Genomes and Genes
rho guanine nucleotide exchange factors
Summary: Signaling proteins which function as master molecular switches by activating Rho GTPases through conversion of guanine nucleotides. Rho GTPases in turn control many aspects of cell behavior through the regulation of multiple downstream signal transduction pathways.
- Singh N, Janjanam J, Rao G. p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation. J Biol Chem. 2017;292:14080-14091 pubmed publisher..diseases is well studied, little is known about the role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs)...
- Graessl M, Koch J, Calderon A, Kamps D, Banerjee S, Mazel T, et al. An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns. J Cell Biol. 2017;216:4271-4285 pubmed publisher..Thus, our study reveals a mechanism that integrates intracellular biochemical and extracellular mechanical signals into subcellular activity patterns to control cellular contractility dynamics. ..
- Donnelly S, Cabrera R, Mao S, Christin J, Wu B, Guo W, et al. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. J Cell Biol. 2017;216:4331-4349 pubmed publisher..The Rac3-dependent mechanisms we show in this study are critical for balancing proteolytic activity and adhesive activity to achieve a maximally invasive phenotype. ..
- de Groot C, Floriou Servou A, Tsai Y, Früh S, Kohler M, Parkin G, et al. RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of ?2 GABAA receptors. PLoS Genet. 2017;13:e1007073 pubmed publisher..Overall, our results uncover previously unexpected role for CB isoforms downstream of ?2-containing GABAARs during neuron maturation in a Cdc42 dependent mechanism. ..