tuftsin

Summary

Summary: N(2)-((1-(N(2)-L-Threonyl)-L-lysyl)-L-prolyl)-L-arginine. A tetrapeptide produced in the spleen by enzymatic cleavage of a leukophilic gamma-globulin. It stimulates the phagocytic activity of blood polymorphonuclear leukocytes and neutrophils in particular. The peptide is located in the Fd fragment of the gamma-globulin molecule.

Top Publications

  1. Khan M, Nasti T, Saima K, Mallick A, Firoz A, Wajahul H, et al. Co-administration of immunomodulator tuftsin and liposomised nystatin can combat less susceptible Candida albicans infection in temporarily neutropenic mice. FEMS Immunol Med Microbiol. 2004;41:249-58 pubmed
    ..To resolve the hypothesis, we studied the role of immunomodulator tuftsin against experimental murine candidiasis in temporarily neutropenic Balb/c mice...
  2. Wardowska A, Dzierzbicka K, Mysliwski A. [Tuftsin--new analogues and properties]. Postepy Biochem. 2007;53:60-5 pubmed
    b>Tuftsin, a natural tetrapeptide of sequence TKPR, occuring in the blood of humans and other mammals, capable of stimulating certain white blood cells (monocytes, macrophages, and neutrophils), was isolated at Tufts University in 1970 by ..
  3. Foschi F, Trevisani F, Loggi E, Parazza M, Melotti C, Bedeschi E, et al. Effect of liver transplantation on tuftsin activity and phagocytic activity of neutrophil granulocytes in patients with liver cirrhosis. Int Arch Allergy Immunol. 2005;137:258-62 pubmed
    b>Tuftsin activity (TA) is reduced in cirrhosis. This contributes to the defective phagocytic activity (PA) of neutrophil granulocytes and is related to the impairment of splenic function...
  4. Khan A, Khan A, Dwivedi V, Ahmad M, Hakeem S, Owais M. Tuftsin augments antitumor efficacy of liposomized etoposide against fibrosarcoma in Swiss albino mice. Mol Med. 2007;13:266-76 pubmed
    ..the present study, we evaluated augmentation of the antitumor activity of etoposide (ETP) by the immunomodulator tuftsin in Swiss albino mice with fibrosarcoma...
  5. Bhasin M, Wu M, Tsirka S. Modulation of microglial/macrophage activation by macrophage inhibitory factor (TKP) or tuftsin (TKPR) attenuates the disease course of experimental autoimmune encephalomyelitis. BMC Immunol. 2007;8:10 pubmed
    ..tripeptide macrophage/microglia inhibitory factor MIF (TKP) and the tetrapeptide macrophage/microglial stimulator tuftsin (TKPR) attenuated EAE symptoms and revealed that the timing of macrophage/microglial activation is critical for ..
  6. Wardowska A, Dzierzbicka K, Szaryńska M, Dabrowska Szponar M, Wisniewska K, Mysliwski A, et al. Analogues of muramyl dipeptide (MDP) and tuftsin limit infection and inflammation in murine model of sepsis. Vaccine. 2009;27:369-74 pubmed publisher
    ..of septic shock was developed and chosen conjugates (1a, 1b, 8a, 8c) and analogs (T2) of muramyl dipeptide and tuftsin were tested in this model as prospective anti-bacterial drugs or adjuvants...
  7. Liu X, Guo J, Han S, Yao L, Chen A, Yang Q, et al. Enhanced immune response induced by a potential influenza A vaccine based on branched M2e polypeptides linked to tuftsin. Vaccine. 2012;30:6527-33 pubmed publisher
    ..b>Tuftsin is an immuno-stimulant molecule peptide...
  8. Jain S, Amiji M. Tuftsin-modified alginate nanoparticles as a noncondensing macrophage-targeted DNA delivery system. Biomacromolecules. 2012;13:1074-85 pubmed publisher
    ..The nanoparticle surface was modified with a peptide sequence containing tuftsin (TKPR), and transfection efficiency was determined in J774A.1 macrophages...
  9. von Wronski M, Raju N, Pillai R, Bogdan N, Marinelli E, Nanjappan P, et al. Tuftsin binds neuropilin-1 through a sequence similar to that encoded by exon 8 of vascular endothelial growth factor. J Biol Chem. 2006;281:5702-10 pubmed
    b>Tuftsin, Thr-Lys-Pro-Arg (TKPR), is an immunostimulatory peptide with reported nervous system effects as well...

