algal proteins


Summary: Proteins found in any species of algae.

Top Publications

  1. Fujiwara T, Misumi O, Tashiro K, Yoshida Y, Nishida K, Yagisawa F, et al. Periodic gene expression patterns during the highly synchronized cell nucleus and organelle division cycles in the unicellular red alga Cyanidioschyzon merolae. DNA Res. 2009;16:59-72 pubmed publisher
    ..In other genes, 46 were hypothetical and 19 were hypothetical conserved. The possibility of finding novel organelle division genes from hypothetical and hypothetical conserved genes in the S and G2-M expression groups is discussed. ..
  2. Yagisawa F, Nishida K, Yoshida M, Ohnuma M, Shimada T, Fujiwara T, et al. Identification of novel proteins in isolated polyphosphate vacuoles in the primitive red alga Cyanidioschyzon merolae. Plant J. 2009;60:882-93 pubmed publisher
    ..The results presented here provide insights into the proteome of C. merolae vacuoles and shed light on their functions, as well as indicating new features. ..
  3. Wang Z, Fan Z, Williamson S, Qin H. Intraflagellar transport (IFT) protein IFT25 is a phosphoprotein component of IFT complex B and physically interacts with IFT27 in Chlamydomonas. PLoS ONE. 2009;4:e5384 pubmed publisher
    ..We postulate that the association and disassociation between the subcomplex of IFT25 and IFT27 and complex B might be involved in the regulation of IFT. ..
  4. Moulaei T, Shenoy S, Giomarelli B, Thomas C, McMahon J, Dauter Z, et al. Monomerization of viral entry inhibitor griffithsin elucidates the relationship between multivalent binding to carbohydrates and anti-HIV activity. Structure. 2010;18:1104-15 pubmed publisher
    ..Atomic resolution crystal structure of a complex between mGRFT and nonamannoside revealed that a single mGRFT molecule binds to two different nonamannoside molecules through all three carbohydrate-binding sites present on the monomer. ..
  5. Amelot N, Carrouche A, Danoun S, Bourque S, Haiech J, Pugin A, et al. Cryptogein, a fungal elicitor, remodels the phenylpropanoid metabolism of tobacco cell suspension cultures in a calcium-dependent manner. Plant Cell Environ. 2011;34:149-61 pubmed publisher
  6. Alexandre K, Gray E, Pantophlet R, Moore P, McMahon J, Chakauya E, et al. Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site. J Virol. 2011;85:9039-50 pubmed publisher
    ..This study shows for the first time that GRFT interaction with gp120 exposes the CD4bs through binding the glycan at position 386, which may have implications for how to access this conserved site. ..
  7. van Poppel P, Guo J, van de Vondervoort P, Jung M, Birch P, Whisson S, et al. The Phytophthora infestans avirulence gene Avr4 encodes an RXLR-dEER effector. Mol Plant Microbe Interact. 2008;21:1460-70 pubmed publisher
    ..Deletion of the RXLR-dEER domain neither stimulated nor prevented elicitor activity of PiAvr4. Race 4 strains have frame shift mutations in PiAvr4 that result in truncated peptides; hence, PiAvr4 is apparently not crucial for virulence. ..
  8. Férir G, Palmer K, Schols D. Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C. Virology. 2011;417:253-8 pubmed publisher
    ..Overall, we can conclude that the evaluated two-drug combination increases their antiviral potency and supports further clinical investigations in pre-exposure prophylaxis for GRFT combinations in the context of HIV-1 clade C infection. ..
  9. O Keefe B, Vojdani F, Buffa V, Shattock R, Montefiori D, Bakke J, et al. Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component. Proc Natl Acad Sci U S A. 2009;106:6099-104 pubmed publisher
    ..Moreover, GRFT-P is potently active in preventing infection of cervical explants by HIV-1 and has no mitogenic activity on cultured human lymphocytes. ..

More Information


  1. Yoshida Y, Kuroiwa H, Misumi O, Yoshida M, Ohnuma M, Fujiwara T, et al. Chloroplasts divide by contraction of a bundle of nanofilaments consisting of polyglucan. Science. 2010;329:949-53 pubmed publisher
    ..Thus, the chloroplasts are divided by the PD ring, which is a bundle of PDR1-mediated polyglucan filaments. ..
  2. Amelot N, Dorlhac de Borne F, San Clemente H, Mazars C, Grima Pettenati J, Briere C. Transcriptome analysis of tobacco BY-2 cells elicited by cryptogein reveals new potential actors of calcium-dependent and calcium-independent plant defense pathways. Cell Calcium. 2012;51:117-30 pubmed publisher
    ..This genome-wide study strongly supports the importance of Ca(2+)-dependent transcriptional regulation of regulatory and defense-related genes contributing to cryptogein responses in tobacco. ..
