Summary: Peptides that inhibit mitosis (ANTIMITOTICS). During the 1960's the term referred to crude extracts that inhibited cell proliferation; the activity was later attributed to PYROGLUTAMATE type oligopeptides.

Top Publications

  1. Elgjo K, Reichelt K. Chalones: from aqueous extracts to oligopeptides. Cell Cycle. 2004;3:1208-11 pubmed
    ..A large number of "chalones" were reported in the 1970's and early 80's...
  2. Bakthavatsalam D, Brock D, Nikravan N, Houston K, Hatton R, Gomer R. The secreted Dictyostelium protein CfaD is a chalone. J Cell Sci. 2008;121:2473-80 pubmed publisher
    ..These results suggest that two interacting proteins may function together as a chalone signal in a negative feedback loop that slows Dictyostelium cell proliferation...
  3. Mashanova O, Romanov Y, Evstafyev V, Semyonova M. Effect of chalone system on proliferation of Ehrlich ascitic tumor cells under conditions of modified photoregimen. Bull Exp Biol Med. 2006;141:453-6 pubmed
    ..Cell kinetics attested to possible mechanisms of the effect of the chalone system on the status of Ehrlich ascitic tumor; these mechanisms were independent on each other. ..
  4. Jiang H, Zhan W, Liu X, Jiang S. Antioxidant activities of extracts and flavonoid compounds from Oxytropis falcate Bunge. Nat Prod Res. 2008;22:1650-6 pubmed publisher
    ..15 mg mL(-1)) exhibited considerable antioxidant activities, but the antioxidant activities of the two dihydrochalcones were very weak. Although these flavonoids are known, this is the first report of antioxidant activity in this plant...
  5. Huan Y, He Y, Liu M, Jin X, Li X, Liu X, et al. A comparative study of tumor-suppression effects of enterotoxin B and Chalone 19-peptide on experimental gastric carcinoma. Hepatogastroenterology. 2009;56:270-5 pubmed
    ..Data suggested that this model could effectively simulate the microenvironment of human gastric carcinoma, hence providing a platform for study on this cancer. ..
  6. Keppel Hesselink J. The terms 'autacoid', 'hormone' and 'chalone' and how they have shifted with time. Auton Autacoid Pharmacol. 2015;35:51-8 pubmed publisher
    ..Our exploration demonstrates that biomedical concepts can be constructed and defined differently as time goes by, while concept transformations seem to emerge without arguments. ..
  7. Gaussin V, Depre C. Myostatin, the cardiac chalone of insulin-like growth factor-1. Cardiovasc Res. 2005;68:347-9 pubmed
  8. Lander A, Gokoffski K, Wan F, Nie Q, Calof A. Cell lineages and the logic of proliferative control. PLoS Biol. 2009;7:e15 pubmed publisher
    ..Here, we consider how secreted negative feedback factors ("chalones") may be used to control the output of multistage cell lineages, as exemplified by the actions of GDF11 and ..
  9. dos Santos D, de C Braga P, da Silva M, Fernandes J, Vieira P, Magalhães A, et al. Anti-African trypanocidal and antimalarial activity of natural flavonoids, dibenzoylmethanes and synthetic analogues. J Pharm Pharmacol. 2009;61:257-66 pubmed publisher
    ..7-9.5 microm) against P. falciparum. Dibenzoylmethanes represent a novel class of compounds tested for the first time as antimalarial and trypanocidal agents. ..

More Information


  1. Slesarev S, Arav V, Antohin A, Pashkov A. Effect of epiphysectomy on the circadian dynamics of antiradical activity of chalone-antichalone system of albino rat liver. Bull Exp Biol Med. 2008;146:358-60 pubmed
    ..Active phase of the rhythm of antiradical activity falls on night hours. Epiphysectomy caused disappearance of the circadian rhythm of activity of the liver chalone-antichalone system in albino rat. ..
  2. Bakthavatsalam D, Choe J, Hanson N, Gomer R. A Dictyostelium chalone uses G proteins to regulate proliferation. BMC Biol. 2009;7:44 pubmed publisher
    ..of tumor metastases, may be regulated by negative feedback loops in which autocrine secreted factors called chalones inhibit proliferation. However, very little is known about chalones, and how cells sense them...
  3. Bowman R, Xiong Y, Kirsten J, Singleton C. eIF2? kinases control chalone production in Dictyostelium discoideum. Eukaryot Cell. 2011;10:494-501 pubmed publisher
    Growing Dictyostelium cells secrete CfaD and AprA, two proteins that have been characterized as chalones. They exist within a high-molecular-weight complex that reversibly inhibits cell proliferation, but not growth, via cell surface ..
  4. Wang G, Wu W, Peng F, Cao D, Yang Z, Ma L, et al. Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents. Eur J Med Chem. 2012;54:793-803 pubmed publisher
    ..Further studies confirmed that 15 significantly suppressed the growth of tumor volume and exerted more potent anticancer potency than millepachine and anticancer drug cisplatin in A549 lung xenograft tumor model. ..
  5. Cao D, Han X, Wang G, Yang Z, Peng F, Ma L, et al. Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents. Eur J Med Chem. 2013;62:579-89 pubmed publisher
    ..Further studies confirmed that 10i significantly suppressed the growth of tumor volume in HepG2 xenograft tumor model. Our study demonstrated that 10i could have beneficial antitumor activity as a novel microtubule stabilizing agent. ..
  6. Modzelewska A, Pettit C, Achanta G, Davidson N, Huang P, Khan S. Anticancer activities of novel chalcone and bis-chalcone derivatives. Bioorg Med Chem. 2006;14:3491-5 pubmed
    ..Furthermore, bis-chalcone 8 exhibited a more potent inhibition of colon cancer cells expressing wild-type p53 than of an isogenic cell line that was p53-null. ..