enalapril

Summary

Summary: An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.

Top Publications

  1. Nedogoda S, Ledyaeva A, Chumachok E, Tsoma V, Mazina G, Salasyuk A, et al. Randomized trial of perindopril, enalapril, losartan and telmisartan in overweight or obese patients with hypertension. Clin Drug Investig. 2013;33:553-61 pubmed publisher
    ..Patients were randomly allocated to perindopril 10 mg/day, enalapril 20 mg/day, losartan 100 mg/day or telmisartan 80 mg/day. Nonpharmacological interventions were also recommended...
  2. Lima C, Ueti O, Ueti A, Franchini K, Costa F, Saad S. Enalapril therapy and cardiac remodelling in sickle cell disease patients. Acta Cardiol. 2008;63:599-602 pubmed
    ..b>Enalapril was administered to 9 SCD patients with microalbuminuria...
  3. Adriano A, Gomes Neto A, Hamester G, Nunes D, Di Giunta G. Pemphigus vegetans induced by use of enalapril. An Bras Dermatol. 2011;86:1197-200 pubmed
    ..involvement of mucous membrane and flexor surfaces in an elderly female patient, associated with the use of enalapril as possible trigger factor...
  4. Mao G, Hong X, Xing H, Liu P, Liu H, Yu Y, et al. Efficacy of folic acid and enalapril combined therapy on reduction of blood pressure and plasma glucose: a multicenter, randomized, double-blind, parallel-controlled, clinical trial. Nutrition. 2008;24:1088-96 pubmed publisher
    We compared the efficacy of folic acid (FA) plus enalapril with enalapril alone on the reduction of blood pressure (BP) and fasting plasma glucose (FPG) in adult Chinese hypertensive patients...
  5. Avanza A, Mansur A, Ramires J. Efficacy of exercise, losartan, enalapril, atenolol and rilmenidine in subjects with blood pressure hyperreactivity at treadmill stress test and left ventricular hypertrophy. J Hum Hypertens. 2009;23:259-66 pubmed publisher
    ..LVH, were randomly assigned to supervised physical exercise, rilmenidine 1 mg day(-1), atenolol 50 mg day(-1), enalapril 10 mg day(-1) or losartan 50 mg day(-1)...
  6. Mauer M, Zinman B, Gardiner R, Suissa S, Sinaiko A, Strand T, et al. Renal and retinal effects of enalapril and losartan in type 1 diabetes. N Engl J Med. 2009;361:40-51 pubmed publisher
    ..with type 1 diabetes and normoalbuminuria and who were randomly assigned to receive losartan (100 mg daily), enalapril (20 mg daily), or placebo and followed for 5 years...
  7. de Paula Costa G, Silva R, Pedrosa M, Pinho V, de Lima W, Teixeira M, et al. Enalapril prevents cardiac immune-mediated damage and exerts anti-Trypanosoma cruzi activity during acute phase of experimental Chagas disease. Parasite Immunol. 2010;32:202-8 pubmed publisher
    ..b>Enalapril, an angiotensin converting enzyme (ACE) inhibitor, is an important drug used to ameliorate heart functional ..
  8. Lima D, dos Santos L, Lima E. Stability and in vitro release profile of enalapril maleate from different commercially available tablets: possible therapeutic implications. J Pharm Biomed Anal. 2008;47:934-7 pubmed publisher
    Stability of enalapril maleate formulations can be affected when the product is exposed to higher temperature and humidity, with the formation of two main degradation products: enalaprilat and a diketopiperazine derivative...
  9. Zamani P, Ganz P, Libby P, Sutradhar S, Rifai N, Nicholls S, et al. Relationship of antihypertensive treatment to plasma markers of vascular inflammation and remodeling in the Comparison of Amlodipine versus Enalapril to Limit Occurrences of Thrombosis study. Am Heart J. 2012;163:735-40 pubmed publisher
    ..reflecting specific inflammatory and remodeling processes over 2 years in the Comparison of Amlodipine versus Enalapril to Limit Occurrences of Thrombosis (CAMELOT) study...

More Information

Publications69

  1. Carter C, Giovannini S, Giovaninni S, Seo D, Dupree J, Morgan D, et al. Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats. Age (Dordr). 2011;33:167-83 pubmed publisher
    ..set of studies was to provide a direct comparison of the effects of the angiotensin-converting enzyme inhibitor enalapril and the angiotensin receptor blocker losartan on body composition, physical performance, and muscle quality when ..
