neurotensin

Summary

Summary: A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.

Top Publications

  1. Cochrane D, Carraway R, Harrington K, Laudano M, Rawlings S, Feldberg R. HMC-1 human mast cells synthesize neurotensin (NT) precursor, secrete bioactive NT-like peptide(s) and express NT receptor NTS1. Inflamm Res. 2011;60:1139-51 pubmed publisher
    To determine if mast cells synthesize the inflammatory peptide, neurotensin (NT), secrete immunoreactive and bioactive NT, and express the NT receptor NTS1...
  2. Sahu A. A role of phosphodiesterase-3B pathway in mediating leptin action on proopiomelanocortin and neurotensin neurons in the hypothalamus. Neurosci Lett. 2010;479:18-21 pubmed publisher
    ..leptin signaling through the PDE3B pathway is responsible for the activation of proopiomelanocortin (POMC) and neurotensin (NT) neurons, which are known to play a critical role in energy homeostasis...
  3. Rudholm T, Wallin B, Theodorsson E, Naslund E, Hellstrom P. Release of regulatory gut peptides somatostatin, neurotensin and vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats. Regul Pept. 2009;152:8-12 pubmed publisher
    ..mucosa to acid and hyperosmolal solutions on the release of the inhibitory gut peptides somatostatin (SOM), neurotensin (NT) and vasoactive intestinal peptide (VIP) was studied in conscious rats during pentagastrin-stimulated ..
  4. Loum Ribot E, Lafon P, Chaigniau M, Pape J, Tramu G, Corio M. Paraventricular nucleus neurons producing neurotensin after lipopolysaccharide treatment project to the median eminence. Brain Res. 2004;1030:294-6 pubmed
    ..nucleus (PVN) whose multipeptidergic phenotype changes: both corticotropin-releasing hormone mRNAs and neurotensin mRNAs are up-regulated...
  5. Saada S, Marget P, Fauchais A, Lise M, Chemin G, Sindou P, et al. Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes. J Immunol. 2012;189:5293-303 pubmed publisher
    b>Neurotensin, a neuropeptide growth factor, and its two specific neurotensin receptors, NTSR1 and NTSR2, were shown to be expressed by human B cell lines...
  6. Koon H, Kim Y, Xu H, Kumar A, Zhao D, Karagiannides I, et al. Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis. Proc Natl Acad Sci U S A. 2009;106:8766-71 pubmed publisher
    ..b>Neurotensin (NT) and neurotensin receptor 1 (NTR1) have been shown to play a major role in the pathogenesis of intestinal ..
  7. Mustain W, Rychahou P, Evers B. The role of neurotensin in physiologic and pathologic processes. Curr Opin Endocrinol Diabetes Obes. 2011;18:75-82 pubmed publisher
    b>Neurotensin is a 13-amino acid peptide found in the central nervous system central nervous system and the gastrointestinal tract...
  8. László K, Tóth K, Kertes E, Péczely L, Ollmann T, Madarassy Szücs A, et al. The role of neurotensin in passive avoidance learning in the rat central nucleus of amygdala. Behav Brain Res. 2012;226:597-600 pubmed publisher
    Tridecapeptide neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reinforcement...
  9. Shibata Y, White J, Serrano Vega M, Magnani F, Aloia A, Grisshammer R, et al. Thermostabilization of the neurotensin receptor NTS1. J Mol Biol. 2009;390:262-77 pubmed publisher
    ..In contrast to these receptors, the neurotensin (NT) receptor NTS1 is much less stable in detergent solution...

More Information

Publications98

  1. Wang X, Jackson L, Johnson S, Wang Q, Evers B. Suppression of neurotensin receptor type 1 expression and function by histone deacetylase inhibitors in human colorectal cancers. Mol Cancer Ther. 2010;9:2389-98 pubmed publisher
    b>Neurotensin, a gut peptide, stimulates the growth of colorectal cancers that possess the high-affinity neurotensin receptor (NTR1)...
  2. da Silva L, Neves B, Moura L, Cruz M, Carvalho E. Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression. Biochim Biophys Acta. 2011;1813:1863-71 pubmed publisher
    In the last decades some reports reveal the neuropeptide neurotensin (NT) as an immune mediator in the Central Nervous System and in the gastrointestinal tract, however its effects on skin immunity were not identified...
  3. Feifel D, Mexal S, Melendez G, Liu P, Goldenberg J, Shilling P. The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog. Neuropsychopharmacology. 2009;34:2011-8 pubmed publisher
    ..effects of the atypical antipsychotic, clozapine, and the putative antipsychotic, PD149163, a brain-penetrating neurotensin-1 agonist, on social discrimination in these rats...
