olfactory marker protein

Summary

Summary: A ubiquitous, cytoplasmic protein found in mature OLFACTORY RECEPTOR NEURONS of all VERTEBRATES. It is a modulator of the olfactory SIGNAL TRANSDUCTION PATHWAY.

Top Publications

  1. Czarnecki L, Moberly A, Rubinstein T, Turkel D, Pottackal J, McGann J. In vivo visualization of olfactory pathophysiology induced by intranasal cadmium instillation in mice. Neurotoxicology. 2011;32:441-9 pubmed publisher
    ..epithelium could be quantified by their expression of a genetically encoded fluorescent marker for olfactory marker protein. At the highest dose tested, cadmium exposure reduced the density of these projections by 20%...
  2. Moberly A, Czarnecki L, Pottackal J, Rubinstein T, Turkel D, Kass M, et al. Intranasal exposure to manganese disrupts neurotransmitter release from glutamatergic synapses in the central nervous system in vivo. Neurotoxicology. 2012;33:996-1004 pubmed publisher
  3. Levai O, Strotmann J. Projection pattern of nerve fibers from the septal organ: DiI-tracing studies with transgenic OMP mice. Histochem Cell Biol. 2003;120:483-92 pubmed
    ..Another significant portion of the axons targets a few glomeruli which appear to receive input exclusively from the septal organ neurons. ..
  4. Kass M, Moberly A, Rosenthal M, Guang S, McGann J. Odor-specific, olfactory marker protein-mediated sparsening of primary olfactory input to the brain after odor exposure. J Neurosci. 2013;33:6594-602 pubmed publisher
    ..In animals heterozygous for the olfactory marker protein (OMP), this adaptive plasticity was strongest in the populations of OSNs that originally responded to the ..
  5. Matsuoka M, Osada T, Yoshida Matsuoka J, Ikai A, Ichikawa M, Norita M, et al. A comparative immunocytochemical study of development and regeneration of chemosensory neurons in the rat vomeronasal system. Brain Res. 2002;946:52-63 pubmed
    ..This failure to reestablish connections with target cells in the AOB could explain why OMP-positive cells were rarely observed among the regenerated cells in the vomeronasal epithelium. ..
  6. Youngentob S, Pyrski M, Margolis F. Adenoviral vector-mediated rescue of the OMP-null behavioral phenotype: enhancement of odorant threshold sensitivity. Behav Neurosci. 2004;118:636-42 pubmed
    Mice from which the olfactory marker protein (OMP) gene has been deleted demonstrate a number of neurophysiologic and behavioral defects that suggest OMP is an important component in olfactory signal transduction and is critically ..
  7. Youngentob S, Margolis F, Youngentob L. OMP gene deletion results in an alteration in odorant quality perception. Behav Neurosci. 2001;115:626-31 pubmed
    To test the hypothesis that odorant quality perception is altered in olfactory marker protein (OMP)-null mice, we trained and tested adult OMP-null and control mice, using a 5-odorant identification confusion matrix task (animal odorant ..
  8. Koo J, Gill S, Pannell L, Menco B, Margolis J, Margolis F. The interaction of Bex and OMP reveals a dimer of OMP with a short half-life. J Neurochem. 2004;90:102-16 pubmed
    b>Olfactory marker protein (OMP) participates in the olfactory signal transduction pathway...
  9. Fleischer J, Hass N, Schwarzenbacher K, Besser S, Breer H. A novel population of neuronal cells expressing the olfactory marker protein (OMP) in the anterior/dorsal region of the nasal cavity. Histochem Cell Biol. 2006;125:337-49 pubmed
    The olfactory marker protein (OMP) is expressed in mature chemosensory neurons in the nasal neuroepithelium...

