complement c2b


Summary: The N-terminal fragment of COMPLEMENT 2, released by the action of activated COMPLEMENT C1S.

Top Publications

  1. Visnjic D, Curic J, Crljen V, Batinic D, Volinia S, Banfic H. Nuclear phosphoinositide 3-kinase C2beta activation during G2/M phase of the cell cycle in HL-60 cells. Biochim Biophys Acta. 2003;1631:61-71 pubmed
    ..These results demonstrate the calpain-mediated activation of the nuclear PI3K-C2beta during G(2)/M phase of the cell cycle in HL-60 cells. ..
  2. Jaworska H, Gregorek H, Madalinski K. [Angioedema is caused by a defect in C1-inhibitor synthesis]. Przegl Lek. 2000;57:483-8 pubmed
    ..We want to verify the practical use of probiotics as natural inductors of IFN-gamma synthesis for elevating C1-inh level. ..
  3. Krishnan V, Xu Y, Macon K, Volanakis J, Narayana S. The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation. Acta Crystallogr D Biol Crystallogr. 2009;65:266-74 pubmed publisher
    ..The results of this study also suggest that upon cleavage by C1s, C2a domains undergo conformational rotation while bound to C4b and the released C2b domains may remain folded together similar to as observed in the intact protein. ..
  4. Halili M, Ruiz Gómez G, Le G, Abbenante G, Fairlie D. Complement component C2, inhibiting a latent serine protease in the classical pathway of complement activation. Biochemistry. 2009;48:8466-72 pubmed publisher
    ..These results provide a new avenue and valuable new insights to inhibiting CP complement activation relevant to inflammatory diseases. ..
  5. Barber C, Jorquera R, Melom J, Littleton J. Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains. J Cell Biol. 2009;187:295-310 pubmed publisher
    ..These data suggest that Syt 4 regulates activity-dependent release of postsynaptic retrograde signals that promote synaptic plasticity, similar to the role of Syt 1 as a Ca(2+) sensor for presynaptic vesicle fusion. ..
  6. Sasakawa N, Ohara Imaizumi M, Fukuda M, Kabayama H, Mikoshiba K, Kumakura K. Dissociation of inositol polyphosphates from the C2B domain of synaptotagmin facilitates spontaneous release of catecholamines in adrenal chromaffin cells. A suggestive evidence of a fusion clamp by synaptotagmin. Neuropharmacology. 2011;60:1364-70 pubmed publisher
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'. ..