antibodies

Summary

Summary: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

Top Publications

  1. Rubicz R, Yolken R, DRIGALENKO E, Carless M, Dyer T, Bauman L, et al. A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). PLoS Genet. 2013;9:e1003147 pubmed publisher
    ..order to localize genetic factors influencing levels of Epstein Barr virus (EBV) nuclear antigen-1 (EBNA-1) IgG antibodies, as a measure of history of infection with this pathogen, in large Mexican American families...
  2. Metushi I, Sanders C, Lee W, Uetrecht J. Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure. Hepatology. 2014;59:1084-93 pubmed publisher
    ..fever or rash, does not recur more rapidly on rechallenge, and previous studies have failed to identify anti-INH antibodies (Abs). In this study, we found Abs present in sera of 15 of 19 cases of INH-induced liver failure...
  3. Yu Y, Watts R. Developing therapeutic antibodies for neurodegenerative disease. Neurotherapeutics. 2013;10:459-72 pubmed publisher
    ..However, recent advances in preclinical and clinical drug development suggest that antibodies can cross the blood-brain barrier in limited quantities and act centrally to mediate their effects...
  4. Amarri S, Alvisi P, De Giorgio R, Gelli M, Cicola R, Tovoli F, et al. Antibodies to deamidated gliadin peptides: an accurate predictor of coeliac disease in infancy. J Clin Immunol. 2013;33:1027-30 pubmed publisher
    Immunoglobulin G antibodies against deamidated gliadin peptides are now known to have diagnostic accuracy comparable to tissue transglutaminase and endomysium autoantibodies in patients with coeliac disease...
  5. Riquelme M, Kar R, Gu S, Jiang J. Antibodies targeting extracellular domain of connexins for studies of hemichannels. Neuropharmacology. 2013;75:525-32 pubmed publisher
    ..This task is accomplished through the use of specifics antibodies that target the extracellular sites of desired connexin subtype...
  6. Li N, Fu L, Uchtenhagen H, Achour A, Burshtyn D. Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18. Eur J Immunol. 2013;43:1042-52 pubmed publisher
    ..Here we show that MHC-I expressed in cis has an impact on the detection of LIR-1 with various antibodies. We found the cis interaction alters recognition by only one of two antibodies known to block functional trans ..
  7. Rodríguez Zhurbenko N, Martínez D, Blanco R, Rondón T, Griñán T, Hernandez A. Human antibodies reactive to NeuGcGM3 ganglioside have cytotoxic antitumor properties. Eur J Immunol. 2013;43:826-37 pubmed publisher
    ..We demonstrate the existence of antibodies that bind (N-glycolylneuraminyl)-lactosylceramide (NeuGcGM3) and are detectable in the sera of 65 from the 100 ..
  8. Reinsmoen N. Role of angiotensin II type 1 receptor-activating antibodies in solid organ transplantation. Hum Immunol. 2013;74:1474-7 pubmed publisher
    ..Overactivity of the AT1R and angiotensin II interaction results in hypertension and vascular remodeling. Antibodies to AT1R have been implicated in several vascular pathologies...
  9. Steenholdt C, Ainsworth M, Tovey M, Klausen T, Thomsen O, Brynskov J, et al. Comparison of techniques for monitoring infliximab and antibodies against infliximab in Crohn's disease. Ther Drug Monit. 2013;35:530-8 pubmed publisher
    Several techniques are used to measure infliximab (IFX) and anti-IFX antibodies (Abs) in Crohn's disease. The aim of this study was to compare different assays for this purpose...

More Information

Publications74

  1. Collin M, Ehlers M. The carbohydrate switch between pathogenic and immunosuppressive antigen-specific antibodies. Exp Dermatol. 2013;22:511-4 pubmed publisher
    IgG antibodies have one conserved N-glycosylation site at Asn 297 in each of their constant heavy chain regions. These Fc glycans influence the overall structure and pro- or anti-inflammatory effector functions of IgG antibodies...
