Summary: A member of the epidermal growth factor (EGF) family of peptide growth factors that is synthesized as a transmembrane protein which can be cleaved to release a soluble active form. Epiregulin has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR.
Kohsaka S, Hinohara K, Wang L, Nishimura T, Urushido M, Yachi K, et al
. Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastoma. Neuro Oncol. 2014;16:960-70 pubmed
..Adipocyte enhancer binding protein 1, epiregulin (EREG), and microfibrillar associated protein 5 were identified as candidate genes associated with higher tumor ..
Xu X, Chen W, Leng S, Padilla M, Saxton B, Hutt J, et al
. Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop. Carcinogenesis. 2017;38:604-614 pubmed publisher
..The EGFR/AKT pathway was unexpectedly activated, and expression of the EGFR ligand epiregulin (EREG) was increased in the lung tissues of the Muc1 KO compared to the WT mice...
Morimoto A, Kannari M, Tsuchida Y, Sasaki S, Saito C, Matsuta T, et al
. An HNF4?-microRNA-194/192 signaling axis maintains hepatic cell function. J Biol Chem. 2017;292:10574-10585 pubmed publisher
..leukocyte cell adhesion molecule (Alcam
)), tumorigenesis and tumor progression (Rap2b
)), protein SUMOylation (Sumo2
), epigenetic regulation (Setd5
and Cullin 4B (Cln4b
Hennenberg E, Eyking A, Reis H, Cario E. MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis. PLoS ONE. 2017;12:e0180834 pubmed publisher
..In conclusion, we provide first evidence that loss of ABCB1/MDR1 function may represent an essential tumor-suppressive host defense mechanism in CAC. ..
Martin L, Smith S, Khoutorsky A, Magnussen C, Samoshkin A, Sorge R, et al
. Epiregulin and EGFR interactions are involved in pain processing. J Clin Invest. 2017;127:3353-3366 pubmed publisher
..In the present study, we have demonstrated a role for EGFR and its natural ligand, epiregulin (EREG), in pain processing...
Freed D, Bessman N, Kiyatkin A, Salazar Cavazos E, Byrne P, Moore J, et al
. EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell. 2017;171:683-695.e18 pubmed publisher
..Using crystallography and other approaches, we show how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region...