paxillin

Summary

Summary: Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.

Top Publications

  1. Hamamura K, Tsuji M, Ohkawa Y, Nakashima H, Miyazaki S, Urano T, et al. Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells. Biochim Biophys Acta. 2008;1780:513-9 pubmed
    ..Also, it was shown that FAK is located up-stream of p130Cas and paxillin in the enhanced signaling pathway...
  2. Parsons S, Sharma R, Roccamatisi D, Zhang H, Petri B, Kubes P, et al. Endothelial paxillin and focal adhesion kinase (FAK) play a critical role in neutrophil transmigration. Eur J Immunol. 2012;42:436-46 pubmed publisher
    ..We found that there was selective loss of paxillin and focal adhesion kinase (FAK) from focal adhesions in proximity to transmigrating neutrophils; in contrast the ..
  3. Moody T, Leyton J, Jensen R. Pituitary adenylate cyclase-activating polypeptide causes increased tyrosine phosphorylation of focal adhesion kinase and paxillin. J Mol Neurosci. 2012;46:68-74 pubmed publisher
    ..adenylate cyclase-activating polypeptide (PACAP) on tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin were investigated using lung cancer cells...
  4. Cai H, Zhang T, Tang W, Li S. [Expression of paxillin in breast cancer cell with high and low metastatic potentiality]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2010;41:91-4 pubmed
    To study the expression of paxillin in the two subgroups of human breast cancer cells with high and low metastatic potentialities and the effect of paxillin on tumor metastasis and adhesion...
  5. Berginski M, Vitriol E, Hahn K, Gomez S. High-resolution quantification of focal adhesion spatiotemporal dynamics in living cells. PLoS ONE. 2011;6:e22025 pubmed publisher
    ..This analysis system was used to quantify the dynamics of fluorescently tagged Paxillin and FAK in NIH 3T3 fibroblasts followed via Total Internal Reflection Fluorescence Microscopy (TIRF)...
  6. Tabassam F, Graham D, Yamaoka Y. Paxillin is a novel cellular target for converging Helicobacter pylori-induced cellular signaling. Am J Physiol Gastrointest Liver Physiol. 2011;301:G601-11 pubmed publisher
    b>Paxillin is involved in the regulation of Helicobacter pylori-mediated gastric epithelial cell motility. We investigated the signaling pathways regulating H. pylori-induced paxillin phosphorylation and the effect of the H...
  7. Wang X, Fukuda K, Byeon I, Velyvis A, Wu C, Gronenborn A, et al. The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. J Biol Chem. 2008;283:21113-9 pubmed publisher
    ..contains two calponin homology (CH) domains and its C-terminal CH2 domain binds multiple targets including paxillin LD motifs for regulating the FA network and signaling...
  8. Ishitani T, Ishitani S, Matsumoto K, Itoh M. Nemo-like kinase is involved in NGF-induced neurite outgrowth via phosphorylating MAP1B and paxillin. J Neurochem. 2009;111:1104-18 pubmed publisher
    ..NLK directly phosphorylates microtubule-associated protein-1B (MAP1B) and the focal adhesion adaptor protein, paxillin. Knockdown of NLK attenuates the phosphorylation of both paxillin and MAP1B and inhibits both the NGF-induced re-..
  9. Huang Z, Yan D, Ge B. JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin. Cell Signal. 2008;20:2002-12 pubmed publisher
    The adaptor protein paxillin plays an important role in cell migration...

More Information

Publications62

  1. Wu Y, Tang J, Zhao P, Chen Z, Jiang J. Enhanced expression of Hab18g/CD147 and activation of integrin pathway in HCC cells under 3-D co-culture conditions. Cell Biol Int. 2009;33:199-206 pubmed publisher
    ..01), and was obviously accompanied with enhanced expressions of paxillin, FAK and p-FAK in 3-D cell co-culture model...
