dual specificity phosphatase 3
Summary: A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by inactivating MITOGEN-ACTIVATED PROTEIN KINASES. It has specificity for EXTRACELLULAR SIGNAL-REGULATED MAP KINASES.
Cui D, Beaumont V, Ginther P, Lipchock J, Loria J. Leveraging Reciprocity to Identify and Characterize Unknown Allosteric Sites in Protein Tyrosine Phosphatases. J Mol Biol. 2017;429:2360-2372 pubmed publisher
..This work outlines a simple method for identification of new allosteric sites in PTP, and given the basis of this method in thermodynamics, it is expected to be generally useful in other systems. ..
Vandereyken M, Jacques S, Van Overmeire E, Amand M, Rocks N, Delierneux C, et al
. Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner. PLoS ONE. 2017;12:e0185786 pubmed publisher
..Our study demonstrates that DUSP3 phosphatase plays a key role in metastatic growth through a mechanism involving the recruitment of macrophages towards LLC-bearing lungs. ..
Kim J, Cho H, Ryu S, Choi M. Effects of metal ions on the activity of protein tyrosine phosphatase VHR: highly potent and reversible oxidative inactivation by Cu2+ ion. Arch Biochem Biophys. 2000;382:72-80 pubmed
..Thus, we conclude that the highly potent Cu2+ inactivation of VHR is a consequence of the oxidation of the active-site cysteine and the mode of Zn2+ inactivation is distinct from that of Cu2+. ..
Wagner K, Alam H, Dhar S, Giri U, Li N, Wei Y, et al
. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest. 2013;123:5231-46 pubmed publisher
..These findings uncover an unexpected role for a histone methylation modifier in activating ERK1/2 in lung tumorigenesis and metastasis, suggesting that KDM2A may be a promising therapeutic target in NSCLC. ..
Torres T, Russo L, Santos A, Marques G, Magalhaes Y, Tabassum S, et al
. Loss of DUSP3 activity radiosensitizes human tumor cell lines via attenuation of DNA repair pathways. Biochim Biophys Acta Gen Subj. 2017;1861:1879-1894 pubmed publisher
..The radioresistance of tumor cells is effectively reduced by a combination of approaches through the inhibition of DUSPs. ..