  4. Roussy G, Dansereau M, Doré Savard L, Belleville K, Beaudet N, Richelson E, et al. Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model. J Neurochem. 2008;105:1100-14 pubmed publisher
    Central administration of the neuropeptide neurotensin (NT) was shown to induce antinociceptive responses both spinally and supraspinally...
  5. St Gelais F, Jomphe C, Trudeau L. The role of neurotensin in central nervous system pathophysiology: what is the evidence?. J Psychiatry Neurosci. 2006;31:229-45 pubmed
    The peptide neurotensin has been studied for more than 30 years...
  6. Wice B, Wang S, Crimmins D, Diggs Andrews K, Althage M, Ford E, et al. Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism. J Biol Chem. 2010;285:19842-53 pubmed publisher
    ..Xenin-25, or molecules that increase acetylcholine receptor signaling in beta-cells, may represent a novel approach to overcome GIP resistance and therefore treat humans with T2DM. ..
  7. Dobner P. Neurotensin and pain modulation. Peptides. 2006;27:2405-14 pubmed
    b>Neurotensin (NT) can produce a profound analgesia or enhance pain responses, depending on the circumstances. Recent evidence suggests that this may be due to a dose-dependent recruitment of distinct populations of pain modulatory neurons...
  8. Jomphe C, Bourque M, Fortin G, St Gelais F, Okano H, Kobayashi K, et al. Use of TH-EGFP transgenic mice as a source of identified dopaminergic neurons for physiological studies in postnatal cell culture. J Neurosci Methods. 2005;146:1-12 pubmed
    ..Autoreceptor stimulation inhibited the activity of dopaminergic neurons while neurotensin receptor activation produced the opposite effect...
  9. Stolakis V, Kalafatakis K, Botis J, Zarros A, Liapi C. The regulatory role of neurotensin on the hypothalamic-anterior pituitary axons: emphasis on the control of thyroid-related functions. Neuropeptides. 2010;44:1-7 pubmed publisher
    b>Neurotensin (NT) is a 13 amino acid neurohormone and/or neuromodulator, located in the synaptic vesicles and released from the neuronal terminals in a calcium-dependent manner...
  10. Lee M, Hinton D, Unal S, Richelson E, Choi D. Increased ethanol consumption and preference in mice lacking neurotensin receptor type 2. Alcohol Clin Exp Res. 2011;35:99-107 pubmed publisher
    b>Neurotensin receptors (NTS) regulate a variety of the biological functions of neurotensin (NT) in the central nervous system...
  11. Kim H, Yumkham S, Choi J, Lee S, Kim T, Ryu S, et al. Neurotensin enhances nitric oxide generation via the JAK2-STAT1 pathway in murine macrophage Raw264.7 cells during costimulation with LPS and IFNgamma. Neuropeptides. 2006;40:221-9 pubmed
    b>Neurotensin has been known to be implicated in immune function, but its molecular mechanisms remain largely unclear. In this study, we report that neurotensin increased the intracellular calcium levels of murine macrophage Raw264...
  12. Cui H, Cai F, Belsham D. Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1. FASEB J. 2006;20:2654-6 pubmed
    ..We describe here the analysis of leptin signaling in a clonal population of mouse neurotensin (NT) -expressing hypothalamic neurons, N-39...
  13. Li J, Chen L, Townsend C, Evers B. PKD1, PKD2, and their substrate Kidins220 regulate neurotensin secretion in the BON human endocrine cell line. J Biol Chem. 2008;283:2614-21 pubmed
    b>Neurotensin (NT) is a gut peptide that plays an important role in gastrointestinal secretion, motility, and growth as well as the proliferation of NT receptor-positive cancers...
  14. Wang Q, Zhou Y, Evers B. Neurotensin phosphorylates GSK-3alpha/beta through the activation of PKC in human colon cancer cells. Neoplasia. 2006;8:781-7 pubmed
    b>Neurotensin (NT), a gastrointestinal hormone, binds its receptor [neurotensin receptor (NTR)] to regulate the growth of normal and neoplastic intestinal cells; molecular mechanisms remain largely undefined...
  15. Sigalet D, Wallace L, Holst J, Martin G, Kaji T, Tanaka H, et al. Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2. Am J Physiol Gastrointest Liver Physiol. 2007;293:G211-21 pubmed
    ..They support further studies to examine the role of neural signaling in the regulation of intestinal inflammation. ..
  16. Perron A, Sarret P, Gendron L, Stroh T, Beaudet A. Identification and functional characterization of a 5-transmembrane domain variant isoform of the NTS2 neurotensin receptor in rat central nervous system. J Biol Chem. 2005;280:10219-27 pubmed
    ..Binding studies also showed that the truncated receptor displayed a 5000-fold lower affinity for neurotensin (NT) than its full-length counterpart (IC(50) of 10 mum and 2 nm, respectively)...