  2. Kondo N, Temma T, Shimizu Y, Watanabe H, Higano K, Takagi Y, et al. Miniaturized antibodies for imaging membrane type-1 matrix metalloproteinase in cancers. Cancer Sci. 2013;104:495-501 pubmed publisher
    ..Thus, in this study, our aim was to develop miniaturized antibodies, a single chain antibody fragment (MT1-scFv) and a dimer of two molecules of scFv (MT1-diabody), as the basic ..
  3. Skvortsov A, Gray P. A simple model for assessment of anti-toxin antibodies. Biomed Res Int. 2013;2013:230906 pubmed publisher
    ..Many antibodies have been generated for this purpose, and the objective of this study was to develop a simple mathematical model ..
  4. Smith L, Schiess M, Coffey M, Klaver A, Loeffler D. ?-Synuclein and anti-?-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls. PLoS ONE. 2012;7:e52285 pubmed publisher
    ..There are conflicting reports as to whether serum and plasma concentrations of ?-synuclein and anti-?-synuclein antibodies differ between PD and control subjects...
  5. Sonati T, Reimann R, Falsig J, Baral P, O CONNOR T, Hornemann S, et al. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature. 2013;501:102-6 pubmed publisher
    ..Ligands included seven distinct monoclonal antibodies, monovalent Fab1 fragments and recombinant single-chain variable fragment miniantibodies...
  6. Tran H, Piro B, Reisberg S, Duc H, Pham M. Antibodies directed to RNA/DNA hybrids: an electrochemical immunosensor for microRNAs detection using graphene-composite electrodes. Anal Chem. 2013;85:8469-74 pubmed publisher
    ..To double-check its selectivity, two specific RNA-DNA antibodies recognizing miRNA-DNA heteroduplexes, antipoly(A)-poly(dT) and anti-S9.6, were used...
  7. Qundos U, Hong M, Tybring G, Divers M, Odeberg J, Uhlen M, et al. Profiling post-centrifugation delay of serum and plasma with antibody bead arrays. J Proteomics. 2013;95:46-54 pubmed publisher
    ..Multiplexed protein profiles of post-centrifugation delay were generated in 384 biotinylated samples using 373 antibodies that targeted 343 unique proteins...
  8. Hansson S, Korsgren S, Ponten F, Korsgren O. Enteroviruses and the pathogenesis of type 1 diabetes revisited: cross-reactivity of enterovirus capsid protein (VP1) antibodies with human mitochondrial proteins. J Pathol. 2013;229:719-28 pubmed publisher
    ..These findings call for revisiting the presence of enteroviruses in pancreatic islets of patients with type 1 diabetes. ..
  9. Johnson L, Huseni M, Smyczek T, Lima A, Yeung S, Cheng J, et al. Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy. J Clin Invest. 2013;123:3997-4009 pubmed publisher
    ..Recombinant EGFL7 protein supported EC adhesion and protected ECs from stress-induced apoptosis. Anti-EGFL7 antibodies inhibited both of these key processes and augmented anti-VEGF-mediated vascular damage in various murine tumor ..
  10. Polo J, Campbell J, Crenshaw J, Rodriguez C, Pujol N, Navarro N, et al. Half-life of porcine antibodies absorbed from a colostrum supplement containing porcine immunoglobulins. J Anim Sci. 2012;90 Suppl 4:308-10 pubmed publisher
    ..The objective was to evaluate the half-life of antibodies absorbed in the bloodstream of newborn piglets orally fed a colostrum supplement (CS) containing energy (fat and ..
  11. de Magistris L, Picardi A, Siniscalco D, Riccio M, Sapone A, Cariello R, et al. Antibodies against food antigens in patients with autistic spectrum disorders. Biomed Res Int. 2013;2013:729349 pubmed publisher
    ..The prevalence of antibodies to gliadin and milk proteins in autistic children with paired/impaired intestinal permeability and under dietary ..
  12. De Meyer T, Eeckhout D, De Rycke R, De Buck S, Muyldermans S, Depicker A. Generation of VHH antibodies against the Arabidopsis thaliana seed storage proteins. Plant Mol Biol. 2014;84:83-93 pubmed publisher
    b>Antibodies and antibody derived fragments are excellent tools for the detection and purification of proteins. However, only few antibodies targeting Arabidopsis seed proteins are currently available...
