nlr proteins


Summary: Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.

Top Publications

  1. Fan K, Ma J, Xiao W, Chen J, Wu J, Ren J, et al. Mangiferin attenuates blast-induced traumatic brain injury via inhibiting NLRP3 inflammasome. Chem Biol Interact. 2017;271:15-23 pubmed publisher
    ..Therefore, this research allows us to speculate that, for first time, NLRP3 is involved in the anti-inflammatory effect of mangiferin in the cerebral cortex, and mangiferin could be a potential therapy drug for bTBI. ..
  2. Trnovska J, Silhavy J, Kuda O, Landa V, Zidek V, Mlejnek P, et al. Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls. PLoS ONE. 2017;12:e0179063 pubmed publisher
    ..These findings suggest that salsalate has metabolic effects beyond suppressing inflammation. ..
  3. Cui X, Yan Q, Gan S, Xue D, Dou D, Guo N, et al. Overexpression of gma-miR1510a/b suppresses the expression of a NB-LRR domain gene and reduces resistance to Phytophthora sojae. Gene. 2017;621:32-39 pubmed publisher
    ..Collectively, the results obtained in the current study reveal that gma-miR1510 regulates the target NB-LRR immune receptor gene Glyma.16G135500 and thus plays a crucial role in regulating the resistance of soybean to P. sojae. ..
  4. Alvarez C, Ramírez Cepeda F, Santana P, Torres E, Cortes J, Guzman F, et al. Insights into the diversity of NOD-like receptors: Identification and expression analysis of NLRC3, NLRC5 and NLRX1 in rainbow trout. Mol Immunol. 2017;87:102-113 pubmed publisher
    ..Future studies will focus on gills which could be related with a key sensor mucosal system in one of the most environmentally fish exposed tissues. ..
  5. Agrawal S, Srivastava R, Rahmatpanah F, Madiraju C, BenMohamed L, Agrawal A. Airway epithelial cells enhance the immunogenicity of human myeloid dendritic cells under steady state. Clin Exp Immunol. 2017;189:279-289 pubmed publisher
    ..These results indicate that AECs prime mDCs to enhance their immunogenicity, which could be one of the mechanisms that compensates for the immunosuppressive mucosal environment. ..
  6. Huh S, Cevik V, Ding P, Duxbury Z, Ma Y, Tomlinson L, et al. Protein-protein interactions in the RPS4/RRS1 immune receptor complex. PLoS Pathog. 2017;13:e1006376 pubmed publisher
    ..Some NLR proteins function in pairs, forming receptor complexes for the perception of specific effectors...
  7. Kuri P, Schieber N, Thumberger T, Wittbrodt J, Schwab Y, Leptin M. Dynamics of in vivo ASC speck formation. J Cell Biol. 2017;216:2891-2909 pubmed publisher
    ..The effector caspase is recruited through PYD, whose overexpression induced pyroptosis but only after substantial delay. Therefore, formation of a single, compact speck and rapid cell-death induction in vivo requires a full-length ASC. ..
  8. Wilhelm I, Nyúl Tóth Á, Kozma M, Farkas A, Krizbai I. Role of pattern recognition receptors of the neurovascular unit in inflamm-aging. Am J Physiol Heart Circ Physiol. 2017;313:H1000-H1012 pubmed publisher
  9. Hayakawa K, Formica A, Zhou Y, Ichikawa D, Asano M, Li Y, et al. NLR Nod1 signaling promotes survival of BCR-engaged mature B cells through up-regulated Nod1 as a positive outcome. J Exp Med. 2017;214:3067-3083 pubmed publisher
    ..These findings demonstrate a role for microbial products in promoting survival of mature B cells through up-regulated Nod1, providing a positive effect of BCR engagement on development of most B cells. ..

More Information


  1. Loquet A, Saupe S. Diversity of Amyloid Motifs in NLR Signaling in Fungi. Biomolecules. 2017;7: pubmed publisher
    ..Among them, the PP-motif bears resemblance with the RHIM amyloid motif involved in the necroptosis pathway in mammals suggesting an evolutionary conservation of amyloid signaling from fungi to mammals. ..
  2. Mondragón Palomino M, Stam R, John Arputharaj A, Dresselhaus T. Diversification of defensins and NLRs in Arabidopsis species by different evolutionary mechanisms. BMC Evol Biol. 2017;17:255 pubmed publisher