myocardial depressant factor

Summary

Summary: A low molecular weight peptide of about 800-1000 having a negative inotropic effect. It is released into the circulation during experimental hemorrhagic pancreatitis, severe ischemia, and postoligemic shock.

Top Publications

  1. Pathan N, Sandiford C, Harding S, Levin M. Characterization of a myocardial depressant factor in meningococcal septicemia. Crit Care Med. 2002;30:2191-8 pubmed
    ..Further characterization of the myocardial depressant factor was undertaken by using cell culture supernatants from whole blood and peripheral blood mononuclear ..
  2. Blake P, Hasegawa Y, Khosla M, Fouad Tarazi F, Sakura N, Paganini E. Isolation of "myocardial depressant factor(s)" from the ultrafiltrate of heart failure patients with acute renal failure. ASAIO J. 1996;42:M911-5 pubmed
    ..Group III was weakly biphasic. The data indicate there was myocardial depressive activity, most pronounced in Groups I and II, after method interference was corrected. ..
  3. Bitterman H, Stahl G, Lefer A. Protective effects of CG-4203, a novel stable prostacyclin analog, in traumatic shock. Prostaglandins. 1988;35:41-50 pubmed
    ..trauma and was characterized by marked hypotension, a 4- to 5-fold increase in plasma cathepsin D and myocardial depressant factor activities, and survival time of 95 +/- 15 minutes...
  4. Karasawa A, Guo J, Ma X, Lefer A. Beneficial effects of transforming growth factor-beta and tissue plasminogen activator in splanchnic artery occlusion and reperfusion in cats. J Cardiovasc Pharmacol. 1991;18:95-105 pubmed
    ..The mean survival time was 75 +/- 8 min. Plasma amino-nitrogen concentrations and cathepsin D and myocardial depressant factor (MDF) activities were markedly elevated following reperfusion...
  5. Rämä O, Rämö P, Karhunen M, Kiviniemi H, Kettunen R. Impaired venous return causes circulatory failure in experimental pancreatitic shock in dogs. Intensive Care Med. 1989;15:111-5 pubmed
    ..Hence, the existence of a myocardial depressant factor in the early phase of experimental AP does not gain support from the present results.
  6. Karasawa A, Taylor P, Lefer A. Protective effects of KW-3635, a novel thromboxane A2 antagonist, in murine traumatic shock. Eur J Pharmacol. 1990;182:1-8 pubmed
    ..6-fold), free amino-nitrogen (4.0-fold), and myocardial depressant factor (5.2-fold) activities, and a survival time of 1.90 +/- 0.23 h...
  7. Aoki N, Johnson G, Siegfried M, Lefer A. Protective effects of a combination thromboxane synthesis inhibitor-receptor antagonist, R-68070, during murine traumatic shock. Eicosanoids. 1989;2:169-74 pubmed
    ..05), as well as free amino-nitrogen concentration (p less than 0.05) and myocardial depressant factor activity (p less than 0.02). Additionally, R-68070 significantly prolonged survival time to 2.85 +/- 0...
  8. Bitterman H, Aoki N, Lefer A. Anti-shock effects of human superoxide dismutase in splanchnic artery occlusion (SAO) shock. Proc Soc Exp Biol Med. 1988;188:265-71 pubmed
    ..05 from vehicle). Furthermore, the plasma activity of a myocardial depressant factor was significantly lower in h-SOD-treated rats than in SAO rats receiving only the vehicle (27 +/- 1 vs ..
  9. Mehta P, Kloner R. Effects of acid base disturbance, septic shock, and calcium and phosphorous abnormalities on cardiovascular function. Crit Care Clin. 1987;3:747-58 pubmed
    ..There is a need for elucidating the biochemical characteristics of the myocardial depressant factor (or factors).

