dishevelled proteins


Summary: A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.

Top Publications

  1. Lei Y, Zhang T, Li H, Wu B, Jin L, Wang H. VANGL2 mutations in human cranial neural-tube defects. N Engl J Med. 2010;362:2232-5 pubmed publisher
  2. Wald J, Hatakeyama J, Printsev I, Cuevas A, Fry W, Saldana M, et al. Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Oncogene. 2017;36:5158-5167 pubmed publisher
    ..We propose that the upregulation of core PCP components, together with the loss of the key negative regulator Nrdp1, act coordinately to promote GBM invasiveness and malignancy. ..
  3. Rauschenberger V, Bernkopf D, Krenn S, Jalal K, Heller J, Behrens J, et al. The phosphatase Pgam5 antagonizes Wnt/?-Catenin signaling in embryonic anterior-posterior axis patterning. Development. 2017;144:2234-2247 pubmed publisher
  4. Lee S, Seo S, Lee D, Pi L, Lee W, Choi K. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis. J Invest Dermatol. 2017;137:2260-2269 pubmed publisher
    ..Overall, these findings suggest that the CXXC5-Dishevelled interaction is a potential target for the treatment of hair loss. ..
  5. Roarty K, Pfefferle A, Creighton C, Perou C, Rosen J. Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression. Oncogene. 2017;36:5958-5968 pubmed publisher
  6. Pecina Slaus N, Kafka A, Bukovac A, Vladusić T, Tomas D, Hrascan R. Genetic changes of MLH1 and MSH2 genes could explain constant findings on microsatellite instability in intracranial meningioma. Tumour Biol. 2017;39:1010428317705791 pubmed publisher
    ..14; p?=?0.01). Our study contributes to better understanding of the genetic profile of human intracranial meningiomas and suggests that meningiomas harbor defective cellular DNA mismatch repair mechanisms. ..
  7. Yuan H, Li N, Fu D, Ren J, Hui J, Peng J, et al. Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis. J Clin Invest. 2017;127:3375-3391 pubmed publisher
    ..Together, our studies highlight SETD2 as an integral regulator of Wnt signaling through epigenetic regulation of RNA processing during tissue regeneration and tumorigenesis. ..
  8. Lee H, Wang N, Shi D, Zheng J. Sulindac inhibits canonical Wnt signaling by blocking the PDZ domain of the protein Dishevelled. Angew Chem Int Ed Engl. 2009;48:6448-52 pubmed publisher
  9. Han Q, Lin X, Zhang X, Jiang G, Zhang Y, Miao Y, et al. WWC3 regulates the Wnt and Hippo pathways via Dishevelled proteins and large tumour suppressor 1, to suppress lung cancer invasion and metastasis. J Pathol. 2017;242:435-447 pubmed publisher
    ..Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..