ceruletide

Summary

Summary: A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.

Top Publications

  1. Liu Y, Chen X, Yu J, Chi J, Long F, Yang H, et al. Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity. Cell Death Dis. 2017;8:e2685 pubmed publisher
    ..The critical role of XIAP in cell death and inflammation suggests that inhibition of XIAP represents a potential therapeutic strategy for the treatment of acute pancreatitis. ..
  2. Shao Z. SPATHOLOBUS SUBERECTUS STEM EXTRACT IMPROVES THE PROTECTIVE EFFECT OF HEPARIN ON CERULEIN-INDUCED PANCREATITIS. Afr J Tradit Complement Altern Med. 2017;14:187-193 pubmed publisher
    ..Present study concludes that treatment with SS alone effectively manages the pancreatitis by ceasing the inflammatory pathway and potentiates the effect of heparin in the management of pancreatitis. ..
  3. Ding L, Liou G, Schmitt D, Storz P, Zhang J, Billadeau D. Glycogen synthase kinase-3? ablation limits pancreatitis-induced acinar-to-ductal metaplasia. J Pathol. 2017;243:65-77 pubmed publisher
    ..Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  4. Sharmila G, Venkateswaran G. Protective effect of bacillopeptidase CFR5 from Bacillus subtilis CFR5 on cerulein-induced pancreatitis. Biochem Biophys Res Commun. 2017;491:455-462 pubmed publisher
    ..Thus, BPC based pretreatment protocol is a novel intervention to prevent acute pancreatitis. ..
  5. Jia R, Ma J, Xiang S, Meng W, Wang N. Caerulin-induced pro-inflammatory response in macrophages requires TRAF3-p38 signaling activation. Biochem Biophys Res Commun. 2017;494:358-364 pubmed publisher
    ..Thus, TRAF3 is required for caerulin-induced p38 activation and macrophage-mediated pro-inflammatory responses. TRAF3 expression in macrophages could be a novel therapeutic target protein for the treatment of acute pancreatitis...
  6. Zechner D, Knapp N, Bobrowski A, Radecke T, Genz B, Vollmar B. Diabetes increases pancreatic fibrosis during chronic inflammation. Exp Biol Med (Maywood). 2014;239:670-6 pubmed
    ..We conclude that diabetes has a detrimental influence on the progression of chronic pancreatitis by aggravating fibrosis, inflammation and pancreatic atrophy. ..
  7. Charrier A, Chen R, Kemper S, Brigstock D. Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2). Immunology. 2014;141:564-76 pubmed publisher
    ..The early production of CTGF/CCN2 by PAC to drive inflammation is distinct from its previously reported production by pancreatic stellate cells to drive fibrosis at later stages of pancreatic injury. ..