bone morphogenetic protein 4


Summary: A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.

Top Publications

  1. Ritter S, Davies P. Identification of a transforming growth factor-beta1/bone morphogenetic protein 4 (TGF-beta1/BMP4) response element within the mouse tissue transglutaminase gene promoter. J Biol Chem. 1998;273:12798-806 pubmed
    ..The results of these experiments suggest that TGF-beta1, BMP2, and BMP4 regulation of mouse tissue transglutaminase gene expression requires a composite TRE located in the 5'-flanking DNA. ..
  2. Koshiba Takeuchi K, Takeuchi J, Matsumoto K, Momose T, Uno K, Hoepker V, et al. Tbx5 and the retinotectum projection. Science. 2000;287:134-7 pubmed
    ..Thus, Tbx5 is involved in eye morphogenesis and is a topographic determinant of the visual projections between retina and tectum. ..
  3. Wang G, Xie L, Hu J, Lu H, Liu X, Cao Y, et al. Osteopontin, Bone Morphogenetic Protein-4, and Vitamin D Receptor Gene Polymorphisms in the Susceptibility and Clinical Severity of Spinal Tuberculosis. Cell Physiol Biochem. 2017;41:1881-1893 pubmed publisher
    ..These three genes may collaborate in the development of spinal TB. ..
  4. Ma J, Zeng S, Zhang Y, Deng G, Qu Y, Guo C, et al. BMP4 enhances hepatocellular carcinoma proliferation by promoting cell cycle progression via ID2/CDKN1B signaling. Mol Carcinog. 2017;56:2279-2289 pubmed publisher
    ..So BMP4 is overexpressed in HCC tissues and acts as a poor prognostic factor of HCC patients. BMP4-induced ID2/CDKN1B signaling facilitates proliferation of HCC. ..
  5. Lohmann K, Redin C, Tonnies H, Bressman S, Subero J, Wiegers K, et al. Complex and Dynamic Chromosomal Rearrangements in a Family With Seemingly Non-Mendelian Inheritance of Dopa-Responsive Dystonia. JAMA Neurol. 2017;74:806-812 pubmed publisher
    ..The clinical management and diagnostics of such patients requires an interdisciplinary approach in modern clinical-diagnostic care. ..
  6. Canali S, Wang C, Zumbrennen Bullough K, Bayer A, Babitt J. Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6. Am J Hematol. 2017;92:1204-1213 pubmed publisher
    ..Together, these data demonstrate that in addition to BMP6, endothelial cell BMP2 has a non-redundant role in hepcidin regulation by iron. ..
  7. Lin S, Lee Y, Yu G, Cheng C, Zhou X, Chu K, et al. Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer. Dev Cell. 2017;41:467-480.e3 pubmed publisher
    ..Thus, tumor-induced EC-to-OSB conversion is one mechanism that leads to osteoblastic bone metastasis of PCa. ..
  8. Watanabe R, Shirai T, Namkoong H, Zhang H, Berry G, Wallis B, et al. Pyruvate controls the checkpoint inhibitor PD-L1 and suppresses T cell immunity. J Clin Invest. 2017;127:2725-2738 pubmed publisher
    ..pyruvate in mitochondria from CAD macrophages promoted expression of PD-L1 via induction of the bone morphogenetic protein 4/phosphorylated SMAD1/5/IFN regulatory factor 1 (BMP4/p-SMAD1/5/IRF1) signaling pathway...
  9. Nemashkalo A, Ruzo A, Heemskerk I, Warmflash A. Morphogen and community effects determine cell fates in response to BMP4 signaling in human embryonic stem cells. Development. 2017;144:3042-3053 pubmed publisher
    ..Using live cell imaging to correlate signaling histories with cell fates, we demonstrate that interactions between neighbors result in sustained, homogenous signaling necessary for differentiation. ..

