gamma subunit interferon stimulated gene factor 3


Summary: An interferon regulatory factor that recruits STAT1 PROTEIN and STAT2 PROTEIN heterodimers to interferon-stimulated response elements and functions as an immediate-early protein.

Top Publications

  1. Poat B, Hazari S, Chandra P, Gunduz F, Alvarez X, Balart L, et al. Intracellular expression of IRF9 Stat fusion protein overcomes the defective Jak-Stat signaling and inhibits HCV RNA replication. Virol J. 2010;7:265 pubmed publisher
  2. Lin L, Noyce R, Pham T, Wilson J, Sisson G, Michalak T, et al. Replication of subgenomic hepatitis C virus replicons in mouse fibroblasts is facilitated by deletion of interferon regulatory factor 3 and expression of liver-specific microRNA 122. J Virol. 2010;84:9170-80 pubmed publisher
    ..miR-122 and IRF-3 are independent host factors that are capable of influencing HCV replication, and our findings could help to establish mouse models and other cell systems that support HCV growth and particle formation. ..
  3. Lou Y, Pan X, Jia P, Li D, Xiao S, Zhang Z, et al. IRF-9/STAT2 [corrected] functional interaction drives retinoic acid-induced gene G expression independently of STAT1. Cancer Res. 2009;69:3673-80 pubmed publisher
  4. Russell Harde D, Wagner T, Rani M, Vogel D, Colamonici O, Ransohoff R, et al. Role of the intracellular domain of the human type I interferon receptor 2 chain (IFNAR2c) in interferon signaling. Expression of IFNAR2c truncation mutants in U5A cells. J Biol Chem. 2000;275:23981-5 pubmed
    ..In addition, human and murine cells appear to require different regions of the cytoplasmic domain of IFNAR2c for regulation of IFN responses. ..
  5. Tsuno T, Mejido J, Zhao T, Schmeisser H, Morrow A, Zoon K. IRF9 is a key factor for eliciting the antiproliferative activity of IFN-alpha. J Immunother. 2009;32:803-16 pubmed publisher
    ..Thus, this study suggests that IRF9 is the key factor for eliciting the antiproliferative activity of IFN-alpha and TRAIL may be one of the potential mediators. ..
  6. Rani M, Croze E, Wei T, Shrock J, Josyula A, Kalvakolanu D, et al. STAT-phosphorylation-independent induction of interferon regulatory factor-9 by interferon-beta. J Interferon Cytokine Res. 2010;30:163-70 pubmed publisher
    ..These studies provide the first evidence that signaling pathways leading to gene transcription are activated by IFN-beta independent of STAT phosphorylation. ..
  7. Maiwald T, Schneider A, Busch H, Sahle S, Gretz N, Weiss T, et al. Combining theoretical analysis and experimental data generation reveals IRF9 as a crucial factor for accelerating interferon ?-induced early antiviral signalling. FEBS J. 2010;277:4741-54 pubmed publisher
    ..Thus, the amount of cellular IRF9 is a crucial determinant for amplification of early dynamics of IFN?-mediated signal transduction. ..
  8. Hofer M, Li W, Lim S, Campbell I. The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9. J Neurosci. 2010;30:1149-57 pubmed publisher
  9. Shah K, Stewart S, Wei W, Woodman C, O Neil J, Dawson C, et al. The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation. Oncogene. 2009;28:3903-14 pubmed publisher
    ..This function may form part of EBV's strategy to limit anti-viral responses and define a novel function for LMP2A and LMP2B in modulating signalling from receptors that participate in innate immune responses...

More Information


  1. Kamei Y, Suganami T, Ehara T, Kanai S, Hayashi K, Yamamoto Y, et al. Increased expression of DNA methyltransferase 3a in obese adipose tissue: studies with transgenic mice. Obesity (Silver Spring). 2010;18:314-21 pubmed publisher
    ..The data highlight the potential role of Dnmt3a in the adult tissue as well as in the developing embryo and cancer. ..
  2. Bisson S, Page A, Ganem D. A Kaposi's sarcoma-associated herpesvirus protein that forms inhibitory complexes with type I interferon receptor subunits, Jak and STAT proteins, and blocks interferon-mediated signal transduction. J Virol. 2009;83:5056-66 pubmed publisher
    ..The presence in the viral genome of potent inhibitors of type I IFN signaling, along with several viral genes that block IFN induction, highlights the importance of the IFN pathway in the control of this human tumor virus infection...
  3. Chessa B, Pittau M, Puricelli M, Zobba R, Coradduzza E, Dall ara P, et al. Genetic immunization with the immunodominant antigen P48 of Mycoplasma agalactiae stimulates a mixed adaptive immune response in BALBc mice. Res Vet Sci. 2009;86:414-20 pubmed publisher
    ..Nucleic acid immunization could be a new strategy against M. agalactiae infections and may be potentially used to develop vaccines for other Mycoplasma diseases...
  4. Molle C, Goldman M, Goriely S. Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process. J Immunol. 2010;184:1784-92 pubmed publisher
    ..These results highlight the complex molecular interplay between TLRs and type I IFNs for the control of IL-27 synthesis. ..
  5. Zhong B, Zhang L, Lei C, Li Y, Mao A, Yang Y, et al. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity. 2009;30:397-407 pubmed publisher
    ..These findings suggest that RNF5 negatively regulates virus-triggered signaling by targeting MITA for ubiquitination and degradation at the mitochondria. ..
  6. Tan K, Chen Y, Lim Y, Tan G, Liu Y, Lim Y, et al. Suppression of host innate immune response by Burkholderia pseudomallei through the virulence factor TssM. J Immunol. 2010;184:5160-71 pubmed publisher
    ..Abs to TssM can be detected in the sera of melioidosis patients, indicating that TssM is functionally expressed in vivo and thus could contribute to bacterial pathogenesis in human melioidosis...
  7. Watanabe T, Asano N, Fichtner Feigl S, Gorelick P, Tsuji Y, Matsumoto Y, et al. NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. J Clin Invest. 2010;120:1645-62 pubmed publisher
    ..pylori and possibly other mucosal infections. ..
  8. Jaworska J, Gravel A, Flamand L. Divergent susceptibilities of human herpesvirus 6 variants to type I interferons. Proc Natl Acad Sci U S A. 2010;107:8369-74 pubmed publisher
    ..Our work is unique in demonstrating type I IFN signaling defects in HHV-6B-infected cells and highlights a major biological difference between HHV-6 variants...
  9. De Marchis M, Ballarino M, Salvatori B, Puzzolo M, Bozzoni I, Fatica A. A new molecular network comprising PU.1, interferon regulatory factor proteins and miR-342 stimulates ATRA-mediated granulocytic differentiation of acute promyelocytic leukemia cells. Leukemia. 2009;23:856-62 pubmed publisher
    ..Moreover, we showed that enforced expression of miR-342 in APL cells stimulated ATRA-induced differentiation. These data identified miR-342 as a new player in the granulocytic differentiation program activated by ATRA in APL. ..