transforming growth factor beta3
Summary: A TGF-beta subtype that plays role in regulating epithelial-mesenchymal interaction during embryonic development. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta3 and TGF-beta3 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
Elicora A, Liman Ş, Yegin B, Akgül A, Eroglu H, Yildiz K, et al
. Effect of locally applied transforming growth factor Beta3 on wound healing and stenosis development in tracheal surgery. Respir Care. 2014;59:1281-6 pubmed
..In this study, a transforming growth factor beta3 (TGF-?3)/chitosan combination was used for this purpose...
Matyas G, Naef P, Tollens M, Oexle K. De novo mutation of the latency-associated peptide domain of TGFB3 in a patient with overgrowth and Loeys-Dietz syndrome features. Am J Med Genet A. 2014;164A:2141-3 pubmed publisher
Deb D, Chen Y, Sun J, Wang Y, Li Y. ATP-citrate lyase is essential for high glucose-induced histone hyperacetylation and fibrogenic gene upregulation in mesangial cells. Am J Physiol Renal Physiol. 2017;313:F423-F429 pubmed publisher
..Therefore, ACL plays a critical role in epigenetic regulation of diabetic renal fibrosis. ..
Richardson R, Mitchell K, Hammond N, Mollo M, Kouwenhoven E, Wyatt N, et al
. p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017;13:e1006828 pubmed publisher
Wang T, Muhetaer H, Li J. [Experimental study of transforming growth factor-?3 combined with dental pulp stem cells in promoting the implant's osseointegration]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2017;52:367-373 pubmed publisher
..05??dpsc??pbs????????????p>0.05????8??tgf-?3+dpsc?cblw?ibcr?tw?ta?????dpsc??pbs??p<0.05??dpsc??pbs???????????p>0.05?? ??? dpsc??????????tgf-?3?dpsc????????????tgf-?3??dpsc?????????????. ..
Ndaw V, Abebayehu D, Spence A, Paez P, Kolawole E, Taruselli M, et al
. TGF-?1 Suppresses IL-33-Induced Mast Cell Function. J Immunol. 2017;199:866-873 pubmed publisher
..These findings, consistent with our previously reported effects of TGF-?1 on IgE-mediated activation, demonstrate that TGF-?1 can provide broad inhibitory signals to activated mast cells. ..
Sriram S, Tran J, Guo X, Hutcheon A, Lei H, Kazlauskas A, et al
. PDGFR? Is a Key Regulator of T1 and T3's Differential Effect on SMA Expression in Human Corneal Fibroblasts. Invest Ophthalmol Vis Sci. 2017;58:1179-1186 pubmed publisher
..Understanding the role of PDGFR? in TGF-?3's ability to stimulate SMA may potentially help in understanding the differential functions of TGF-?1 and TGF-?3 in corneal wound healing. ..
Wang L, Tu L, Zhang J, Xu K, Qian W. Stellate Cell Activation and Imbalanced Expression of TGF-?1/TGF-?3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice. Biomed Res Int. 2017;2017:2540540 pubmed publisher
..2) Early activation of HSC and imbalance expression of TGF-?1 and TGF-?3 existed in ConA-induced acute autoimmune liver injury, which may be associated with liver dysfunction and the mechanisms of progression to fibrosis. ..
WANG G, Yu Y, Guo J, Qiu L. [Inhibiting effect of transforming growth factor ?3 on IL-6 expression in MG63 induced by lipopolysaccharide]. Shanghai Kou Qiang Yi Xue. 2017;26:21-25 pubmed
..01), while with 10 ng/mL TGF-?3, the effect of P.e-LPS on ERK1/2 was blocked(P<0.05). TGF-?3 is more potent than TGF-?1 in inhibiting MG63, and ERK1/2 is involved in its anti-inflammatory effect. ..