cyclic nucleotide regulated protein kinases


Summary: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues of proteins and is dependent on cyclic nucleotides.

Top Publications

  1. Kim S, Katz S, Pelech S. Expression of second messenger- and cyclin-dependent protein kinases during postnatal development of rat heart. J Cell Biochem. 1998;69:506-21 pubmed
    ..All of the proteins that were detected in ventricular extracts were also identified in isolated cardiac myocytes in equivalent amounts and analyzed for their relative expression in ten other adult rat tissues. ..
  2. Carter N. Assays of protein kinases using exogenous substrates. Curr Protoc Protein Sci. 2001;Chapter 13:Unit13.7 pubmed publisher
  3. Lu Z, Hasmeda M, Mahabusarakam W, Ternai B, Ternai P, Polya G. Inhibition of eukaryote protein kinases and of a cyclic nucleotide-binding phosphatase by prenylated xanthones. Chem Biol Interact. 1998;114:121-40 pubmed
    ..Prenylated xanthones having relatively small and non-protonatable R' and R groups inhibit a high-affinity cyclic nucleotide binding Pase in a non-competitive fashion. ..
  4. Peterson R, Schreiber S. Kinase phosphorylation: Keeping it all in the family. Curr Biol. 1999;9:R521-4 pubmed
    ..Recent findings suggest that the elusive PDK2 may actually be a familiar kinase with an atypical associate. ..
  5. Arbogast L. Calmodulin and a cyclic nucleotide-dependent protein kinase facilitate the prolactin-induced increase in tyrosine hydroxylase activity in tuberoinfundibular dopaminergic neurons. Endocrine. 2001;16:105-12 pubmed
  6. Peshenko I, Olshevskaya E, Dizhoor A. Ca(2+)-dependent conformational changes in guanylyl cyclase-activating protein 2 (GCAP-2) revealed by site-specific phosphorylation and partial proteolysis. J Biol Chem. 2004;279:50342-9 pubmed
    ..These changes also cause the release of the C-terminal Ser(201) from the constraint caused by the Ca(2+)-bound conformation. ..
  7. Wu B, Tu H, Welsh D, Chen I. KMUP-1 activates BKCa channels in basilar artery myocytes via cyclic nucleotide-dependent protein kinases. Br J Pharmacol. 2005;146:862-71 pubmed
    ..Physiologically, this activation would result in the closure of voltage-dependent calcium channels and the relaxation of cerebral arteries. ..
  8. Turner N, Li J, Gosby A, To S, Cheng Z, Miyoshi H, et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes. 2008;57:1414-8 pubmed publisher
    ..The identification of a novel derivative of BBR with improved in vivo efficacy highlights the potential importance of BBR as a novel therapy for the treatment of type 2 diabetes. ..
  9. Sisson J, Pavlik J, Wyatt T. Alcohol stimulates ciliary motility of isolated airway axonemes through a nitric oxide, cyclase, and cyclic nucleotide-dependent kinase mechanism. Alcohol Clin Exp Res. 2009;33:610-6 pubmed publisher

More Information


  1. Uneyama C, Uneyama H, Akaike N, Takahashi M. Cyclic GMP inhibits cytoplasmic Ca2+ oscillation by increasing Ca2+-ATPase activity in rat megakaryocytes. Eur J Pharmacol. 1998;347:355-61 pubmed
    ..These results suggested that cGMP depressed Ca2+ mobilization by improving Ca2+-ATPase activity by phosphorylation. ..
  2. Wagner L, Li W, Yule D. Phosphorylation of type-1 inositol 1,4,5-trisphosphate receptors by cyclic nucleotide-dependent protein kinases: a mutational analysis of the functionally important sites in the S2+ and S2- splice variants. J Biol Chem. 2003;278:45811-7 pubmed
    ..Collectively, these data indicate that phosphoregulation of InsP3R-1 has dramatic effects on Ca2+ release and defines the molecular sites phosphorylated in the major variants expressed in neuronal and peripheral tissues. ..
  3. Schafer C, Hoffmann L, Heldt K, Lornejad Schäfer M, Brauers G, Gehrmann T, et al. Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1089-98 pubmed
    ..The osmotic regulation of BHMT may be part of a cell volume-regulatory response and additionally lead to metabolic alterations that depend on the availability of betaine-derived methyl groups. ..