tumor necrosis factor ligand superfamily member 14


Summary: A member of tumor necrosis factor superfamily found on activated LYMPHOCYTES and MONOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to LYMPHOTOXIN BETA RECEPTOR and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14.

Top Publications

  1. Lee E, Kim E, Ji K, Park A, Choi H, Lee H, et al. Axl acts as a tumor suppressor by regulating LIGHT expression in T lymphoma. Oncotarget. 2017;8:20645-20655 pubmed publisher
    ..These data strongly suggested that Axl exerts novel tumor suppressor effects by inducing upregulation of LIGHT in the tumor microenvironment of T lymphoma. ..
  2. Yuan X, Gu Y, Lai X, Gu Q. LIGHT is increased in patients with coronary disease and regulates inflammatory response and lipid metabolism in oxLDL-induced THP-1 macrophages. Biochem Biophys Res Commun. 2017;490:732-738 pubmed publisher
    ..Taken together our study has demonstrated that LIGHT NF-?B-dependently exacerbates inflammation response and promotes lipid accumulation, and provided a new potential target for treatment of hyperlipidemia-related disease. ..
  3. Johansson Percival A, He B, Li Z, Kjellén A, Russell K, Li J, et al. De novo induction of intratumoral lymphoid structures and vessel normalization enhances immunotherapy in resistant tumors. Nat Immunol. 2017;18:1207-1217 pubmed publisher