  3. Stanislas T, Bouyssie D, Rossignol M, Vesa S, Fromentin J, Morel J, et al. Quantitative proteomics reveals a dynamic association of proteins to detergent-resistant membranes upon elicitor signaling in tobacco. Mol Cell Proteomics. 2009;8:2186-98 pubmed publisher
    ..This suggests that the ways by which the dynamic association of proteins to microdomains could participate in the regulation of the signaling process may be conserved between plant and animals. ..
  4. Imamura S, Kanesaki Y, Ohnuma M, Inouye T, Sekine Y, Fujiwara T, et al. R2R3-type MYB transcription factor, CmMYB1, is a central nitrogen assimilation regulator in Cyanidioschyzon merolae. Proc Natl Acad Sci U S A. 2009;106:12548-53 pubmed publisher
    ..Thus, the presented results indicated that CmMYB1 is a central nitrogen regulator in C. merolae. ..
  5. Iomini C, Li L, Esparza J, Dutcher S. Retrograde intraflagellar transport mutants identify complex A proteins with multiple genetic interactions in Chlamydomonas reinhardtii. Genetics. 2009;183:885-96 pubmed publisher
    ..Since these tests show different levels of phenotypic sensitivity, we propose they illustrate different gradations of gene interaction between complex A proteins themselves and with a complex B protein (IFT172). ..
  6. Lindberg P, Melis A. The chloroplast sulfate transport system in the green alga Chlamydomonas reinhardtii. Planta. 2008;228:951-61 pubmed publisher
    ..reinhardtii, specifically recognized by polyclonal antibodies against SulP and Sabc. These results suggest the presence and function in C. reinhardtii of a Sbp-SulP-SulP2-Sabc chloroplast envelope sulfate transporter holocomplex. ..
  7. Yoshida Y, Kuroiwa H, Hirooka S, Fujiwara T, Ohnuma M, Yoshida M, et al. The bacterial ZapA-like protein ZED is required for mitochondrial division. Curr Biol. 2009;19:1491-7 pubmed publisher
  8. Davidi L, Katz A, Pick U. Characterization of major lipid droplet proteins from Dunaliella. Planta. 2012;236:19-33 pubmed publisher
    ..These results can lead to a better understanding of the structure and function of Volvocales green algae MLDP proteins. ..
  9. Wang Z, Ullrich N, Joo S, Waffenschmidt S, Goodenough U. Algal lipid bodies: stress induction, purification, and biochemical characterization in wild-type and starchless Chlamydomonas reinhardtii. Eukaryot Cell. 2009;8:1856-68 pubmed publisher
    ..Nitrogen stress-induced LB production in C. reinhardtii has the hallmarks of a discrete pathway that should be amenable to additional genetic and culture condition manipulation. ..
  10. Moellering E, Benning C. RNA interference silencing of a major lipid droplet protein affects lipid droplet size in Chlamydomonas reinhardtii. Eukaryot Cell. 2010;9:97-106 pubmed publisher
    ..Repression of MLDP gene expression using an RNA interference approach led to increased lipid droplet size, but no change in triacylglycerol content or metabolism was observed. ..
  11. Bayer Giraldi M, Uhlig C, John U, Mock T, Valentin K. Antifreeze proteins in polar sea ice diatoms: diversity and gene expression in the genus Fragilariopsis. Environ Microbiol. 2010;12:1041-52 pubmed publisher
    ..cylindrus and F. curta strongly expressed selected afps. An E/G point mutation in the Fragilariopsis AFPs may play a role in gene expression activity and protein function. ..
  12. Prochnik S, Umen J, Nedelcu A, Hallmann A, Miller S, Nishii I, et al. Genomic analysis of organismal complexity in the multicellular green alga Volvox carteri. Science. 2010;329:223-6 pubmed publisher
    ..Our analysis shows that increases in organismal complexity can be associated with modifications of lineage-specific proteins rather than large-scale invention of protein-coding capacity...
  13. Vatsa P, Chiltz A, Bourque S, Wendehenne D, Garcia Brugger A, Pugin A. Involvement of putative glutamate receptors in plant defence signaling and NO production. Biochimie. 2011;93:2095-101 pubmed publisher
    ..Taken together, our results demonstrate for the first time, an involvement of a putative iGluR in plant defence signaling and NO production, by mechanisms that show homology with glutamate mode of action in mammals. ..