  17. Carraway R, Hassan S. Neurotensin receptor binding and neurotensin-induced growth signaling in prostate cancer PC3 cells are sensitive to metabolic stress. Regul Pept. 2007;141:140-53 pubmed
    b>Neurotensin (NT) stimulates the proliferation of prostate cancer PC3 cells, which express high levels of its G protein-coupled receptor NTS1...
  18. Frankel P, Hoonakker A, Alburges M, McDougall J, McFadden L, Fleckenstein A, et al. Effect of methamphetamine self-administration on neurotensin systems of the basal ganglia. J Pharmacol Exp Ther. 2011;336:809-15 pubmed publisher
    ..For this reason, we and others have examined the METH-induced responses of neurotensin (NT) systems in the basal ganglia...
  19. Alysandratos K, Asadi S, Angelidou A, Zhang B, Sismanopoulos N, Yang H, et al. Neurotensin and CRH interactions augment human mast cell activation. PLoS ONE. 2012;7:e48934 pubmed publisher
    Stress affects immunity, but the mechanism is not known. Neurotensin (NT) and corticotropin-releasing hormone (CRH) are secreted under stress in various tissues, and have immunomodulatory actions...
  20. Harper D, Stopa E, Kuo Leblanc V, McKee A, Asayama K, Volicer L, et al. Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia. Brain. 2008;131:1609-17 pubmed publisher
    ..The human dorsomedial SCN contains populations of non-species-specific vasopressin and species-specific neurotensin neurons...
  21. Hanson G, Hoonakker A, Alburges M, McFadden L, Robson C, Frankel P. Response of limbic neurotensin systems to methamphetamine self-administration. Neuroscience. 2012;203:99-107 pubmed publisher
    ..Thus, we and others have studied the METH-induced responses of neurotensin (NT) systems...
  22. Melis M, Krenning E, Bernard B, de Visser M, Rolleman E, de Jong M. Renal uptake and retention of radiolabeled somatostatin, bombesin, neurotensin, minigastrin and CCK analogues: species and gender differences. Nucl Med Biol. 2007;34:633-41 pubmed
    ..Newly developed peptides are evaluated preclinically in different animal models before their application in humans. In this study, the renal retention of several radiolabeled peptides was compared in male and female rats and mice...
  23. White J, Grisshammer R. Stability of the neurotensin receptor NTS1 free in detergent solution and immobilized to affinity resin. PLoS ONE. 2010;5:e12579 pubmed publisher
    ..We have previously reported a robust two-step purification procedure for the recombinant rat neurotensin receptor NTS1 to give milligram quantities of functional receptor protein...
  24. László K, Tóth K, Kertes E, Péczely L, Ollmann T, Lenard L. Effects of neurotensin in amygdaloid spatial learning mechanisms. Behav Brain Res. 2010;210:280-3 pubmed publisher
    b>Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms...
  25. Kinkead B, Nemeroff C. Novel treatments of schizophrenia: targeting the neurotensin system. CNS Neurol Disord Drug Targets. 2006;5:205-18 pubmed
    Evidence implicating neural circuits that utilize the neuropeptide transmitter neurotensin (NT) in the pathophysiology of schizophrenia and in the mechanism of action of antipsychotic drugs has previously been reviewed...
  26. Brun P, Mastrotto C, Beggiao E, Stefani A, Barzon L, Sturniolo G, et al. Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation. Am J Physiol Gastrointest Liver Physiol. 2005;288:G621-9 pubmed
    Because neurotensin (NT) and its high-affinity receptor (NTR1) modulate immune responses, chloride secretion, and epithelial cell proliferation, we sought to investigate their role in the repair process that follows the development of ..
  27. Müller K, Tveteraas I, Aasrum M, Ødegård J, Dawood M, Dajani O, et al. Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells. BMC Cancer. 2011;11:421 pubmed publisher
    b>Neurotensin has been found to promote colon carcinogenesis in rats and mice, and proliferation of human colon carcinoma cell lines, but the mechanisms involved are not clear...
  28. Law I, Murphy J, Bakirtzi K, Bunnett N, Pothoulakis C. Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by ?-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1. J Biol Chem. 2012;287:15066-75 pubmed publisher
    The neuropeptide/hormone neurotensin (NT) mediates intestinal inflammation and cell proliferation by binding of its high affinity receptor, neurotensin receptor-1 (NTR1)...
  29. Cooke J, Patterson M, Patel S, Smith K, Ghatei M, Bloom S, et al. Peripheral and central administration of xenin and neurotensin suppress food intake in rodents. Obesity (Silver Spring). 2009;17:1135-43 pubmed publisher
    Xenin is a 25-amino acid peptide highly homologous to neurotensin. Xenin and neurotensin are reported to have similar biological effects. Both reduce food intake when administered centrally to fasted rats...
