matrix metalloproteinase 12


Summary: A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a role in INFLAMMATION and WOUND HEALING.

Top Publications

  1. Wolf M, Maltseva I, Clay S, Pan P, Gajjala A, Chan M. Effects of MMP12 on cell motility and inflammation during corneal epithelial repair. Exp Eye Res. 2017;160:11-20 pubmed publisher
    ..These data support a role of MMP12 in promoting early repair processes following corneal epithelial injury by enhancing epithelial cell migration and neutrophil infiltration. ..
  2. Caria C, Gotardo E, Santos P, Acedo S, de Morais T, Ribeiro M, et al. Extracellular matrix remodeling and matrix metalloproteinase inhibition in visceral adipose during weight cycling in mice. Exp Cell Res. 2017;359:431-440 pubmed publisher
    ..Our results suggest that MMPs inhibition could be an interesting target to improve adipose tissue inflammation during WL and to support weight cyclers. ..
  3. Wang J, Wei G, Hu W, Li L, Ye Y, Wang H, et al. Expression of matrix metalloproteinases-12 in ST-segment elevation myocardial infarction: A case-control study. Medicine (Baltimore). 2017;96:e8035 pubmed publisher
    ..05).This study demonstrated that MMP12 exists in human coronary thrombus. Patients with STEMI have elevated plasma level of MMP12 and the imbalance of MMP12/TIMP1. These data supported that MMP12 might be of potential relevance in STEMI. ..
  4. Matsye P, Zheng L, Si Y, Kim S, Luo W, Crossman D, et al. HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases. Glia. 2017;65:945-963 pubmed publisher
    ..These findings underscore an important role for HuR in sculpting the molecular signature and phenotype of activated microglia, and as a possible therapeutic target in ALS and other neurodegenerative diseases. ..
  5. Fujimura T, Kakizaki A, Sato Y, Tanita K, Furudate S, Aiba S. The Immunological Roles of Periostin/Tumor-Associated Macrophage Axis in Development of Dermatofibrosarcoma Protuberans. Anticancer Res. 2017;37:2867-2873 pubmed
    ..Increased levels of MMP1 and MMP12 on TAMs in the peripheral areas of DFSP might contribute to local invasion. ..
  6. Krueger F, Kappert K, Foryst Ludwig A, Kramer F, Clemenz M, Grzesiak A, et al. AT1-receptor blockade attenuates outward aortic remodeling associated with diet-induced obesity in mice. Clin Sci (Lond). 2017;131:1989-2005 pubmed publisher
    ..The HFD-induced vascular pathology was reduced by AT1-receptor antagonist telmisartan. ..
  7. Tacheva T, Dimov D, Aleksandrova E, Bialecka M, Gulubova M, Vlaykova T. The G allele of MMP12 -82 A?>?G promoter polymorphism as a protective factor for COPD in Bulgarian population. Arch Physiol Biochem. 2017;123:371-376 pubmed publisher
    ..682, p?=?.002). Our results suggest that carriers of genotypes with at least one copy of minor G allele of rs2276109 might have lower risk for COPD development, with no marked effect on the lung function and severity of the disease. ..
  8. Ehling J, Bartneck M, Fech V, Butzbach B, CESATI R, Botnar R, et al. Elastin-based molecular MRI of liver fibrosis. Hepatology. 2013;58:1517-8 pubmed publisher
  9. Dandachi N, Shapiro S. A protean protease: MMP-12 fights viruses as a protease and a transcription factor. Nat Med. 2014;20:470-2 pubmed publisher

More Information


  1. Mahdessian H, Perisic Matic L, Lengquist M, Gertow K, Sennblad B, Baldassarre D, et al. Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke. J Intern Med. 2017;282:429-444 pubmed publisher
    ..Our study supports the notion that MMP12 is implicated in large-artery atherosclerotic stroke, functionally by enhancing elastin degradation and macrophage invasion in plaques. ..
  2. Xu J, Tao B, Guo X, Zhou S, Li Y, Zhang Y, et al. Macrophage-Restricted Shp2 Tyrosine Phosphatase Acts as a Rheostat for MMP12 through TGF-? Activation in the Prevention of Age-Related Emphysema in Mice. J Immunol. 2017;199:2323-2332 pubmed publisher
    ..Together, our findings define a novel physiological function of Shp2 in TGF-?1/MMP12-dependent emphysema, adding insights into potential etiologies for this chronic lung disorder. ..