  2. Karimian G, Mohammadi Karakani A, Sotoudeh M, Ghazi Khansari M, Ghobadi G, Shakiba B. Attenuation of hepatic fibrosis through captopril and enalapril in the livers of bile duct ligated rats. Biomed Pharmacother. 2008;62:312-6 pubmed publisher
    ..This study is aimed at comparing the anti-fibrogenesis effects of two ACE inhibitors, captopril and enalapril, in the livers of rats with bile duct ligation through biochemical and histopathological parameters...
  3. Schwander B, Gradl B, Zöllner Y, Lindgren P, Diener H, Lüders S, et al. Cost-utility analysis of eprosartan compared to enalapril in primary prevention and nitrendipine in secondary prevention in Europe--the HEALTH model. Value Health. 2009;12:857-71 pubmed publisher
    To investigate the cost-utility of eprosartan versus enalapril (primary prevention) and versus nitrendipine (secondary prevention) on the basis of head-to-head evidence from randomized controlled trials...
  4. Cozzoli A, Nico B, Sblendorio V, Capogrosso R, Dinardo M, Longo V, et al. Enalapril treatment discloses an early role of angiotensin II in inflammation- and oxidative stress-related muscle damage in dystrophic mdx mice. Pharmacol Res. 2011;64:482-92 pubmed publisher
    ..The present study has been aimed at evaluating the effects of an early treatment with enalapril on the pathology signs of exercised mdx mouse model. The effects of 1 and 5 mg/kg enalapril i.p...
  5. Nakhoul F, Khankin E, Yaccob A, Kawachi H, Karram T, Awaad H, et al. Eplerenone potentiates the antiproteinuric effects of enalapril in experimental nephrotic syndrome. Am J Physiol Renal Physiol. 2008;294:F628-37 pubmed
    ..The proteinuria and effects of eplerenone alone or combined with enalapril on nephrin/podocin abundance in rats with NS have not yet been studied...
  6. Tocci G, Palano F, Pagannone E, Chin D, Ferrucci A, Volpe M. Fixed-combination therapies in hypertension management: focus on enalapril/lercanidipine. Expert Rev Cardiovasc Ther. 2009;7:115-23 pubmed publisher
    ..blocker angiotensin-converting enzyme inhibitor fixed-dose combination based on a new-generation dihiidropiridinic calcium-channel blocker (lercanidipine) and the prototype angiotensin-converting enzyme inhibitor (enalapril).
  7. Hermida R, Ayala D, Khder Y, Calvo C. Ambulatory blood pressure-lowering effects of valsartan and enalapril after a missed dose in previously untreated patients with hypertension: a prospective, randomized, open-label, blinded end-point trial. Clin Ther. 2008;30:108-20 pubmed publisher
    ..ambulatory blood pressure monitoring (ABPM) to compare the blood pressure (BP)-lowering effects of valsartan and enalapril over the 24 hours after missing 1 dose in previously untreated patients with mild to moderate essential ..
  8. Barrios V, Escobar C, Echarri R. Fixed combinations in the management of hypertension: perspectives on lercanidipine-enalapril. Vasc Health Risk Manag. 2008;4:847-53 pubmed
    ..b>Enalapril is an effective and well tolerated angiotensin converting enzyme inhibitor...
  9. Tyralla K, Adamczak M, Benz K, Campean V, Gross M, Hilgers K, et al. High-dose enalapril treatment reverses myocardial fibrosis in experimental uremic cardiomyopathy. PLoS ONE. 2011;6:e15287 pubmed publisher
    ..Therefore, we investigated the effect of high dose enalapril treatment on these alterations...
  10. Sicouri S, Cordeiro J, Talarico M, Antzelevitch C. Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations. J Cardiovasc Electrophysiol. 2011;22:698-705 pubmed publisher
    ..The ARB losartan (1 ?M, n = 5) and the ACE inhibitor enalapril (10 ?M, n = 5) produced no significant change in action potential duration, maximum rate of rise of action ..
  11. van de Ven L, van Veldhuisen D, Goulder M, Zilahi Z, Meyer W, Willenheimer R. The effect of treatment with bisoprolol-first versus enalapril-first on cardiac structure and function in heart failure. Int J Cardiol. 2010;144:59-63 pubmed publisher
    ..d.) followed by combination therapy with enalapril (target dose 10 mg b.i.d...