  2. Kummer C, Petrich B, Rose D, Ginsberg M. A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation. J Biol Chem. 2010;285:9462-9 pubmed publisher
    ..Inhibition of alpha 4 integrin signaling by mutations of alpha 4 that block paxillin binding inhibits inflammation while limiting mechanism-based toxicities...
  3. Cai H, Yang L, Song X, Liu Z, Chen Y, Dong G. Expression of paxillin and FAK mRNA and the related clinical significance in esophageal carcinoma. Mol Med Rep. 2012;5:469-72 pubmed publisher
    The objective of the present study was to investigate the expression of paxillin and focal adhesion kinase (FAK) mRNA in esophageal carcinoma tissues, and their relationship with clinicopathological parameters, as ..
  4. Athanasopoulou A, Aroukatos P, Nakas D, Repanti M, Papadaki H, Bravou V. Decreased ezrin and paxillin expression in human urothelial bladder tumors correlate with tumor progression. Urol Oncol. 2013;31:836-42 pubmed publisher
    F-actin binding proteins ezrin and paxillin are involved in cell adhesion and cell migration/invasion. The aim of the study was to investigate their role in urothelial bladder carcinogenesis.
  5. MacKinnon A, Tretiakova M, Henderson L, Mehta R, Yan B, Joseph L, et al. Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease. J Clin Pathol. 2011;64:16-24 pubmed publisher
    b>Paxillin is a modular protein that localises to cell adhesion sites where it facilitates bidirectional communication between the intracellular actin cytoskeleton and the extracellular matrix...
  6. Duran M, Rahman A, Colten M, Brazill D. Dictyostelium discoideum paxillin regulates actin-based processes. Protist. 2009;160:221-32 pubmed publisher
    b>Paxillin is a key player in integrating the actin cytoskeleton with adhesion, and thus is essential to numerous cellular processes, including proliferation, differentiation, and migration in animal cells...
  7. Patla I, Volberg T, Elad N, Hirschfeld Warneken V, Grashoff C, Fassler R, et al. Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nat Cell Biol. 2010;12:909-15 pubmed publisher
    ..Our findings clarify the internal architecture of focal adhesions at molecular resolution, and provide insights into their scaffolding and mechanosensory functions...
  8. Pinar M, Coll P, Rincon S, Perez P. Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis. Mol Biol Cell. 2008;19:1727-38 pubmed publisher
    ..This gene, named pxl1(+), encodes a protein with three LIM domains that is similar to paxillin. Pxl1 does not interact with Cdc42 but it interacts with Rho1, and it negatively regulates this GTPase...
  9. Pasapera A, Schneider I, Rericha E, Schlaepfer D, Waterman C. Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol. 2010;188:877-90 pubmed publisher
    ..Myosin II activity promotes FAK/Src-mediated phosphorylation of paxillin on tyrosines 31 and 118 and vinculin association with paxillin...
  10. Lulo J, Yuzawa S, Schlessinger J. Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2. Biochem Biophys Res Commun. 2009;383:347-52 pubmed publisher
    ..the non-receptor tyrosine kinases FAK and Pyk2 to cellular focal adhesion areas, where the signaling molecule paxillin is also located...
  11. Smadja Lamère N, Boulanger M, Champagne C, Branton P, Lavoie J. JNK-mediated phosphorylation of paxillin in adhesion assembly and tension-induced cell death by the adenovirus death factor E4orf4. J Biol Chem. 2008;283:34352-64 pubmed publisher
    ..Remarkably, the dramatic enlargement of focal adhesions, actin remodeling, and cell death all rely on paxillin phosphorylation at Ser-178, which is induced by E4orf4 in a JNK-dependent way...
  12. Yun S, Ryu J, Han H. Involvement of ?1-integrin via PIP complex and FAK/paxillin in dexamethasone-induced human mesenchymal stem cells migration. J Cell Physiol. 2011;226:683-92 pubmed publisher
    ..In addition, DEX increased focal adhesion kinase (FAK) and paxillin expression, which were attenuated by ILK and ?-parvin siRNAs...
