation. Exp Mol Pathol. 2010;88:278-86 pubmed publisher
    ..The data provide a mechanism explaining the role of annexin II in breast cancer progression and suggest that annexin II may be an attractive target for therapeutic strategies aimed to inhibit angiogenesis and breast cancer. ..
  57. Su S, Maxwell S, Bayless K. Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity. J Biol Chem. 2010;285:40624-34 pubmed publisher
    ..Collectively, we report that annexin 2 regulates endothelial morphogenesis through an adherens junction-mediated pathway upstream of Akt. ..
  58. Pathuri P, Vogeley L, Luecke H. Crystal structure of metastasis-associated protein S100A4 in the active calcium-bound form. J Mol Biol. 2008;383:62-77 pubmed publisher
    ..change opens up a hydrophobic binding pocket that is capable of binding to target proteins such as annexin A2, the tumor-suppressor protein p53 and myosin IIA...
  59. Zibouche M, Vincent M, Illien F, Gallay J, Ayala Sanmartin J. The N-terminal domain of annexin 2 serves as a secondary binding site during membrane bridging. J Biol Chem. 2008;283:22121-7 pubmed publisher
    b>Annexin A2 (AnxA2) is a Ca(2+)- and acidic phospholipid-binding protein involved in many cellular processes...
  60. Singh N, Rondeau P, Hoareau L, Bourdon E. Identification of preferential protein targets for carbonylation in human mature adipocytes treated with native or glycated albumin. Free Radic Res. 2007;41:1078-88 pubmed
    ..It identified eight oxidatively modified proteins, two of which (ACTB and Annexin A2) appeared as significantly more carbonylated in adipocytes treated with glycated albumin than with native ..
  61. Wang P, Chintagari N, Gou D, Su L, Liu L. Physical and functional interactions of SNAP-23 with annexin A2. Am J Respir Cell Mol Biol. 2007;37:467-76 pubmed
    ..b>Annexin A2, a Ca(2+)- and phospholipid-binding protein, promotes the fusion of lamellar bodies with the plasma membrane...
  62. Gong X, Lv Y, Li X, Xu F, Ma Q. Gemcitabine resistance induced by interaction between alternatively spliced segment of tenascin-C and annexin A2 in pancreatic cancer cells. Biol Pharm Bull. 2010;33:1261-7 pubmed
    ..In the current study, we explored the gemcitabine resistance induced by the interaction between Annexin A2 (ANXA2) and alternatively spliced segment of tenascin-C (TNfnA-D)...