bone morphogenetic protein 5


Summary: A bone morphogenetic protein that may play a role in CARTILAGE formation. It is a potent regulator of the growth of CHONDROCYTES and the synthesis of cartilage matrix proteins. Evidence for its role in cartilage formation can be seen in MICE, where genetic mutations that cause loss of bone morphogenetic protein 5 function result in the formation of small malformed ears.

Top Publications

  1. Rodriguez Fontenla C, Carr A, Gomez Reino J, Tsezou A, Loughlin J, Gonzalez A. Association of a BMP5 microsatellite with knee osteoarthritis: case-control study. Arthritis Res Ther. 2012;14:R257 pubmed publisher
    ..This result also shows the interest of analysing other multiallelic polymorphisms. ..
  2. Penn M, Mausner Fainberg K, Golan M, Karni A. High serum levels of BMP-2 correlate with BMP-4 and BMP-5 levels and induce reduced neuronal phenotype in patients with relapsing-remitting multiple sclerosis. J Neuroimmunol. 2017;310:120-128 pubmed publisher
    ..These results suggest that BMP-2 sera levels may play a role in the failure of remyelination and neuro-regeneration in RR-MS. ..