  12. Theken K, Deng Y, Schuck R, Oni Orisan A, Miller T, Kannon M, et al. Enalapril reverses high-fat diet-induced alterations in cytochrome P450-mediated eicosanoid metabolism. Am J Physiol Endocrinol Metab. 2012;302:E500-9 pubmed publisher
    ..Treatment with enalapril, but not metformin or losartan, reversed the suppression of hepatic CYP epoxygenase metabolic activity and ..
  13. Husain K, Suarez E, Isidro A, Ferder L. Effects of paricalcitol and enalapril on atherosclerotic injury in mouse aortas. Am J Nephrol. 2010;32:296-304 pubmed publisher
    ..the protective effect of vitamin D analog paricalcitol combined with angiotensin-converting enzyme inhibitor (enalapril) on aortic oxidative injury in atherosclerotic mice...
  14. Guerrero P, Fuchs F, Moreira L, Martins V, Bertoluci C, Fuchs S, et al. Blood pressure-lowering efficacy of amiloride versus enalapril as add-on drugs in patients with uncontrolled blood pressure receiving hydrochlorothiazide. Clin Exp Hypertens. 2008;30:553-64 pubmed publisher
    ..5-5 mg/day (n = 39) or enalapril 10-20 mg/day (n = 43)...
  15. Rastogi S, Sharov V, Mishra S, Gupta R, Blackburn B, Belardinelli L, et al. Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure. Am J Physiol Heart Circ Physiol. 2008;295:H2149-55 pubmed publisher
    ..This study examined the effects of treatment with Ran alone and in combination with metoprolol (Met) or enalapril (Ena) on LV function and remodeling in dogs with HF...
  16. de Mello V, Zelmanovitz T, Azevedo M, de Paula T, Gross J. Long-term effect of a chicken-based diet versus enalapril on albuminuria in type 2 diabetic patients with microalbuminuria. J Ren Nutr. 2008;18:440-7 pubmed publisher
    ..to assess these effects over a long-term period, comparing the effects of a chicken-based diet (CD) versus enalapril on renal function and lipid profile in microalbuminuric type 2 diabetic patients...
  17. Silva P, Fontana V, Luizon M, Lacchini R, Silva W, Biagi C, et al. eNOS and BDKRB2 genotypes affect the antihypertensive responses to enalapril. Eur J Clin Pharmacol. 2013;69:167-77 pubmed publisher
    ..oxide synthase (eNOS) and bradykinin receptor B2 (BDKRB2) genes may affect the antihypertensive response to enalapril. We evaluated 106 hypertensive patients treated only with enalapril for 60 days...
  18. Di Marco F, Guazzi M, Vicenzi M, Santus P, Cazzola M, Pappalettera M, et al. Effect of enalapril on exercise cardiopulmonary performance in chronic obstructive pulmonary disease: A pilot study. Pulm Pharmacol Ther. 2010;23:159-64 pubmed publisher
    ..4 weeks treatment with enalapril (10 mg od) or placebo was evaluated in 21 COPD patients (FEV(1) < 60%) and without cardiovascular disease in ..
  19. Kim H, Kim J, Lee H, Hur D, Yun I, Kim S. Enalapril alters expression of key growth factors in experimental diabetic retinopathy. Curr Eye Res. 2009;34:976-87 pubmed publisher
    ..the retinas of diabetes-induced rats and determined the effects of an angiotensin-converting enzyme inhibitor (enalapril) on the expression of angiogenic factors...
  20. Gumustas M, Sanlı S, Sanli N, Ozkan S. Determination of pK(a) values of some antihypertensive drugs by liquid chromatography and simultaneous assay of lercanidipine and enalapril in their binary mixtures. Talanta. 2010;82:1528-37 pubmed publisher
    ..the dependence of the retention factor on the pH of the mobile phase for three ionizable substances, namely, enalapril, lercanidipine and ramipril (IS)...
  21. Rump L. Efficacy and tolerability of the fixed lercanidipine-enalapril combination in the treatment of patients with essential hypertension. Arzneimittelforschung. 2010;60:124-30 pubmed publisher
    ..CAS 132866-11-6), a third-generation calcium antagonist, and the angiotensin converting enzyme (ACE) inhibitor enalapril maleate (CAS 76095-16-4) in patients with essential hypertension in daily practice...
