matrix metalloproteinase 3


Summary: An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)

Top Publications

  1. Shlopov B, Lie W, Mainardi C, Cole A, Chubinskaya S, Hasty K. Osteoarthritic lesions: involvement of three different collagenases. Arthritis Rheum. 1997;40:2065-74 pubmed
    ..Retinoic acid, an agent which induces autodigestion of cartilage in vitro, stimulated only the expression of MMP-13. These findings suggest a key role of MMP-13 and MMP-8, as well as MMP-1 in osteoarthritis. ..
  2. Miyazawa K, Mori A, Okudaira H. Establishment and characterization of a novel human rheumatoid fibroblast-like synoviocyte line, MH7A, immortalized with SV40 T antigen. J Biochem. 1998;124:1153-62 pubmed
    ..Our results clearly indicate the usefulness of MH7A cells for investigating the regulation of rheumatoid FLSs and the IL-1 signal transduction pathway to develop future RA therapy. ..
  3. Calamia V, Lourido L, Fernández Puente P, Mateos J, Rocha B, Montell E, et al. Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties. Arthritis Res Ther. 2012;14:R202 pubmed publisher
    ..We have also provided novel evidences of its anti-angiogenic, anti-inflammatory, and anti-catabolic properties. Demonstration of the anti-angiogenic action of CS might provide a novel therapeutic approach for OA targeting. ..
  4. Wang F, Xu L, Feng X, Guo D, Tan W, Zhang M. Interleukin-29 modulates proinflammatory cytokine production in synovial inflammation of rheumatoid arthritis. Arthritis Res Ther. 2012;14:R228 pubmed publisher
  5. Pelletier J, Mineau F, Raynauld J, Woessner J, Gunja Smith Z, Martel Pelletier J. Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis. Arthritis Rheum. 1994;37:414-23 pubmed
    ..These findings provide additional evidence for the protective effect of corticosteroid injections on OA lesions, and indicate that the effect of this drug may be mediated through the suppression of stromelysin synthesis. ..
  6. Sun Y, Fan X, Zhang Q, Shi X, Xu G, Zou C. Cancer-associated fibroblasts secrete FGF-1 to promote ovarian proliferation, migration, and invasion through the activation of FGF-1/FGFR4 signaling. Tumour Biol. 2017;39:1010428317712592 pubmed publisher
    ..Therefore, this fibroblast growth factor-1/fibroblast growth factor receptor 4 axis may become a potential target for the treatment of ovarian cancer. ..
  7. Karpec D, Rudys R, Leonaviciene L, Mackiewicz Z, Bradunaite R, Kirdaite G, et al. The impact of high-dose narrowband ultraviolet A1 on dermal thickness, collagen and matrix-metalloproteinases in animal model of scleroderma. J Photochem Photobiol B. 2017;173:448-455 pubmed publisher
    ..002). Our study has demonstrated that a cumulative 365±5nm UVA1 radiation dosage of 1200J/cm2 not only prevents the progression of dermal fibrosis, but also induces a regression of pre-existing fibrotic changes. ..
  8. Lefèvre S, Schwarz M, Meier F, Zimmermann Geller B, Tarner I, Rickert M, et al. Disease-Specific Effects of Matrix and Growth Factors on Adhesion and Migration of Rheumatoid Synovial Fibroblasts. J Immunol. 2017;198:4588-4595 pubmed publisher
    ..Fibroblast adhesion and alterations in proinflammatory/prodestructive properties (e.g., IL-6/matrix metalloproteinase 3-release) in response to matrix-associated molecules were compared...
  9. Koyama Y, Ukita A, Abe K, Iwamae K, Tokuyama S, Tanaka K, et al. Dexamethasone Downregulates Endothelin Receptors and Reduces Endothelin-Induced Production of Matrix Metalloproteinases in Cultured Rat Astrocytes. Mol Pharmacol. 2017;92:57-66 pubmed publisher
    ..These results indicate that Dex downregulates astrocytic ET receptors and reduces ET-induced MMP production. ..