More Information

Publications62

  1. Minovi A, Witt M, Prescher A, Gudziol V, Dazert S, Hatt H, et al. Expression and distribution of the intermediate filament protein nestin and other stem cell related molecules in the human olfactory epithelium. Histol Histopathol. 2010;25:177-87 pubmed publisher
    ..These observations emphasize an essential role of nestin for the process of regeneration, and also highlight this factor as a candidate marker for sustentacular cells in the human olfactory epithelium. ..
  2. Nunzi M, Grillo M, Margolis F, Mugnaini E. Compartmental organization of Purkinje cells in the mature and developing mouse cerebellum as revealed by an olfactory marker protein-lacZ transgene. J Comp Neurol. 1999;404:97-113 pubmed
    In a line of transgenic mice (HpY-1), the pattern of expression of an olfactory marker protein (OMP)-lacZ fusion gene was analyzed in the cerebellum, where, in adult mice, OMP-lacZ was expressed primarily in Purkinje cells (PCs) of the ..
  3. Kondo K, Suzukawa K, Sakamoto T, Watanabe K, Kanaya K, Ushio M, et al. Age-related changes in cell dynamics of the postnatal mouse olfactory neuroepithelium: cell proliferation, neuronal differentiation, and cell death. J Comp Neurol. 2010;518:1962-75 pubmed publisher
    ..from 2 hours to 3 months after the injection and examined using double immunostaining for BrdU and olfactory marker protein (OMP), and double staining with terminal deoxynucleotidyl transferase-mediated biotinylated dUTP nick end ..
  4. Buiakova O, Baker H, Scott J, Farbman A, Kream R, Grillo M, et al. Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons. Proc Natl Acad Sci U S A. 1996;93:9858-63 pubmed
    b>Olfactory marker protein (OMP) is an abundant, phylogentically conserved, cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons...
  5. Rogers K, Dasgupta P, Gubler U, Grillo M, Khew Goodall Y, Margolis F. Molecular cloning and sequencing of a cDNA for olfactory marker protein. Proc Natl Acad Sci U S A. 1987;84:1704-8 pubmed
    cDNA clones corresponding to mRNA for rat olfactory marker protein (OMP) were isolated from a cDNA library...
  6. Buron G, Hacquemand R, Pourie G, Brand G. Carbon dioxide effects on olfactory functioning: behavioral, histological and immunohistochemical measurements. Toxicol Lett. 2009;188:251-7 pubmed publisher
    ..Thirdly, immunohistochemical quantification of olfactory marker protein (OMP)- and proliferating cell nuclear antigen (PCNA)-positive cells revealed that the number of mature ..
  7. Kondo K, Watanabe K, Sakamoto T, Suzukawa K, Nibu K, Kaga K, et al. Distribution and severity of spontaneous lesions in the neuroepithelium and Bowman's glands in mouse olfactory mucosa: age-related progression. Cell Tissue Res. 2009;335:489-503 pubmed publisher
    ..and eosin staining, high-iron diamine-Alcian blue (HID-AB) staining, and immunohistochemistry for olfactory marker protein (OMP), betaIII tubulin (betaIIIT), and Ki67...
  8. Ferrando S, Bottaro M, Gallus L, Girosi L, Vacchi M, Tagliafierro G. First detection of olfactory marker protein (OMP) immunoreactivity in the olfactory epithelium of a cartilaginous fish. Neurosci Lett. 2007;413:173-6 pubmed
    b>Olfactory marker protein (OMP) is a protein expressed in the mature olfactory and vomeronasal neurons of many vertebrates, such as mammals, amphibians and bony fishes...
  9. Waguespack A, Reems M, Butman M, Cherry J, Coppola D. Naris occlusion alters olfactory marker protein immunoreactivity in olfactory epithelium. Brain Res. 2005;1044:1-7 pubmed
    Though its function remains obscure, olfactory marker protein (OMP) has been implicated in olfactory transduction and the enhancement of neurogenesis within olfactory epithelium...