  22. Salardi S, Balsamo C, Zucchini S, Maltoni G, Scipione M, Rollo A, et al. High rate of regression from micro-macroalbuminuria to normoalbuminuria in children and adolescents with type 1 diabetes treated or not with enalapril: the influence of HDL cholesterol. Diabetes Care. 2011;34:424-9 pubmed publisher
  23. Yamazaki T, Tanimoto M, Gohda T, Ohara I, Hagiwara S, Murakoshi M, et al. Combination effects of enalapril and losartan on lipid peroxidation in the kidneys of KK-Ay/Ta mice. Nephron Exp Nephrol. 2009;113:e66-76 pubmed publisher
    ..peroxidation via adiponectin and AMPK activation in the kidneys of KK-A(y)/Ta mice by RAS inhibitors, such as enalapril and/or losartan. KK-A(y)/Ta mice were given enalapril (2...
  24. Fallahzadeh A, Khazaei M, Sharifi M. Restoration of angiogenesis by enalapril in diabetic hindlimb ischemic rats. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011;155:137-42 pubmed
    ..The aim of this study was to investigate the effect of enalapril on skeletal muscle angiogenesis in diabetic and diabetic hind limb ischemic rats.
  25. McMurray J. CONSENSUS to EMPHASIS: the overwhelming evidence which makes blockade of the renin-angiotensin-aldosterone system the cornerstone of therapy for systolic heart failure. Eur J Heart Fail. 2011;13:929-36 pubmed publisher
    We will shortly celebrate the 25th anniversary of the publication of the Co-operative North Scandinavian Enalapril Survival Study (CONSENSUS), a clinical trial which revolutionized the treatment of heart failure and highlighted the ..
  26. Bowling C, Sanders P, Allman R, Rogers W, Patel K, Aban I, et al. Effects of enalapril in systolic heart failure patients with and without chronic kidney disease: insights from the SOLVD Treatment trial. Int J Cardiol. 2013;167:151-6 pubmed publisher
    ..5mg/dl were randomized to receive either placebo (n=1284) or enalapril (n=1285)...
  27. Funck Brentano C, van Veldhuisen D, van de Ven L, Follath F, Goulder M, Willenheimer R. Influence of order and type of drug (bisoprolol vs. enalapril) on outcome and adverse events in patients with chronic heart failure: a post hoc analysis of the CIBIS-III trial. Eur J Heart Fail. 2011;13:765-72 pubmed publisher
    ..We also assessed the relations between dose levels and baseline variables or adverse events...
  28. Schaefer F, Litwin M, Zachwieja J, Zurowska A, Turi S, Grosso A, et al. Efficacy and safety of valsartan compared to enalapril in hypertensive children: a 12-week, randomized, double-blind, parallel-group study. J Hypertens. 2011;29:2484-90 pubmed publisher
    This study compares efficacy and safety of valsartan with enalapril in hypertensive children aged 6-17 years. This was a 12-week, randomized, double-blind, parallel-group, active-controlled study...
  29. Kushwaha S, Jena G. Enalapril reduces germ cell toxicity in streptozotocin-induced diabetic rat: investigation on possible mechanisms. Naunyn Schmiedebergs Arch Pharmacol. 2012;385:111-24 pubmed publisher
    ..The purpose of the present study is to determine the possible protective effects of enalapril against the germ cell toxicity in diabetic rat...
  30. Purclutepe O, Iskender G, Kiper H, Tezcanli B, Selvi N, Avci C, et al. Enalapril-induced apoptosis of acute promyelocytic leukaemia cells involves STAT5A. Anticancer Res. 2012;32:2885-93 pubmed
    In this study, we aimed at evaluating the cytotoxic and apoptotic effects of enalapril on human HL60 acute promyelocytic leukaemia cells and at clarifying the roles of signal transducers and activator of transcription proteins (STATs) on ..
  31. Georgakopoulos P, Roussou P, Matsakas E, Karavidas A, Anagnostopoulos N, Marinakis T, et al. Cardioprotective effect of metoprolol and enalapril in doxorubicin-treated lymphoma patients: a prospective, parallel-group, randomized, controlled study with 36-month follow-up. Am J Hematol. 2010;85:894-6 pubmed publisher
    ..or subclinical cardiotoxicity in lymphoma patients after concomitant prophylactic therapy with metoprolol or enalapril or no concomitant treatment...
