vitronectin

Summary

Summary: A blood plasma glycoprotein that mediates cell adhesion and interacts with proteins of the complement, coagulation, and fibrinolytic cascade. (From Segen, Dictionary of Modern Medicine, 1992)

Top Publications

  1. Sano K, Asanuma Date K, Arisaka F, Hattori S, Ogawa H. Changes in glycosylation of vitronectin modulate multimerization and collagen binding during liver regeneration. Glycobiology. 2007;17:784-94 pubmed
    ..b>Vitronectin (VN) is a multifunctional glycoprotein present in plasma and ECM...
  2. Madsen C, Sidenius N. The interaction between urokinase receptor and vitronectin in cell adhesion and signalling. Eur J Cell Biol. 2008;87:617-29 pubmed publisher
    ..role in ECM degradation, uPAR modulates cell-matrix contact through a direct engagement with the ECM component, vitronectin (Vn), and by regulating the activity state of integrins thus promoting or inhibiting integrin signalling and ..
  3. Li Y, Gautam A, Yang J, Qiu L, Melkoumian Z, Weber J, et al. Differentiation of oligodendrocyte progenitor cells from human embryonic stem cells on vitronectin-derived synthetic peptide acrylate surface. Stem Cells Dev. 2013;22:1497-505 pubmed publisher
    ..Here we describe a defined culture system that uses a vitronectin-derived synthetic peptide acrylate surface (VN-PAS; commercially available as Corning(®) Synthemax(®) surface)..
  4. Milner R. Microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin. Glia. 2009;57:714-23 pubmed publisher
    ..The extracellular matrix (ECM) protein vitronectin is a strong inducer of microglial activation, switching microglia from a resting into an activated potentially ..
  5. Derer W, Barnathan E, Safak E, Agarwal P, Heidecke H, Mockel M, et al. Vitronectin concentrations predict risk in patients undergoing coronary stenting. Circ Cardiovasc Interv. 2009;2:14-9 pubmed publisher
    b>Vitronectin is a multifunctional protein with a multiple binding domain that interacts with a variety of plasma and cell proteins. Vitronectin binds multiple ligands, including the soluble vitronectin receptor...
  6. Nishimoto S, Nishimoto M. Matrix Gla protein C-terminal region binds to vitronectin. Co-localization suggests binding occurs during tissue development. Matrix Biol. 2005;24:353-61 pubmed
    ..Assay by far-western gel overlays and gel filtration shift shows MGP binds vitronectin. Binding is saturable and consistent with a single class of binding sites...
  7. Chauhan A, Moore T. Presence of plasma complement regulatory proteins clusterin (Apo J) and vitronectin (S40) on circulating immune complexes (CIC). Clin Exp Immunol. 2006;145:398-406 pubmed
    The complement regulatory (CR) proteins clusterin and vitronectin bind to the membrane attack complex (MAC) and thus prevent cytolysis...
  8. Lynn G, Heller W, Mayasundari A, Minor K, Peterson C. A model for the three-dimensional structure of human plasma vitronectin from small-angle scattering measurements. Biochemistry. 2005;44:565-74 pubmed
    Small-angle X-ray scattering (SAXS) measurements were used to characterize vitronectin, a circulatory protein found in human plasma that functions in regulating cell adhesion and migration, as well as proteolytic cascades that affect ..
  9. Thibault M, Hoemann C, Buschmann M. Fibronectin, vitronectin, and collagen I induce chemotaxis and haptotaxis of human and rabbit mesenchymal stem cells in a standardized transmembrane assay. Stem Cells Dev. 2007;16:489-502 pubmed
    ..standardized transmembrane chemotaxis assay to assess the chemotactic and haptotactic potential of fibronectin, vitronectin, and collagen type 1 on MSCs from both rabbit and human origin...

More Information

Publications61

  1. Hurt E, Chan K, Serrat M, Thomas S, Veenstra T, Farrar W. Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation. Stem Cells. 2010;28:390-8 pubmed publisher
    ..Here we show that vitronectin is the component of human serum driving stem cell differentiation through an integrin alpha V beta 3-dependent ..