  13. Li Y, Weber N, Fisher J, Yolken R, Cowan D, Larsen R, et al. Association between antibodies to multiple infectious and food antigens and new onset schizophrenia among US military personnel. Schizophr Res. 2013;151:36-42 pubmed publisher
    ..While existing studies have found single-agent associations of antibodies to food and neurotropic infectious agents with schizophrenia, a simultaneous examination of multiple agents may ..
  14. O Connor M, Lind C, Tang X, Gossett J, Weber J, Monos D, et al. Persistence of anti-human leukocyte antibodies in congenital heart disease late after surgery using allografts and whole blood. J Heart Lung Transplant. 2013;32:390-7 pubmed publisher
    ..Three groups of patients aged 8 to 18 years old underwent analysis for class I and II anti-HLA antibodies using Luminex...
  15. Rose M. Role of anti-vimentin antibodies in allograft rejection. Hum Immunol. 2013;74:1459-62 pubmed publisher
    Production of anti-vimentin antibodies (AVA) after solid organ transplantation are common...
  16. Desoubeaux G, Daguet A, Watier H. Therapeutic antibodies and infectious diseases, Tours, France, November 20-22, 2012. MAbs. 2013;5:626-32 pubmed publisher
    The Therapeutic Antibodies and Infectious Diseases international congress was held in Tours, France on November 20-22, 2012...
  17. Plantone D, Renna R, Grossi D, Plantone F, Iorio R. Teaching NeuroImages: Basal ganglia involvement in facio-brachial dystonic seizures associated with LGI1 antibodies. Neurology. 2013;80:e183-4 pubmed publisher
  18. Morris Berry C, Pollard M, Gao S, Thompson C, Singer H. Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: single-point and longitudinal assessments. J Neuroimmunol. 2013;264:106-13 pubmed publisher
    Single-point-in-time ELISA optical densities for three putative antibodies identified in Sydenham's chorea, the streptococcal group A carbohydrate antigen, N-acetyl-beta-d-glucosamine, tubulin, and the dopamine 2 receptor, showed no ..
  19. Marzouki S, Abdeladhim M, Abdessalem C, Oliveira F, Ferjani B, Gilmore D, et al. Salivary antigen SP32 is the immunodominant target of the antibody response to Phlebotomus papatasi bites in humans. PLoS Negl Trop Dis. 2012;6:e1911 pubmed publisher
    ..We recently showed that the presence of anti-saliva antibodies was associated with an enhanced risk for leishmaniasis and identified the immunodominant salivary protein of ..
  20. Holveck M, Grégoire A, Staszewski V, Guerreiro R, Perret P, Boulinier T, et al. Eggshell spottiness reflects maternally transferred antibodies in blue tits. PLoS ONE. 2012;7:e50389 pubmed publisher
    ..both predictions in testing if brown-spotted eggshell could reflect the quality of maternal investment in antibodies and carotenoids in the egg, and at improving between-study comparisons in correlating several common ..
  21. Sawicka M, Pawlikowski J, Wilson S, Ferdinando D, Wu H, Adams P, et al. The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding. PLoS ONE. 2013;8:e53313 pubmed publisher
    The validity of the identification and classification of human cancer using antibodies to detect biomarker proteins depends upon antibody specificity...
  22. Baek J, Darlington C, Smith P, Ashton J. Antibody testing for brain immunohistochemistry: brain immunolabeling for the cannabinoid CB? receptor. J Neurosci Methods. 2013;216:87-95 pubmed publisher
    ..One reason for these apparent discrepancies is the reliance on incompletely validated CB? receptor antibodies and immunohistochemical procedures...
  23. Zhao W, Shan S, Ma Z, Wan L, Xu J, Chen H. Acetylcholine esterase antibodies on BiOI nanoflakes/TiO2 nanoparticles electrode: a case of application for general photoelectrochemical enzymatic analysis. Anal Chem. 2013;85:11686-90 pubmed publisher
    ..Integrated with other enzyme-based biosystems, this simple configuration could serve as a general method for assaying enzyme inhibition or activities. ..