More Information

Publications44

  1. Goraca A, Traczyk W. Increase in cardiodepressant factor release from the posterior pituitary lobe after angiotensin II infusion into the internal carotid artery. J Physiol Pharmacol. 1997;48:225-37 pubmed
    ..The present results indicate that angiotensin II increase the release of cardiodepressant factor from the posterior pituitary lobe into blood in a dose-dependent manner. ..
  2. Felix S, Stangl V, Pietsch P, Bramlage P, Staudt A, Bartel S, et al. Soluble substances released from postischemic reperfused rat hearts reduce calcium transient and contractility by blocking the L-type calcium channel. J Am Coll Cardiol. 2001;37:668-75 pubmed
    ..Negative inotropic substances released from isolated postischemic hearts reduce Ca2+ transient and cell contraction through cAMP-independent and cGMP-independent blockage of L-type Ca2+ channels. ..
  3. Kumar A, Parrillo J. Myocardial depressant substances in meningococcal septic shock. Crit Care Med. 2002;30:2379-80 pubmed
  4. Zingarelli B, Squadrito F, Altavilla D, Calapai G, Campo G, Calo M, et al. Evidence for a role of nitric oxide in hypovolemic hemorrhagic shock. J Cardiovasc Pharmacol. 1992;19:982-6 pubmed
    ..Survival rate, survival time, plasma myocardial depressant factor (MDF) activity, MAP, and microscopic gastric alterations were then evaluated...
  5. Terashita Z, Stahl G, Lefer A. Protective effects of a platelet activating factor (PAF) antagonist and its combined treatment with prostaglandin (PG) E1 in traumatic shock. J Cardiovasc Pharmacol. 1988;12:505-11 pubmed
    ..the plasma accumulation of the lysosomal hydrolase, cathepsin D, and a cardiotoxic peptide, myocardial depressant factor (MDF), were also attenuated by CV-6209 in traumatic shock...
  6. Canale P, Squadrito F, Altavilla D, Ioculano M, Campo G, Squadrito G, et al. Beneficial effects of BAY u3405, a novel thromboxane A2 receptor antagonist, in splanchnic artery occlusion shock. Pharmacology. 1994;49:376-85 pubmed
    ..levels of thromboxane B2 and 6-keto-PGF1 alpha, macrophage phagocytosis activity and plasma levels of myocardial depressant factor were evaluated...
  7. Johnson G, Lefer A. Protective effects of a novel 21-aminosteroid during splanchnic artery occlusion shock. Circ Shock. 1990;30:155-64 pubmed
    ..05) and myocardial depressant factor (MDF) (P less than .01)...
  8. Stahl G, Bitterman H, Lefer A. Protective effects of a specific platelet activating factor (PAF) antagonist, WEB 2086, in traumatic shock. Thromb Res. 1989;53:327-38 pubmed
    ..Furthermore, the production of the cardiotoxic peptide, myocardial depressant factor (MDF) was also blunted by WEB 2086...
  9. Pathan N, Hemingway C, Alizadeh A, Stephens A, Boldrick J, Oragui E, et al. Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet. 2004;363:203-9 pubmed
    ..We then selected for further analysis those genes whose protein products had properties of a myocardial depressant factor--specifically a 12-25 kDa heat-stable protein that is released into serum shortly after onset of ..
  10. Karasawa A, Rochester J, Lefer A. Effects of adenosine, an adenosine-A1 antagonist, and their combination in splanchnic occlusion shock in rats. Circ Shock. 1992;36:154-61 pubmed
    ..Final plasma free amino-nitrogen concentrations, cathepsin D and myocardial depressant factor (MDF) activities were significantly elevated in rats receiving only the vehicle...
  11. Ao L, Song Y, Fullerton D, Dinarello C, Meng X. The interaction between myocardial depressant factors in endotoxemic cardiac dysfunction: role of TNF-alpha in TLR4-mediated ICAM-1 expression. Cytokine. 2007;38:124-9 pubmed
    ..ICAM-1 contributes to the mechanism of endotoxemic cardiac dysfunction. TNF-alpha is involved in the regulation of myocardial ICAM-1 expression by TLR4. ..
  12. Stahl G, Bitterman H, Terashita Z, Lefer A. Salutary consequences of blockade of platelet activating factor in hemorrhagic shock. Eur J Pharmacol. 1988;149:233-40 pubmed
    ..decreased the plasma accumulation of free amino-nitrogen compounds and the plasma activity of a myocardial depressant factor (MDF) compared to hemorrhaged rats receiving 0.9% NaCl...
