bone morphogenetic protein 7


Summary: A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.

Top Publications

  1. Murena L, Canton G, Vulcano E, Surace M, Cherubino P. Treatment of humeral shaft aseptic nonunions in elderly patients with opposite structural allograft, BMP-7, and mesenchymal stem cells. Orthopedics. 2014;37:e201-6 pubmed publisher
    ..This study reports the authors' experience using opposite cortical allograft combined with bone morphogenetic protein 7 and mesenchymal stem cells to treat humeral shaft atrophic nonunions in 2 elderly patients...
  2. Macias D, Gañan Y, Sampath T, Piedra M, Ros M, Hurle J. Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development. Development. 1997;124:1109-17 pubmed
  3. Costalonga E, de Freitas L, Aragone D, Silva F, Noronha I. Anti-fibrotic effects of valproic acid in experimental peritoneal fibrosis. PLoS ONE. 2017;12:e0184302 pubmed publisher
    ..Interestingly, VPA treatment induced a higher expression of antifibrotic factors, such as Smad7. These results suggest that VPA may represent a potential strategy for treating long term PD complications. ..
  4. Tenno M, Shiroguchi K, Muroi S, Kawakami E, Koseki K, Kryukov K, et al. Cbfβ2 deficiency preserves Langerhans cell precursors by lack of selective TGFβ receptor signaling. J Exp Med. 2017;214:2933-2946 pubmed publisher
    ..Collectively, our results reveal an essential requirement for the Cbfβ2 variant in LC differentiation and provide novel insight into how the establishment and homeostasis of the LC network is regulated. ..
  5. Brun J, Berthou F, Trajkovski M, Maechler P, Foti M, Bonnet N. Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPAR? Expression. Diabetes. 2017;66:2541-2554 pubmed publisher
    ..We further identify bone morphogenetic protein 7 as one of them...
  6. Soofi A, Wolf K, Emont M, Qi N, Martinez Santibañez G, Grimley E, et al. The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice. J Biol Chem. 2017;292:9051-9062 pubmed publisher
    ..These findings demonstrate that shifting the TGF-? superfamily signaling with a secreted protein can alter the physiology and thermogenic properties of adipose tissue to reduce obesity even when mice are fed a high-fat diet. ..
  7. Kargozar S, Hashemian S, Soleimani M, Milan P, Askari M, Khalaj V, et al. Acceleration of bone regeneration in bioactive glass/gelatin composite scaffolds seeded with bone marrow-derived mesenchymal stem cells over-expressing bone morphogenetic protein-7. Mater Sci Eng C Mater Biol Appl. 2017;75:688-698 pubmed publisher
  8. Mori H, Kondo E, Kawaguchi Y, Kitamura N, Nagai N, Iida H, et al. Development of a salmon-derived crosslinked atelocollagen sponge disc containing osteogenic protein-1 for articular cartilage regeneration: in vivo evaluations with rabbits. BMC Musculoskelet Disord. 2013;14:174 pubmed publisher
  9. Yonemori K, Imamura T, Ishidou Y, Okano T, Matsunaga S, Yoshida H, et al. Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament. Am J Pathol. 1997;150:1335-47 pubmed
    ..The high expression of BMPRs and ActRs in the ectopic ossified ligament suggests that BMPs and activin may be tightly involved in the pathological ossification process of OPLL. ..

More Information


  1. Mao Y. Hypermethylation of RASAL1: A Key for Renal Fibrosis. EBioMedicine. 2015;2:7-8 pubmed publisher
  2. Liu L, Fu W, Xu J, Shao L, Wang Y. Effect of BMP7 on podocyte transdifferentiation and Smad7 expression induced by hyperglycemia. Clin Nephrol. 2015;84:95-9 pubmed publisher
    ..HG, p < 0.01). BMP7 can inhibit the epithelial-to-mesenchymal cell transformation (EMT) of podocytes induced by high glucose; Smad7 may mediate the blunting effects of BMP7 on high glucose in podocytes. ..
  3. Bhutia S, Sherpa M, Dewan S, Singh T. Correlation of cartilage metabolic markers & antioxidants with the severity of knee osteoarthritis. Indian J Med Res. 2016;144:932-934 pubmed publisher
    ..Oxidative stress has been implicated as a mediator of cartilage damage in patients with osteoarthritis. The aim of this study was to correlate the cartilage metabolic markers and antioxidants with the severity of knee osteoarthritis. ..
  4. Bollum L, Huse K, Oksvold M, Bai B, Hilden V, Forfang L, et al. BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-? receptor type I ALK5. PLoS ONE. 2017;12:e0177188 pubmed publisher
    ..Altogether, we identified BMP-7 as a negative regulator of GC B-cell survival. The effect was counteracted by truncated ALK5, suggesting greater complexity in regulating BMP-7 signaling than previously believed. ..
  5. Flevaris P, Khan S, Eren M, Schuldt A, Shah S, Lee D, et al. Plasminogen Activator Inhibitor Type I Controls Cardiomyocyte Transforming Growth Factor-? and Cardiac Fibrosis. Circulation. 2017;136:664-679 pubmed publisher
    ..Thus, PAI-1 is a molecular switch that controls the cardiac TGF-? axis and its early transcriptional effects that lead to myocardial fibrosis. ..
  6. Chen F, Chen R, Liu H, Sun R, Huang J, Huang Z, et al. BMP-7 ameliorates cobalt alloy particle-induced inflammation by suppressing Th17 responses. APMIS. 2017;125:880-887 pubmed publisher
    ..Together, these results demonstrated that BMP-7 could serve as a therapeutic agent in treating patients with metal wear debris-induced inflammation. ..
  7. Neppl R, Wu C, Walsh K. lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy. J Cell Biol. 2017;216:3497-3507 pubmed publisher
    ..Inhibition of Chronos induces myofiber hypertrophy both in vitro and in vivo, in part, through the epigenetic modulation of Bmp7 signaling. ..
  8. Zhang Y, Wan L, He X, Ni Y, Wang C, Liu C, et al. Gremlin1 Accelerates Hepatic Stellate Cell Activation Through Upregulation of TGF-Beta Expression. DNA Cell Biol. 2017;36:603-610 pubmed publisher
    ..The findings suggest that gremlin1 might play an important role in the progression of hepatic fibrosis and that it modulates HSC activation. ..
  9. Neuwirt H, Perco P, Kainz A, Mühlberger I, Leierer J, Braniff S, et al. A 3-biomarker-panel predicts renal outcome in patients with proteinuric renal diseases. BMC Med Genomics. 2014;7:75 pubmed publisher
    ..0115). We identified and validated a panel of three genes in kidney biopsies which predicted serum creatinine at follow-up and therefore might serve as biomarkers for kidney disease progression. ..