  30. Assimakopoulos S, Scopa C, Zervoudakis G, Mylonas P, Georgiou C, Nikolopoulou V, et al. Bombesin and neurotensin reduce endotoxemia, intestinal oxidative stress, and apoptosis in experimental obstructive jaundice. Ann Surg. 2005;241:159-67 pubmed
    To evaluate the effect of bombesin (BBS) and neurotensin (NT) on intestinal histopathology, intestinal oxidative stress, and endotoxemia in experimental obstructive jaundice...
  31. Vasiadi M, Therianou A, Alysandratos K, Katsarou Katsari A, Petrakopoulou T, Theoharides A, et al. Serum neurotensin (NT) is increased in psoriasis and NT induces vascular endothelial growth factor release from human mast cells. Br J Dermatol. 2012;166:1349-52 pubmed publisher
    ..A peptide, neurotensin (NT), can trigger skin histamine release and augment the ability of CRH to increase skin vascular permeability...
  32. Grimond Billa S, Norman C, G W B, Cassaday H. Selectively increased trace conditioning under the neurotensin agonist PD 149163 in an aversive procedure in which SR 142948A was without intrinsic effect. J Psychopharmacol. 2008;22:290-9 pubmed publisher
    There is evidence to suggest that neurotensin (NT) may enhance cognitive function. The present study, therefore, examined the role of NT in associative learning between a conditioned stimulus (CS) and an unconditioned stimulus (UCS)...
  33. Zhao D, Pothoulakis C. Effects of NT on gastrointestinal motility and secretion, and role in intestinal inflammation. Peptides. 2006;27:2434-44 pubmed
    ..Among them, neurotensin has been identified as an important mediator in the development and progress of several gastrointestinal ..
  34. Green B, White K, McDougle D, Zhang L, Klein B, Scholl E, et al. Introduction of lipidization-cationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities. J Pept Sci. 2010;16:486-95 pubmed publisher
    The neuropeptides galanin (GAL), neuropeptide Y (NPY) or neurotensin (NT) exhibit anticonvulsant activities mediated by their respective receptors in the brain...
  35. Ferraro L, Tomasini M, Fuxe K, Agnati L, Mazza R, Tanganelli S, et al. Mesolimbic dopamine and cortico-accumbens glutamate afferents as major targets for the regulation of the ventral striato-pallidal GABA pathways by neurotensin peptides. Brain Res Rev. 2007;55:144-54 pubmed
    The tridecapeptide neurotensin (NT) acts in the mammalian brain as a primary neurotransmitter or neuromodulator of classical neurotransmitters...
  36. Zhao D, Zhan Y, Zeng H, Koon H, Moyer M, Pothoulakis C. Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells. Int J Cancer. 2007;120:1652-6 pubmed
    b>Neurotensin (NT) is a highly expressed gastrointestinal (GI) neuropeptide, which modulates GI motility, secretion and cell growth as well as intestinal inflammation...
  37. Jomphe C, Lemelin P, Okano H, Kobayashi K, Trudeau L. Bidirectional regulation of dopamine D2 and neurotensin NTS1 receptors in dopamine neurons. Eur J Neurosci. 2006;24:2789-800 pubmed
    Several lines of evidence suggest a close association between dopamine (DA) and neurotensin (NT) systems in the CNS...
  38. Li J, Liu J, Song J, Wang X, Weiss H, Townsend C, et al. mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Am J Physiol Cell Physiol. 2011;301:C213-26 pubmed publisher
    The mammalian target of rapamycin (mTOR) signaling exists in two complexes: mTORC1 and mTORC2. Neurotensin (NT), an intestinal hormone secreted by enteroendocrine (N) cells in the small bowel, has important physiological effects in the ..
  39. Leinninger G, Opland D, Jo Y, Faouzi M, Christensen L, Cappellucci L, et al. Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance. Cell Metab. 2011;14:313-23 pubmed publisher
    ..We found that the majority of LepRb neurons in the lateral hypothalamic area (LHA) contain neurotensin (Nts)...
  40. Béraud Dufour S, Abderrahmani A, Noel J, Brau F, Waeber G, Mazella J, et al. Neurotensin is a regulator of insulin secretion in pancreatic beta-cells. Int J Biochem Cell Biol. 2010;42:1681-8 pubmed publisher
    b>Neurotensin (NT) is secreted from neurons and gastrointestinal endocrine cells...
  41. Boules M, Liang Y, Briody S, Miura T, Fauq I, Oliveros A, et al. NT79: A novel neurotensin analog with selective behavioral effects. Brain Res. 2010;1308:35-46 pubmed publisher
    b>Neurotensin, a tridecapeptide, is widely distributed in the brain and gastrointestinal tract. It possesses analgesic, hypothermic, and antipsychotic-like properties...