  10. Dhawale A, Hagiwara A, Bhalla U, Murthy V, Albeanu D. Non-redundant odor coding by sister mitral cells revealed by light addressable glomeruli in the mouse. Nat Neurosci. 2010;13:1404-12 pubmed publisher
  11. Bozza T, McGann J, Mombaerts P, Wachowiak M. In vivo imaging of neuronal activity by targeted expression of a genetically encoded probe in the mouse. Neuron. 2004;42:9-21 pubmed
    ..Targeted expression of synapto-pHluorin in mouse will permit the analysis of previously inaccessible neuronal populations and chronic imaging from genetically identified neurons in vivo. ..
  12. Kishida T, Thewissen J. Evolutionary changes of the importance of olfaction in cetaceans based on the olfactory marker protein gene. Gene. 2012;492:349-53 pubmed publisher
    ..The olfactory marker protein (OMP) is almost exclusively expressed in vertebrate olfactory receptor neurons, and is considered to play ..
  13. Danciger E, Mettling C, Vidal M, Morris R, Margolis F. Olfactory marker protein gene: its structure and olfactory neuron-specific expression in transgenic mice. Proc Natl Acad Sci U S A. 1989;86:8565-9 pubmed
    b>Olfactory marker protein (OMP) genomic clones were isolated from a Charon 4A phage lambda rat genomic library. A 16.5-kilobase (kb) fragment of the rat genome containing the gene was isolated and characterized...
  14. Behrens M, Margolis J, Margolis F. Identification of members of the Bex gene family as olfactory marker protein (OMP) binding partners. J Neurochem. 2003;86:1289-96 pubmed
    b>Olfactory marker protein (OMP) expression is a hallmark of mature vertebrate olfactory receptor neurons (ORNs). Evidence for OMP function derives from altered behavioral and electrophysiological activities of OMP-KO mice...
  15. Baldisseri D, Margolis J, Weber D, Koo J, Margolis F. Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction. J Mol Biol. 2002;319:823-37 pubmed
    b>Olfactory marker protein (OMP) is a ubiquitous, cytoplasmic protein found in mature olfactory receptor neurons of all vertebrates...
  16. Buiakova O, Krishna N, Getchell T, Margolis F. Human and rodent OMP genes: conservation of structural and regulatory motifs and cellular localization. Genomics. 1994;20:452-62 pubmed
    Immunocytochemical analysis has demonstrated that expression of the olfactory marker protein (OMP) is highly restricted to mature olfactory receptor neurons in virtually all vertebrate species from fish to man...
  17. Lee A, He J, Ma M. Olfactory marker protein is critical for functional maturation of olfactory sensory neurons and development of mother preference. J Neurosci. 2011;31:2974-82 pubmed publisher
    ..Remarkably, these changes are prevented by genetic ablation of olfactory marker protein (OMP), which is exclusively expressed in mature OSNs...
  18. Ivic L, Pyrski M, Margolis J, Richards L, Firestein S, Margolis F. Adenoviral vector-mediated rescue of the OMP-null phenotype in vivo. Nat Neurosci. 2000;3:1113-20 pubmed
    ..Here we used an adenoviral vector to replace the olfactory marker protein (OMP) gene in olfactory receptor neurons of adult OMP-null mice and demonstrated the subsequent re-..
  19. Hao S, Yu F, Yan A, Zhang Y, Han J, Jiang X. In utero and lactational lanthanum exposure induces olfactory dysfunction associated with downregulation of ?III-tubulin and olfactory marker protein in young rats. Biol Trace Elem Res. 2012;148:383-91 pubmed publisher
    ..The expression of ?III-tubulin and olfactory marker protein (OMP) in the tissue sections and homogenates of OE were, respectively, measured by immunodetection and ..
  20. Koo J, Saraswati M, Margolis F. Immunolocalization of Bex protein in the mouse brain and olfactory system. J Comp Neurol. 2005;487:1-14 pubmed
    ..Bex1 and 2 have been characterized as interacting partners of the olfactory marker protein (OMP)...