  2. Zhang D, Hudson A, Delostrinos C, Carmean N, Eastman R, Hicks B, et al. Dual sources of vitronectin in the human lower urinary tract: synthesis by urothelium vs. extravasation from the bloodstream. Am J Physiol Renal Physiol. 2011;300:F475-87 pubmed publisher
    b>Vitronectin (VN), secreted into the bloodstream by liver hepatocytes, is known to anchor epithelial cells to basement membranes through interactions with cell surface integrin receptors...
  3. Leroy Dudal J, Heyman L, Gauduchon P, Carreiras F. Adhesion of human ovarian adenocarcinoma IGROV1 cells to endothelial cells is partly mediated by the alphav integrins-vitronectin adhesive system and induces an alteration of endothelial integrity. Cell Biol Int. 2005;29:482-8 pubmed
    ..Considering the ability of ovarian carcinoma to disseminate by a haematogenous way, these in vitro events could mimic a preliminary step for carcinoma cells crossing the endothelial barrier to extravasate. ..
  4. Gargiulo L, Longanesi Cattani I, Bifulco K, Franco P, Raiola R, Campiglia P, et al. Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide. J Biol Chem. 2005;280:25225-32 pubmed
    ..Cell exposure to SRSRY peptide promotes directional migration on vitronectin-coated filters, regardless of uPAR expression, in a specific and dose-dependent manner, with maximal effect at ..
  5. Xu X, Gardsvoll H, Yuan C, Lin L, Ploug M, Huang M. Crystal structure of the urokinase receptor in a ligand-free form. J Mol Biol. 2012;416:629-41 pubmed publisher
    ..Consistent with this multifunctional role, uPAR binds several extracellular ligands, including uPA and vitronectin. Structural studies suggest that uPAR possesses structural flexibility...
  6. Welser Alves J, Milner R. Microglia are the major source of TNF-? and TGF-?1 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin. Neurochem Int. 2013;63:47-53 pubmed publisher
    ..not astrocytes, produce TNF-?, and that this expression is increased by LPS, IFN-?, and to a lesser extent by vitronectin, but decreased by TGF-?1...
  7. Singh B, Jalalvand F, Morgelin M, Zipfel P, Blom A, Riesbeck K. Haemophilus influenzae protein E recognizes the C-terminal domain of vitronectin and modulates the membrane attack complex. Mol Microbiol. 2011;81:80-98 pubmed publisher
    ..region comprising amino acids PE 84-108 also interferes with complement-mediated bacterial killing by capturing vitronectin (Vn) that prevents complement deposition and formation of the membrane attack complex (MAC)...
  8. Jin Y, Park I, Hong I, Byun H, Choi J, Kim Y, et al. Fibronectin and vitronectin induce AP-1-mediated matrix metalloproteinase-9 expression through integrin ?(5)?(1)/?(v)?(3)-dependent Akt, ERK and JNK signaling pathways in human umbilical vein endothelial cells. Cell Signal. 2011;23:125-34 pubmed publisher
    ..Among the ECM molecules examined, fibronectin (FN) and vitronectin (VN) increased the expression and activity of MMP-9 in human umbilical vein endothelial cells (HUVECs)...
  9. Singh B, Blom A, Unal C, Nilson B, Morgelin M, Riesbeck K. Vitronectin binds to the head region of Moraxella catarrhalis ubiquitous surface protein A2 and confers complement-inhibitory activity. Mol Microbiol. 2010;75:1426-44 pubmed publisher
    ..UspA2 also has the capacity to attract vitronectin that in turn binds C9 and hereby inhibits membrane attack complex (MAC) formation...
  10. Li L, Welser J, Milner R. Absence of the alpha v beta 3 integrin dictates the time-course of angiogenesis in the hypoxic central nervous system: accelerated endothelial proliferation correlates with compensatory increases in alpha 5 beta 1 integrin expression. J Cereb Blood Flow Metab. 2010;30:1031-43 pubmed publisher
    ..alpha v beta 3 integrin was strongly induced on angiogenic brain endothelial cells (BEC), along with its ligand vitronectin. In the hypoxia model, beta 3 integrin-null mice showed no obvious defect in cerebral angiogenesis...