More Information

Publications81

  1. Dutta T, Garg M, Jain N. Targeting of efavirenz loaded tuftsin conjugated poly(propyleneimine) dendrimers to HIV infected macrophages in vitro. Eur J Pharm Sci. 2008;34:181-9 pubmed publisher
    HIV infected macrophages are considered as reservoirs for spreading the virus in AIDS patients. Tuftsin not only binds specifically to the mononuclear phagocytic cells but also enhances their natural killer activity...
  2. Wang J, Tsirka S. Tuftsin fragment 1-3 is beneficial when delivered after the induction of intracerebral hemorrhage. Stroke. 2005;36:613-8 pubmed
    ..Activated microglia/macrophages are important contributors to brain injury after ICH. MIF could be a valuable neuroprotective agent for the treatment of ICH, if treatment is initiated soon after the onset of hemorrhage. ..
  3. Yuan W, Xia G, Zhao C, Sui C, Ma J. Anti-idiotypic single chain mimicking CA125 linked with tuftsin provides protective immunity against ovarian cancer in mice. Mol Med Rep. 2012;5:388-94 pubmed publisher
    ..fusion protein composed of an anti?idiotypic single chain mimicking CA125 connected with tuftsin by an artificial linker was constructed...
  4. Wu M, Nissen J, Chen E, Tsirka S. Tuftsin promotes an anti-inflammatory switch and attenuates symptoms in experimental autoimmune encephalomyelitis. PLoS ONE. 2012;7:e34933 pubmed publisher
    ..We have previously shown that administration of tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune ..
  5. Tripathi S, Goyal R, Kashyap M, Pant A, Haq W, Kumar P, et al. Depolymerized chitosans functionalized with bPEI as carriers of nucleic acids and tuftsin-tethered conjugate for macrophage targeting. Biomaterials. 2012;33:4204-19 pubmed publisher
    ..Further, tuftsin, a known macrophage targeting molecule, was tethered to C7P3 and the resulting complex, i.e...
  6. Shakya N, Sane S, Haq W, Gupta S. Augmentation of antileishmanial efficacy of miltefosine in combination with tuftsin against experimental visceral leishmaniasis. Parasitol Res. 2012;111:563-70 pubmed publisher
    ..efficacy of a subcurative dose of miltefosine in combination with free as well as liposomal palmitoyl tuftsin (p-tuftsin) using a Leishmania donovani/BALB/c mouse model. When miltefosine (2...
  7. Bai K, Láng O, Orbán E, Szabó R, Kohidai L, Hudecz F, et al. Design, synthesis, and in vitro activity of novel drug delivery systems containing tuftsin derivatives and methotrexate. Bioconjug Chem. 2008;19:2260-9 pubmed publisher
    ..These constructs are composed of methotrexate (Mtx) attached to a tuftsin-like peptide carrier through an enzyme-labile pentapeptide spacer (GFLGC) and several copies of a chemotactic ..
  8. Wang J, Rogove A, Tsirka A, Tsirka S. Protective role of tuftsin fragment 1-3 in an animal model of intracerebral hemorrhage. Ann Neurol. 2003;54:655-64 pubmed
    ..Activated microglia persist around the injury site. When microglial activation is inhibited by tuftsin fragment 1-3 macrophage/microglial inhibitory factor (MIF), the stroke injury volume is significantly reduced, ..
  9. Khan M, Syed F, Nasti H, Saima Dagger K, Haq W, Shehbaz A, et al. Use of tuftsin bearing nystatin liposomes against an isolate of Candida albicans showing less in vivo susceptibility to amphotericin B. J Drug Target. 2003;11:93-9 pubmed
    In the present study, we evaluated tuftsin bearing nystatin liposomes for their potential against an isolate of Candida albicans (C. albicans) showing less in vivo susceptibility to amphotericin B (Amp B)...
  10. Agrawal A, Agrawal A, Pal A, Guru P, Gupta C. Superior chemotherapeutic efficacy of amphotericin B in tuftsin-bearing liposomes against Leishmania donovani infection in hamsters. J Drug Target. 2002;10:41-5 pubmed
    ..using antimonials, has been examined in the Leishmania donovani infected hamsters after encapsulating the drug in tuftsin-free as well as tuftsin-bearing liposomes. The activity was significantly increased (p < 0...
  11. Khan M, Aljarbou A, Khan A, Owais M. Immune stimulating and therapeutic potential of tuftsin-incorporated nystatin liposomes against Cryptococcus neoformans in leukopenic BALB/C mice. FEMS Immunol Med Microbiol. 2012;66:88-97 pubmed publisher
    ..Treatment with tuftsin-incorporated liposomes increased the anti-cryptococcal activity of murine peritoneal macrophages...