  13. Jun Q, Zhiwei W, Lilin M, Jing K, Qichao N. Effects of paxillin on HCT-8 human colorectal cancer cells. Hepatogastroenterology. 2011;58:1951-5 pubmed publisher
    The aim of this study was to investigate the effects of paxillin on proliferation, migration, invasion, adhesion and apoptosis of HCT-8 human colorectal cancer cells in vitro...
  14. Rosse C, Formstecher E, Boeckeler K, Zhao Y, Kremerskothen J, White M, et al. An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. PLoS Biol. 2009;7:e1000235 pubmed publisher
    ..The migration associated control of JNK by aPKCs determines JNK phosphorylation of the plasma membrane substrate Paxillin, but not the phosphorylation of the nuclear JNK substrate, c-jun...
  15. Deng B, Zhang S, Miao Y, Han Z, Zhang X, Wen F, et al. Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin ?5?1 and phosphorylating FAK and paxillin. J Exp Clin Cancer Res. 2012;31:19 pubmed publisher
    ..Western blot was used to examine the phosphorylation of FAK and paxillin. We found that patients with high AM expression showed a higher incidence of metastasis, larger residual size of ..
  16. Dikeman D, Rivera Rosado L, Horn T, Alves C, Konstantopoulos K, Yang J. alpha4 beta1-Integrin regulates directionally persistent cell migration in response to shear flow stimulation. Am J Physiol Cell Physiol. 2008;295:C151-9 pubmed publisher
    ..been shown to regulate the front-back polarity of migrating cells via localized inhibition of alpha(4)-integrin/paxillin binding by phosphorylation at the alpha(4)-integrin cytoplasmic tail...
  17. Romanova L, Mushinski J. Central role of paxillin phosphorylation in regulation of LFA-1 integrins activity and lymphocyte migration. Cell Adh Migr. 2011;5:457-62 pubmed publisher
    ..Here we discuss the central role of the actin-regulating adaptor protein, paxillin, during lymphocyte transition from a polarized, motile cell phenotype with partially active LFA-1 integrins to a ..
  18. Dai Y, Pierson S, Dudney W, Stack B. Extraribosomal function of metallopanstimulin-1: reducing paxillin in head and neck squamous cell carcinoma and inhibiting tumor growth. Int J Cancer. 2010;126:611-9 pubmed publisher
    ..Further gene array analysis, immunohistochemistry staining and Western blotting reveal that MPS-1 reduces paxillin mRNA and protein levels in UMSCC-1 cells both in vitro and in vivo...
  19. Teranishi S, Kimura K, Nishida T. Role of formation of an ERK-FAK-paxillin complex in migration of human corneal epithelial cells during wound closure in vitro. Invest Ophthalmol Vis Sci. 2009;50:5646-52 pubmed publisher
    ..The tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin, as well as the association of FAK with paxillin and ERK, were evaluated by immunoprecipitation and immunoblot ..
  20. Efimov A, Kaverina I. Significance of microtubule catastrophes at focal adhesion sites. Cell Adh Migr. 2009;3:285-7 pubmed
    ..We were able to track down one of the focal adhesion proteins paxillin which is involved in this process...
  21. Kanteti R, Yala S, Ferguson M, Salgia R. MET, HGF, EGFR, and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples and prognostic significance. J Environ Pathol Toxicol Oncol. 2009;28:89-98 pubmed
    ..such as MET, hepatocyte growth factor [(HGF), ligand for MET), epidermal growth factor receptor (EGFR), and paxillin (PXN), is likely to determine both the type of treatment and prognosis...
  22. Shan Y, Yu L, Li Y, Pan Y, Zhang Q, Wang F, et al. Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin. PLoS Biol. 2009;7:e1000116 pubmed publisher
    ..Nudel bound to paxillin, a scaffold protein of focal contacts, and colocalized with it in areas of active membrane protrusions, ..
