rho guanine nucleotide exchange factors


Summary: Signaling proteins which function as master molecular switches by activating Rho GTPases through conversion of guanine nucleotides. Rho GTPases in turn control many aspects of cell behavior through the regulation of multiple downstream signal transduction pathways.

Top Publications

  1. Hall A. G proteins and small GTPases: distant relatives keep in touch. Science. 1998;280:2074-5 pubmed
  2. Zaritsky A, Tseng Y, Rabadán M, Krishna S, Overholtzer M, Danuser G, et al. Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration. J Cell Biol. 2017;216:1543-1556 pubmed publisher
    ..We conclude that for effective collective migration, the RHOA-GEFs ? RHOA/C ? actomyosin pathways must be optimally tuned to compromise between generation of motility forces and restriction of intercellular communication. ..
  3. Fort P, Blangy A. The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals. Genome Biol Evol. 2017;9:1471-1486 pubmed publisher
    ..Overall, our analysis supports the conclusion that Dbl-like RhoGEFs were present at the origin of eukaryotes and evolved as highly adaptive cell signaling mediators. ..
  4. Zou S, Teixeira A, Kostadima M, Astle W, Radhakrishnan A, Simon L, et al. SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume. PLoS ONE. 2017;12:e0178095 pubmed publisher
    ..Arhgef3 KO mice partially recapitulate the human phenotype. ..
  5. Takano T, Wu M, Nakamuta S, Naoki H, Ishizawa N, Namba T, et al. Discovery of long-range inhibitory signaling to ensure single axon formation. Nat Commun. 2017;8:33 pubmed publisher
    ..Here, the authors offer in vivo evidence from a Drosophila model that supports a role for gut microbiota in modulating the progression of Alzheimer's disease. ..
  6. Randazzo D, Pierantozzi E, Rossi D, Sorrentino V. The potential of obscurin as a therapeutic target in muscle disorders. Expert Opin Ther Targets. 2017;21:897-910 pubmed publisher
  7. McGowan S, McCoy D. Platelet-derived growth factor receptor-α and Ras-related C3 botulinum toxin substrate-1 regulate mechano-responsiveness of lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2017;313:L1174-L1187 pubmed publisher
    ..Because emphysema and interstitial fibrosis disrupt the parenchymal mechanical continuum, understanding how mechanical factors regulate fibroblast migration could elicit strategies for alveolar repair and regeneration. ..
  8. Ravindran E, Hu H, Yuzwa S, Hernández Miranda L, Kraemer N, Ninnemann O, et al. Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation. PLoS Genet. 2017;13:e1006746 pubmed publisher
    ..Our results highlight the crucial function of ARHGEF2 in human brain development and identify a mutation in ARHGEF2 as novel cause of a neurodevelopmental disorder. ..
  9. Bodmann E, Krett A, Bünemann M. Potentiation of receptor responses induced by prolonged binding of G?13 and leukemia-associated RhoGEF. FASEB J. 2017;31:3663-3676 pubmed publisher
    ..Bodmann, E.-L., Krett, A.-L., Bünemann, M. Potentiation of receptor responses induced by prolonged binding of G?13 and leukemia-associated RhoGEF. ..

More Information


  1. Singh N, Janjanam J, Rao G. p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation. J Biol Chem. 2017;292:14080-14091 pubmed publisher
    ..diseases is well studied, little is known about the role of their upstream regulators, the Rho guanine nucleotide exchange factors (RhoGEFs)...
  2. Klarin D, Zhu Q, Emdin C, Chaffin M, Horner S, McMillan B, et al. Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease. Nat Genet. 2017;49:1392-1397 pubmed publisher
  3. Jiang H, Deng R, Yang X, Shang J, Lu S, Zhao Y, et al. Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat Chem Biol. 2017;13:994-1001 pubmed publisher
  4. Graessl M, Koch J, Calderon A, Kamps D, Banerjee S, Mazel T, et al. An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns. J Cell Biol. 2017;216:4271-4285 pubmed publisher
    ..Thus, our study reveals a mechanism that integrates intracellular biochemical and extracellular mechanical signals into subcellular activity patterns to control cellular contractility dynamics. ..
  5. Donnelly S, Cabrera R, Mao S, Christin J, Wu B, Guo W, et al. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. J Cell Biol. 2017;216:4331-4349 pubmed publisher
    ..The Rac3-dependent mechanisms we show in this study are critical for balancing proteolytic activity and adhesive activity to achieve a maximally invasive phenotype. ..
  6. de Groot C, Floriou Servou A, Tsai Y, Früh S, Kohler M, Parkin G, et al. RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of ?2 GABAA receptors. PLoS Genet. 2017;13:e1007073 pubmed publisher
    ..Overall, our results uncover previously unexpected role for CB isoforms downstream of ?2-containing GABAARs during neuron maturation in a Cdc42 dependent mechanism. ..