wnt3a protein


Summary: A Wnt protein subtype that plays a role in cell-cell signaling during EMBRYONIC DEVELOPMENT and the morphogenesis of the developing NEURAL TUBE.

Top Publications

  1. Asciolla J, Miele M, Hendrickson R, Resh M. An in vitro fatty acylation assay reveals a mechanism for Wnt recognition by the acyltransferase Porcupine. J Biol Chem. 2017;292:13507-13513 pubmed publisher
    ..These findings illustrate the unique enzyme-substrate selectivity exhibited by members of the membrane-bound O-acyl transferase family. ..
  2. Liu S, Yin Y, Yu R, Li Y, Zhang W. R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin. Biochem Biophys Res Commun. 2018;499:59-65 pubmed publisher
    ..Notably, knockdown of β-catenin in hepatocytes completely abolished the effect of Rspo3 pretreatment on the expression levels of PCNA and CyclinD1. Rspo3-LGR4 axis protects hepatocytes from H/R injury via activating β-catenin. ..
  3. Hübner K, Grassme K, Rao J, Wenke N, Zimmer C, Korte L, et al. Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1. Dev Biol. 2017;430:142-155 pubmed publisher
    ..Our data indicate a novel role of ?-catenin dependent Wnt signaling in regulating EC specification during vasculogenesis. ..
  4. Zaghloul R, Elsherbiny N, Kenawy H, El Karef A, Eissa L, El Shishtawy M. Hepatoprotective effect of hesperidin in hepatocellular carcinoma: Involvement of Wnt signaling pathways. Life Sci. 2017;185:114-125 pubmed publisher
    ..HP has a prophylactic effect against hepatocarcinogenesis via preventing the induction of both canonical and non-canonical Wnt pathways. ..
  5. Voloshanenko O, Gmach P, Winter J, Kranz D, Boutros M. Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. FASEB J. 2017;31:4832-4844 pubmed publisher
    ..Voloshanenko, O., Gmach, P., Winter, J., Kranz, D., Boutros, M. Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. ..
  6. Narendra Talabattula V, Morgan P, Frech M, Uhrmacher A, Herchenröder O, Pützer B, et al. Non-canonical pathway induced by Wnt3a regulates ?-catenin via Pyk2 in differentiating human neural progenitor cells. Biochem Biophys Res Commun. 2017;491:40-46 pubmed publisher
    ..Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of ?-catenin in the crosstalk between Wnt/?-catenin and Wnt/Ca2+ signaling pathways upon Wnt3a stimulation in differentiating hNPCs. ..
  7. Sezgin E, Azbazdar Y, Ng X, Teh C, Simons K, Weidinger G, et al. Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments. FEBS J. 2017;284:2513-2526 pubmed publisher
    ..We thus conclude that ordered plasma membrane environments are essential for binding of canonical Wnts to their receptor complexes and downstream signaling activity. ..
  8. Xu M, Bi C, Liu E, Dong T, Tsim K. Wnt3a induces the expression of acetylcholinesterase during osteoblast differentiation via the Runx2 transcription factor. J Biol Chem. 2017;292:12667-12678 pubmed publisher
    ..We conclude that AChE plays a role in osteoblastic differentiation and is regulated by both Wnt3a and Runx2. ..
  9. Bonci D, Coppola V, Musumeci M, Addario A, Giuffrida R, Memeo L, et al. The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med. 2008;14:1271-7 pubmed publisher
    ..These findings have therapeutic implications and may be exploited for future treatment of prostate cancer. ..

More Information


  1. Liu T, Zhang L, Wang Y, Zhang H, Li L, Bao X. Dickkopf-1 inhibits Wnt3a-induced migration and epithelial-mesenchymal transition of human lens epithelial cells. Exp Eye Res. 2017;161:43-51 pubmed publisher
    ..Our results indicate that Dkk1 inhibits Wnt3a-induced migration and the EMT of human LECs.The results contribute to the prevention of PCO formation and development. ..
  2. Coussy F, Lallemand F, Vacher S, Schnitzler A, Chemlali W, Caly M, et al. Clinical value of R-spondins in triple-negative and metaplastic breast cancers. Br J Cancer. 2017;116:1595-1603 pubmed publisher
    ..RSPO overexpression could therefore be a new prognostic biomarker and therapeutic target for TNBC. ..
  3. Krishnamoorthy A, Witkowski A, Tran J, Weers P, Ryan R. Characterization of secondary structure and lipid binding behavior of N-terminal saposin like subdomain of human Wnt3a. Arch Biochem Biophys. 2017;630:38-46 pubmed publisher
    ..Moreover, SLD function(s) in Wnt proteins appear to have evolved away from those commonly attributed to SAPLIP family members. ..
  4. Boretto M, Cox B, Noben M, Hendriks N, Fassbender A, Roose H, et al. Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability. Development. 2017;144:1775-1786 pubmed publisher
    ..This novel model provides a powerful tool for studying mechanisms underlying the biology as well as the pathology of this key reproductive organ. ..
  5. Anderson K, Hamilton W, Roske F, Azad A, Knudsen T, Canham M, et al. Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm. Nat Cell Biol. 2017;19:1164-1177 pubmed publisher
    ..Self-renewal of these PrE cultures is robust and, on the basis of gene expression, these cells resemble early blastocyst-stage PrE, a naive endoderm state able to make both visceral and parietal endoderm. ..
  6. Kirsch N, Chang L, Koch S, Glinka A, Dolde C, Colozza G, et al. Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover. Dev Cell. 2017;43:71-82.e6 pubmed publisher
    ..This unexpected function of ANGPTL4 invites re-interpretation of its diverse physiological effects in light of Wnt signaling and may open therapeutic avenues for human disease...
  7. Diehl A. Neighborhood watch orchestrates liver regeneration. Nat Med. 2012;18:497-9 pubmed publisher
  8. Seo W, Park S, Gwak J, Ju B, Chung J, Kang P, et al. Wnt signaling promotes androgen-independent prostate cancer cell proliferation through up-regulation of the hippo pathway effector YAP. Biochem Biophys Res Commun. 2017;486:1034-1039 pubmed publisher
    ..Thus, our findings provide mechanistic insight into the proposed cross-talk between the Wnt/?-catenin and Hippo pathways in androgen-independent prostate cancer development. ..