  23. Humphries J, Wang P, Streuli C, Geiger B, Humphries M, Ballestrem C. Vinculin controls focal adhesion formation by direct interactions with talin and actin. J Cell Biol. 2007;179:1043-57 pubmed
    ..Surprisingly, paxillin recruitment, induced by active vinculin constructs, occurs independently of its potential binding site in the ..
  24. Wolfenson H, Lubelski A, Regev T, Klafter J, Henis Y, Geiger B. A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions. PLoS ONE. 2009;4:e4304 pubmed publisher
    ..studies in live cells, with in silico simulations and mathematical modeling, we show that the FA plaque proteins paxillin and vinculin exist in four dynamic states: an immobile FA-bound fraction, an FA-associated fraction undergoing ..
  25. Lim Y, Lim S, Tomar A, Gardel M, Bernard Trifilo J, Chen X, et al. PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol. 2008;180:187-203 pubmed publisher
    ..These studies elucidate a compensatory function for Pyk2 upon FAK loss and identify the FAK-p190RhoGEF complex as an important integrin-proximal regulator of FA formation during FN-stimulated cell motility. ..
  26. Sachdev S, Bu Y, Gelman I. Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion. BMC Cancer. 2009;9:12 pubmed publisher
    ..Specifically, in the absence of FAK, Src induced higher phosphorylation of p190RhoGAP, paxillin (poY118) and Crk irrespective of adhesion state, PKC-delta (poY311), connexin-43 (poY265) and Sam68 only under ..
  27. Bai X, Zhang W, Liu N, Jiang H, Lou K, Peng T, et al. Focal adhesion kinase: important to prostaglandin E2-mediated adhesion, migration and invasion in hepatocellular carcinoma cells. Oncol Rep. 2009;21:129-36 pubmed
    ..Furthermore, the downstream proteins of FAK, paxillin and Erk2, were also activated by PGE2...
  28. Ge W, Balasubramanian M. Pxl1p, a paxillin-related protein, stabilizes the actomyosin ring during cytokinesis in fission yeast. Mol Biol Cell. 2008;19:1680-92 pubmed publisher
    ..Here, we identify and characterize a paxillin-related protein Pxl1p in the fission yeast Schizosaccharomyces pombe...
  29. Li B, Lei W, Zhang C, Zhou F, Li N, Shi S, et al. Increased expression of paxillin is found in human oesophageal squamous cell carcinoma: a tissue microarray study. J Int Med Res. 2008;36:273-8 pubmed
    ..Research has, therefore, concentrated on searching for specific biomarkers. Paxillin has been shown to play an important role in controlling cell spread and migration...
  30. Dong J, Lau L, Ng Y, Lim L, Manser E. Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation. Biochem J. 2009;418:173-84 pubmed publisher
    b>Paxillin, a major focal-adhesion complex component belongs to the subfamily of LIM domain proteins and participates in cell adhesion-mediated signal transduction...
  31. Sero J, German A, Mammoto A, Ingber D. Paxillin controls directional cell motility in response to physical cues. Cell Adh Migr. 2012;6:502-8 pubmed publisher
    ..b>Paxillin is a focal adhesion (FA) scaffold protein that mediates integrin anchorage to the cytoskeleton, and has been ..
  32. Chua G, Patra A, Tan S, Bhattacharjya S. NMR structure of integrin ?4 cytosolic tail and its interactions with paxillin. PLoS ONE. 2013;8:e55184 pubmed publisher
    ..3-D structure of the full-length ?4 CT (Lys968-Asp999) and characterize its interactions with the adaptor protein paxillin. The ?4 CT assumes an overall helical structure with a kink in its membrane proximal region...
  33. Rondas D, Tomas A, Halban P. Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin. Diabetes. 2011;60:1146-57 pubmed publisher
    ..This led us to study the role of two key focal adhesion proteins, focal adhesion kinase (FAK) and paxillin, in GSIS. All studies were performed using rat primary ?-cells or isolated islets...