  13. Goraca A, Traczyk W. Increase of cardiodepressant activity in medium incubating the posterior pituitary lobe in situ during vagal nerve stimulation in rat. J Physiol Pharmacol. 1991;42:333-41 pubmed
  14. Lento P, Saukkonen K, Aoki N, Lefer A, Slivjak M, Smith E. Beneficial effects of a specific leukotriene receptor antagonist in splanchnic artery occlusion shock. Eur J Pharmacol. 1989;165:241-9 pubmed
    ..increase in the plasma activities of the lysosomal hydrolase, cathepsin D, and the cardiotoxic peptide, myocardial depressant factor, were significantly attenuated in comparison to the splanchnic artery occlusion shock + vehicle group (..
  15. Gomez A, Wang R, Unruh H, Light R, Bose D, Chau T, et al. hemofiltration reverses left ventricular dysfunction during sepsis in dogs. Anesthesiology. 1990;73:671-85 pubmed
    ..The results show that during experimental sepsis, a circulating substance of less than 30,000 d produces a decrease in LV contractility and that this LV dysfunction may be improved by hemofiltration. ..
  16. Mink S, Jacobs H, Duke K, Bose D, Cheng Z, Light R. N,N',N"-triacetylglucosamine, an inhibitor of lysozyme, prevents myocardial depression in Escherichia coli sepsis in dogs. Crit Care Med. 2004;32:184-93 pubmed
    ..Only specific NAG structures are inhibitory to Lzm-S's depressant activity. TAC may be useful in attenuating cardiovascular collapse in sepsis. ..
  17. Sambol J, White J, Horton J, Deitch E. Burn-induced impairment of cardiac contractile function is due to gut-derived factors transported in mesenteric lymph. Shock. 2002;18:272-6 pubmed
  18. Zingarelli B, Squadrito F, Ioculano M, Altavilla D, Bussolino F, Campo G, et al. Platelet activating factor interaction with tumor necrosis factor and myocardial depressant factor in splanchnic artery occlusion shock. Eur J Pharmacol. 1992;222:13-9 pubmed
    ..Treatment with L-659,989 significantly increased survival rate, blunted the rise in plasma myocardial depressant factor activity and lowered serum and macrophage levels of tumor necrosis factor (TNF-alpha)...
  19. Bitterman H, Lefer A. Use of a novel peptide leukotriene receptor antagonist, Ly-163443, in splanchnic artery occlusion shock. Prostaglandins Leukot Essent Fatty Acids. 1988;32:63-70 pubmed
    ..05 from vehicle). Furthermore, the plasma activity of a myocardial depressant factor (MDF) was significantly lower in the pre-treatment group than in the vehicle group (27 +/- 3 vs 51 +/- ..
  20. Bitterman H, Smith B, Lefer A. Beneficial actions of antagonism of peptide leukotrienes in hemorrhagic shock. Circ Shock. 1988;24:159-68 pubmed
    ..05). Furthermore, the plasma activity of a myocardial depressant factor (MDF) was significantly lower in rats treated with L-649,923 (1 mg/kg/h) than in rats receiving the ..
  21. Aoki N, Siegfried M, Tsao P, Lento P, Lefer A. Beneficial mechanisms of action of a prostacyclin enhancing agent in splanchnic artery occlusion shock. Res Commun Chem Pathol Pharmacol. 1988;60:275-89 pubmed
    ..05 from vehicle) and myocardial depressant factor (p less than 0...
  22. Aoki N, Siegfried M, Tsao P, Lefer A. Acute effects of unsaturated fatty acids in splanchnic artery occlusion shock. Prostaglandins Leukot Essent Fatty Acids. 1989;37:89-95 pubmed
    ..of the lysosomal protease, cathepsin D, free amino-nitrogen compounds, and the cardiotoxic peptide, myocardial depressant factor. These results indicate that omega-3 unsaturated fatty acids, especially EPA, have some acute ..
  23. Reilly J, Cunnion R, Burch Whitman C, Parker M, Shelhamer J, Parrillo J. A circulating myocardial depressant substance is associated with cardiac dysfunction and peripheral hypoperfusion (lactic acidemia) in patients with septic shock. Chest. 1989;95:1072-80 pubmed
    ..05). These findings suggest that a circulating MDS is a cause of the myocardial depression frequently accompanying human septic shock. ..
  24. Bitterman H, Smith B, Lefer A. Use of the novel cardiotonic and vasodilator agent pimobendan in traumatic shock. Arzneimittelforschung. 1988;38:1389-93 pubmed