  42. Held C, Plomer M, Hubner H, Meltretter J, Pischetsrieder M, Gmeiner P. Development of a metabolically stable neurotensin receptor?2 (NTS2) ligand. ChemMedChem. 2013;8:75-81 pubmed publisher
    Subtype-selective neurotensin receptor?2 (NTS2) ligands can be used as molecular probes to investigate the physiological role of neurotensinergic systems and serve as lead compounds to initiate the development of drugs for the treatment ..
  43. Tang K, Ma S, Lee T, Chan Y, Kwan P, Tong C, et al. CD133(+) liver tumor-initiating cells promote tumor angiogenesis, growth, and self-renewal through neurotensin/interleukin-8/CXCL1 signaling. Hepatology. 2012;55:807-20 pubmed publisher
    ..Subsequent studies of the IL-8 functional network identified neurotensin (NTS) and CXCL1 to be preferentially expressed in CD133(+) liver TICs...
  44. Mechanic J, Sutton J, Berson A, Wu X, Kwan J, Schreiber R, et al. Involvement of the neurotensin receptor 1 in the behavioral effects of two neurotensin agonists, NT-2 and NT69L: lack of hypothermic, antinociceptive and antipsychotic actions in receptor knockout mice. Eur Neuropsychopharmacol. 2009;19:466-75 pubmed publisher
    b>Neurotensin (NT) is a neuropeptide implicated in the pathophysiology of schizophrenia and in mediating the efficacy of antipsychotic drugs. NT is also involved in the regulation of body temperature and pain sensitivity...
  45. Bredeloux P, Costentin J, Dubuc I. Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice. Behav Brain Res. 2006;175:399-407 pubmed
    The intracerebroventricular administration of the tridecapeptide neurotensin (NT) produces strong analgesic effects in tests evaluating acute pain. We investigated whether these effects are mediated by the opioid receptors...
  46. Yuan J, Rozengurt E. PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells. J Cell Biochem. 2008;103:648-62 pubmed
    ..Here, we show that neurotensin induced a rapid and striking increase in Hsp27 Ser-82 phosphorylation in PANC-1 cells, which was closely ..
  47. Martinez Fong D, Bannon M, Trudeau L, Gonzalez Barrios J, Arango Rodríguez M, Hernandez Chan N, et al. NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease. Nanomedicine. 2012;8:1052-69 pubmed publisher
    ..b>Neurotensin (NTS)-polyplex is a "Trojan horse" synthetic nanocarrier system that enters dopaminergic neurons ..
  48. Schulz S, Rocken C, Ebert M, Schulz S. Immunocytochemical identification of low-affinity NTS2 neurotensin receptors in parietal cells of human gastric mucosa. J Endocrinol. 2006;191:121-8 pubmed
    The biological effects of neurotensin (NT) are mediated by two distinct G protein-coupled receptors, NTS(1) and NTS(2)...
  49. Shugalev N, Stavrovskaya A, Ol shanskii A, Hartmann G, Lenard L. Serotoninergic mechanisms of the effects of neurotensin on passive avoidance behavior in rats. Neurosci Behav Physiol. 2008;38:517-21 pubmed publisher
    The aim of the present work was to identify the features of the actions of neurotensin on administration into the substantia nigra or dorsal cervical nucleus on the reproduction of passive avoidance reactions in rats...
  50. Liu J, Zhao J, Di Y, Guo X, Zhai G, Huang X. The dynamic changes of plasma neuropeptide y and neurotensin and their role in regulating cerebral hemodynamics in neonatal hypoxic-ischemic encephalopathy. Am J Perinatol. 2007;24:435-40 pubmed
    ..The purpose of this study was to explore the dynamic changes in plasma neuropeptide Y (NPY) and neurotensin (NT) as well as their role in regulating cerebral hemodynamics in HIE patients...
  51. Li S, Geiger J, Lei S. Neurotensin enhances GABAergic activity in rat hippocampus CA1 region by modulating L-type calcium channels. J Neurophysiol. 2008;99:2134-43 pubmed publisher
    b>Neurotensin (NT) is a tridecapeptide that interacts with three NT receptors; NTS1, NTS2, and NTS3...
  52. Katsanos G, Anogianaki A, Castellani M, Ciampoli C, De Amicis D, Orso C, et al. Biology of neurotensin: revisited study. Int J Immunopathol Pharmacol. 2008;21:255-9 pubmed
    The tridecapeptide neurotensin (NT) acts in the mammalian brain as a primary neurotransmitter or neuromodulator of classical neurotransmitters...
  53. Kempadoo K, Touriño C, Cho S, Magnani F, LEINNINGER G, Stuber G, et al. Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA. J Neurosci. 2013;33:7618-26 pubmed publisher
    ..In the present study, we identify the effect of neurotensin (NT), one of the most abundant peptides in the LH to VTA projection, on excitatory synaptic transmission in the ..