More Information


  1. Dame K, Cincotta S, Lang A, Sanghrajka R, Zhang L, Choi J, et al. Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1. Stem Cell Reports. 2017;8:216-225 pubmed publisher
    ..Our findings demonstrate that NKX2-1 overexpression converts AFE to thyroid epithelium in a developmental time-sensitive manner and suggest a general methodology for manipulation of cell-fate decisions of developmental intermediates. ..
  2. Osmundsen A, Keisler J, Taketo M, Davis S. Canonical WNT Signaling Regulates the Pituitary Organizer and Pituitary Gland Formation. Endocrinology. 2017;158:3339-3353 pubmed publisher
  3. Penn M, Mausner Fainberg K, Golan M, Karni A. High serum levels of BMP-2 correlate with BMP-4 and BMP-5 levels and induce reduced neuronal phenotype in patients with relapsing-remitting multiple sclerosis. J Neuroimmunol. 2017;310:120-128 pubmed publisher
    ..These results suggest that BMP-2 sera levels may play a role in the failure of remyelination and neuro-regeneration in RR-MS. ..
  4. Liao K, Chang S, Chang H, Chien C, Huang T, Feng T, et al. Endothelial angiogenesis is directed by RUNX1T1-regulated VEGFA, BMP4 and TGF-?2 expression. PLoS ONE. 2017;12:e0179758 pubmed publisher
    ..Therefore, the discovery and application of pharmaceutical activators for RUNX1T1 will improve therapeutic efficacy toward ischemia by promoting neovascularization. ..
  5. Panaliappan T, Wittmann W, Jidigam V, Mercurio S, Bertolini J, Sghari S, et al. Sox2 is required for olfactory pit formation and olfactory neurogenesis through BMP restriction and Hes5 upregulation. Development. 2018;145: pubmed publisher
    ..Taken together, our results indicate that Sox2 is essential to establish, maintain and expand the neuronal progenitor pool by suppressing Bmp4 and upregulating Hes5 expression. ..
  6. Zhang P, Wang G, Lin Z, Wu Y, Zhang J, Liu M, et al. Alcohol exposure induces chick craniofacial bone defects by negatively affecting cranial neural crest development. Toxicol Lett. 2017;281:53-64 pubmed publisher
    ..In addition, ethanol affected the delamination, epithelial-mesenchymal transition (EMT) and cell migration of cranial NCCs, which may have contributed to the etiology of the craniofacial defects. ..
  7. Bohnenpoll T, Wittern A, Mamo T, Weiss A, Rudat C, Kleppa M, et al. A SHH-FOXF1-BMP4 signaling axis regulating growth and differentiation of epithelial and mesenchymal tissues in ureter development. PLoS Genet. 2017;13:e1006951 pubmed publisher
  8. Sallon C, Callebaut I, Boulay I, Fontaine J, Logeart Avramoglou D, Henriquet C, et al. Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells. J Biol Chem. 2017;292:15352-15368 pubmed publisher
    ..In conclusion, our findings provide new insights into the involvement of TSP-1 in the BMP-2/-4 mechanisms of action. ..
  9. Yokoyama Y, Watanabe T, Tamura Y, Hashizume Y, Miyazono K, Ehata S. Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorectal Cancer. Cancer Res. 2017;77:4026-4038 pubmed publisher
    ..Here, we demonstrate that expression of bone morphogenetic protein 4 (BMP-4) is universally upregulated in human colorectal cancer cells and tissues, resulting in activated ..
  10. Liu Y, Du S, Ding M, Dou X, Zhang F, Wu Z, et al. The BMP4-Smad signaling pathway regulates hyperandrogenism development in a female mouse model. J Biol Chem. 2017;292:11740-11750 pubmed publisher
    ..b>Bone morphogenetic protein 4 (BMP4) is an essential regulator of embryonic development and organ formation, and recent studies have ..
  11. Taghiyar L, Hesaraki M, Sayahpour F, Satarian L, Hosseini S, Aghdami N, et al. Msh homeobox 1 (Msx1)- and Msx2-overexpressing bone marrow-derived mesenchymal stem cells resemble blastema cells and enhance regeneration in mice. J Biol Chem. 2017;292:10520-10533 pubmed publisher
    ..We propose that Msx-transduced cells that can regenerate epithelial and mesenchymal tissues may potentially be utilized in limb regeneration. ..
  12. Modica S, Wolfrum C. The dual role of BMP4 in adipogenesis and metabolism. Adipocyte. 2017;6:141-146 pubmed publisher
    ..Besides this, Bmp4 seems to have a dual role in metabolism either promoting or repressing oxidative metabolism in a cell context dependent manner. ..
  13. Gustafson B, Hammarstedt A, Hedjazifar S, Smith U. Restricted adipogenesis in hypertrophic obesity: the role of WISP2, WNT, and BMP4. Diabetes. 2013;62:2997-3004 pubmed publisher
  14. Tojais N, Cao A, Lai Y, Wang L, Chen P, Alcazar M, et al. Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2017;37:1559-1569 pubmed publisher
    ..Disrupting BMPR2 impairs TGFβ1- and BMP4-mediated elastic fiber assembly and is of pathophysiologic significance in PAH. ..
  15. Li Y, Yang J, Zhang J, Liu J, Zheng Z, Hu D. BMP4 rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate: A meta-analysis. Medicine (Baltimore). 2017;96:e7676 pubmed publisher
    Previous studies have investigated the relationship between human bone morphogenetic protein 4 gene (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate (NSCL/P). However, the results remained inconsistent...
  16. Kwon H, Jia S, Lan Y, Liu H, Jiang R. Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis. J Dent Res. 2017;96:1145-1152 pubmed publisher