  32. Frimodt Møller M, Kamper A, Strandgaard S, Kreiner S, Nielsen A. Beneficial effects on arterial stiffness and pulse-wave reflection of combined enalapril and candesartan in chronic kidney disease--a randomized trial. PLoS ONE. 2012;7:e41757 pubmed publisher
    ..73 m(2)) participated in an open randomized study of 16 weeks of monotherapy with either enalapril or candesartan followed by 8 weeks of dual blockade aiming at a total dose of 16 mg candesartan and 20 mg ..
  33. Wojcikowski K, Wohlmuth H, Johnson D, Gobe G. Effect of Astragalus membranaceus and Angelica sinensis combined with Enalapril in rats with obstructive uropathy. Phytother Res. 2010;24:875-84 pubmed publisher
    ..The present investigation aimed to determine whether an ACEi (Enalapril) and A&A together have a better antifibrotic effect in unilateral ureteral obstruction (UUO) than ..
  34. Albuquerque D, Nihei J, Cardillo F, Singh R. The ACE inhibitors enalapril and captopril modulate cytokine responses in Balb/c and C57Bl/6 normal mice and increase CD4(+)CD103(+)CD25(negative) splenic T cell numbers. Cell Immunol. 2010;260:92-7 pubmed publisher
    ..To verify that, in this work, we investigated the effects of treatment with the ACE inhibitors enalapril and captopril on cytokine synthesis in C57Bl/6 and Balb/c mice...
  35. Kang Y, Ko G, Lee M, Song H, Han S, Han K, et al. Effect of eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats. Nephrol Dial Transplant. 2009;24:73-84 pubmed publisher
    ..this study, we investigated the dose-dependent effect of eplerenone and a combined treatment with eplerenone and enalapril compared with each drug alone on renal function in type II diabetic rats...
  36. Bunout D, Barrera G, De la Maza M, Leiva L, Backhouse C, Hirsch S. Effects of enalapril or nifedipine on muscle strength or functional capacity in elderly subjects. A double blind trial. J Renin Angiotensin Aldosterone Syst. 2009;10:77-84 pubmed publisher
    ..We compared in a prospective double blind trial, the effects of treatment with enalapril or nifedipine on muscle performance in hypertensive elderly subjects...
  37. Lu S, Jiang K, Qin F, Lu X, Li F. Simultaneous quantification of enalapril and enalaprilat in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study. J Pharm Biomed Anal. 2009;49:163-7 pubmed publisher
    ..liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed to simultaneously determine enalapril and enalaprilat in human plasma...
  38. Fendrich V, Chen N, Neef M, Waldmann J, Buchholz M, Feldmann G, et al. The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer. Gut. 2010;59:630-7 pubmed publisher
    ..LsL-Trp53(R172H); Pdx1-Cre transgenic mice were randomly assigned to receive either mock treatment, aspirin, enalapril, or a combination of both. After 3 and 5 months, animals were killed...
  39. Srivastava K, Chandra S, Bhatia J, Narang R, Saluja D. Association of angiotensinogen (M235T) gene polymorphism with blood pressure lowering response to angiotensin converting enzyme inhibitor (Enalapril). J Pharm Pharm Sci. 2012;15:399-406 pubmed
    ..between polymorphism in the angiotensinogen (M235T) gene and blood pressure response to ACE inhibitor (Enalapril) in patients with essential hypertension from northern Indian subjects...
  40. Bartha E, Kiss G, Kalman E, Kulcsar G, Kalai T, Hideg K, et al. Effect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure. J Cardiovasc Pharmacol. 2008;52:253-61 pubmed publisher
    ..The primary aim of our recent work was to compare the effect and efficacy of a potent PARP-inhibitor (L-2286) to enalapril, a widely used angiotensin-converting enzyme (ACE) inhibitor. in experimental heart failure model...
  41. Husain K, Ferder L, Mizobuchi M, Finch J, Slatopolsky E. Combination therapy with paricalcitol and enalapril ameliorates cardiac oxidative injury in uremic rats. Am J Nephrol. 2009;29:465-72 pubmed publisher
    This study investigated the protective effect of the angiotensin-converting enzyme inhibitor, enalapril, and the vitamin D analog, paricalcitol, alone or in combination, on cardiac oxidative stress in uremic rats...