  12. Fridkin M, Tsubery H, Tzehoval E, Vonsover A, Biondi L, Filira F, et al. Tuftsin-AZT conjugate: potential macrophage targeting for AIDS therapy. J Pept Sci. 2005;11:37-44 pubmed
    The IgG-derived immunomodulating peptide tuftsin, Thr-Lys-Pro-Arg, is recognized by specific receptors on phagocytic cells, notably macrophages, and is capable of targeting proteins and peptides to these sites...
  13. Siemion I, Kluczyk A. Tuftsin: on the 30-year anniversary of Victor Najjar's discovery. Peptides. 1999;20:645-74 pubmed
    After a short description of the results of Victor Najjar's research on tuftsin and of the discoveries done by other authors in the early stage of tuftsin investigation, the current state of work on tuftsin is presented, based mainly on ..
  14. Krasowski H, Stehle P, Furst P, Kraus W. [The effect of the calf spleen and calf thymus extracts, thymopentin and tuftsin, on the phagocytosis activity of neutrophilic granulocytes]. Arzneimittelforschung. 1992;42:147-51 pubmed
    ..proteolytic as well as untreated spleen and thymus extracts and, as a comparison, of biologically active peptides tuftsin and thymopentin on the phagocytic activities of human polymorphonuclear leukocytes was investigated...
  15. Kovalenko E, Pashkina E, Kanazhevskaya L, Masliy A, Kozlov V. Chemical and biological properties of a supramolecular complex of tuftsin and cucurbit[7]uril. Int Immunopharmacol. 2017;47:199-205 pubmed publisher
    Cucurbit[7]uril (CB7) is an uncharged and water-soluble macrocyclic host. CB7 binds to doubly protonated tuftsin, which is the tetrapeptide Thr-Lys-Pro-Arg, with moderate affinity (Ka=2.1×103M-1)...
  16. Abraham A, Baranyai Z, Gyulai G, Pari E, Horvati K, Bosze S, et al. Comparative analysis of new peptide conjugates of antitubercular drug candidates-Model membrane and in vitro studies. Colloids Surf B Biointerfaces. 2016;147:106-115 pubmed publisher
    Novel peptide conjugates of two antitubercular drug candidates were synthesised and characterised using new tuftsin peptide derivative (OT14) as carrier moiety...
  17. Szkaradkiewicz A. Phagocytosis and microbicidal capacity of human monocytes in the course of HIV infection. Immunol Lett. 1992;33:145-50 pubmed
    ..The latter patients also exhibited a decreased bactericidal activity of the cells. Tuftsin and even serum from healthy donors were found to normalise the disturbed monocyte function, the effect of tuftsin ..
  18. Wleklik M, Panasiak W, Luczak M, Konopinska D. Tuftsin a natural peptide with antiviral activity--structural basis of its action. Acta Virol. 1988;32:79-82 pubmed
    The influence of tuftsin--the natural phagocytosis stimulating tetrapeptide and its elongated analogues--on the mortality of encephalomyocarditis virus-infected NMRI mice was investigated...
  19. Kusunoki H, Tanaka T, Kohno T, Matsuhashi K, Hosoda K, Wakamatsu K, et al. A novel neuropilin-1-binding sequence in the human T-cell lymphotropic virus type 1 envelope glycoprotein. Biochim Biophys Acta Proteins Proteom. 2018;1866:541-548 pubmed publisher
    ..4 and 17.7??M, respectively. The binding modes of both peptides were almost identical to those observed for Tuftsin and vascular endothelial growth factor A binding to the Nrp1 b1 domain...
  20. Januchta W, Serocki M, Dzierzbicka K, Cholewiński G, Skladanowski A. Synthesis of functionalized new conjugates of batracylin with tuftsin/retro-tuftsin derivatives and their biological evaluation. Eur J Med Chem. 2015;106:85-94 pubmed publisher
    New batracylin conjugates with tuftsin/retro-tuftsin derivatives were designed and synthesized using T3P as a coupling agent...
  21. Khan A, Alanazi A, Jabeen M, Hassan I, Bhat M. Targeted nano-delivery of novel omega-3 conjugate against hepatocellular carcinoma: Regulating COX-2/bcl-2 expression in an animal model. Biomed Pharmacother. 2016;81:394-401 pubmed publisher
    The present approach enumerates the effectiveness of tuftsin tagged nano-liposome for the cytosolic transport of 2,6-di-isopropylphenol-linolenic acid conjugate against liver cancer in mice...