  11. Heng B, Li J, Chen A, Reuveny S, Cool S, Birch W, et al. Translating human embryonic stem cells from 2-dimensional to 3-dimensional cultures in a defined medium on laminin- and vitronectin-coated surfaces. Stem Cells Dev. 2012;21:1701-15 pubmed publisher
    ..b>Vitronectin (VN) and laminin (LN) were chosen as matrices for the long-term propagation of hESCs in a defined culture ..
  12. Schar C, Jensen J, Christensen A, Blouse G, Andreasen P, Peterson C. Characterization of a site on PAI-1 that binds to vitronectin outside of the somatomedin B domain. J Biol Chem. 2008;283:28487-96 pubmed publisher
    b>Vitronectin and plasminogen activator inhibitor-1 (PAI-1) are proteins that interact in the circulatory system and pericellular region to regulate fibrinolysis, cell adhesion, and migration...
  13. Su Y, Jalalvand F, Morgelin M, Blom A, Singh B, Riesbeck K. Haemophilus influenzae acquires vitronectin via the ubiquitous Protein F to subvert host innate immunity. Mol Microbiol. 2013;87:1245-66 pubmed publisher
    Acquisition of the complement inhibitor vitronectin (Vn) is important for the respiratory tract pathogen nontypeable Haemophilus influenzae (NTHi) to escape complement-mediated killing...
  14. Mahabeleshwar G, Feng W, Reddy K, Plow E, Byzova T. Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis. Circ Res. 2007;101:570-80 pubmed
  15. Pang T, Zhao Y, Zhang N, Jin S, Pan S. Transient limb ischemia alters serum protein expression in healthy volunteers: complement C3 and vitronectin may be involved in organ protection induced by remote ischemic preconditioning. Oxid Med Cell Longev. 2013;2013:859056 pubmed publisher
    ..Complement C3, vitronectin, and apolipoprotein A-I were further confirmed by western blotting, and the results showed that their contents ..
  16. Madsen C, Ferraris G, Andolfo A, Cunningham O, Sidenius N. uPAR-induced cell adhesion and migration: vitronectin provides the key. J Cell Biol. 2007;177:927-39 pubmed
    ..the molecular defect of all of these mutants was a specific reduction in integrin-independent cell binding to vitronectin. A membrane-tethered plasminogen activator inhibitor-1, which has the same binding site in vitronectin as uPAR, ..
  17. Naik M, Naik U. Junctional adhesion molecule-A-induced endothelial cell migration on vitronectin is integrin alpha v beta 3 specific. J Cell Sci. 2006;119:490-9 pubmed
    ..expressed in human umbilical vein endothelial cells (HUVECs), JAM-A induced enhanced cell migration on vitronectin, but had no effect on fibronectin...
  18. Hajj G, Lopes M, Mercadante A, Veiga S, da Silveira R, Santos T, et al. Cellular prion protein interaction with vitronectin supports axonal growth and is compensated by integrins. J Cell Sci. 2007;120:1915-26 pubmed
    ..We report that PrP(C) interacts with vitronectin but not with fibronectin or collagen...
  19. Voss S, Hallström T, Saleh M, Burchhardt G, Pribyl T, Singh B, et al. The choline-binding protein PspC of Streptococcus pneumoniae interacts with the C-terminal heparin-binding domain of vitronectin. J Biol Chem. 2013;288:15614-27 pubmed publisher
    ..Pneumococci engage vitronectin, the human adhesive glycoprotein and complement inhibitor, to facilitate attachment to epithelial cells of the ..
  20. Franzen C, Todorovic V, Desai B, Mirzoeva S, Yang X, Green K, et al. The desmosomal armadillo protein plakoglobin regulates prostate cancer cell adhesion and motility through vitronectin-dependent Src signaling. PLoS ONE. 2012;7:e42132 pubmed publisher
    ..PG silencing resulted in elevated levels of the ECM protein vitronectin (VN), and exposing PG-expressing cells to VN induced Src activity...
  21. Hellriegel C, Caiolfa V, Corti V, Sidenius N, Zamai M. Number and brightness image analysis reveals ATF-induced dimerization kinetics of uPAR in the cell membrane. FASEB J. 2011;25:2883-97 pubmed publisher
    ..We also provide the first methodological guide on N&B to discern minor changes in molecular composition such as those due to dimerization events, which are involved in fundamental cell signaling mechanisms. ..
