dual specificity phosphatase 6
Summary: A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES and is primarily localized to the CYTOSOL.
Hu X, Chang N, Wang X, Zhou F, Zhou X, Zhu X, et al
. Heritable gene-targeting with gRNA/Cas9 in rats. Cell Res. 2013;23:1322-5 pubmed publisher
Pfuhlmann K, Pfluger P, Schriever S, Müller T, Tschop M, Stemmer K. Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice. PLoS ONE. 2017;12:e0183488 pubmed publisher
..Reasons for the discrepancies remain elusive, but may entail differential genetic backgrounds, environmental factors such as the type and source of HFD, or alterations in the gut microbiome between facilities. ..
Kumar R, Deep G, Wempe M, Surek J, Kumar A, Agarwal R, et al
. Procyanidin B2 3,3?-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK. Mol Carcinog. 2018;57:57-69 pubmed publisher
..These results offer a unique opportunity to control this deadly malignancy through B2G2 use. ..
Buffet C, Hecale Perlemoine K, Bricaire L, Dumont F, Baudry C, Tissier F, et al
. DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers. PLoS ONE. 2017;12:e0184861 pubmed publisher
..Our results are in favor of a stronger activation of the MAPK pathway in BRAFV600E PTCs. DUSP5 and DUSP6 have pro-tumorigenic properties in two BRAFV600E PTC cell line models. ..
Wittig Blaich S, Wittig R, Schmidt S, Lyer S, Bewerunge Hudler M, Gronert Sum S, et al
. Systematic screening of isogenic cancer cells identifies DUSP6 as context-specific synthetic lethal target in melanoma. Oncotarget. 2017;8:23760-23774 pubmed publisher