  22. Wardowska A, Dzierzbicka K, Menderska A, Trzonkowski P. New conjugates of tuftsin and muramyl dipeptide as stimulators of human monocyte-derived dendritic cells. Protein Pept Lett. 2013;20:200-4 pubmed
    Muramyl dipeptide (MDP) and tuftsin are known biologically active compound displaying a significant influence on various cell populations of innate immune response...
  23. Dzierzbicka K, Trzonkowski P, Sewerynek P, Kolodziejczyk A, Mysliwski A. Synthesis and biological activity of tuftsin, its analogue and conjugates containing muramyl dipeptides or nor-muramyl dipeptides. J Pept Sci. 2005;11:123-35 pubmed
    Several conjugates of muramyl dipeptide (MDP) or nor-muramyl dipeptide (nor-MDP) with tuftsin were synthesized. Conjugates 8a-f were prepared by acylation of protected tuftsin with the isoglutamine carboxyl group of MDP or nor-MDP 2a-f...
  24. Ashmarin I. [Anticipated and unexpected physiological effects of oligopeptides (glyprolines, ACTH (4-10) analogs, taftsin, and thyroliberin)]. Ross Fiziol Zh Im I M Sechenova. 2001;87:1471-6 pubmed
    ..and nootrops, and revealing of unexpected biological activities of some other peptides (behavioural effects of tuftsin, lymph flow stimulation by thyroliberin, etc.)...
  25. Sega Y, Versini M, Shoenfeld Y. [Of worms and men--Administration of helminth products as an innovative approach to treatment of autoimmune diseases]. Harefuah. 2015;154:428-31, 470, 469 pubmed
    ..vitae) combined with the protein tuftsin, which is produced by human splenocytes, was shown to exert the aforementioned positive effects on a murine model ..
  26. Jain S, Tran T, Amiji M. Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis. Biomaterials. 2015;61:162-77 pubmed publisher
    ..into non-condensing alginate based nanoparticles and the surface of the nano-carriers was modified with tuftsin peptide to achieve active macrophage targeting...
  27. Khan M, Faisal S, Mohammad O. Safety, efficacy and pharmacokinetics of tuftsin-loaded nystatin liposomes in murine model. J Drug Target. 2006;14:233-41 pubmed
    ..evaluate the efficacy, toxicity and pharmacokinetics of antifungal drug nystatin incorporated in immunomodulator tuftsin-bearing liposomes...
  28. Wardowska A, Dzierzbicka K, Trzonkowski P, Mysliwski A. Immunomodulatory properties of new conjugates of muramyl dipeptide and nor-muramyl dipeptide with retro-tuftsin (Arg-Pro-Lys-Thr-OMe). Int Immunopharmacol. 2006;6:1560-8 pubmed
    Six new conjugates of muramyl dipeptide and nor-muramyl dipeptide with retro-tuftsin were synthesised at Gdansk University of Technology. All compounds were investigated at Medical University of Gdansk...
  29. Manea M, Mezo G, Hudecz F, Przybylski M. Mass spectrometric identification of the trypsin cleavage pathway in lysyl-proline containing oligotuftsin peptides. J Pept Sci. 2007;13:227-36 pubmed
    ..These results obtained of oligotuftsin derivatives might have implications for the proteolytic degradation of target peptides that require specific conformational preconditions. ..
  30. Jiang X, Hou X, Tang L, Jiang Y, Ma G, Li Y. A phase trial of the oral Lactobacillus casei vaccine polarizes Th2 cell immunity against transmissible gastroenteritis coronavirus infection. Appl Microbiol Biotechnol. 2016;100:7457-69 pubmed publisher
    ..In this L. casei vaccine, repetitive peptides expressed by L. casei (specifically the MDP and tuftsin fusion protein (MT)) were repeated 20 times and the D antigenic site of the TGEV spike (S) protein was repeated 6 ..
  31. Bashi T, Shovman O, Fridkin M, Volkov A, Barshack I, Blank M, et al. Novel therapeutic compound tuftsin-phosphorylcholine attenuates collagen-induced arthritis. Clin Exp Immunol. 2016;184:19-28 pubmed publisher
    ..We aimed to decipher the tolerogenic potential of tuftsin-PC (TPC), a novel helminth-based compound in collagen-induced arthritis (CIA) a mouse model of rheumatoid ..
