Genomes and Genes


alpha subunit interferon stimulated gene factor 3


Summary: A heterodimeric complex of STAT1 PROTEIN and STAT2 PROTEIN that interacts with ISGF3GAMMA and is a subunit of the ISGF3 COMPLEX.

Top Publications

  1. Flammer J, Dobrovolna J, Kennedy M, Chinenov Y, Glass C, Ivashkiv L, et al. The type I interferon signaling pathway is a target for glucocorticoid inhibition. Mol Cell Biol. 2010;30:4564-74 pubmed publisher
    ..Thus, type I IFN is a cytokine uniquely controlled by GR at the levels of not only production but also signaling through antagonism with the ISGF3 effector function, revealing a novel facet of the immunosuppressive properties of GCs. ..