  54. Fantegrossi W, Ko M, Woods J, Richelson E. Antinociceptive, hypothermic, hypotensive, and reinforcing effects of a novel neurotensin receptor agonist, NT69L, in rhesus monkeys. Pharmacol Biochem Behav. 2005;80:341-9 pubmed
    b>Neurotensin (NT) is a tridecapeptide found in the nervous system, as well as elsewhere in the body. It has anatomic and functional relationships to dopaminergic neurons in brain...
  55. Ghanizadeh A. Targeting neurotensin as a potential novel approach for the treatment of autism. J Neuroinflammation. 2010;7:58 pubmed publisher
    The pathophysiology of autism remains obscure. Recently, serum neurotensin levels in children with autistic disorder have been found to be higher than those of normal children...
  56. Garcia Garayoa E, Bläuenstein P, Blanc A, Maes V, Tourwe D, Schubiger P. A stable neurotensin-based radiopharmaceutical for targeted imaging and therapy of neurotensin receptor-positive tumours. Eur J Nucl Med Mol Imaging. 2009;36:37-47 pubmed publisher
    b>Neurotensin (NT) and its high affinity receptor (NTR1) are involved in several neoplastic processes. Thus, NT-based radiopharmaceuticals are potential tracers for targeted diagnosis and therapy of NTR-positive tumours...
  57. Feifel D, Goldenberg J, Melendez G, Shilling P. The acute and subchronic effects of a brain-penetrating, neurotensin-1 receptor agonist on feeding, body weight and temperature. Neuropharmacology. 2010;58:195-8 pubmed publisher
    The neurotensin-1 (NT1) receptor has been implicated in mediating a number of important neurotensin effects...
  58. Martorana A, Martella G, D Angelo V, Fusco F, Spadoni F, Bernardi G, et al. Neurotensin effects on N-type calcium currents among rat pallidal neurons: an electrophysiological and immunohistochemical study. Synapse. 2006;60:371-83 pubmed
    The tridecapeptide neurotensin (NT) is involved in the modulation of dopamine (DA)-mediated functions in the nigrostriatal and mesocorticolimbic pathways. Its relevance in mammalian globus pallidus (GP) is questioned...
  59. Boules M, Fredrickson P, Richelson E. Bioactive analogs of neurotensin: focus on CNS effects. Peptides. 2006;27:2523-33 pubmed
    b>Neurotensin (NT) is a 13-amino acid neuropeptide found in the central nervous system and in the gastrointestinal tract...
  60. Dicou E, Vincent J, Mazella J. Neurotensin receptor-3/sortilin mediates neurotensin-induced cytokine/chemokine expression in a murine microglial cell line. J Neurosci Res. 2004;78:92-9 pubmed
    We show that the type I neurotensin receptor-3 (also called sortilin) is the only known neurotensin receptor expressed in a murine microglial cell line and that its activation leads to phosphorylation of both extracellular signaling-..
  61. Li Z, Boules M, Williams K, Peris J, Richelson E. The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex. Brain Res. 2010;1311:28-36 pubmed publisher
    ..provide optimal therapy, we have been developing novel treatments that focus on receptors for the neuropeptide neurotensin (NT)...
  62. Smith K, Boules M, Williams K, Richelson E. NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain. Behav Brain Res. 2012;232:93-7 pubmed publisher
    b>Neurotensin (NT) analogs, NT69L, NT72, and NT79, differentially bind the two major neurotensin receptors, NTS1 and NTS2, to elicit effects similar to those of endogenous NT, including analgesia...
  63. Griebel G, Holsboer F. Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?. Nat Rev Drug Discov. 2012;11:462-78 pubmed publisher
    ..trials for psychiatric diseases, including agents that target the receptors for tachykinins, corticotropin-releasing factor, vasopressin and neurotensin, and suggest new ways to exploit the full potential of these candidate drugs.
  64. Kortleven C, Bruneau L, Trudeau L. Neurotensin inhibits glutamate-mediated synaptic inputs onto ventral tegmental area dopamine neurons through the release of the endocannabinoid 2-AG. Neuropharmacology. 2012;63:983-91 pubmed publisher
    b>Neurotensin (NT), a neuropeptide abundant in the ventral midbrain, is known to act as a key regulator of the mesolimbic dopamine (DA) system, originating in the ventral tegmental area (VTA)...
  65. Mergler S, Strowski M, Kaiser S, Plath T, Giesecke Y, Neumann M, et al. Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells. Neuroendocrinology. 2007;85:81-92 pubmed
    ..by investigating the expression of TRPM8 and characterizing its impact on [Ca(2+)](i) and the secretion of neurotensin (NT)...
  66. Scarpa R, Carraway R, Cochrane D. Insulin-like growth factor (IGF) induced proliferation of human lung fibroblasts is enhanced by neurotensin. Peptides. 2005;26:2201-10 pubmed
    ..b>Neurotensin (NT) has been suggested to participate in inflammation and in tissue repair and is an autocrine or paracrine ..