  32. Siebert A, Gensicka Kowalewska M, Cholewinski G, Dzierzbicka K. Tuftsin - Properties and Analogs. Curr Med Chem. 2017;24:3711-3727 pubmed publisher
    ..An example of such a substance is tuftsin (TKPA) 3 (Fig. (1))...
  33. Nissen J, Tsirka S. Tuftsin-driven experimental autoimmune encephalomyelitis recovery requires neuropilin-1. Glia. 2016;64:923-36 pubmed publisher
    ..We have previously shown that treatment with tuftsin, a tetrapeptide generated from IgG proteolysis, dramatically improves disease symptoms in EAE...
  34. Dzierzbicka K, Sowinski P, Kołodziejczyk A. Synthesis of analogues of anthraquinones linked to tuftsin or retro-tuftsin residues as potential topoisomerase inhibitors. J Pept Sci. 2006;12:670-8 pubmed
    A novel group of [(4-, 5- or 8)-hydroxy-9,10-anthraquinone-1-yl]-(tuftsin or retro-tuftsin) acids and methyl esters has been synthesized as potential anticancer compounds...
  35. Siemion I, Kluczyk A, Wieczorek Z. Anti-IL-1 activity of peptide fragments of IL-1 family proteins. Peptides. 1998;19:373-82 pubmed
    A series of peptides containing retro-tuftsin- and tuftsin-like motifs from IL-1 proteins inhibits IL-1-induced IL-2 production and reduces the humoral immune response, thus supporting our hypothesis that tuftsin (Thr-Lys-Pro-Arg)-IL-1 ..
  36. Kozlovskaya M, Kozlovskii I, Val dman E, Seredenin S. Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress. Neurosci Behav Physiol. 2003;33:853-60 pubmed
    ..the basis of the type of emotional reactivity, were used to compare the effects of ten peptide compounds of the tuftsin family and Selank on the behavioral manifestations of emotional stress created by a conflict situation...
  37. Saravanabava K, Nachimuthu K, Padmanaban V. Effect of tuftsin on embryo vaccination with Newcastle disease virus vaccine. Comp Immunol Microbiol Infect Dis. 2005;28:269-76 pubmed
    The effect of tuftsin of embryo and post-hatch vaccination with NDV-F was studied. The embryo vaccination with NDV-F resulted in more number of dead-in-shell embryos...
  38. Mezo G, Láng O, Jakab A, Bai K, Szabo I, Schlosser G, et al. Synthesis of oligotuftsin-based branched oligopeptide conjugates for chemotactic drug targeting. J Pept Sci. 2006;12:328-36 pubmed
    ..The spacer with N-terminal methotrexate was coupled to the chloroacetylated chemotactic carrier molecule by thioether bond formation. The chemotactic activity and cytotoxity of Mtx conjugates were also studied. ..
  39. Owais M, Misra Bhattacharya S, Haq W, Gupta C. Immunomodulator tuftsin augments antifilarial activity of diethylcarbamazine against experimental brugian filariasis. J Drug Target. 2003;11:247-51 pubmed
    In the present study, we evaluated the potential of an immunomodulator tuftsin in increasing the efficacy of liposomised diethylcarbamazine (DEC) against experimental filarial infection of Brugia malayi...
  40. Gokulan K, Khare S, Rao D. Increase in the immunogenicity of HIV peptide antigens by chemical linkage to polytuftsin (TKPR40). DNA Cell Biol. 1999;18:623-30 pubmed
    ..reported herein, we examined the role of polytuftsin (TKPR40), a synthetic polymer of the natural immunomodulator tuftsin, as a carrier for synthetic peptides of HIV derived from the gp41 and gp120 proteins...
  41. Khan M, Nasti T, Owais M. Incorporation of amphotericin B in tuftsin-bearing liposomes showed enhanced efficacy against systemic cryptococcosis in leucopenic mice. J Antimicrob Chemother. 2005;56:726-31 pubmed
    The role of the immunomodulator tuftsin in enhancing the antifungal activity of liposomal amphotericin B against Cryptococcus neoformans in leucopenic mice was assessed...
  42. Kolomin T, Morozova M, Volkova A, Shadrina M, Andreeva L, Slominsky P, et al. The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Mol Immunol. 2014;58:50-5 pubmed publisher
    Previous studies have shown that synthetic tuftsin analogue Selank and its fragments cause a number of alterations in the expression of certain genes involved in inflammation in mouse spleen...
