bone morphogenetic protein 6


Summary: A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL DIFFERENTIATION of non-osteoblastic cell types and epithelial-mesenchymal interactions.

Top Publications

  1. Canali S, Wang C, Zumbrennen Bullough K, Bayer A, Babitt J. Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6. Am J Hematol. 2017;92:1204-1213 pubmed publisher
    ..Together, these data demonstrate that in addition to BMP6, endothelial cell BMP2 has a non-redundant role in hepcidin regulation by iron. ..
  2. Ulug P, Vasavda N, Awogbade M, Cunningham J, Menzel S, Thein S. Association of sickle avascular necrosis with bone morphogenic protein 6. Ann Hematol. 2009;88:803-5 pubmed publisher
  3. Kwon S, Lee G, Lee J, Iwakura Y, Kim W, Kim I. Mechanism of pro-tumorigenic effect of BMP-6: neovascularization involving tumor-associated macrophages and IL-1a. Prostate. 2014;74:121-33 pubmed
    ..CONCLUSIONS. Prostate cancer-derived BMP-6 stimulates tumor-associated macrophages to produce IL-1a through a crosstalk between Smad1 and NF-kB1; IL-1a, in turn, promotes angiogenesis and prostate cancer growth. ..
  4. Garrison P, Yue S, Hanson J, Baron J, Lui J. Spatial regulation of bone morphogenetic proteins (BMPs) in postnatal articular and growth plate cartilage. PLoS ONE. 2017;12:e0176752 pubmed publisher
  5. Zeng M, Szymczak M, Ahuja M, Zheng C, Yin H, Swaim W, et al. Restoration of CFTR Activity in Ducts Rescues Acinar Cell Function and Reduces Inflammation in Pancreatic and Salivary Glands of Mice. Gastroenterology. 2017;153:1148-1159 pubmed publisher
    ..Our findings reveal that correcting ductal function is sufficient to rescue acinar cell function and suggests that CFTR correctors are strong candidates for the treatment of Sjögren's syndrome and pancreatitis. ..