  24. Shi J, van Veelen P, Mahler M, Janssen G, Drijfhout J, Huizinga T, et al. Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun Rev. 2014;13:225-30 pubmed publisher
    ..We identified anti-carbamylated protein (anti-CarP) antibodies in rheumatoid arthritis (RA) patients and in patients having 'pre-RA' symptoms, arthralgia...
  25. Baniukevic J, Hakkı Boyacı I, Goktug Bozkurt A, Tamer U, Ramanavicius A, Ramanaviciene A. Magnetic gold nanoparticles in SERS-based sandwich immunoassay for antigen detection by well oriented antibodies. Biosens Bioelectron. 2013;43:281-8 pubmed publisher
    ..Magnetic gold nanoparticles (MNP-Au) modified by antibodies in oriented or random manner were used for the binding of gp51...
  26. Prüss H, Finke C, Höltje M, Hofmann J, Klingbeil C, Probst C, et al. N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis. Ann Neurol. 2012;72:902-11 pubmed publisher
    To determine the presence and kinetics of antibodies against synaptic proteins in patients with herpes simplex virus encephalitis (HSE)...
  27. Bakchoul T, Zöllner H, Amiral J, Panzer S, Selleng S, Kohlmann T, et al. Anti-protamine-heparin antibodies: incidence, clinical relevance, and pathogenesis. Blood. 2013;121:2821-7 pubmed publisher
    ..after protamine administration, we determined the incidence and clinical relevance of protamine-reactive antibodies in patients undergoing cardiac-surgery...
  28. Paterson R, Zandi M, Armstrong R, Vincent A, Schott J. Clinical relevance of positive voltage-gated potassium channel (VGKC)-complex antibodies: experience from a tertiary referral centre. J Neurol Neurosurg Psychiatry. 2014;85:625-30 pubmed publisher
    Voltage-gated potassium channel (VGKC)-complex antibodies can be associated with a range of immunotherapy-responsive clinical presentations including limbic encephalitis, Morvan's syndrome and acquired neuromyotonia...
  29. Gou S, Xu P, Chen M, Zhao M. Epitope analysis of anti-myeloperoxidase antibodies in patients with ANCA-associated vasculitis. PLoS ONE. 2013;8:e60530 pubmed publisher
    Increasing evidences have suggested the pathogenic role of anti-neutrophil cytoplasmic antibodies (ANCA) directing myeloperoxidase (MPO) in ANCA-associated vasculitis (AAV)...
  30. Lilleker J, Jones M, Mohanraj R. VGKC complex antibodies in epilepsy: diagnostic yield and therapeutic implications. Seizure. 2013;22:776-9 pubmed publisher
    ..b>Antibodies directed against the voltage gated potassium channel complex (VGKC Ab) have been identified in various cohorts ..
  31. Fattore L, Marra E, Pisanu M, Noto A, De Vitis C, Belleudi F, et al. Activation of an early feedback survival loop involving phospho-ErbB3 is a general response of melanoma cells to RAF/MEK inhibition and is abrogated by anti-ErbB3 antibodies. J Transl Med. 2013;11:180 pubmed publisher
    ..Western blot analysis was performed on total protein extracts using anti-ErbB3, anti-AKT and anti-ERK 1/2 antibodies. The expression of neuregulin after vemurafenib treatment was assessed by Real Time PCR and Western blotting...
  32. Reinsmoen N, Lai C, Mirocha J, Cao K, Ong G, Naim M, et al. Increased negative impact of donor HLA-specific together with non-HLA-specific antibodies on graft outcome. Transplantation. 2014;97:595-601 pubmed publisher
    De novo donor HLA-specific (dnDSA) and non-HLA antibodies including antiangiotensin type 1 receptor antibodies (AT1R-abs) have been associated with antibody-mediated rejection (AMR) and decreased graft survival as well as cellular-..