More Information


  1. Li N, Xu Q, Liu Q, Pan D, Jiang Y, Liu M, et al. Leonurine attenuates fibroblast-like synoviocyte-mediated synovial inflammation and joint destruction in rheumatoid arthritis. Rheumatology (Oxford). 2017;56:1417-1427 pubmed publisher
    ..Our findings show that leonurine reduces synovial inflammation and joint destruction in RA through the NF-κB and mitogen-activated protein kinases pathways. Leonurine has potential as a therapeutic agent for RA. ..
  2. Maccarana M, Svensson R, Knutsson A, Giannopoulos A, Pelkonen M, Weis M, et al. Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS ONE. 2017;12:e0184028 pubmed publisher
    ..Also, decorin and biglycan were doubled in Aspn-/- skin. Overall, asporin deficiency changes skin glycosaminoglycan composition, and decorin and biglycan content, which may explain the changes in skin mechanical properties. ..
  3. Bonaventura P, Lamboux A, Albaréde F, Miossec P. Regulatory effects of zinc on cadmium-induced cytotoxicity in chronic inflammation. PLoS ONE. 2017;12:e0180879 pubmed publisher
    ..Zinc counteracts the deleterious effect of Cd by reducing its import and accumulation in the cell, without the reactivation of destructive pathways such as MMPs. ..
  4. Deb S, Gottschall P. Increased production of matrix metalloproteinases in enriched astrocyte and mixed hippocampal cultures treated with beta-amyloid peptides. J Neurochem. 1996;66:1641-7 pubmed
    ..In addition, both cultures express MMP-3 (stromelysin-1) in response to A beta peptides. These results suggest that MMPs may play a role in the development or progression of neuritic plaques, i.e., abnormal neurite outgrowth. ..
  5. Kizaki K, Yoshizumi Y, Takahashi T, Era S. Elevated oxidative stress monitored via the albumin-thiol redox state is correlated with matrix metalloproteinase-3 elevation in patients with rheumatoid arthritis. Clin Lab. 2015;61:175-8 pubmed
    ..52). DAS-28 and CRP were also correlated with the percentage of oxidized albumin-thiol (r = 0.46, r = 0.44). The albumin-thiol redox state was significantly oxidized in correlation with serum MMP-3 elevation in RA. ..
  6. Cao Y, Wei P, Bailey M, Kauwe J, Maxwell T. A versatile omnibus test for detecting mean and variance heterogeneity. Genet Epidemiol. 2014;38:51-59 pubmed
  7. Padala C, Tupurani M, Puranam K, Gantala S, Shyamala N, Kondapalli M, et al. Synergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer. PLoS ONE. 2017;12:e0184448 pubmed publisher
    ..The interactions of MMPs clinical risk factors such as lymph node involvement has shown a strong correlation and might influence the 5-years survival rate, suggesting their potential role in the breast carcinogenesis. ..
  8. Sasaki K, Hattori T, Fujisawa T, Takahashi K, Inoue H, Takigawa M. Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. J Biochem. 1998;123:431-9 pubmed
  9. Peeters S, Engelen L, Buijs J, Chaturvedi N, Fuller J, Schalkwijk C, et al. Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study. Cardiovasc Diabetol. 2015;14:31 pubmed publisher
    ..These data support the hypothesis that impaired regulation of matrix remodeling by actions of MMP-2, -3 and-10 and TIMP-1 contributes to the pathogenesis of vascular complications in type 1 diabetes. ..
  10. Huang W, Ao P, Li J, Wu T, Xu L, Deng Z, et al. Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes. Biomed Res Int. 2017;2017:6341919 pubmed publisher
    ..We therefore demonstrated that autophagy is linked with AGE-related pathology in rat chondrocytes and plays a protective role in AGE-induced apoptosis and expression of MMP-3 and MMP-13. ..
  11. Kondo A, Nonaka A, Shimamura T, Yamamoto S, Yoshida T, Kodama T, et al. Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation. Mol Cell Biol. 2017;37: pubmed publisher
    ..Our results provide evidence that increased JHDM1D-AS1 expression under nutrient starvation accelerates tumor growth by upregulating angiogenesis, thus laying the foundation for improved therapeutic strategies. ..
  12. Yokoyama W, Kohsaka H, Kaneko K, Walters M, Takayasu A, Fukuda S, et al. Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice. Arthritis Res Ther. 2014;16:445 pubmed publisher
    ..The interaction between CCL25 and CCR9 may play important roles in cell infiltration into the RA synovial tissues and inflammatory mediator production. Blocking CCL25 or CCR9 may represent a novel safe therapy for RA. ..
  13. McCracken B, Spurlock M, Roos M, Zuckermann F, Gaskins H. Weaning anorexia may contribute to local inflammation in the piglet small intestine. J Nutr. 1999;129:613-9 pubmed
    ..Together the results indicate that inadequate feed intake during the immediate postweaning period may contribute to intestinal inflammation and thereby compromise villus-crypt structure and function. ..
  14. Ikeda K, Watanabe K, Hirai T, Tanji K, Miyashita T, Nakajima S, et al. Mizoribine Synchronized Methotrexate Therapy should be Considered when Treating Rheumatoid Arthritis Patients with an Inadequate Response to Various Combination Therapies. Intern Med. 2017;56:1147-1152 pubmed publisher
