Summary: The founding member of the nodal signaling ligand family of proteins. Nodal protein was originally discovered in the region of the mouse embryo primitive streak referred to as HENSEN'S NODE. It is expressed asymmetrically on the left side in chordates and plays a critical role in the genesis of left-right asymmetry during vertebrate development.
Papanayotou C, Collignon J. Activin/Nodal signalling before implantation: setting the stage for embryo patterning. Philos Trans R Soc Lond B Biol Sci. 2014;369: pubmed publisher
Wang L, Wu G, Qin X, Ma Q, Zhou Y, Liu S, et al
. Expression of Nodal on Bronchial Epithelial Cells Influenced by Lung Microbes Through DNA Methylation Modulates the Differentiation of T-Helper Cells. Cell Physiol Biochem. 2015;37:2012-22 pubmed publisher
..P. aeruginosa or A.baumanni may be hopeful for the treatment of airway hyperresponsveness by inhibition Nodal expression through DNA methylation modification in the promoter. ..
Koop D, Cisternas P, Morris V, Strbenac D, Yang J, Wray G, et al
. Nodal and BMP expression during the transition to pentamery in the sea urchin Heliocidaris erythrogramma: insights into patterning the enigmatic echinoderm body plan. BMC Dev Biol. 2017;17:4 pubmed publisher
..We suggest that the Nodal and BMP2/4 signalling cascades might have been duplicated or split during the evolution to pentamery. ..
Bian S, Zheng X, Sun H, Chen J, Lu Y, Liu Y, et al
. Clock1a affects mesoderm development and primitive hematopoiesis by regulating Nodal-Smad3 signaling in the zebrafish embryo. J Biol Chem. 2017;292:14165-14175 pubmed publisher
Nemashkalo A, Ruzo A, Heemskerk I, Warmflash A. Morphogen and community effects determine cell fates in response to BMP4 signaling in human embryonic stem cells. Development. 2017;144:3042-3053 pubmed publisher
..Using live cell imaging to correlate signaling histories with cell fates, we demonstrate that interactions between neighbors result in sustained, homogenous signaling necessary for differentiation. ..
Anderson K, Hamilton W, Roske F, Azad A, Knudsen T, Canham M, et al
. Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm. Nat Cell Biol. 2017;19:1164-1177 pubmed publisher
..Self-renewal of these PrE cultures is robust and, on the basis of gene expression, these cells resemble early blastocyst-stage PrE, a naive endoderm state able to make both visceral and parietal endoderm. ..
Barone V, Lang M, Krens S, Pradhan S, Shamipour S, Sako K, et al
. An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate. Dev Cell. 2017;43:198-211.e12 pubmed publisher
..Thus, the interdependent activities of cell-cell signaling and contact formation control fate diversification within the developing embryo...
Cristo F, Inácio J, De Almeida S, Mendes P, Martins D, Maio J, et al
. Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects. BMC Med Genet. 2017;18:77 pubmed publisher
..Altogether, our results provide new insight into the molecular mechanism of the laterality defects and related CHDs, priming for the first time DAND5 as one of multiple candidate determinants for CHDs in humans. ..
Xiang Z, Liang Z, Yanfeng H, Leitao K. Persistence of RSV promotes proliferation and epithelial-mesenchymal transition of bronchial epithelial cells through Nodal signaling. J Med Microbiol. 2017;66:1499-1505 pubmed publisher
..Our data showed that persistence of RSV promoted the proliferation, epithelial-mesenchymal transition and expression of oncogenes through Nodal signaling, which may be associated with the occurrence and development of lung cancers. ..