  14. Meuleman P, Albecka A, Belouzard S, Vercauteren K, Verhoye L, Wychowski C, et al. Griffithsin has antiviral activity against hepatitis C virus. Antimicrob Agents Chemother. 2011;55:5159-67 pubmed publisher
    ..GRFT treatment of chronically infected HCV patients undergoing liver transplantation may be a suitable strategy to prevent infection of the liver allograft. ..
  15. Peers G, Truong T, Ostendorf E, Busch A, Elrad D, Grossman A, et al. An ancient light-harvesting protein is critical for the regulation of algal photosynthesis. Nature. 2009;462:518-21 pubmed publisher
    ..Thus, these data indicate that plants and algae use different proteins to dissipate harmful excess light energy and protect the photosynthetic apparatus from damage. ..
  16. Imamura S, Terashita M, Ohnuma M, Maruyama S, Minoda A, Weber A, et al. Nitrate assimilatory genes and their transcriptional regulation in a unicellular red alga Cyanidioschyzon merolae: genetic evidence for nitrite reduction by a sulfite reductase-like enzyme. Plant Cell Physiol. 2010;51:707-17 pubmed publisher
    ..Immunofluorescent analysis indicated the localization of CMG021C in chloroplasts, and hence we propose an overall scheme for nitrate assimilation in C. merolae. ..
  17. Cock J, Sterck L, Rouze P, Scornet D, Allen A, Amoutzias G, et al. The Ectocarpus genome and the independent evolution of multicellularity in brown algae. Nature. 2010;465:617-21 pubmed publisher
  18. Qutob D, Tedman Jones J, Dong S, Kuflu K, Pham H, Wang Y, et al. Copy number variation and transcriptional polymorphisms of Phytophthora sojae RXLR effector genes Avr1a and Avr3a. PLoS ONE. 2009;4:e5066 pubmed publisher
    ..However, recognition of these effectors by plant immune systems results in selection for pathogen strains with deleted or transcriptionally silenced gene copies...
  19. Curtis B, Tanifuji G, Burki F, Gruber A, Irimia M, Maruyama S, et al. Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs. Nature. 2012;492:59-65 pubmed publisher
    ..Mitochondrion-to-nucleus gene transfer still occurs in both organisms but plastid-to-nucleus and nucleomorph-to-nucleus transfers do not, which explains why a small residue of essential genes remains locked in each nucleomorph...
  20. Grouffaud S, van West P, Avrova A, Birch P, Whisson S. Plasmodium falciparum and Hyaloperonospora parasitica effector translocation motifs are functional in Phytophthora infestans. Microbiology. 2008;154:3743-51 pubmed publisher
    ..These results suggest common mechanisms for protein translocation in both malaria and oomycete pathosystems. ..
  21. Kianianmomeni A, Nematollahi G, Hallmann A. A gender-specific retinoblastoma-related protein in Volvox carteri implies a role for the retinoblastoma protein family in sexual development. Plant Cell. 2008;20:2399-419 pubmed publisher
    ..Thus, the gender-specific presence of RBR1 provides evidence for an additional, novel role for retinoblastoma family proteins in sexual development...
  22. Hu Q, Sommerfeld M, Jarvis E, Ghirardi M, Posewitz M, Seibert M, et al. Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances. Plant J. 2008;54:621-39 pubmed publisher
  23. Popłońska K, Kwiatkowska M, Wojtczak A, Polit J. Immunogold evidence suggests that endoplasmic reticulum is the site of protamine-type protein synthesis and participates in translocation of these proteins into the nucleus during Chara vulgaris spermiogenesis. Biol Reprod. 2009;80:572-80 pubmed publisher
  24. Zhu S, Green B. Photoprotection in the diatom Thalassiosira pseudonana: role of LI818-like proteins in response to high light stress. Biochim Biophys Acta. 2010;1797:1449-57 pubmed publisher
  25. Huang X, Jin W, Griffin G, Shattock R, Hu Q. Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin. J Gen Virol. 2011;92:2367-73 pubmed publisher
    ..This was further strengthened by the results of GRFT-Env binding experiments. Our study identifies GRFT-specific gp120 glycans and may provide information for the design of novel CBA antiviral strategies. ..
  26. Rebuffet E, Barbeyron T, Jeudy A, Jam M, Czjzek M, Michel G. Identification of catalytic residues and mechanistic analysis of family GH82 iota-carrageenases. Biochemistry. 2010;49:7590-9 pubmed publisher
    ..The third residue, Q222, that bridges the catalytic water molecule and a chloride ion, plays a crucial role in structuring the water network in the active site of A. fortis iota-carrageenase. ..