  15. Fan P, He L, Hu N, Luo J, Zhang J, Mo L, et al. Effect of 1,25-(OH)2D3 on Proliferation of Fibroblast-Like Synoviocytes and Expressions of Pro-Inflammatory Cytokines through Regulating MicroRNA-22 in a Rat Model of Rheumatoid Arthritis. Cell Physiol Biochem. 2017;42:145-155 pubmed publisher
    ..Our study demonstrated that 1,25-(OH)2D3 inhibits the proliferation of FLS and alleviates inflammatory response in RA rats by down-regulating miR-22. ..
  16. Jia C, Zhang F, Zhu Y, Qi X, Wang Y. Public data mining plus domestic experimental study defined involvement of the old-yet-uncharacterized gene matrix-remodeling associated 7 (MXRA7) in physiopathology of the eye. Gene. 2017;632:43-49 pubmed publisher
  17. Krueger F, Kappert K, Foryst Ludwig A, Kramer F, Clemenz M, Grzesiak A, et al. AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice. Clin Sci (Lond). 2017;131:1989-2005 pubmed publisher
    ..The HFD-induced vascular pathology was reduced by AT1-receptor antagonist telmisartan. ..
  18. Lauridsen H, Pellowe A, Ramanathan A, Liu R, Miller Jensen K, McNiff J, et al. Tumor Necrosis Factor-? and IL-17A Activation Induces Pericyte-Mediated Basement Membrane Remodeling in Human Neutrophilic Dermatoses. Am J Pathol. 2017;187:1893-1906 pubmed publisher
    ..These data indicate that pericyte-neutrophil interactions play a role in mediating microvascular changes in SS and suggest that targeting MMP-3 may be effective in protecting vascular wall integrity. ..
  19. Caria C, Gotardo E, Santos P, Acedo S, de Morais T, Ribeiro M, et al. Extracellular matrix remodeling and matrix metalloproteinase inhibition in visceral adipose during weight cycling in mice. Exp Cell Res. 2017;359:431-440 pubmed publisher
    ..Our results suggest that MMPs inhibition could be an interesting target to improve adipose tissue inflammation during WL and to support weight cyclers. ..
  20. Loupasakis K, Kuo D, Sokhi U, Sohn C, Syracuse B, Giannopoulou E, et al. Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes. PLoS ONE. 2017;12:e0179762 pubmed publisher
    ..These results provide the first insights into genome-wide regulation of mRNA stability in RA FLS and highlight the potential contribution of dynamic regulation of the mRNA stabilome by TNF to chronic synovitis. ..
  21. Lassig A, Joseph A, Lindgren B, Yueh B. Association of Oral Cavity and Oropharyngeal Cancer Biomarkers in Surgical Drain Fluid With Patient Outcomes. JAMA Otolaryngol Head Neck Surg. 2017;143:670-678 pubmed publisher
    ..Survival rates for head and neck cancer have been relatively stable for several decades. Individualized prognostic indicators are needed to identify patients at risk for poorer outcomes...
  22. Elayyan J, Lee E, Gabay O, Smith C, Qiq O, Reich E, et al. LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes. FASEB J. 2017;31:3116-3125 pubmed publisher
    ..Elayyan, J., Lee, E.-J., Gabay, O., Smith, C. A., Qiq, O., Reich, E., Mobasheri, A., Henrotin, Y., Kimber, S. J., Dvir-Ginzberg, M. LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes. ..
  23. Li P, Gan Y, Wang H, Xu Y, Song L, Zhang C, et al. Biological Responses of the Immature Annulus Fibrosus to Dynamic Compression in a Disc Perfusion Culture. Cells Tissues Organs. 2016;202:296-306 pubmed
  24. Segura A, Luna R, Horiba K, Stetler Stevenson W, McAllister H, Willerson J, et al. Immunohistochemistry of matrix metalloproteinases and their inhibitors in thoracic aortic aneurysms and aortic valves of patients with Marfan's syndrome. Circulation. 1998;98:II331-7; discussion II337-8 pubmed
  25. Miwa Y, Takahashi R, Ikari Y, Maeoka A, Nishimi S, Oguro N, et al. Clinical Characteristics of Rheumatoid Arthritis Patients Achieving Functional Remission with Six Months of Biological DMARDs Treatment. Intern Med. 2017;56:903-906 pubmed publisher
    ..Conclusion These findings suggested that RA patients with lower HAQ-DI and lower depression scores at baseline were more likely to achieve functional remission using bDMARDs treatment than those without these variables. ..
  26. Yoon S, Armstrong B, Habib N, Rossi J. Blind SELEX Approach Identifies RNA Aptamers That Regulate EMT and Inhibit Metastasis. Mol Cancer Res. 2017;15:811-820 pubmed publisher
    ..b>Implications: This study reveals that anti-vimentin RNA aptamers selected via blind-SELEX inhibit the tumor cell metastasis. Mol Cancer Res; 15(7); 811-20. ©2017 AACR. ..
  27. Wang C, Guo L, Tian F, An N, Luo L, Hao R, et al. Naringenin regulates production of matrix metalloproteinases in the knee-joint and primary cultured articular chondrocytes and alleviates pain in rat osteoarthritis model. Braz J Med Biol Res. 2017;50:e5714 pubmed publisher
    ..Thus, naringenin could be a potent therapeutic option for the treatment of osteoarthritis. ..
  28. Aoshima M, Ito T, Tokura Y. Erosive pustular dermatosis of the scalp arising concomitantly with elevation of serum matrix metalloproteinase-3 in a patient with rheumatoid arthritis. J Dermatol. 2015;42:540-1 pubmed publisher
  29. Wu Y, Bu J, Yang Y, Lin X, Cai X, Huang C, et al. Therapeutic Effect of MK2 Inhibitor on Experimental Murine Dry Eye. Invest Ophthalmol Vis Sci. 2017;58:4898-4907 pubmed publisher
    ..To investigate the role of mitogen-activated protein kinase-activated protein kinase-2 (MK2) in ocular surface damage of dry eye...