  22. Schleicher I, Parker A, Leavesley D, Crawford R, Upton Z, Xiao Y. Surface modification by complexes of vitronectin and growth factors for serum-free culture of human osteoblasts. Tissue Eng. 2005;11:1688-98 pubmed
    ..Complexes composed of vitronectin (VN), insulin-like growth factors (IGFs), and insulin growth factor-binding proteins (IGFBPs) have been ..
  23. Geblinger D, Addadi L, Geiger B. Nano-topography sensing by osteoclasts. J Cell Sci. 2010;123:1503-10 pubmed publisher
    ..The mechanisms whereby the physical properties of the substrate influence osteoclast behavior and their involvement in osteoclast function are discussed. ..
  24. Ainscough S, Barnard Z, Upton Z, Harkin D. Vitronectin supports migratory responses of corneal epithelial cells to substrate bound IGF-I and HGF, and facilitates serum-free cultivation. Exp Eye Res. 2006;83:1505-14 pubmed
    b>Vitronectin (VN) is a multi-functional glycoprotein best known for its effects on cell attachment and spreading, but has more recently been shown to mediate cellular responses to growth factors...
  25. Blumenstein M, Prakash R, Cooper G, North R. Aberrant processing of plasma vitronectin and high-molecular-weight kininogen precedes the onset of preeclampsia. Reprod Sci. 2009;16:1144-52 pubmed publisher
    ..Difference gel electrophoresis (DIGE) identified the plasma proteins vitronectin (VN) and high-molecular-weight kininogen (HK) in association with preeclampsia...
  26. Li X, Zou G, Yuan W, Lu W. Defining the native disulfide topology in the somatomedin B domain of human vitronectin. J Biol Chem. 2007;282:5318-26 pubmed
    The N-terminal 44 amino acid residues of the human plasma glycoprotein vitronectin, known as the somatomedin B (SMB) domain, mediates the interaction between vitronectin and plasminogen activator inhibitor 1 (PAI-1) in a variety of ..
  27. Previtali S, Malaguti M, Riva N, Scarlato M, Dacci P, Dina G, et al. The extracellular matrix affects axonal regeneration in peripheral neuropathies. Neurology. 2008;71:322-31 pubmed publisher
    ..Fibronectin was abundantly expressed in regenerating nerves, whereas vitronectin and fibrin(ogen) prevailed in nonregenerating nerves...
  28. Salasznyk R, Zappala M, Zheng M, Yu L, Wilkins Port C, McKeown Longo P. The uPA receptor and the somatomedin B region of vitronectin direct the localization of uPA to focal adhesions in microvessel endothelial cells. Matrix Biol. 2007;26:359-70 pubmed
    b>Vitronectin is a plasma protein which can deposit into the extracellular matrix where it supports integrin and uPA dependent cell migration...
  29. Adair J, Stober V, Sobhany M, Zhuo L, Roberts J, Negishi M, et al. Inter-alpha-trypsin inhibitor promotes bronchial epithelial repair after injury through vitronectin binding. J Biol Chem. 2009;284:16922-30 pubmed publisher
    ..The extracellular matrix (ECM) plays an important role in epithelial repair after injury. Vitronectin is a major ECM component that promotes epithelial repair...
  30. Kundu A, Putnam A. Vitronectin and collagen I differentially regulate osteogenesis in mesenchymal stem cells. Biochem Biophys Res Commun. 2006;347:347-57 pubmed
    ..To investigate this question, we cultured MSCs on purified vitronectin or type-I collagen, motivated by our earlier tissue engineering work demonstrating that MSC adhesion to polymer ..
  31. Paradis V, Degos F, Dargere D, Pham N, Belghiti J, Degott C, et al. Identification of a new marker of hepatocellular carcinoma by serum protein profiling of patients with chronic liver diseases. Hepatology. 2005;41:40-7 pubmed
    ..peak (8900 Da) was purified further and was characterized as the C-terminal part of the V10 fragment of vitronectin. An in vitro study suggested that the increase of the 8900-Da fragment in the serum of patients with HCC may ..