  43. Arif K, Ejaj A, Maroof A, Azmat A, Arun C, Fatima N, et al. Protective effect of liposomal formulation of tuftsin (a naturally occurring tetrapeptide) against cyclophosphamide-induced genotoxicity and oxidative stress in mice. Indian J Biochem Biophys. 2009;46:45-52 pubmed
    b>Tuftsin, a naturally occurring tetrapeptide with a sequence Thr-Lys-Pro-Arg was evaluated for its in vivo protective effect against cyclophosphamide-induced genotoxicity and oxidative stress in Swiss albino mice...
  44. Gu R, He Y, Han S, Yuan S, An Y, Meng Z, et al. Pharmacokinetics and bioavailability of tuftsin-derived T peptide, a promising antitumor agent, in beagles. Drug Metab Pharmacokinet. 2016;31:51-56 pubmed publisher
    b>Tuftsin, a natural phagocytosis-stimulating tetrapeptide, had aroused much interest in tumor immunotherapy, but the poor pharmacokinetics hampered its clinical developments, for that it was extremely susceptible to degradation by ..
  45. Khan M, Owais M. Toxicity, stability and pharmacokinetics of amphotericin B in immunomodulator tuftsin-bearing liposomes in a murine model. J Antimicrob Chemother. 2006;58:125-32 pubmed
    In the present study we evaluated the pharmacokinetics and toxicity of amphotericin B in immunomodulator tuftsin-loaded liposomes in a murine model...
  46. Nissen J, Selwood D, Tsirka S. Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway. J Neurochem. 2013;127:394-402 pubmed publisher
    b>Tuftsin (Thr-Lys-Pro-Arg) is a natural immunomodulating peptide found to stimulate phagocytosis in macrophages/microglia. Tuftsin binds to the receptor neuropilin-1 (Nrp1) on the surface of cells...
  47. Rafat M, Devereux M, Popelier P. Rendering of quantum topological atoms and bonds. J Mol Graph Model. 2005;24:111-20 pubmed
    ..This algorithm, in conjunction with the graphical user interface of the computer program MORPHY enables robust and efficient rendering of complicated interatomic surfaces, as found in larger systems. ..
  48. Xu Y, Zhu J, Xiang K, Li Y, Sun R, Ma J, et al. Synthesis and immunomodulatory activity of [60]fullerene-tuftsin conjugates. Biomaterials. 2011;32:9940-9 pubmed publisher
    Immunomodulating peptide tuftsin (Thr-Lys-Pro-Arg) was covalently conjugated to fullerene C(60) by two different ways to prepare NH(2)-tuftsin-C(60) and C(60)-tuftsin-COOH. The two new compounds were intensively characterized...
  49. Baranyai Z, Krátký M, Vosátka R, Szabó E, Senoner Z, Dávid S, et al. In vitro biological evaluation of new antimycobacterial salicylanilide-tuftsin conjugates. Eur J Med Chem. 2017;133:152-173 pubmed publisher
    ..with remarkable antimycobacterial activity were conjugated to macrophage receptor specific tuftsin based peptide carriers through oxime bond directly or by insertion of a GFLG tetrapeptide spacer...
  50. Dutta R, Puri A, Anand N. Immunomodulatory potential of hydrophobic analogs of Rigin and their role in providing protection against Plasmodium berghei infection in mice. Int Immunopharmacol. 2001;1:843-55 pubmed
    ..Their activity profiles are compared with native tuftsin (NT) and/or N-palmitoyl-amino-ethyl-tuftsin amide (PT) taken as positive control...
  51. Khan M, Ahmad N, Moin S, Mannan A, Wajahul H, Pasha S, et al. Tuftsin-mediated immunoprophylaxis against an isolate of Aspergillus fumigatus shows less in vivo susceptibility to amphotericin B. FEMS Immunol Med Microbiol. 2005;44:269-76 pubmed
    In the present study, we evaluated the immunopotentiating efficacy of tuftsin against experimental murine aspergillosis in both normal and immunodebilitant BALB/c mice...
  52. Mezo G, Manea M, Jakab A, Kapuvári B, Bosze S, Schlosser G, et al. Synthesis and structural characterization of bioactive peptide conjugates using thioether linkage approaches. J Pept Sci. 2004;10:701-13 pubmed
    ..C-terminal Cys residues gave thioether conjugates with significantly diminished epitope-dimerization, while Cys at the N-terminal caused rapid disulfide-dimerization, thereby preventing efficient conjugation. ..
