interferon stimulated gene factor 3


Summary: A multimeric complex that functions as a ligand-dependent transcription factor. ISGF3 is assembled in the CYTOPLASM and translocated to the CELL NUCLEUS in response to INTERFERON signaling. It consists of ISGF3-GAMMA and ISGF3-ALPHA, and it regulates expression of many interferon-responsive GENES.

Top Publications

  1. Tsuno T, Mejido J, Zhao T, Schmeisser H, Morrow A, Zoon K. IRF9 is a key factor for eliciting the antiproliferative activity of IFN-alpha. J Immunother. 2009;32:803-16 pubmed publisher
    ..Thus, this study suggests that IRF9 is the key factor for eliciting the antiproliferative activity of IFN-alpha and TRAIL may be one of the potential mediators. ..
  2. van Boxel Dezaire A, Zula J, Xu Y, Ransohoff R, Jacobberger J, Stark G. Major differences in the responses of primary human leukocyte subsets to IFN-beta. J Immunol. 2010;185:5888-99 pubmed publisher
  3. Abu Dayyeh I, Hassani K, Westra E, Mottram J, Olivier M. Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signaling and functions. Infect Immun. 2010;78:2438-45 pubmed publisher
  4. Axtell R, de Jong B, Boniface K, van der Voort L, Bhat R, De Sarno P, et al. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med. 2010;16:406-12 pubmed publisher
    ..Hence, IFN-beta is proinflammatory in T(H)17-induced EAE. Moreover, a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFN-beta. ..
  5. Huang Y, Sook Kim M, Ratovitski E. Midkine promotes tetraspanin-integrin interaction and induces FAK-Stat1alpha pathway contributing to migration/invasiveness of human head and neck squamous cell carcinoma cells. Biochem Biophys Res Commun. 2008;377:474-478 pubmed publisher
    ..The major finding of this study is a novel MK-triggered signaling mechanism implicated in migration and invasiveness of HNSCC cells. ..
  6. Wegert M, La Monica N, Tripodi M, Adler G, Dikopoulos N. Impaired interferon type I signalling in the liver modulates the hepatic acute phase response in hepatitis C virus transgenic mice. J Hepatol. 2009;51:271-8 pubmed publisher
    ..Besides antiviral defence mechanisms, interruption of IFN type I signalling by HCV modulates the APR which is aimed at a variety of pathogens. ..
  7. Frey K, Ahmed C, Dabelic R, Jager L, Noon Song E, Haider S, et al. HSV-1-induced SOCS-1 expression in keratinocytes: use of a SOCS-1 antagonist to block a novel mechanism of viral immune evasion. J Immunol. 2009;183:1253-62 pubmed publisher
    ..The use of SOCS-1 antagonist to abrogate this refractiveness could have a transformational effect on therapy against viral infections. ..
  8. Zhao H, Boije H, Granberg F, Pettersson U, Svensson C. Activation of the interferon-induced STAT pathway during an adenovirus type 12 infection. Virology. 2009;392:186-95 pubmed publisher
    ..Significantly, none of these ISGs was activated in Ad2 infected IMR90 cells. Thus, the inability of Ad12 to evade the interferon response might explain its restricted virulence. ..
  9. Sherry B. Rotavirus and reovirus modulation of the interferon response. J Interferon Cytokine Res. 2009;29:559-67 pubmed publisher
    ..In sum, members of the family Reoviridae have evolved a variety of mechanisms to subvert the host's innate protective response. ..

More Information


  1. Farlik M, Reutterer B, Schindler C, Greten F, Vogl C, Muller M, et al. Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Immunity. 2010;33:25-34 pubmed publisher
    ..Thus, STATs and NF-kappaB cooperate through pol II promoter recruitment and the phosphorylation of its CTD, respectively, as a prerequisite for productive elongation of iNOS mRNA. ..
  2. Choudhry N, Korbel D, Edwards L, Bajaj Elliott M, McDonald V. Dysregulation of interferon-gamma-mediated signalling pathway in intestinal epithelial cells by Cryptosporidium parvum infection. Cell Microbiol. 2009;11:1354-64 pubmed publisher
    ..These findings indicate C. parvum interferes with IFN-gamma-dependent gene expression in enterocytes and suggest this activity could be a novel immuno-evasive strategy employed by the parasite. ..
  3. Russell Harde D, Wagner T, Rani M, Vogel D, Colamonici O, Ransohoff R, et al. Role of the intracellular domain of the human type I interferon receptor 2 chain (IFNAR2c) in interferon signaling. Expression of IFNAR2c truncation mutants in U5A cells. J Biol Chem. 2000;275:23981-5 pubmed
    ..In addition, human and murine cells appear to require different regions of the cytoplasmic domain of IFNAR2c for regulation of IFN responses. ..
  4. Schmidt N, Pautz A, Art J, Rauschkolb P, Jung M, Erkel G, et al. Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes. Biochem Pharmacol. 2010;79:722-32 pubmed publisher
    ..In summary, we demonstrate for the first time that differentiated human immortalized C-28/I2 chondrocytes are a representative cell culture model to investigate iNOS gene expression in human joint diseases. ..
  5. Bingfa X, Qinglin F, Hui H, Canjun W, Wei W, Lihua S. Anti-hepatitis B virus activity and mechanisms of recombinant human serum albumin-interferon-alpha-2b fusion protein in vitro and in vivo. Pharmacology. 2009;83:323-32 pubmed publisher
    ..The anti-HBV mechanism probably operates by triggering the JAK-STAT signaling pathway and increasing the expression of OAS1. ..
  6. Watanabe T, Asano N, Fichtner Feigl S, Gorelick P, Tsuji Y, Matsumoto Y, et al. NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. J Clin Invest. 2010;120:1645-62 pubmed publisher
    ..pylori and possibly other mucosal infections. ..
  7. Matte C, Descoteaux A. Leishmania donovani amastigotes impair gamma interferon-induced STAT1alpha nuclear translocation by blocking the interaction between STAT1alpha and importin-alpha5. Infect Immun. 2010;78:3736-43 pubmed publisher
    ..donovani amastigotes to interfere with IFN-gamma-activated macrophage functions and provide a better understanding of the strategies deployed by this parasite to ensure its intracellular survival. ..
  8. Patel D, Nan Y, Shen M, Ritthipichai K, Zhu X, Zhang Y. Porcine reproductive and respiratory syndrome virus inhibits type I interferon signaling by blocking STAT1/STAT2 nuclear translocation. J Virol. 2010;84:11045-55 pubmed publisher
    ..These findings suggest that PRRSV interferes with the activation and signaling pathway of type I IFNs by blocking ISG factor 3 (ISGF3) nuclear translocation...
  9. Lee S, Qin H, Benveniste E. The IFN-gamma-induced transcriptional program of the CIITA gene is inhibited by statins. Eur J Immunol. 2008;38:2325-36 pubmed publisher
    ..The recruitment of USF-1 to CIITA pIV is also reduced by statins, as is the recruitment of RNA polymerase II (Pol II), p300 and Brg-1. These data indicate that statins inhibit the transcriptional program of the CIITA gene. ..