  32. Sa E Cunha C, Griffiths N, Virji M. Neisseria meningitidis Opc invasin binds to the sulphated tyrosines of activated vitronectin to attach to and invade human brain endothelial cells. PLoS Pathog. 2010;6:e1000911 pubmed publisher
    ..bacteria can increase human brain endothelial cell line (HBMEC) adhesion and entry by first binding to serum vitronectin and, to a lesser extent, fibronectin...
  33. Singh B, Su Y, Riesbeck K. Vitronectin in bacterial pathogenesis: a host protein used in complement escape and cellular invasion. Mol Microbiol. 2010;78:545-60 pubmed publisher
    The multifunctional human glycoprotein vitronectin (Vn) plays a significant role in cell migration, tissue repair and regulation of membrane attack complex (MAC) formation...
  34. Griffiths N, Hill D, Borodina E, Sessions R, Devos N, Feron C, et al. Meningococcal surface fibril (Msf) binds to activated vitronectin and inhibits the terminal complement pathway to increase serum resistance. Mol Microbiol. 2011;82:1129-49 pubmed publisher
    ..Previously, we have shown that Nm Opc binds to serum vitronectin to inhibit complement-mediated killing...
  35. Trelle M, Hirschberg D, Jansson A, Ploug M, Roepstorff P, Andreasen P, et al. Hydrogen/deuterium exchange mass spectrometry reveals specific changes in the local flexibility of plasminogen activator inhibitor 1 upon binding to the somatomedin B domain of vitronectin. Biochemistry. 2012;51:8256-66 pubmed publisher
    ..Binding of the somatomedin B domain (SMB) of the endogenous cofactor vitronectin to PAI-1 delays the transition to the latent state and increases the thermal stability of the protein ..
  36. Kulka M, Metcalfe D. TLR3 activation inhibits human mast cell attachment to fibronectin and vitronectin. Mol Immunol. 2006;43:1579-86 pubmed
    ..affect mast cells via an influence on adhesion, we employed huMC; and as substrates, fibronectin (FN) and vitronectin (VN). huMC were thus treated with double-stranded RNA (dsRNA) and adhesion to ECM was quantified...
  37. Wasmuth S, Lueck K, Baehler H, Lommatzsch A, Pauleikhoff D. Increased vitronectin production by complement-stimulated human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2009;50:5304-9 pubmed publisher
    ..Drusen and basal laminar deposits are hallmarks of this AMD manifestation that contain vitronectin as a major component...
  38. Ku Y, Chung C, Jang J. The effect of the surface modification of titanium using a recombinant fragment of fibronectin and vitronectin on cell behavior. Biomaterials. 2005;26:5153-7 pubmed
    ..Fibronectin (FN) and vitronectin (VN) are major cell adhesive proteins found in the extracellular matrix (ECM) of various tissues, and in ..
  39. Elia C, Cassol E, Sidenius N, Blasi F, Castagna A, Poli G, et al. Inhibition of HIV replication by the plasminogen activator is dependent on vitronectin-mediated cell adhesion. J Leukoc Biol. 2007;82:1212-20 pubmed
    ..Moreover, U1 cells were also maintained in the presence or absence of vitronectin (VN)-containing sera or serum from VN(-/-) mice...
  40. Upton Z, Cuttle L, Noble A, Kempf M, Topping G, Malda J, et al. Vitronectin: growth factor complexes hold potential as a wound therapy approach. J Invest Dermatol. 2008;128:1535-44 pubmed publisher
    ..We report herein that complexes comprising IGF and IGF-binding proteins bound to the ECM protein vitronectin (VN) significantly enhance cellular functions relevant to wound repair in human skin keratinocytes in two- and ..
  41. Pirazzoli V, Ferraris G, Sidenius N. Direct evidence of the importance of vitronectin and its interaction with the urokinase receptor in tumor growth. Blood. 2013;121:2316-23 pubmed publisher
    ..studies have substantiated the importance of the interaction between uPAR and the extracellular matrix protein vitronectin (VN) for the signaling activity of the receptor in vitro, however, the possible relevance of this interaction ..
  42. Hollier B, Harkin D, Leavesley D, Upton Z. Responses of keratinocytes to substrate-bound vitronectin: growth factor complexes. Exp Cell Res. 2005;305:221-32 pubmed
    Insulin-like growth factor-1 (IGF-I) can associate with the extracellular matrix protein vitronectin (VN) via select IGF-binding proteins, and the resulting complex stimulates responses in a variety of cell types...
