matrix metalloproteinase 7


Summary: The smallest member of the MATRIX METALLOPROTEINASES. It plays a role in tumor progression.

Top Publications

  1. Jang B, Jung H, Choi S, Lee Y, Lee S, Oh E. Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase C?-mediated FAK/ERK signaling pathway in colon cancer. J Biol Chem. 2017;292:16321-16332 pubmed publisher
    ..Taken together, these findings suggest that syndecan-2's cytoplasmic domain up-regulates MMP-7 expression in colon cancer cells via PKC?-mediated activation of FAK/ERK signaling. ..
  2. Kambayashi Y, Fujimura T, Furudate S, Asano M, Kakizaki A, Aiba S. The Possible Interaction between Receptor Activator of Nuclear Factor Kappa-B Ligand Expressed by Extramammary Paget Cells and its Ligand on Dermal Macrophages. J Invest Dermatol. 2015;135:2547-2550 pubmed publisher
  3. Yoshida K, Matsuyama R, Mori R, Kumamoto T, Matsuo K, Takeda K, et al. Immunohistochemical Comparison of Malignancy Between Radial Invasion and Mucosal Extension in Hilar Cholangiocarcinoma. Anticancer Res. 2017;37:5805-5812 pubmed
    ..To compare the cells of mucosal extension (ME) and radial invasion (RI) in hilar cholangiocarcinoma (HCCA) for optimal resection...
  4. Kaufmann B, Wang B, Zhong S, Laschinger M, Patil P, Lu M, et al. BRG1 promotes hepatocarcinogenesis by regulating proliferation and invasiveness. PLoS ONE. 2017;12:e0180225 pubmed publisher
    ..These results support the hypothesis that overexpression of BRG1 increases cell growth and invasiveness in HCC. Furthermore, the data highlight cyclin B, E and MMP7 to be associated with BRG1 during hepatocarcinogenesis. ..
  5. Brilha S, Wysoczanski R, Whittington A, Friedland J, Porter J. Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Are Regulated by Integrin ?V?3 in Mycobacterium tuberculosis Infection. J Immunol. 2017;199:982-991 pubmed publisher
    ..This leads to increased monocyte recruitment and collagenase activity, which will drive inflammatory tissue damage. ..
  6. Dong X, Liao W, Zhang L, Tu X, Hu J, Chen T, et al. RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway. Cancer Lett. 2017;402:153-165 pubmed publisher
  7. Liu J, Dai Y, Li X, Cao K, Xie D, Tong Z, et al. Solute carrier family 12 member 5 promotes tumor invasion/metastasis of bladder urothelial carcinoma by enhancing NF-κB/MMP-7 signaling pathway. Cell Death Dis. 2017;8:e2691 pubmed publisher
    ..Thus, SLC12A5 might be a prognostic marker as well as a therapeutic target for BUC. ..
  8. Guiot J, Henket M, Corhay J, Moermans C, Louis R. Sputum biomarkers in IPF: Evidence for raised gene expression and protein level of IGFBP-2, IL-8 and MMP-7. PLoS ONE. 2017;12:e0171344 pubmed publisher
    ..001) but not to HS. Our data show clear increase in expression and production of IGFBP-2, IL-8 and MMP-7 in sputum from patients with IPF that may contribute to the disease. ..
  9. López Boado Y, Wilson C, Hooper L, Gordon J, Hultgren S, Parks W. Bacterial exposure induces and activates matrilysin in mucosal epithelial cells. J Cell Biol. 2000;148:1305-15 pubmed
    ..These findings indicate that bacterial exposure is a potent and physiologically relevant signal regulating matrilysin expression in epithelial cells. ..

More Information


  1. Juchniewicz A, Kowalczuk O, Milewski R, Laudanski W, Dziegielewski P, Kozłowski M, et al. MMP-10, MMP-7, TIMP-1 and TIMP-2 mRNA expression in esophageal cancer. Acta Biochim Pol. 2017;64:295-299 pubmed publisher
    ..037). We conclude that in the resected esophageal cancer an increased mRNA expression of MMP-7, MMP-10 and TIMP-1 correlated with clinicopathologic features. We suggest that these genes may play a role during progression of the disease. ..
  2. Li W, Cui N, Mazzuca M, Mata K, Khalil R. Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-?. Am J Physiol Heart Circ Physiol. 2017;313:H491-H507 pubmed publisher
    ..The data suggest that targeting MMP-1 and MMP-7 and their upstream modulators, such as TNF-?, could provide a new approach in the management of hypertension in pregnancy and preeclampsia. ..
  3. Xu Y, Chen F, Zhang Y, Zhao Q, Guan X, Wang H, et al. The long noncoding RNA FOXCUT promotes proliferation and migration by targeting FOXC1 in nasopharyngeal carcinoma. Tumour Biol. 2017;39:1010428317706054 pubmed publisher
    ..and migration of nasopharyngeal carcinoma cell lines and resulted in downregulated expression of the matrix metalloproteinase 7 and matrix metalloproteinase 9, as well as vascular endothelial growth factor A and ?-catenin...
  4. Xu L, Hou Y, Tu G, Chen Y, Du Y, Zhang H, et al. Nuclear Drosha enhances cell invasion via an EGFR-ERK1/2-MMP7 signaling pathway induced by dysregulated miRNA-622/197 and their targets LAMC2 and CD82 in gastric cancer. Cell Death Dis. 2017;8:e2642 pubmed publisher
    ..Our findings suggest that nuclear Drosha potentially has a role in the development of GC. ..
  5. Chou A, Hsiao C, Shih T, Wang H, Tsai C, Chang W, et al. The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes in Breast Cancer in Taiwan. Anticancer Res. 2017;37:4973-4977 pubmed
  6. Yang X, Chen C, Teng S, Fu X, Zha Y, Liu H, et al. Urinary Matrix Metalloproteinase-7 Predicts Severe AKI and Poor Outcomes after Cardiac Surgery. J Am Soc Nephrol. 2017;28:3373-3382 pubmed publisher
    ..In conclusion, uMMP-7 is a promising predictor for severe AKI and poor in-hospital outcomes in patients after cardiac surgery. ..
  7. Jayakar S, Loudig O, Brandwein Gensler M, Kim R, Ow T, Ustun B, et al. Apolipoprotein E Promotes Invasion in Oral Squamous Cell Carcinoma. Am J Pathol. 2017;187:2259-2272 pubmed publisher
    ..Expression of matrix metalloproteinase 7 (MMP7), an AP-1 target, was also significantly decreased...
  8. Song N, Liu H, Ma X, Zhang S. Placental growth factor promotes metastases of ovarian cancer through MiR-543-regulated MMP7. Cell Physiol Biochem. 2015;37:1104-12 pubmed publisher
    ..MiR-543 inhibits translation of MMP7 through binding to the 3'-UTR of MMP7 mRNA in OC. PLGF suppresses miR-543, which activates MMP7-mediated cancer invasion. ..