  67. Sarret P, Esdaile M, Perron A, Martinez J, Stroh T, Beaudet A. Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors. J Neurosci. 2005;25:8188-96 pubmed
    Intrathecal administration of the neuropeptide neurotensin (NT) was shown previously to exert antinociceptive effects in a variety of acute spinal pain paradigms including hotplate, tail-flick, and writhing tests...
  68. Li J, Hossain M, Southerland L, Waller E. Pharmacological inhibition of VIP signaling enhances antiviral immunity and improves survival in murine cytomegalovirus-infected allogeneic bone marrow transplant recipients. Blood. 2013;121:2347-51 pubmed publisher
    ..These results demonstrate that administration of a VIP antagonist after allo-BMT is a promising safely therapeutic approach to enhance antiviral cellular immunity. ..
  69. Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, et al. Nanoparticles exposing neurotensin tumor-specific drivers. J Pept Sci. 2013;19:198-204 pubmed publisher
    ..We reported, recently, that tetrabranched neurotensin peptides (NT4) may be used to selectively target tumor cells with liposomes...
  70. Alifano M, Loi M, Camilleri Broet S, Dupouy S, Regnard J, Forgez P. Neurotensin expression and outcome of malignant pleural mesothelioma. Biochimie. 2010;92:164-70 pubmed publisher
    ..Here, we evaluate the prognostic impact of the neurotensin (NTS) and its cognate receptor (NTSR1) known for mediating cellular proliferation, survival, invasiveness, and ..
  71. Young S, Rozengurt E. Crosstalk between insulin receptor and G protein-coupled receptor signaling systems leads to Ca²+ oscillations in pancreatic cancer PANC-1 cells. Biochem Biophys Res Commun. 2010;401:154-8 pubmed publisher
    ..cells that display an increase in intracellular [Ca²+] induced by picomolar concentrations of the GPCR agonist neurotensin. Interestingly, insulin increased the proportion of a subpopulation of cells that exhibit intracellular [Ca²+] ..
  72. Popp E, Schneider A, Vogel P, Teschendorf P, Böttiger B. Time course of the hypothermic response to continuously administered neurotensin. Neuropeptides. 2007;41:349-54 pubmed
    Intracerebroventricular administration of the tridecapeptide neurotensin is known to elicit hypothermia in rodents for few hours...
  73. Bossard C, Souazé F, Jarry A, Bezieau S, Mosnier J, Forgez P, et al. Over-expression of neurotensin high-affinity receptor 1 (NTS1) in relation with its ligand neurotensin (NT) and nuclear beta-catenin in inflammatory bowel disease-related oncogenesis. Peptides. 2007;28:2030-5 pubmed
    We investigated the expression of the neurotensin high-affinity receptor 1 (NTS1) during inflammatory bowel disease (IBD)-related colorectal oncogenesis, in colonic samples from 30 patients with IBD-related adenocarcinomas, dysplasias, ..
  74. Dobner P. Multitasking with neurotensin in the central nervous system. Cell Mol Life Sci. 2005;62:1946-63 pubmed
    The 13-amino acid peptide neurotensin (NT) was discovered over 30 years ago and has been implicated in a wide variety of neurotransmitter and endocrine functions...
  75. Vias M, Burtt G, Culig Z, Veerakumarasivam A, Neal D, Mills I. A role for neurotensin in bicalutamide resistant prostate cancer cells. Prostate. 2007;67:190-202 pubmed
    ..b>Neurotensin/Neuromedin N (NTS) was upregulated in the LNCaP-Bic line at both the transcript and protein level...
  76. Egerod K, Engelstoft M, Grunddal K, Nøhr M, Secher A, Sakata I, et al. A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology. 2012;153:5782-95 pubmed publisher
    ..of not only CCK but also glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide (GIP), peptide YY (PYY), neurotensin, and secretin, but not somatostatin. Immunohistochemistry confirmed this expression pattern...
  77. Maes V, Garcia Garayoa E, Bläuenstein P, Tourwe D. Novel 99mTc-labeled neurotensin analogues with optimized biodistribution properties. J Med Chem. 2006;49:1833-6 pubmed
    Two new 99mTc-labeled neurotensin(8-13) analogues containing the retro-N(alpha)-carboxymethyl-histidine ((N(alpha)His)Ac) chelator were synthesized as potential radiopharmaceuticals for visualization of pancreatic carcinoma...
  78. Gammie S, Lee G, Scotti M, Stevenson S, Gessay G. Neurotensin induced Egr-1 activity is altered in the postpartum period in mice. Brain Res. 2012;1433:47-55 pubmed publisher
    b>Neurotensin (NT) is a 13 amino acid neuropeptide that is identical in mice and humans and is released from and acts upon a number of social brain regions...
