tumor necrosis factor ligand superfamily member 15


Summary: A member of tumor necrosis factor superfamily found on ENDOTHELIAL CELLS that plays a role in the inhibition of endothelial cell growth and PHYSIOLOGIC ANGIOGENESIS.

Top Publications

  1. Lan X, Lan X, Chang Y, Zhang X, Liu J, Vikash V, et al. Identification of Two Additional Susceptibility Loci for Inflammatory Bowel Disease in a Chinese Population. Cell Physiol Biochem. 2017;41:2077-2090 pubmed publisher
    ..Most importantly, we found that ZMIZ1 expression was markedly higher in both IBD patients and mice with experimentally induced colitis, suggesting that ZMIZ1 plays important roles in the pathogenesis of IBD. ..
  2. Connelly T, Choi C, Berg A, Harris L, Coble J, Koltun W. Diverticulitis and Crohn's disease have distinct but overlapping tumor necrosis superfamily 15 haplotypes. J Surg Res. 2017;214:262-269 pubmed publisher
    ..This study strengthens the role for a genetic predisposition to diverticulitis that involves the TNFSF15 gene. ..
  3. Zhao Q, Deng X, Hong B, Wang F, Tang X, Yang Y, et al. Protein of Vascular Endothelial Growth Inhibitor 174 Inhibits Epithelial-Mesenchymal Transition in Renal Cell Carcinoma In Vivo. Anticancer Res. 2017;37:4269-4275 pubmed
    ..Our findings indicate that VEGI174 prevents progression and tumor metastasis through inhibiting EMT in RCC in vivo. This may provide a new approach for the treatment of RCC. ..
  4. Zhao Q, Kun D, Hong B, Deng X, Guo S, Tang X, et al. Identification of Novel Proteins Interacting with Vascular Endothelial Growth Inhibitor 174 in Renal Cell Carcinoma. Anticancer Res. 2017;37:4379-4388 pubmed
    ..AKR1C3 was a new factor that may correlate with the progression of RCC. The results indicated that VEGI174 has more functions than we currently know in the development and progression of RCC. ..