  42. White M, Rouleau J, Afzal R, Floras J, Yusuf S, McKelvie R. Effects of enalapril, candesartan or both on neurohumoral activation and LV volumes and function in patients with heart failure not treated with a beta-blocker. Ther Adv Cardiovasc Dis. 2009;3:113-21 pubmed publisher
    ..The long-term effects of the angiotensin-receptor blocker candesartan, the angiotensin-converting enzyme inhibitor enalapril or their combination have been incompletely studied in a large cohort of patients with heart failure not treated ..
  43. Scholze J, Bramlage P, Trenkwalder P, Kreutz R. Efficacy and safety of a fixed-dose combination of lercanidipine and enalapril in daily practice. A comparison of office, self-measured and ambulatory blood pressure. Expert Opin Pharmacother. 2011;12:2771-9 pubmed publisher
    A fixed-dose combination (FDC) of enalapril and lercanidipine has been shown to be effective and safe in reducing blood pressure in randomized clinical trials. This study aims to determine effectiveness and safety in daily practice...
  44. Piotrkowski B, Koch O, de Cavanagh E, Fraga C. Cardiac mitochondrial function and tissue remodelling are improved by a non-antihypertensive dose of enalapril in spontaneously hypertensive rats. Free Radic Res. 2009;43:390-9 pubmed publisher
    ..Here, it is investigated whether a non-antihypertensive enalapril dose protects cardiac tissue and mitochondria function...
  45. Santos E, de Picoli Souza K, Guimarães P, Reis F, Silva S, Costa Neto C, et al. Effect of angiotensin converting enzyme inhibitor enalapril on body weight and composition in young rats. Int Immunopharmacol. 2008;8:247-53 pubmed publisher
    ..b>Enalapril, an angiotensin-I converting enzyme inhibitor (ACEi), is classically used in anti-hypertensive therapies, ..
  46. Oltman C, Davidson E, Coppey L, Kleinschmidt T, Lund D, Yorek M. Attenuation of vascular/neural dysfunction in Zucker rats treated with enalapril or rosuvastatin. Obesity (Silver Spring). 2008;16:82-9 pubmed publisher
    ..The purpose of this study was to determine whether drugs used to treat cardiovascular dysfunction in metabolic syndrome also protect nerve function...
  47. Bondarenko A, Panasiuk O, Stepanenko L, Goswami N, Sagach V. Reduced hyperpolarization of endothelial cells following high dietary Na+: effects of enalapril and tempol. Clin Exp Pharmacol Physiol. 2012;39:608-13 pubmed publisher
    ..diet (HSD) for 1 month and, if so, whether chronic treatment with the angiotensin-converting enzyme inhibitor enalapril or the anti-oxidant tempol could normalize the response...
  48. Bosch X, Esteve J, Sitges M, De Caralt T, Domènech A, Ortiz J, et al. Prevention of chemotherapy-induced left ventricular dysfunction with enalapril and carvedilol: rationale and design of the OVERCOME trial. J Card Fail. 2011;17:643-8 pubmed publisher
    ..of acute leukemia or undergoing autologous HSCT and with normal LV ejection fraction will be randomized to enalapril and carvedilol or to the control group...
  49. Santos E, de Picoli Souza K, da Silva E, Batista E, Martins P, D Almeida V, et al. Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats. Biochem Pharmacol. 2009;78:951-8 pubmed publisher
    ..We analyzed the influence of long term angiotensin I converting enzyme (ACE) inhibitor enalapril treatment in normotensive adult Wistar rats fed with standard or palatable hyperlipidic diets...
  50. Liu E, Xu Z, Li J, Yang S, Yang W, Li G. Enalapril, irbesartan, and angiotensin-(1-7) prevent atrial tachycardia-induced ionic remodeling. Int J Cardiol. 2011;146:364-70 pubmed publisher
    ..The purpose of this study was to investigate the effects of the ACE inhibitor enalapril, the angiotensin-receptor blocker (ARB) irbesartan, and Ang-(1-7) on the chronic atrial ionic remodeling...