  43. Gardsvoll H, Ploug M. Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region. J Biol Chem. 2007;282:13561-72 pubmed
    ..In contrast, the structural basis for the interaction between uPAR and the extracellular matrix protein vitronectin, which is involved in the regulation of cell adhesion and motility, remains to be clarified...
  44. Beck V, Herold H, Benge A, Luber B, Hutzler P, Tschesche H, et al. ADAM15 decreases integrin alphavbeta3/vitronectin-mediated ovarian cancer cell adhesion and motility in an RGD-dependent fashion. Int J Biochem Cell Biol. 2005;37:590-603 pubmed
    We have recently described that integrin alphavbeta3 upon interaction with its major extracellular matrix ligand vitronectin induces adhesion, motility, and proliferation of human ovarian cancer cells...
  45. Sakuta R, Murakami N, Jin Y, Nagai T, Nonaka I, Nishino I. Diagnostic significance of membrane attack complex and vitronectin in childhood dermatomyositis. J Child Neurol. 2005;20:597-602 pubmed
    In the current study, whether particular histologic distributions of membrane attack complex and vitronectin are correlated to clinical characteristics of patients with childhood dermatomyositis was investigated...
  46. Alessi M, Nicaud V, Scroyen I, Lange C, Saut N, Fumeron F, et al. Association of vitronectin and plasminogen activator inhibitor-1 levels with the risk of metabolic syndrome and type 2 diabetes mellitus. Results from the D.E.S.I.R. prospective cohort. Thromb Haemost. 2011;106:416-22 pubmed publisher
    It was the objective of this study to investigate the relation between vitronectin and plasminogen activator inhibitor (PAI)-1 plasma levels with nine-year incidences of the metabolic syndrome (MetS) and of type 2 diabetes mellitus (T2DM)..
  47. Mesnard L, Rafat C, Vandermeersch S, Hertig A, Cathelin D, Xu Dubois Y, et al. Vitronectin dictates intraglomerular fibrinolysis in immune-mediated glomerulonephritis. FASEB J. 2011;25:3543-53 pubmed publisher
    ..Here, we evaluated the role of vitronectin (VTN; also known as complement S protein), the principal cofactor of the plasminogen activator inhibitor-1 (PAI-..
  48. Reuning U. Integrin ?v?3 promotes vitronectin gene expression in human ovarian cancer cells by implicating rel transcription factors. J Cell Biochem. 2011;112:1909-19 pubmed publisher
    We previously showed that integrin ?v?3 expression upon engagement by its major ligand vitronectin (VN) correlated with enhanced human ovarian cancer cell adhesion, motility, and proliferation, by triggering intracellular signaling ..
  49. Montuori N, Bifulco K, Carriero M, La Penna C, Visconte V, Alfano D, et al. The cross-talk between the urokinase receptor and fMLP receptors regulates the activity of the CXCR4 chemokine receptor. Cell Mol Life Sci. 2011;68:2453-67 pubmed publisher
    ..We show that CXCR4-transfected cells migrate toward SDF1 on collagen (CG) and do not on vitronectin (VN)...
  50. Ekmekci O, Ekmekci H. Vitronectin in atherosclerotic disease. Clin Chim Acta. 2006;368:77-83 pubmed
    ..b>Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood ..
  51. Kamocka M, Rozalski M, Krajewska U, Wierzbicki R, Mielicki W. Effect of cancer procoagulant (CP) on the growth and adhesion of MCF-7 cells to vitronectin in vitro. Cancer Lett. 2005;222:89-94 pubmed
    ..Effects of anti-CP antibody on the growth of MCF-7 breast cancer cells and on the cells adhesion to vitronectin have been analyzed in vitro...
  52. Taliana L, Evans M, Ang S, McAvoy J. Vitronectin is present in epithelial cells of the intact lens and promotes epithelial mesenchymal transition in lens epithelial explants. Mol Vis. 2006;12:1233-42 pubmed
    Extracellular matrix (ECM) accumulates during the development of posterior capsule opacification (PCO). Vitronectin, an ECM component that is generally prominent in wound healing, has been detected in PCO specimens...