transforming growth factor beta3


Summary: A TGF-beta subtype that plays role in regulating epithelial-mesenchymal interaction during embryonic development. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta3 and TGF-beta3 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.

Top Publications

  1. Elicora A, Liman Ş, Yegin B, Akgül A, Eroglu H, Yildiz K, et al. Effect of locally applied transforming growth factor Beta3 on wound healing and stenosis development in tracheal surgery. Respir Care. 2014;59:1281-6 pubmed
    ..In this study, a transforming growth factor beta3 (TGF-?3)/chitosan combination was used for this purpose...
  2. Matyas G, Naef P, Tollens M, Oexle K. De novo mutation of the latency-associated peptide domain of TGFB3 in a patient with overgrowth and Loeys-Dietz syndrome features. Am J Med Genet A. 2014;164A:2141-3 pubmed publisher
  3. Deb D, Chen Y, Sun J, Wang Y, Li Y. ATP-citrate lyase is essential for high glucose-induced histone hyperacetylation and fibrogenic gene upregulation in mesangial cells. Am J Physiol Renal Physiol. 2017;313:F423-F429 pubmed publisher
    ..Therefore, ACL plays a critical role in epigenetic regulation of diabetic renal fibrosis. ..
  4. Richardson R, Mitchell K, Hammond N, Mollo M, Kouwenhoven E, Wyatt N, et al. p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate. PLoS Genet. 2017;13:e1006828 pubmed publisher
  5. Wang T, Muhetaer H, Li J. [Experimental study of transforming growth factor-?3 combined with dental pulp stem cells in promoting the implant's osseointegration]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2017;52:367-373 pubmed publisher
    ..05??dpsc??pbs????????????p>0.05????8??tgf-?3+dpsc?cblw?ibcr?tw?ta?????dpsc??pbs??p<0.05??dpsc??pbs???????????p>0.05?? ??? dpsc??????????tgf-?3?dpsc????????????tgf-?3??dpsc?????????????. ..
  6. Ndaw V, Abebayehu D, Spence A, Paez P, Kolawole E, Taruselli M, et al. TGF-?1 Suppresses IL-33-Induced Mast Cell Function. J Immunol. 2017;199:866-873 pubmed publisher
    ..These findings, consistent with our previously reported effects of TGF-?1 on IgE-mediated activation, demonstrate that TGF-?1 can provide broad inhibitory signals to activated mast cells. ..
  7. Sriram S, Tran J, Guo X, Hutcheon A, Lei H, Kazlauskas A, et al. PDGFR? Is a Key Regulator of T1 and T3's Differential Effect on SMA Expression in Human Corneal Fibroblasts. Invest Ophthalmol Vis Sci. 2017;58:1179-1186 pubmed publisher
    ..Understanding the role of PDGFR? in TGF-?3's ability to stimulate SMA may potentially help in understanding the differential functions of TGF-?1 and TGF-?3 in corneal wound healing. ..
  8. Wang L, Tu L, Zhang J, Xu K, Qian W. Stellate Cell Activation and Imbalanced Expression of TGF-?1/TGF-?3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice. Biomed Res Int. 2017;2017:2540540 pubmed publisher
    ..2) Early activation of HSC and imbalance expression of TGF-?1 and TGF-?3 existed in ConA-induced acute autoimmune liver injury, which may be associated with liver dysfunction and the mechanisms of progression to fibrosis. ..
  9. WANG G, Yu Y, Guo J, Qiu L. [Inhibiting effect of transforming growth factor ?3 on IL-6 expression in MG63 induced by lipopolysaccharide]. Shanghai Kou Qiang Yi Xue. 2017;26:21-25 pubmed
    ..01), while with 10 ng/mL TGF-?3, the effect of P.e-LPS on ERK1/2 was blocked(P<0.05). TGF-?3 is more potent than TGF-?1 in inhibiting MG63, and ERK1/2 is involved in its anti-inflammatory effect. ..

More Information


  1. Sriram S, Tran J, Guo X, Hutcheon A, Kazlauskas A, Zieske J. Development of wound healing models to study TGF?3's effect on SMA. Exp Eye Res. 2017;161:52-60 pubmed publisher
    ..Understanding the mechanism of T3's action in these systems and how they differ from simple cell culture models, may potentially help in developing T3 as an anti-scarring therapy. ..
  2. Angelov S, Hu J, Wei H, Airhart N, Shi M, Dichek D. TGF-β (Transforming Growth Factor-β) Signaling Protects the Thoracic and Abdominal Aorta From Angiotensin II-Induced Pathology by Distinct Mechanisms. Arterioscler Thromb Vasc Biol. 2017;37:2102-2113 pubmed publisher
    ..Smooth muscle extrinsic signaling protects the abdominal aorta and smooth muscle intrinsic signaling protects the thoracic aorta. ..