  33. Hamid O, Carvajal R. Anti-programmed death-1 and anti-programmed death-ligand 1 antibodies in cancer therapy. Expert Opin Biol Ther. 2013;13:847-61 pubmed publisher
    ..If future data continue to support encouraging clinical profiles of anti-PD-1 and anti-programmed death-ligand 1 antibodies, the current paradigm of cancer therapy may shift...
  34. Sun J, Tu M, Han B, Xue X, Zhang Y, Wei J, et al. Generation and characterization of rabbit polyclonal antibodies against Vasohibin-2 for determination of its intracellular localization. Int J Oncol. 2013;43:255-61 pubmed publisher
    ..Currently there are no reported antibodies affordable for intracellular localization...
  35. Kyi C, Postow M. Checkpoint blocking antibodies in cancer immunotherapy. FEBS Lett. 2014;588:368-76 pubmed publisher
    ..The development of checkpoint blocking antibodies, such as those directed against cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed death 1 receptor (PD-1),..
  36. Krishnan N, Zehnder D, Daga S, Lowe D, Lam F, Kashi H, et al. Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation. PLoS ONE. 2013;8:e68663 pubmed publisher
    HLA directed antibodies play an important role in acute and chronic allograft rejection. During viral infection of a patient with HLA antibodies, the HLA antibody levels may rise even though there is no new immunization with antigen...
  37. Bates D, Mavrou A, Qiu Y, Carter J, Hamdollah Zadeh M, Barratt S, et al. Detection of VEGF-A(xxx)b isoforms in human tissues. PLoS ONE. 2013;8:e68399 pubmed publisher
  38. Walter J, Werther R, Brison C, Cragerud R, Healey J, Meeks S, et al. Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes. Blood. 2013;122:4270-8 pubmed publisher
    The factor VIII C2 domain is a highly immunogenic domain, whereby inhibitory antibodies develop following factor VIII replacement therapy for congenital hemophilia A patients...
  39. Chen W, Weng S, Zhang F, Allen S, Li X, Bao L, et al. Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies. ACS Nano. 2013;7:566-75 pubmed publisher
    ..Here we report a simple yet effective strategy for capturing CTCs without using capture antibodies. Our method uniquely utilized the differential adhesion preference of cancer cells to nanorough surfaces when ..
  40. Balint B, Jarius S, Nagel S, Haberkorn U, Probst C, Blöcker I, et al. Progressive encephalomyelitis with rigidity and myoclonus: a new variant with DPPX antibodies. Neurology. 2014;82:1521-8 pubmed publisher
    ..a novel and distinct variant of progressive encephalomyelitis with rigidity and myoclonus (PERM) associated with antibodies directed against dipeptidyl peptidase-like protein 6 (DPPX), a regulatory subunit of the Kv4...
  41. Dama E, Cornelie S, Bienvenu Somda M, Camara M, Kambire R, Courtin F, et al. Identification of Glossina palpalis gambiensis specific salivary antigens: towards the development of a serologic biomarker of human exposure to tsetse flies in West Africa. Microbes Infect. 2013;15:416-27 pubmed publisher
    ..These results represent a first attempt to identify Glossina salivary proteins or synthetic peptides to develop a standardized and specific biomarker of tsetse exposure in West Africa...
  42. Gad H. The potential role of anti tumor necrosis factor-alpha antibodies on some renal functions and vasoregulatory factors in preeclamptic pregnant Wistar rats. Saudi Med J. 2013;34:490-6 pubmed
    To investigate the potential role of anti-tumor necrosis factor-alpha (TNF-alpha) antibodies on some renal functions and release of vasoregulatory peptides using nitric oxide synthase deprived pregnant rats...
  43. Vale A, Kapoor P, Skibinski G, Elgavish A, Mahmoud T, Zemlin C, et al. The link between antibodies to OxLDL and natural protection against pneumococci depends on D(H) gene conservation. J Exp Med. 2013;210:875-90 pubmed
    Selection and physiological production of protective natural antibodies (NAbs) have been associated with exposure to endogenous antigens. The extent to which this association depends on germline NAb sequence is uncertain...