  21. Behrens M, Venkatraman G, Gronostajski R, Reed R, Margolis F. NFI in the development of the olfactory neuroepithelium and the regulation of olfactory marker protein gene expression. Eur J Neurosci. 2000;12:1372-84 pubmed
    ..experiments in HEK 293 cells using constructs that place luciferase expression under the control of an olfactory marker protein (OMP)-promoter fragment containing the NFI binding site...
  22. Wright N, Margolis J, Margolis F, Weber D. Refinement of the solution structure of rat olfactory marker protein (OMP). J Biomol NMR. 2005;33:63-8 pubmed
  23. Griff E, Greer C, Margolis F, Ennis M, Shipley M. Ultrastructural characteristics and conduction velocity of olfactory receptor neuron axons in the olfactory marker protein-null mouse. Brain Res. 2000;866:227-36 pubmed
    ..diameters and the conduction velocity of the compound action potential along ORN axons were studied in olfactory marker protein (OMP)-null mice and genotypically matched controls...
  24. Youngentob S, Kent P, Margolis F. OMP gene deletion results in an alteration in odorant-induced mucosal activity patterns. J Neurophysiol. 2003;90:3864-73 pubmed
    Previous behavioral work, using a complex five-odorant identification task, demonstrated that olfactory marker protein (OMP) is critically involved in odor processing to the extent that its loss results in an alteration in odorant quality ..
  25. Leung C, Coulombe P, Reed R. Contribution of olfactory neural stem cells to tissue maintenance and regeneration. Nat Neurosci. 2007;10:720-6 pubmed
    ..Our data support a new model of adult neurogenesis in which distinct cell populations mediate normal neuronal turnover and neuronal replacement upon traumatic injury. ..
  26. Youngentob S, Margolis F. OMP gene deletion causes an elevation in behavioral threshold sensitivity. Neuroreport. 1999;10:15-9 pubmed
    ..01 x 10(-8) vs 1.06 x 10(-5), respectively; t=4.09, p=0.015). These in vivo behavioral results provide support for the hypothesis that OMP plays a modulatory role in the odor detection/signal transduction process. ..
  27. Kwon H, Koo J, Zufall F, Leinders Zufall T, Margolis F. Ca extrusion by NCX is compromised in olfactory sensory neurons of OMP mice. PLoS ONE. 2009;4:e4260 pubmed publisher
    The role of olfactory marker protein (OMP), a hallmark of mature olfactory sensory neurons (OSNs), has been poorly understood since its discovery...
  28. Buron G, Hacquemand R, Pourie G, Brand G. Inhalation exposure to acetone induces selective damage on olfactory neuroepithelium in mice. Neurotoxicology. 2009;30:114-20 pubmed publisher
    ..Finally, different markers, olfactory marker protein (OMP) and proliferating cell nuclear antigen (PCNA), were used to characterize respectively olfactory ..
  29. Reisert J, Yau K, Margolis F. Olfactory marker protein modulates the cAMP kinetics of the odour-induced response in cilia of mouse olfactory receptor neurons. J Physiol. 2007;585:731-40 pubmed
    b>Olfactory marker protein (OMP), a phylogenetically conserved protein, is highly, and almost exclusively, expressed in vertebrate olfactory receptor neurons (ORNs)...
  30. Smith P, Firestein S, Hunt J. The crystal structure of the olfactory marker protein at 2.3 A resolution. J Mol Biol. 2002;319:807-21 pubmed
    b>Olfactory marker protein (OMP) is a highly expressed and phylogenetically conserved cytoplasmic protein of unknown function found almost exclusively in mature olfactory sensory neurons...