  53. Brandt C, Leite C, Manhaes de Castro R, Brandt Filho C, Manhaes de Castro F, Barbosa de Castro C. [Evaluation of the effect of splenectomy with autologous spleen tissue implantation in some monocyte functions in children with hepatosplenic schistosomiasis mansoni]. Rev Soc Bras Med Trop. 2005;38:38-42 pubmed
    Adherence index, superoxide and TNF-alpha production in monocytes, with or without tuftsin treatment, were investigated in hepatosplenic schistosomiasis mansoni bearers with splenectomy with or without autologous implantation of spleen ..
  54. Trevisani F, Castelli E, Foschi F, Parazza M, Loggi E, Bertelli M, et al. Impaired tuftsin activity in cirrhosis: relationship with splenic function and clinical outcome. Gut. 2002;50:707-12 pubmed
    Cirrhotic patients show increased susceptibility to bacterial infections. It is not known whether tuftsin deficiency, which is associated with an increased incidence of infections in many disease states, is present in cirrhosis...
  55. Dzierzbicka K, Wardowska A, Rogalska M, Trzonkowski P. New conjugates of muramyl dipeptide and nor-muramyl dipeptide linked to tuftsin and retro-tuftsin derivatives significantly influence their biological activity. Pharmacol Rep. 2012;64:217-23 pubmed
    ..and biological activity of new conjugates of muramyl dipeptide (MDP) and nor-muramyl dipeptide (nor-MDP) with tuftsin and retro-tuftsin derivatives containing isopeptide bond between ε-amino group of lysine and carboxyl group of ..
  56. Li Y, Feng J, Daniels S, Pickett N, O Brien P. A highly luminescent ZnS/CdSe/ZnS nanocrystals-tetrapeptide biolabeling agent. J Nanosci Nanotechnol. 2007;7:2301-8 pubmed
    ..These nanocrystals, when conjugated with tuftsin in aqueous suspension, formed an effective labeling reagent for macrophages or lymphocytes...
  57. Vander Kooi C, Jusino M, Perman B, Neau D, Bellamy H, Leahy D. Structural basis for ligand and heparin binding to neuropilin B domains. Proc Natl Acad Sci U S A. 2007;104:6152-7 pubmed
    ..Cocrystallization of N1b1b2 with Tuftsin, a peptide mimic of the VEGF C terminus, reveals the site of interaction with the basic tail of VEGF on the b1 ..
  58. Khan M, Khan A, Owais M. Prophylactic use of liposomized tuftsin enhances the susceptibility of Candida albicans to fluconazole in leukopenic mice. FEMS Immunol Med Microbiol. 2006;46:63-9 pubmed
    In the present study, we investigated the immunopotentiating activity of the immunomodulator tuftsin for the treatment of dose-dependent susceptible Candida albicans infection in a murine model...
  59. Kothekar V, Ashish -, Gupta D, Kishore R. Theoretical study of conformational flexibility of tuftsin in vacuum and in aqueous environment. Indian J Biochem Biophys. 1999;36:14-28 pubmed
    Conformational flexibility of tuftsin molecule is studied using all-atom based atom-atom potential and systematic search, simulated annealing molecular dynamics (SAMD) and molecular dynamics (MD) techniques...
  60. Kozlovskaia M, Kozlovskii I, Val dman E, Seredenin S. [Selank and short peptides of Taftsin derivatives in regulation of adaptive behavior of animals in stress]. Ross Fiziol Zh Im I M Sechenova. 2002;88:751-61 pubmed
    Effects of 10 peptides, tuftsin and Selank derivatives upon behavior during emotional stress induced by conflict situation, were studied in Balb/c and C57BL/6 male mice with genetically determined opposite types of emotional stress ..
  61. Navolotskaya E, Kolobov A, Kampe Nemm E, Zargarova T, Malkova N, Krasnova S, et al. Synthetic peptide VKGFY and its cyclic analog stimulate macrophage bactericidal activity through non-opioid beta-endorphin receptors. Biochemistry (Mosc). 2003;68:34-41 pubmed
    ..3 nM), and beta-endorphin (K(i) = 2.8 +/- 0.2 nM). Thus, the effects of pentarphin and cyclopentarphin on macrophages are mediated by naloxone-insensitive receptors common for pentarphin, cyclopentarphin, immunorphin, and beta-endorphin. ..
  62. Leung E, Guo L, Bu J, Maloof M, El Khoury J, Geula C. Microglia activation mediates fibrillar amyloid-? toxicity in the aged primate cortex. Neurobiol Aging. 2011;32:387-97 pubmed publisher
    ..Combined with our earlier observations, these findings suggest that aged primate microglia may display an exaggerated inflammatory response to fA? when compared with young microglia. ..