  27. Lechtreck K, Johnson E, Sakai T, Cochran D, Ballif B, Rush J, et al. The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella. J Cell Biol. 2009;187:1117-32 pubmed publisher
    ..We conclude that the BBSome is carried by IFT but is an adapter rather than an integral component of the IFT machinery. C. reinhardtii BBS4 may be required for the export of signaling proteins from the flagellum via IFT. ..
  28. Dou D, Kale S, Wang X, Jiang R, Bruce N, Arredondo F, et al. RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen-encoded machinery. Plant Cell. 2008;20:1930-47 pubmed publisher
    ..Mutational analysis of the RXLR motif shows that the required residues are very similar in the motifs of Plasmodium and Phytophthora. Thus, the machinery of the hosts (soybean and human) targeted by the effectors may be very ancient. ..
  29. Terauchi A, Lu S, Zaffagnini M, Tappa S, Hirasawa M, Tripathy J, et al. Pattern of expression and substrate specificity of chloroplast ferredoxins from Chlamydomonas reinhardtii. J Biol Chem. 2009;284:25867-78 pubmed publisher
  30. Alexandre K, Gray E, Mufhandu H, McMahon J, Chakauya E, O Keefe B, et al. The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells. Virology. 2012;423:175-86 pubmed publisher
    ..Our data suggest that GRFT, CV-N and SVN can block two important stages of the sexual transmission of HIV-1, DC-SIGN binding and transfer, supporting their further development as microbicides. ..
  31. O Keefe B, Giomarelli B, Barnard D, Shenoy S, Chan P, McMahon J, et al. Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J Virol. 2010;84:2511-21 pubmed publisher
  32. Alexandre K, Gray E, Lambson B, Moore P, Choge I, Mlisana K, et al. Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin. Virology. 2010;402:187-96 pubmed publisher
    ..This data support further research on these lectins as potential microbicides in the context of HIV-1 subtype C infection. ..
  33. Allen M, Kropat J, Tottey S, Del Campo J, Merchant S. Manganese deficiency in Chlamydomonas results in loss of photosystem II and MnSOD function, sensitivity to peroxides, and secondary phosphorus and iron deficiency. Plant Physiol. 2007;143:263-77 pubmed
  34. Govers F, Gijzen M. Phytophthora genomics: the plant destroyers' genome decoded. Mol Plant Microbe Interact. 2006;19:1295-301 pubmed
    ..This MPMI Focus issue on Phytophthora genomics contains a number of more specialized manuscripts centered on gene annotation and genome organization, and complemented with manuscripts that rely on genomics resources. ..
  35. Keskiaho K, Hieta R, Sormunen R, Myllyharju J. Chlamydomonas reinhardtii has multiple prolyl 4-hydroxylases, one of which is essential for proper cell wall assembly. Plant Cell. 2007;19:256-69 pubmed
  36. Allen M, Del Campo J, Kropat J, Merchant S. FEA1, FEA2, and FRE1, encoding two homologous secreted proteins and a candidate ferrireductase, are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas reinhardtii. Eukaryot Cell. 2007;6:1841-52 pubmed
    ..These iron response components are placed in a proposed iron assimilation pathway for Chlamydomonas. ..
  37. Merchant S, Prochnik S, Vallon O, Harris E, Karpowicz S, Witman G, et al. The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science. 2007;318:245-50 pubmed
  38. Qin H, Wang Z, Diener D, Rosenbaum J. Intraflagellar transport protein 27 is a small G protein involved in cell-cycle control. Curr Biol. 2007;17:193-202 pubmed
    ..IFT27, a small G protein, is one of a growing number of flagellar proteins that are now known to have a role in cell-cycle control. ..
  39. Popłońska K, Wojtczak A, Kwiatkowska M, Kazmierczak A. Cytochemical and immunocytochemical studies of the localization of histones and protamine-type proteins in spermatids of Chara vulgaris and Chara tomentosa. Folia Histochem Cytobiol. 2007;45:367-74 pubmed
    ..At phase V spermiogenesis these strong strand-like anti-protamine signals were observed in cytoplasm which might suggest that protamine synthesis took place in ER...
  40. Belbahri L, Calmin G, Mauch F, Andersson J. Evolution of the cutinase gene family: evidence for lateral gene transfer of a candidate Phytophthora virulence factor. Gene. 2008;408:1-8 pubmed
    ..These findings could indeed provide an interesting model system to study acquisition of virulence factors in these important plant pathogens. ..