    ..significantly reduced mean arterial blood pressure (MABP), a 5-fold increase in plasma cathepsin D and myocardial depressant factor (MDF) activities, and a survival time of 80 +/- 12 min...
  25. Sturniolo R, Squadrito F, Campo G, Vinci R, Calatroni A, Prosdocimi M, et al. Protective effect of cloricromene, a coumarine derivative, in hypovolemic hemorrhagic shock in the rat. J Cardiovasc Pharmacol. 1991;17:261-6 pubmed
    ..Survival rate, MAP, plasma myocardial depressant factor (MDF) activity and plasma levels of both TxB2 and 6-keto PGF1 alpha were then evaluated...
  26. Furlan L, Johnson G, Siegfried M, Lefer A. Protective effects of the specific thromboxane receptor antagonist (+)-S145Na in splanchnic artery occlusion shock in rats. J Pharmacol Exp Ther. 1990;253:525-9 pubmed
    ..05), plasma aminonitrogen concentration (P less than .05), and plasma myocardial depressant factor activity (P less than .01) as well as increased survival rate and time (P less than ...
  27. Haglund U. Systemic mediators released from the gut in critical illness. Crit Care Med. 1993;21:S15-8 pubmed
    ..No such factor has been fully identified chemically. Intestinal mucosal injury, as seen in critical illness, may induce increased translocation of bacteria and endotoxin and release of myocardial depressant factors into the circulation. ..
  28. Zingarelli B, Squadrito F, Bussolino F, Calapai G, Altavilla D, Ioculano M, et al. Evidence for a role of platelet activating factor in hypovolemic shock in the rat. J Lipid Mediat Cell Signal. 1994;9:123-34 pubmed
    ..urethane-anaesthetized rats in order to evaluate the key role of platelet-activating factor (PAF) and myocardial depressant factor (MDF) in low flow states...
  29. Aoki N, Lefer A. Protective effects of thromboxane receptor blockade in splanchnic artery occlusion shock. Methods Find Exp Clin Pharmacol. 1988;10:413-8 pubmed
    ..01 from vehicle). Furthermore, the plasma activity of a myocardial depressant factor was significantly lower in BM-13505 treated rats than in non-treated rats (p less than 0...
  30. Levitt M, Stahl G, Lefer A. Efficacy of a combination thromboxane receptor antagonist and lipoxygenase inhibitor in traumatic shock. Resuscitation. 1988;16:211-20 pubmed
    ..min survival time, a 20-fold increase in plasma cathepsin D activity, and a 6-fold increase in plasma myocardial depressant factor (MDF) activity...
  31. Kistler E, Lefer A, Hugli T, Schmid Schönbein G. Plasma activation during splanchnic arterial occlusion shock. Shock. 2000;14:30-4 pubmed
    ..Proteolytically derived plasma factors released during SAO shock may contribute to leukocyte activation and ensuing organ dysfunction. ..
  32. Goraca A. Increase in vasopressin concentration and cardiodepressant activity in the blood dialysates from the sella turcica during acute hypoxia. Endocr Regul. 2000;34:127-34 pubmed
    ..These data suggest that cardiodepressant factor released together with vasopressin from the posterior pituitary lobe decrease the heart contraction rate and improves coronary circulation affected by vasopressin release. ..
  33. Squadrito F, Sturniolo R, Altavilla D, Campo G, Trimarchi G, Scuri R, et al. Effects of fructose 1,6-diphosphate on splanchnic artery occlusion shock in the rat. Resuscitation. 1989;18:299-307 pubmed
    ..Survival rate, peritoneal macrophage phagocytosis and plasma levels of myocardial depressant factor (MDF) were measured. Shocked animals pretreated with vehicle exhibited 24.6 +/- 0...
  34. Karasawa A, Rochester J, Lefer A. Beneficial actions of BN 50739, a new PAF receptor antagonist, in murine traumatic shock. Methods Find Exp Clin Pharmacol. 1990;12:231-7 pubmed
    ..2-fold), free amino-nitrogen (2.8-fold) and myocardial depressant factor (4.7-fold) activities and a survival time of 1.62 +/- 0.16 h. Treatment with BN 50739 (10 mg/kg, i.v...
  35. Karasawa A, Rochester J, Ma X, Lefer A. Protection of endothelial damage and systemic shock by benidipine, a calcium antagonist, in rats subjected to splanchnic ischemia and reperfusion. Circ Shock. 1991;33:135-41 pubmed
    ..5 vs. 7.9 U/ml, P less than 0.05) and myocardial depressant factor (34 vs. 62 U/ml, P less than 0.001)...