  44. Joshi P, Yoon S, Hardin W, EMELIANOV S, Sokolov K. Conjugation of antibodies to gold nanorods through Fc portion: synthesis and molecular specific imaging. Bioconjug Chem. 2013;24:878-88 pubmed publisher
    ..achieved through the carbohydrate moiety, which is located on one of the heavy chains of the Fc portion of most antibodies. The carbohydrate is oxidized under mild conditions to a hydrazide reactive aldehyde group...
  45. Querol L, Nogales Gadea G, Rojas Garcia R, Martinez Hernandez E, Diaz Manera J, Suarez Calvet X, et al. Antibodies to contactin-1 in chronic inflammatory demyelinating polyneuropathy. Ann Neurol. 2013;73:370-80 pubmed publisher
    ..b>Antibodies against the CNTN1/CASPR1 complex occur in a subset of patients with CIDP who share common clinical features...
  46. Gonzalez L, Otero J, Agusil J, Samitier J, Adan J, Mitjans F, et al. Micropattern of antibodies imaged by shear force microscopy: comparison between classical and jumping modes. Ultramicroscopy. 2014;136:176-84 pubmed publisher
    ..In this work, we compare three different working modes for imaging micropatterned antibodies with quartz tuning fork sensors: apart from the classical amplitude and frequency modulation strategies, for ..
  47. Markusic D, Hoffman B, Perrin G, Nayak S, Wang X, LoDuca P, et al. Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies. EMBO Mol Med. 2013;5:1698-709 pubmed publisher
    Formation of pathogenic antibodies is a major problem in replacement therapies for inherited protein deficiencies. For example, antibodies to coagulation factors ('inhibitors') seriously complicate treatment of haemophilia...
  48. Li F, Ravetch J. Antitumor activities of agonistic anti-TNFR antibodies require differential Fc?RIIB coengagement in vivo. Proc Natl Acad Sci U S A. 2013;110:19501-6 pubmed publisher
    Agonistic anti-TNF receptor (TNFR) superfamily member antibodies are a class of promising antitumor therapies in active clinical investigation...
  49. Wan Y, Su Y, Zhu X, Liu G, Fan C. Development of electrochemical immunosensors towards point of care diagnostics. Biosens Bioelectron. 2013;47:1-11 pubmed publisher
    ..Several of them are commercially available for POC use. Herein, we will review briefly the recent achievements and progress in developing EIs towards POC diagnostics. ..
  50. Willis J, Briney B, Deluca S, Crowe J, Meiler J. Human germline antibody gene segments encode polyspecific antibodies. PLoS Comput Biol. 2013;9:e1003045 pubmed publisher
    Structural flexibility in germline gene-encoded antibodies allows promiscuous binding to diverse antigens...
  51. Dunbar J, Fuchs A, Shi J, Deane C. ABangle: characterising the VH-VL orientation in antibodies. Protein Eng Des Sel. 2013;26:611-20 pubmed publisher
    ..Finally, by analysing VH-VL orientation in bound and unbound forms, we find that antibodies specific for protein antigens are significantly more flexible in their unbound form than antibodies specific for ..
  52. Tzoulis C, Vedeler C, Haugen M, Storstein A, Tran G, Gjerde I, et al. Progressive striatal necrosis associated with anti-NMDA receptor antibodies. BMC Neurol. 2013;13:55 pubmed publisher
    ..due to slowly progressive bilateral striatal necrosis associated with anti-N-methyl-D-aspartate receptor (NMDAR) antibodies. This clinical phenotype has not been previously associated with NMDA receptor autoimmunity...
  53. Reed E, Rao P, Zhang Z, Gebel H, Bray R, Guleria I, et al. Comprehensive assessment and standardization of solid phase multiplex-bead arrays for the detection of antibodies to HLA. Am J Transplant. 2013;13:1859-70 pubmed publisher
    Solid phase multiplex-bead arrays for the detection and characterization of HLA antibodies provide increased sensitivity and specificity compared to conventional lymphocyte-based assays...
  54. Madampage C, Maattanen P, Marciniuk K, Brownlie R, Andrievskaia O, Potter A, et al. Binding of bovine T194A PrP(C) by PrP(Sc)-specific antibodies: potential implications for immunotherapy of familial prion diseases. Prion. 2013;7:301-11 pubmed publisher
    ..Polyclonal antibodies were selected to mimic the vaccination outcome and also explore all possible protein conformations of the ..