  34. Chen J, Tang Y, Huang S, Juan H, Wu L, Sun Y, et al. A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways. Cancer Res. 2011;71:473-83 pubmed publisher
    ..decreased the sialic acid modification of integrin-?1 and inhibited the expression of phospho-FAK, phospho-paxillin, and the matrix metalloprotease (MMP) 2 and MMP9...
  35. Choi C, Zareno J, Digman M, Gratton E, Horwitz A. Cross-correlated fluctuation analysis reveals phosphorylation-regulated paxillin-FAK complexes in nascent adhesions. Biophys J. 2011;100:583-592 pubmed publisher
    We used correlation methods to detect and quantify interactions between paxillin and focal adhesion kinase (FAK) in migrating cells...
  36. Ngu H, Feng Y, Lu L, Oswald S, Longmore G, Yin F. Effect of focal adhesion proteins on endothelial cell adhesion, motility and orientation response to cyclic strain. Ann Biomed Eng. 2010;38:208-22 pubmed publisher
    ..To explore how this response is regulated by focal adhesion-associated proteins the expression levels of paxillin, focal adhesion kinase (FAK), and zyxin were knocked down using gene silencing techniques...
  37. Tang J, Wu Y, Zhao P, Yang X, Jiang J, Chen Z. Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways. Cell Mol Life Sci. 2008;65:2933-42 pubmed publisher
    ..01). The expressions of integrin downstream molecules including focal adhesion kinase (FAK), phospho-FAK (p-FAK), paxillin, and phospho-paxillin (p-paxillin) were increased in human hepatoma cells overexpressing HAb18G/CD147...
  38. Chen T, Lai C, Chang J, Chang S. Mitomycin C retardation of corneal fibroblast migration via sustained dephosphorylation of paxillin at tyrosine 118. Invest Ophthalmol Vis Sci. 2012;53:1539-47 pubmed publisher
    ..Both focal adhesion kinase (FAK) and paxillin (PXN) expressions in HCFs were analyzed by semiquantitative real-time PCR, immunoblotting, and immunofluorescence ..
  39. Kimura K, Teranishi S, Yamauchi J, Nishida T. Role of JNK-dependent serine phosphorylation of paxillin in migration of corneal epithelial cells during wound closure. Invest Ophthalmol Vis Sci. 2008;49:125-32 pubmed publisher
    ..The phosphorylation and localization of JNK and paxillin during wound closure were examined by immunoblot and immunofluorescence analyses...
  40. Vatsa A, Semeins C, Smit T, Klein Nulend J. Paxillin localisation in osteocytes--is it determined by the direction of loading?. Biochem Biophys Res Commun. 2008;377:1019-24 pubmed publisher
    ..mechanical loading of cells aligns cytoskeletal stress fibres in the direction of principle strains and localises paxillin to the mechanosensing region...
  41. Metalli D, Lovat F, Tripodi F, Genua M, Xu S, Spinelli M, et al. The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin. Am J Pathol. 2010;176:2997-3006 pubmed publisher
    ..protein kinase (MAPK) pathways as well as IGF-I-induced Akt- and MAPK-dependent phosphorylation of paxillin, which relocated at dynamic focal adhesions and was necessary for promoting motility in bladder cancer cells...
  42. Torii T, Miyamoto Y, Sanbe A, Nishimura K, Yamauchi J, Tanoue A. Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6. J Biol Chem. 2010;285:24270-81 pubmed publisher
    ..Furthermore, we find that the focal adhesion protein paxillin forms a complex with cytohesin-2. Paxillin colocalizes with cytohesin-2 at the leading edges of migrating cells...
  43. Kwak T, Kim H, Jung O, Lee S, Kang M, Kim H, et al. Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells. J Biol Chem. 2010;285:36021-31 pubmed publisher
    ..We found that paxillin, a key adaptor molecule in focal adhesions, could be modified by O-GlcNAc in INS-1 cells treated with GlcN and in ..