  51. Nakamura T, Fujiwara N, Kawagoe Y, Sugaya T, Ueda Y, Koide H. Effects of telmisartan and enalapril on renoprotection in patients with mild to moderate chronic kidney disease. Eur J Clin Invest. 2010;40:790-6 pubmed publisher
    ..The aim of this study was to compare the chronic effects of telmisartan and enalapril on proteinuria, urinary liver-type fatty acid-binding protein (L-FABP) and endothelin (ET)-1 levels in patients ..
  52. Fan F, Huo Y, Wang X, Xu X, Wang B, Xu X, et al. Effect of enalapril on plasma homocysteine levels in patients with essential hypertension. J Zhejiang Univ Sci B. 2010;11:583-91 pubmed publisher
    To investigate the effect of enalapril on plasma homocysteine (Hcy) levels and the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with the changes of Hcy levels in response to enalapril among patients with ..
  53. Bilan V, Salah E, Bastacky S, Jones H, Mayers R, Zinker B, et al. Diabetic nephropathy and long-term treatment effects of rosiglitazone and enalapril in obese ZSF1 rats. J Endocrinol. 2011;210:293-308 pubmed publisher
    ..and late renal manifestations of DN and renal responses to long-term treatments with rosiglitazone or high-dose enalapril in ZSF1 rats, a model of metabolic syndrome, diabetes, and chronic renal disease...
  54. Chen Y, Hsiao C, Tsai T. Interstitial granulomatous drug reaction presenting as erythroderma: remission after discontinuation of enalapril maleate. Br J Dermatol. 2008;158:1143-5 pubmed publisher
  55. Imanishi T, Ikejima H, Tsujioka H, Kuroi A, Kobayashi K, Muragaki Y, et al. Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability. Hypertension. 2008;51:734-41 pubmed publisher
    ..We investigated the effect of a combination of eplerenone, a selective aldosterone antagonist, and enalapril, an angiotensin-converting enzyme inhibitor, on NO bioavailability and spontaneous atherosclerotic changes...
  56. Bosch X, Rovira M, Sitges M, Domènech A, Ortiz Pérez J, De Caralt T, et al. Enalapril and carvedilol for preventing chemotherapy-induced left ventricular systolic dysfunction in patients with malignant hemopathies: the OVERCOME trial (preventiOn of left Ventricular dysfunction with Enalapril and caRvedilol in patients submit. J Am Coll Cardiol. 2013;61:2355-62 pubmed publisher
    This study sought to evaluate the efficacy of enalapril and carvedilol to prevent chemotherapy-induced left ventricular systolic dysfunction (LVSD) in patients with hematological malignancies. Current chemotherapy may induce LVSD...
  57. Ghosh S, Krieg R, Massey H, Sica D, Fakhry I, Ghosh S, et al. Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5/6 nephrectomized rats: role of phospholipase and cyclooxygenase. Am J Physiol Renal Physiol. 2012;302:F439-54 pubmed publisher
    ..To better mimic the scenario for renal disease in humans, we began curcumin and enalapril therapy when proteinuria was already established...
  58. Ellis A, Goto K, Chaston D, Brackenbury T, Meaney K, Falck J, et al. Enalapril treatment alters the contribution of epoxyeicosatrienoic acids but not gap junctions to endothelium-derived hyperpolarizing factor activity in mesenteric arteries of spontaneously hypertensive rats. J Pharmacol Exp Ther. 2009;330:413-22 pubmed publisher
    ..rats, spontaneously hypertensive rats (SHRs), and SHRs treated with the angiotensin-converting enzyme inhibitor, enalapril, using immunohistochemistry, serial-section electron microscopy, electrophysiology and wire myography...
  59. Crespo M, Cruz N, Altieri P, Escobales N. Enalapril and losartan are more effective than carvedilol in preventing dilated cardiomyopathy in the Syrian cardiomyopathic hamster. J Cardiovasc Pharmacol Ther. 2008;13:199-206 pubmed publisher
    ..SCH), echocardiographic parameters were evaluated in 6-month-old animals after 5 months of treatment with enalapril (25 mg/kg/day) plus losartan (10 mg/kg/day), or with carvedilol (1 mg/kg/day)...
  60. Egan C, Pontremoli R. Role of the fixed-dose combination lercanidipine-enalapril in renal protection. J Nephrol. 2011;24:428-37 pubmed publisher
    ..Individually, both the third-generation CCB lercanidipine and the ACE inhibitor enalapril are effective antihypertensive agents...