bone morphogenetic protein 15


Summary: A protein that plays a role in GRANULOSA CELLS where it regulates folliculogenesis. Mutations in the gene for bone morphogenetic protein 15 are linked to reproductive abnormalities such as PREMATURE OVARIAN FAILURE.

Top Publications

  1. Liang Y, Du H, Chang X, Zhao S, Lei L. [Effect of bushen tiaojing recipe on the quality of the oocytes and reproductive hormones in the follicular fluid in IVF-ET patients]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014;34:911-6 pubmed
  2. Lassoued N, Benkhlil Z, Woloszyn F, Rejeb A, Aouina M, Rekik M, et al. FecX Bar a Novel BMP15 mutation responsible for prolificacy and female sterility in Tunisian Barbarine Sheep. BMC Genet. 2017;18:43 pubmed publisher
    Naturally occurring mutations in growth and differentiation factor 9 (GDF9) or bone morphogenetic protein 15 (BMP15) genes are associated with increased ovulation rate (OR) and litter size (LS) but also sterility...
  3. Wu G, Luo J, Li H, Huang C, Chang C. Robust gdf9 and bmp15 expression in the oocytes of ovotestes through the Figla-independent pathway in the hermaphroditic black porgy, Acanthopagrus schlegelii. PLoS ONE. 2017;12:e0186991 pubmed publisher
    ..This functional switch might clarify how oocytes created an appropriate microenvironment during the transition from the ancient gonochorism to the present hermaphroditism. ..

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