  44. Huang S, Hsu P, Chen M, Li W, More S, Lu K, et al. The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse. Int J Cancer. 2012;131:722-32 pubmed publisher
    ..The active phosphorylated form of FAK/Paxillin signaling pathway proteins and active form of RhoA were decreased...
  45. Zhao Y, Zhang X, Guda K, Lawrence E, Sun Q, Watanabe T, et al. Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proc Natl Acad Sci U S A. 2010;107:2592-7 pubmed publisher
    ..However, the cell signaling pathways regulated by PTPRT largely remain to be elucidated. Here, we show that paxillin is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin phosphorylation at tyrosine residue ..
  46. Downey C, Craig D, Basson M. Pressure activates colon cancer cell adhesion via paxillin phosphorylation, Crk, Cas, and Rac1. Cell Mol Life Sci. 2008;65:1446-57 pubmed publisher
    Physical forces can activate colon cancer cell adhesion, critical for metastasis. Paxillin is phosphorylated by FAK and required for pressure-stimulated adhesion...
  47. Chen L, Tu S, Huang C, Chen C, Ho C, Lin H, et al. Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through down-regulation of focal adhesion kinase and the paxillin-signaling pathway. Breast Cancer Res Treat. 2012;134:989-1004 pubmed publisher
    ..cell line MDA-MB-231 was accompanied by the increased phosphorylation of focal adhesion kinase at Tyr-576 and of paxillin at Tyr-118...
  48. Sharma A, Mayer B. Phosphorylation of p130Cas initiates Rac activation and membrane ruffling. BMC Cell Biol. 2008;9:50 pubmed publisher
    ..FIT-mediated tyrosine phosphorylation of NTK substrates p130Cas, paxillin and FAK and cortactin was observed at focal adhesions, while FIT-mediated phosphorylation of cortactin was also ..
  49. Gao W, Zhang C, Feng Y, Chen G, Wen S, Huangfu H, et al. Fascin-1, ezrin and paxillin contribute to the malignant progression and are predictors of clinical prognosis in laryngeal squamous cell carcinoma. PLoS ONE. 2012;7:e50710 pubmed publisher
    Fascin-1, ezrin and paxillin, cytoskeleton-associated proteins, have been implicated in several human cancers, but their role in laryngeal squamous cell carcinoma (LSCC) is unknown...
  50. Eskandarpour M, Huang F, Reeves K, Clark E, Hansson J. Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured in vitro. Int J Cancer. 2009;124:16-26 pubmed publisher
    ..of EphA2 (a receptor tyrosine kinase), uPAR (urokinase receptor) and cytoskeleton proteins such as leupaxin, paxillin and vinculin...
  51. Lu X, Sun W, Ge C, Zhang W, Fan Y. Contribution of the PI3K/MMPs/Ln-5?2 and EphA2/FAK/Paxillin signaling pathways to tumor growth and vasculogenic mimicry of gallbladder carcinomas. Int J Oncol. 2013;42:2103-15 pubmed publisher
    ..and CD31-PAS double staining), electron microscopy, expression of MMP-2, MT1-MMP, PI3K, Ln-5?2, EphA2, FAK and Paxillin-P proteins/mRNAs determined by SABC, ELISA, immunofluorescence, western blotting and qRT-PCR, respectively...
  52. Wei W, Li H, Li N, Sun H, Li Q, Shen X. WNT5A/JNK signaling regulates pancreatic cancer cells migration by Phosphorylating Paxillin. Pancreatology. 2013;13:384-92 pubmed publisher
    ..We detected the expressions of WNT5A, JNK1/p-JNK1 and Paxillin/p-Paxillin in cancer and the para-carcinoma tissues of pancreatic cancer...
  53. Ross S, Spanjaard E, Post A, Vliem M, Kristyanto H, Bos J, et al. Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation. PLoS ONE. 2012;7:e50072 pubmed publisher
    ..Under Src inhibited conditions, the characteristic Src-induced tyrosine phosphorylations of FAK and paxillin did not occur, but Rap1 could induce the formation of actomyosin-connected adhesions, which contained vinculin at ..