  31. Sydor W, Teitelbaum Z, Blacher R, Sun S, Benz W, Margolis F. Amino acid sequence of a unique neuronal protein: rat olfactory marker protein. Arch Biochem Biophys. 1986;249:351-62 pubmed
    A neuron-specific protein, the olfactory marker protein (OMP), has been sequenced. This was achieved by gas phase sequencing of peptides isolated by HPLC following chemical and enzymatic cleavages of the intact rat protein...
  32. Gitti R, Wright N, Margolis J, Varney K, Weber D, Margolis F. Backbone dynamics of the olfactory marker protein as studied by 15N NMR relaxation measurements. Biochemistry. 2005;44:9673-9 pubmed
    Nuclear magnetic resonance (NMR) (15)N relaxation measurements of the olfactory marker protein (OMP) including longitudinal relaxation (T(1)), transverse relaxation (T(2)), and (15)N-{(1)H} NOE data were collected at low protein ..
  33. St John J, Key B. Olfactory marker protein modulates primary olfactory axon overshooting in the olfactory bulb. J Comp Neurol. 2005;488:61-9 pubmed
    b>Olfactory marker protein (OMP) is expressed by mature primary olfactory sensory neurons during development and in adult mice...
  34. Farbman A, Buchholz J, Walters E, Margolis F. Does olfactory marker protein participate in olfactory neurogenesis?. Ann N Y Acad Sci. 1998;855:248-51 pubmed
    b>Olfactory marker protein (OMP) is a phylogenetically conserved, 19-kDa, acidic, soluble protein found abundantly in mature olfactory sensory neurons...
  35. Hagendorf S, Fluegge D, Engelhardt C, Spehr M. Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels. J Neurosci. 2009;29:206-21 pubmed publisher
    ..This novel mechanism of homeostatic plasticity in the periphery of the accessory olfactory system is ideally suited to adjust VNO neurons to a target output range in a layer-specific and use-dependent manner...
  36. Hughes I, Thalmann I, Thalmann R, Ornitz D. Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development. Brain Res. 2006;1091:58-74 pubmed
  37. Alenius M, Bohm S. Differential function of RNCAM isoforms in precise target selection of olfactory sensory neurons. Development. 2003;130:917-27 pubmed
    ..The phenotype specific for Gpi-anchored RNCAM is suppressed in mice overexpressing both isoforms, which suggests that two distinct RNCAM isoform-dependent activities influence segregation of OR-defined axon subclasses. ..
  38. Ubink R, Hokfelt T. Expression of neuropeptide Y in olfactory ensheathing cells during prenatal development. J Comp Neurol. 2000;423:13-25 pubmed
    ..NPY expression was compared with the expression of growth associated protein-43, olfactory marker protein, the low-affinity nerve growth factor receptor (p75) and S-100, factors expressed in the olfactory system ..
  39. Kato H, Chu M, Isaacson J, Komiyama T. Dynamic sensory representations in the olfactory bulb: modulation by wakefulness and experience. Neuron. 2012;76:962-75 pubmed publisher
    ..Together, our results demonstrate the dynamic nature of mitral cell odor representations in awake animals, which is constantly shaped by recent odor experience. ..
  40. Steward O, Sharp K, Selvan G, Hadden A, Hofstadter M, Au E, et al. A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats. Exp Neurol. 2006;198:483-99 pubmed
    ..Our results indicate that, although OLP transplants may stimulate regeneration under some circumstances, the effect is not so robust as to reliably overcome the hostile setting created by a complete transection paradigm. ..
  41. Rogers K, Grillo M, Sydor W, Poonian M, Margolis F. Olfactory neuron-specific protein is translated from a large poly(A)+ mRNA. Proc Natl Acad Sci U S A. 1985;82:5218-22 pubmed
    ..b>Olfactory marker protein (OMP) of Mr 18,500 was faithfully produced by this system upon addition of mucosal mRNA...
  42. Vargas G, Lucero M. A method for maintaining odor-responsive adult rat olfactory receptor neurons in short-term culture. Chem Senses. 1999;24:211-6 pubmed
    ..The cultured neurons exhibit typical voltage-gated currents and are responsive to application of odorants. ..
