growth differentiation factor 5


Summary: A growth differentiation factor that plays a role in early CHONDROGENESIS and joint formation.

Top Publications

  1. Yan J, Yang S, Sun H, Guo D, Wu B, Ji F, et al. Effects of releasing recombinant human growth and differentiation factor-5 from poly(lactic-co-glycolic acid) microspheres for repair of the rat degenerated intervertebral disc. J Biomater Appl. 2014;29:72-80 pubmed publisher
    ..The results of this study suggest that injection of rhGDF-5 loaded in PLGA microspheres into rat tail discs may be as a promising therapy strategy to regenerate or repair the degenerative disc. ..
  2. Ratnayake M, Tselepi M, Bloxham R, Plöger F, Reynard L, Loughlin J. A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5. PLoS ONE. 2017;12:e0176523 pubmed publisher
    ..It is painful, disabling, multifactorial and polygenic. The growth differentiation factor 5 gene GDF5 was one of the first reported OA susceptibility signals that showed consistent association ..
  3. Valdes A, Evangelou E, Kerkhof H, Tamm A, Doherty S, Kisand K, et al. The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance. Ann Rheum Dis. 2011;70:873-5 pubmed publisher
  4. Decker R, Um H, Dyment N, Cottingham N, Usami Y, Enomoto Iwamoto M, et al. Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. Dev Biol. 2017;426:56-68 pubmed publisher
    ..Synovial Prg4+ lineage progenitors are exquisitely responsive to acute injury and may represent pioneers in joint tissue repair. ..
  5. Haro E, Watson B, Feenstra J, Tegeler L, Pira C, Mohan S, et al. Lmx1b-targeted cis-regulatory modules involved in limb dorsalization. Development. 2017;144:2009-2020 pubmed publisher
    ..This is the first report to describe genome-wide Lmx1b binding during limb development, directly linking Lmx1b to targets that accomplish limb dorsalization. ..
  6. Yin J, Zhuang G, Zhu Y, Hu X, Zhao H, Zhang R, et al. MiR-615-3p inhibits the osteogenic differentiation of human lumbar ligamentum flavum cells via suppression of osteogenic regulators GDF5 and FOXO1. Cell Biol Int. 2017;41:779-786 pubmed publisher
    ..In conclusion, miR-615-3p negatively regulates the osteogenic differentiation of hLF cells through post-transcriptionally suppressing osteogenic regulators GDF5 and FOXO1. It can be regarded as a potential target for human OLF therapy. ..
  7. Capellini T, Chen H, Cao J, Doxey A, Kiapour A, Schoor M, et al. Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk. Nat Genet. 2017;49:1202-1210 pubmed publisher
  8. Lettre G. The osteoarthritis and height GDF5 locus yields its secrets. Nat Genet. 2017;49:1165-1166 pubmed publisher
    ..This study provides evidence of positive selection for short stature at GDF5 in modern humans, as well as in archaic Neandertals and Denisovans. ..
  9. Liu W, Xia P, Feng J, Kang L, Huang M, Wang K, et al. MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration. Exp Cell Res. 2017;359:39-49 pubmed publisher
    ..Our findings demonstrated that miR-132 promotes ECM degradation by human NP cells by direct targeting of GDF5. Hence, miR-132 represents a potential therapeutic target in the treatment of IDD. ..

More Information


  1. Yin Y, Wang Y. Association of BMP-14 rs143383 ploymorphism with its susceptibility to osteoarthritis: A meta-analysis and systematic review according to PRISMA guideline. Medicine (Baltimore). 2017;96:e7447 pubmed publisher
    ..Additionally, the polymorphism also reduced hip OA risk in Asian group after stratified analysis by ethnicity. BMP-14 rs143383 polymorphism may be a protective factor against OA occurrence. ..