  63. Jakab A, Schlosser G, Feijlbrief M, Welling Wester S, Manea M, Vila Perello M, et al. Synthesis and antibody recognition of cyclic epitope peptides, together with their dimer and conjugated derivatives based on residues 9-22 of herpes simplex virus type 1 glycoprotein D. Bioconjug Chem. 2009;20:683-92 pubmed publisher
    ..The attachment site in dimers and conjugates, as well as the topology of the construct, had a significant influence on the antibody recognition, while replacement of Met in position 11 by Nle had no marked effect. ..
  64. Gupta C, Haq W. Tuftsin-bearing liposomes as antibiotic carriers in treatment of macrophage infections. Methods Enzymol. 2005;391:291-304 pubmed
    b>Tuftsin is a tetrapeptide (Thr-Lys-Pro-Arg) that specifically binds monocytes, macrophages, and polymorphonuclear leukocytes and potentiates their natural killer activity against tumors and pathogens...
  65. Wardowska A, Dzierzbicka K, Trzonkowski P, Mysliwski A. The biological activity of new tuftsin derivatives--induction of phagocytosis. Acta Pol Pharm. 2006;63:378-81 pubmed
    ..One of them is an endogenous tetrapeptide - tuftsin that occurs in the blood of mammals including human beings...
  66. Wieczorek Z, Słoń J, Kluczyk A, Zbozień R, Stafanowicz P, Siemion I. The immunomodulatory diversity of the proteins of the transforming growth factor beta (TGF beta) family. Int J Pept Protein Res. 1995;46:113-8 pubmed
    ..of immunomodulatory properties of oligopeptides derived from two exposed loops (containing thymopentin-like and tuftsin-like sequences, respectively) of the proteins belonging to TGF beta family suggests that the particular species ..
  67. Mezo G, Hudecz F. Synthesis of linear, branched, and cyclic peptide chimera. Methods Mol Biol. 2005;298:63-76 pubmed
    ..A branched chimera, built from linear peptides, consists of tuftsin oligomers with immunostimulatory activity and an epitope peptide of HSV gD...
  68. Zhang S, Liu G, Xia S, Wu P, Zhang L. "Meshed-Bag Gathered-Bunch" method for solid-phase synthesis of small molecular diverse compounds. J Comb Chem. 2002;4:131-7 pubmed
    ..mimetics including derivatives at the N- and C-terminus, cyclic muramyl dipeptide mimetics, muramyl dipeptide and Tuftsin's analogue conjugates...
  69. Rafat M, Popelier P. Long range behavior of high-rank topological multipole moments. J Comput Chem. 2007;28:832-8 pubmed
    ..With this information, the rank of the expansion for each interaction can be adapted to the required accuracy and the available computing power. ..
  70. Lang O, Mezo G, Hudecz F, Kohidai L. Effect of tuftsin and oligotuftsins on chemotaxis and chemotactic selection in Tetrahymena pyriformis. Cell Biol Int. 2006;30:603-9 pubmed
    The chemotactic properties of tuftsin (H-TKPR-OH), tuftsin derivatives (H-KPR-OH, H-TKPKG-NH(2), Ac-TKPKG-NH(2)) and TKPKG-based oligotuftsins (T20, T30, T40) were investigated in Tetrahymena pyriformis GL...
  71. Khan M, Owais M. Immunomodulator tuftsin increases the susceptibility of Cryptococcus neoformans to liposomal amphotericin B in immunocompetent BALB/c mice. J Drug Target. 2005;13:423-9 pubmed
    ..In the present study, we evaluated the combination of liposomal amphotericin B (lip-Amp B) and immunomodulator tuftsin to cure Cryptococcus neoformans infection in BALB/c mice. Mice infected with C...
  72. Feng J, Meloni M, Allan S, Faulkner S, Narvainen J, Vidyasagar R, et al. Tuftsin derivatives of FITC, Tb-DOTA or Gd-DOTA as potential macrophage-specific imaging biomarkers. Contrast Media Mol Imaging. 2010;5:223-30 pubmed publisher
    Fluorescein- and terbium-labelled tuftsin (Thr-Lys-Pro-Arg) and pentapeptide (Thr-Lys-Pro-Pro-Arg) were synthesized and their properties were evaluated in vitro by luminescence spectrometry and confocal microscopy as fluorescence probes ..