  55. Yu W, Hill W. Lack of specificity shown by P2Y6 receptor antibodies. Naunyn Schmiedebergs Arch Pharmacol. 2013;386:885-91 pubmed publisher
    ..The exact cellular location of the receptor is however unknown. Three commercially available antibodies to P2Y6 receptor gave clean bands on Western blot which were eliminated by specific peptide competition...
  56. Burkovitz A, Sela Culang I, Ofran Y. Large-scale analysis of somatic hypermutations in antibodies reveals which structural regions, positions and amino acids are modified to improve affinity. FEBS J. 2014;281:306-19 pubmed publisher
    The principles of affinity maturation of antibodies (Abs), which underlies B cell-mediated immunity, are still under debate...
  57. Bernal Lopez M, Garrido Sanchez L, Gomez Carrillo V, Gallego Perales J, Llorente Cortes V, Calleja F, et al. Antioxidized LDL antibodies are associated with different metabolic pathways in patients with atherosclerotic plaque and type 2 diabetes. Diabetes Care. 2013;36:1006-11 pubmed publisher
    Oxidized lipoproteins and antioxidized LDL antibodies (antioxLDL abs) have been detected in human plasma and atherosclerotic lesions...
  58. Miyara M, Albesa R, Charuel J, El Amri M, Fritzler M, Ghillani Dalbin P, et al. Clinical phenotypes of patients with anti-DFS70/LEDGF antibodies in a routine ANA referral cohort. Clin Dev Immunol. 2013;2013:703759 pubmed publisher
    To analyze the clinical value of anti-DFS70 antibodies in a cohort of patients undergoing routine antinuclear antibodies (ANAs) testing...
  59. Muyldermans S. Nanobodies: natural single-domain antibodies. Annu Rev Biochem. 2013;82:775-97 pubmed publisher
    Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs)...
  60. Chen Z, Abrams W, Geva E, de Dood C, GONZALEZ J, Tanke H, et al. Development of a generic microfluidic device for simultaneous detection of antibodies and nucleic acids in oral fluids. Biomed Res Int. 2013;2013:543294 pubmed publisher
    ..Diagnosis of HIV infection was used as a model to investigate the simultaneous detection of both human antibodies against the virus and viral RNA...
  61. Loupy A, Lefaucheur C, Vernerey D, Prugger C, Duong Van Huyen J, Mooney N, et al. Complement-binding anti-HLA antibodies and kidney-allograft survival. N Engl J Med. 2013;369:1215-26 pubmed publisher
    Anti-HLA antibodies hamper successful transplantation, and activation of the complement cascade is involved in antibody-mediated rejection...
  62. Capito F, Bauer J, Rapp A, Schroter C, Kolmar H, Stanislawski B. Feasibility study of semi-selective protein precipitation with salt-tolerant copolymers for industrial purification of therapeutic antibodies. Biotechnol Bioeng. 2013;110:2915-27 pubmed publisher
    ..Optimized parameters were used to elucidate yield and purity of various antibodies precipitated at physiological conditions from cell culture fluid of CHO, NS0, and SP2/0 cell culture fluid...
  63. Zauner G, Selman M, Bondt A, Rombouts Y, Blank D, Deelder A, et al. Glycoproteomic analysis of antibodies. Mol Cell Proteomics. 2013;12:856-65 pubmed publisher
    ..Glycoproteomic analyses of IgM and IgE are lagging behind but should complete our picture of glycosylation's influence on antibody function. ..
  64. Persson H, Ye W, Wernimont A, Adams J, Koide A, Koide S, et al. CDR-H3 diversity is not required for antigen recognition by synthetic antibodies. J Mol Biol. 2013;425:803-11 pubmed publisher
    ..regions of the heavy (CDR-H3) and light (CDR-L3) chains, which contrasts with natural antibodies in which CDR-H3 is much more diverse than CDR-L3 due to the genetic mechanisms that generate antibody encoding ..