complement c4b binding protein


Summary: A serum protein that regulates the CLASSICAL COMPLEMENT ACTIVATION PATHWAY. It binds as a cofactor to COMPLEMENT FACTOR I which then hydrolyzes the COMPLEMENT C4B in the CLASSICAL PATHWAY C3 CONVERTASE (C4bC2a).

Top Publications

  1. Jin Y, Manabe T. Differences in protein distribution between human plasma preparations, EDTA-plasma and heparin-plasma, analyzed by non-denaturing micro-2-DE and MALDI-MS PMF. Electrophoresis. 2009;30:931-8 pubmed publisher
    ..These results demonstrated that subtle changes in plasma proteins, caused by the different plasma preparation procedures, can be analyzed by non-denaturing agarose-IEF/micro-2-DE followed by MALDI-MS and PMF. ..
  2. Dieudonné Vatran A, Krentz S, Blom A, Meri S, Henriques Normark B, Riesbeck K, et al. Clinical isolates of Streptococcus pneumoniae bind the complement inhibitor C4b-binding protein in a PspC allele-dependent fashion. J Immunol. 2009;182:7865-77 pubmed publisher
    ..4) as a major ligand for C4BP, revealing a new function for this important pneumococcal virulence factor. Thus pneumococci exploit host C4BP for complement evasion in a PspC allele-dependent manner. ..
  3. Shinya E, Owaki A, Norose Y, Sato S, Takahashi H. Quick method of multimeric protein production for biologically active substances such as human GM-CSF (hGM-CSF). Biochem Biophys Res Commun. 2009;386:40-4 pubmed publisher
  4. Martin M, Gottsäter A, Nilsson P, Mollnes T, Lindblad B, Blom A. Complement activation and plasma levels of C4b-binding protein in critical limb ischemia patients. J Vasc Surg. 2009;50:100-6 pubmed publisher
    ..This knowledge in combination with the found correlations to other biomarkers is useful for understanding the pathophysiology of the disease. ..
  5. Rawal N, Rajagopalan R, Salvi V. Stringent regulation of complement lectin pathway C3/C5 convertase by C4b-binding protein (C4BP). Mol Immunol. 2009;46:2902-10 pubmed publisher
  6. Kaikkonen M, Maatta A, Yla Herttuala S, Airenne K. Screening of complement inhibitors: shielded baculoviruses increase the safety and efficacy of gene delivery. Mol Ther. 2010;18:987-92 pubmed publisher
    ..In conclusion, complement shielded baculovirus vectors represent attractive tools for effective in vivo gene delivery. ..
  7. Carlsson S, Dahlback B. Dependence on vitamin K-dependent protein S for eukaryotic cell secretion of the beta-chain of C4b-binding protein. J Biol Chem. 2010;285:32038-46 pubmed publisher
    ..This provides an explanation for the decreased ?-chain levels observed in PS-deficient patients. ..
  8. Guermazi S, Conard J. [Congenital protein S deficiencies; diagnostic difficulties]. Pathol Biol (Paris). 2009;57:483-7 pubmed publisher
    ..About 200 different mutations were retrieved and, therefore, molecular studies are not of current practice. It is recommended currently to measure in first intention the free PS, if possible in association with PCa cofactor activity. ..
  9. Mallet V, Varthaman A, Lasne D, Viard J, Gouya H, Borgel D, et al. Acquired protein S deficiency leads to obliterative portal venopathy and to compensatory nodular regenerative hyperplasia in HIV-infected patients. AIDS. 2009;23:1511-8 pubmed publisher
    ..Acquired autoimmune protein S paucity and secondary thrombophilia appear to be causes of obliterative portal venopathy and compensatory nodular regenerative hyperplasia in HIV-positive patients. ..

More Information


  1. Leffler J, Herbert A, Norström E, Schmidt C, Barlow P, Blom A, et al. Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells. J Biol Chem. 2010;285:3766-76 pubmed publisher
  2. Pietikäinen J, Meri T, Blom A, Meri S. Binding of the complement inhibitor C4b-binding protein to Lyme disease Borreliae. Mol Immunol. 2010;47:1299-305 pubmed publisher
    ..garinii and B. burgdorferi sensu stricto. Binding of C4bp may thus allow Lyme disease borreliae to escape activation of the classical C pathway and allow chronic infections in humans even in the presence of specific antibodies. ..
  3. Cai X, Shedden K, Ao X, Davis M, Fu X, Lawrence T, et al. Plasma proteomic analysis may identify new markers for radiation-induced lung toxicity in patients with non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2010;77:867-76 pubmed publisher
    ..without RILT2 were 1.60, 1.36, 1.46, and 1.66, 1.34, 1.46, for the above three proteins, respectively. This proteomic approach identified new plasma protein markers for future studies on RILT prediction. ..