  43. Rössler P, Mezler M, Breer H. Two olfactory marker proteins in Xenopus laevis. J Comp Neurol. 1998;395:273-80 pubmed
    Mature olfactory receptor neurons of mammals are characterized by the expression of the highly conserved olfactory marker protein (OMP) encoded by single copy genes...
  44. Yee K, Rawson N. Immunolocalization of retinoic acid receptors in the mammalian olfactory system and the effects of olfactory denervation on receptor distribution. Neuroscience. 2005;131:733-43 pubmed
  45. Schmid A, Pyrski M, Biel M, Leinders Zufall T, Zufall F. Grueneberg ganglion neurons are finely tuned cold sensors. J Neurosci. 2010;30:7563-8 pubmed publisher
    ..These findings establish the Grueneberg ganglion as a sensory organ mediating cold-evoked neural responses, possibly in conjunction with the sensing of other stress- or fear-related chemical social cues. ..
  46. Scolnick J, Cui K, Duggan C, Xuan S, Yuan X, Efstratiadis A, et al. Role of IGF signaling in olfactory sensory map formation and axon guidance. Neuron. 2008;57:847-57 pubmed publisher
    ..Using primary cultures of olfactory and cerebellar neurons, we further show that IGF is a chemoattractant for axon growth cones. Together these observations reveal a role of IGF signaling in sensory map formation and axon guidance. ..
  47. Sriram K, Lin G, Jefferson A, Goldsmith W, Jackson M, McKinney W, et al. Neurotoxicity following acute inhalation exposure to the oil dispersant COREXIT EC9500A. J Toxicol Environ Health A. 2011;74:1405-18 pubmed publisher
    ..Exposure to CE produced partial loss of olfactory marker protein in the olfactory bulb. CE also reduced tyrosine hydroxylase protein content in the striatum...
  48. Yazinski S, Gomez G. Time course of structural and functional maturation of human olfactory epithelial cells in vitro. J Neurosci Res. 2014;92:64-73 pubmed publisher
    ..mature olfactory neurons in vitro attain a unique "phase-bright" morphology and express the olfactory marker protein (OMP)...
  49. Nishizaki K, Yoshinobu J, Tsujigiwa H, Orita Y, Yamada M. The early administration of granulocyte colony-stimulating factor increases the engraftment of transplanted bone marrow-derived cells into the olfactory epithelium damaged by methimazole. Rhinology. 2010;48:228-32 pubmed publisher
  50. Hass N, Haub H, Stevens R, Breer H, Schwarzenbacher K. Expression of adiponectin receptor 1 in olfactory mucosa of mice. Cell Tissue Res. 2008;334:187-97 pubmed publisher
    ..is expressed in mature sensory neurons of the olfactory mucosa of mice, in a pattern reminiscent of the olfactory marker protein. AdipoR1 expression levels in the olfactory mucosa have been observed to increase gradually during late ..
  51. Murayama E, Herbomel P, Kawakami A, Takeda H, Nagasawa H. Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae. Mech Dev. 2005;122:791-803 pubmed
  52. Min Y, Kim J, Hong S, Dhong H, Jarin P, Jin Y. Pathogenetic mechanism of olfactory cell injury after exposure to sulfur dioxide in mice. Laryngoscope. 2003;113:2157-62 pubmed
    ..In the neuroepithelium, where PCNA expression increased, olfactory marker protein (OMP)-positive cells were sparse...
  53. Johnson E. Immunocytochemical characteristics of cells and fibers in the nasal mucosa of young and adult macaques. Anat Rec. 2000;259:215-28 pubmed
    ..the immunolabeling characteristics of primate OM and RM for three important proteins-calretinin (CR), olfactory marker protein (OMP), and protein gene product 9.5 (PGP)...