  41. Lemieux C, Otis C, Turmel M. A clade uniting the green algae Mesostigma viride and Chlorokybus atmophyticus represents the deepest branch of the Streptophyta in chloroplast genome-based phylogenies. BMC Biol. 2007;5:2 pubmed
  42. Sommer M, Gould S, Lehmann P, Gruber A, Przyborski J, Maier U. Der1-mediated preprotein import into the periplastid compartment of chromalveolates?. Mol Biol Evol. 2007;24:918-28 pubmed
    ..We propose herewith that this system was functionally adapted to mediate transport of nucleus-encoded PPC/plastid preproteins from the RER into the periplastid space...
  43. Dou D, Kale S, Wang X, Chen Y, Wang Q, Wang X, et al. Conserved C-terminal motifs required for avirulence and suppression of cell death by Phytophthora sojae effector Avr1b. Plant Cell. 2008;20:1118-33 pubmed publisher
  44. Sato N, Moriyama T. Genomic and biochemical analysis of lipid biosynthesis in the unicellular rhodophyte Cyanidioschyzon merolae: lack of a plastidic desaturation pathway results in the coupled pathway of galactolipid synthesis. Eukaryot Cell. 2007;6:1006-17 pubmed
    ..These results highlight essential differences in lipid biosynthetic pathways between the red algae and the green lineage, which includes plants and green algae. ..
  45. Noble G, Rogers M, Keeling P. Complex distribution of EFL and EF-1alpha proteins in the green algal lineage. BMC Evol Biol. 2007;7:82 pubmed
    ..Overall, we suggest that after the introduction of EFL (in the ancestor of green algae or earlier), both genes co-existed in green algal genomes for some time before one or the other was lost on multiple occasions. ..
  46. Kamoun S. Groovy times: filamentous pathogen effectors revealed. Curr Opin Plant Biol. 2007;10:358-65 pubmed
    ..Recent findings illustrate a diversity of effector structures and activities, as well as validate the view that effector genes are the target of the evolutionary forces that drive the antagonistic interplay between pathogen and host...
  47. Whisson S, Boevink P, Moleleki L, Avrova A, Morales J, Gilroy E, et al. A translocation signal for delivery of oomycete effector proteins into host plant cells. Nature. 2007;450:115-8 pubmed
    ..infestans genome. Identification of this class of proteins provides unparalleled opportunities to determine how oomycetes manipulate hosts to establish infection. ..
  48. Win J, Morgan W, Bos J, Krasileva K, Cano L, Chaparro Garcia A, et al. Adaptive evolution has targeted the C-terminal domain of the RXLR effectors of plant pathogenic oomycetes. Plant Cell. 2007;19:2349-69 pubmed
  49. Naumann B, Busch A, Allmer J, Ostendorf E, Zeller M, Kirchhoff H, et al. Comparative quantitative proteomics to investigate the remodeling of bioenergetic pathways under iron deficiency in Chlamydomonas reinhardtii. Proteomics. 2007;7:3964-79 pubmed
  50. Rentel M, Leonelli L, Dahlbeck D, Zhao B, Staskawicz B. Recognition of the Hyaloperonospora parasitica effector ATR13 triggers resistance against oomycete, bacterial, and viral pathogens. Proc Natl Acad Sci U S A. 2008;105:1091-6 pubmed publisher
    ..We have characterized regions of the RPP13(Nd) resistance protein that are essential for effector recognition and/or downstream signaling, using transient coexpression in Nicotiana benthamiana...
  51. Shimonaga T, Fujiwara S, Kaneko M, Izumo A, Nihei S, Francisco P, et al. Variation in storage alpha-polyglucans of red algae: amylose and semi-amylopectin types in Porphyridium and glycogen type in Cyanidium. Mar Biotechnol (NY). 2007;9:192-202 pubmed
    ..The present investigation indicates that the class Bangiophyceae includes species producing both semi-amylopectin and amylose, and species producing glycogen alone...
  52. Emau P, Tian B, O keefe B, Mori T, McMahon J, Palmer K, et al. Griffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide. J Med Primatol. 2007;36:244-53 pubmed
    ..The in vitro efficacy of GRFT revealed low cytotoxicity, high potency, rapid onset of antiviral activity and long-term stability in cervical/vaginal lavage. GRFT is an excellent candidate for anti-HIV microbicide development. ..
  53. Nakazawa Y, Hiraki M, Kamiya R, Hirono M. SAS-6 is a cartwheel protein that establishes the 9-fold symmetry of the centriole. Curr Biol. 2007;17:2169-74 pubmed
    ..We presume that, in many organisms, SAS-6 is an essential component of the cartwheel, a structure that stabilizes the 9-triplet structure. ..