  79. Carraway R, Plona A. Involvement of neurotensin in cancer growth: evidence, mechanisms and development of diagnostic tools. Peptides. 2006;27:2445-60 pubmed
    Focusing on the literature of the past 15 years, we evaluate the evidence that neurotensin and neurotensin receptors participate in cancer growth and we describe possible mechanisms...
  80. Kitabgi P. Functional domains of the subtype 1 neurotensin receptor (NTS1). Peptides. 2006;27:2461-8 pubmed
    The subtype 1 neurotensin receptor (NTS1) belongs to the family of G protein coupled receptors with seven transmembrane domains and mediates most of the known effects of neurotensin...
  81. Petkova Kirova P, Rakovska A, Della Corte L, Zaekova G, Radomirov R, Mayer A. Neurotensin modulation of acetylcholine, GABA, and aspartate release from rat prefrontal cortex studied in vivo with microdialysis. Brain Res Bull. 2008;77:129-35 pubmed publisher
    The effects of the peptide transmitter neurotensin (NT) on the release of acetylcholine (ACh), gamma-aminobutyric acid (GABA), glutamate (Glu), aspartate (Asp), and taurine from the prefrontal cortex (PFC) of freely moving rats were ..
  82. Heise H, Luca S, de Groot B, Grubmuller H, Baldus M. Probing conformational disorder in neurotensin by two-dimensional solid-state NMR and comparison to molecular dynamics simulations. Biophys J. 2005;89:2113-20 pubmed
    ..For neurotensin, a peptide that binds with high affinity to a G-protein coupled receptor, this method permits the investigation ..
  83. Tomita R, Igarashi S, Fujisaki S, Tanjoh K. The effects of neurotensin in the colon of patients with slow transit constipation. Hepatogastroenterology. 2007;54:1662-6 pubmed
    The cause of dysmotility in the colon of patients with slow transit constipation (STC) is still unknown. Neurotensin (NT) has recently been shown to be a neurotransmitter in the non-adrenergic non-cholinergic (NANC) excitatory nerves of ..
  84. Kisfalvi K, Rey O, Young S, Sinnett Smith J, Rozengurt E. Insulin potentiates Ca2+ signaling and phosphatidylinositol 4,5-bisphosphate hydrolysis induced by Gq protein-coupled receptor agonists through an mTOR-dependent pathway. Endocrinology. 2007;148:3246-57 pubmed
    ..in intracellular Ca2+ concentration produced by the GPCR agonists bradykinin, angiotensin II, vasopressin, neurotensin, and bombesin...
  85. Prus A, Huang M, Li Z, Dai J, Meltzer H. The neurotensin analog NT69L enhances medial prefrontal cortical dopamine and acetylcholine efflux: potentiation of risperidone-, but not haloperidol-, induced dopamine efflux. Brain Res. 2007;1184:354-64 pubmed
    NT69L is a novel neurotensin (8-13) analog that produces atypical antipsychotic-like effects in animal models...
  86. László K, Tóth K, Kertes E, Péczely L, Lenard L. The role of neurotensin in positive reinforcement in the rat central nucleus of amygdala. Behav Brain Res. 2010;208:430-5 pubmed publisher
    In the central nervous system neurotensin (NT) acts as a neurotransmitter and neuromodulator. It was shown that NT has positive reinforcing effects after its direct microinjection into the ventral tegmental area...
  87. Béraud Dufour S, Coppola T, Massa F, Mazella J. Neurotensin receptor-2 and -3 are crucial for the anti-apoptotic effect of neurotensin on pancreatic beta-TC3 cells. Int J Biochem Cell Biol. 2009;41:2398-402 pubmed
    The neuropeptide neurotensin (NT) has been recently shown to protect pancreatic beta cells from toxic agents-induced apoptosis through interaction with the NT receptor-2 (NTSR2) and activation of the phosphatidylinositol-3 kinase pathway...
  88. Heakal Y, Kester M. Nanoliposomal short-chain ceramide inhibits agonist-dependent translocation of neurotensin receptor 1 to structured membrane microdomains in breast cancer cells. Mol Cancer Res. 2009;7:724-34 pubmed publisher
    b>Neurotensin (NTS) receptor 1 (NTSR1) is a G protein-coupled receptor that has been recently identified as a mediator of tumorigenicity and metastasis...
  89. Angelidou A, Francis K, Vasiadi M, Alysandratos K, Zhang B, Theoharides A, et al. Neurotensin is increased in serum of young children with autistic disorder. J Neuroinflammation. 2010;7:48 pubmed publisher
    ..0 ± 0.4 years) and healthy, unrelated controls (n = 16; 13 males and 3 females; mean age 3 ± 1.2 years). Only neurotensin (NT) was significantly increased from 60.5 ± 6.0 pg/ml in controls to 105.6 ± 12...